RESUMEN
The effects of neuropharmacological agents on the motility of irradiated and non-irradiated Angiostrongylus cantonensis adult females were studied. GABA induced complete paralysis in non-irradiated and 5,000 R-irradiated worms, but caused only slight paralysis on 10,000 R-irradiated worms. The paralytic effect of GABA was antagonised by picrotoxin. The reason for low susceptibility of heavily irradiated worms to GABA is not known. There was no difference in susceptibility of non-irradiated and irradiated worms to other neuropharmacological agents including eserine, phenylephrine and dibenamine.
Asunto(s)
Angiostrongylus/efectos de la radiación , Fármacos del Sistema Nervioso Autónomo/farmacología , Convulsivantes/farmacología , Metastrongyloidea/efectos de la radiación , Angiostrongylus/efectos de los fármacos , Angiostrongylus/fisiología , Animales , Dibencilcloretamina/farmacología , Femenino , Rayos gamma , Larva/efectos de la radiación , Masculino , Movimiento/efectos de los fármacos , Fenilefrina/farmacología , Fisostigmina/análogos & derivados , Fisostigmina/farmacología , Picrotoxina/farmacología , Ratas , Ratas Endogámicas , Estricnina/farmacología , Ácido gamma-Aminobutírico/farmacologíaRESUMEN
Effects of gamma ray irradiation on the first-stage larvae of Angiostrongylus cantonensis were studied. Compared to the non-treated controls, infection of rats with third-stage larvae which developed from irradiated first-stage larvae resulted in reduced recovery rates of adults. There was also a change in the male-female adult worm ratio and a reduction in larval output per female in relation to increasing irradiation dosage. Morphological changes in the adults were noted.
Asunto(s)
Angiostrongylus/efectos de la radiación , Fertilidad/efectos de la radiación , Metastrongyloidea/efectos de la radiación , Angiostrongylus/crecimiento & desarrollo , Angiostrongylus/fisiología , Animales , Biomphalaria , Femenino , Rayos gamma , Larva , Pulmón/parasitología , Masculino , RatasRESUMEN
Effects of gamma-ray irradiation on the first-stage larvae of Angiostrongylus cantonensis were studied. There was a significant reduction in the infectivity of the 10,000 R-irradiated larvae to intermediate host snails compared to other groups. In the final host infection, both the worm populations and worm body length of irradiated groups differed markedly from those of the non-irradiated control.