Cultura sanitaria sobre hábitos bucales deformantes relacionados con el micrognatismo transversal superior. Escuela Ciro Redondo, 2017 / Sanitary culture on buccal deforming habits related with the superior transverse micrognatismo. School Ciro Redondo. 2017

Introducción: la salud bucal es parte integrante de la salud general, pues un individuo no puede considerarse completamente sano si existe presencia activa de enfermedad bucal. Objetivo: describir la cultura sanitaria sobre hábitos bucales deformantes relacionados con el micrognatismo transversal superior en escolares y padres de Cuarto Grado de la Escuela Ciro Redondo durante el año 2017. Método: se realizó un estudio de tipo descriptivo transversal sobre hábitos bucales deformantes relacionados con el micrognatismo transversal superior. El universo estuvo constituido por 112 estudiantes de 4to grado de la Escuela Ciro Redondo del municipio Bayamo, en el 2017. Todos formaron parte del estudio. Las variables estudiadas fueron: nivel de conocimiento, necesidades de aprendizaje, hábitos bucales deformantes y micrognatismo transversal superior, apoyados en métodos teóricos, empíricos y estadísticos. Resultados: el nivel de conocimiento fue inadecuado: 67,85 por ciento en escolares y 81,25 por ciento en padres, relacionado con las necesidades de aprendizaje sobre los hábitos: empuje lingual, respiración bucal, succión digital y posturas inadecuadas. El 100 por ciento presentó hábitos bucales deformantes, de ellos el 40,18 por ciento con micrognatismo transversal superior, predominando el sexo femenino. Conclusiones: el nivel de conocimiento fue inadecuado, con ligero predominio en el sexo femenino del micrognatismo transversal superior y la inadecuada cultura sanitaria en pacientes con hábitos deformantes(AU)

Introduction: oral health is an integral part of general health, because an individual can not be considered completely healthy if there is an active presence of oral disease. Objective: to describe the sanitary culture on deforming oral habits related to the superior transverse micrognathism in school children and Fourth Grade parents of the Ciro Redondo School during the year 2017. Method: a cross-sectional descriptive study on deforming buccal habits related to superior transverse micrognathism was carried out. The universe was constituted by 112 students of 4th grade of the School Ciro Redondo of the Bayamo municipality, in 2017. They were all part of the study. The variables studied were: level of knowledge, learning needs, deforming oral habits and superior transverse micrognathism, supported by theoretical, empirical and statistical methods. Results: the level of knowledge was inadequate: 67.85 percent in school children and 81.25 percent in parents, related to the learning needs on habits: tongue thrust, mouth breathing, digital suction and inadequate postures. The 100 percent presented deforming oral habits, of them 40.18 percent with superior transverse micrognathism, predominantly female. Conclusions: the level of knowledge was inadequate, with a slight predominance in the female sex of the superior transverse micrognathism and the inadequate sanitary culture in patients with deforming habits(EU)

Relación entre hábitos bucales deformantes y el micrognatismo transversal / Relationship between deforming oral habits and transverse micrognathism

Introducción: el micrognatismo transversal comprende alteraciones del crecimiento, desarrollo y fisiologismo de los componentes anatómicos que conforman el sistema estomatognático, los hábitos bucales son factores de riesgo en su instalación. Objetivo: evaluar la relación entre hábitos bucales deformantes y el micrognatismo transversal. Método: se realizó un estudio observacional analítico transversal de tipo caso-control en pacientes que ingresaron en la consulta de ortodoncia de la Clínica Universitaria de Especialidades Estomatológicas Manuel Cedeño, entre mayo y diciembre de 2017. La muestra fue de 55 pacientes entre las edades de 7 a 12 años, que cumplieron con los criterios de inclusión. Resultados: la respiración bucal, succión digital, empuje lingual y el uso del biberón, resultaron factores de riesgo en la aparición del micrognatismo transversal con p= 0,0079, p= 0,0029, p= 0,0000 y p= 0,0343; respectivamente. Conclusiones: existe una relación entre la respiración bucal, succión digital, empuje lingual y el uso del biberón como factores etiológicos en la instalación del micrognatismo transversal(AU)

Introduction: transversal micrognathism includes alterations in the growth, development and physiology of the anatomical components that make up the stomatognathic system, oral habits are risk factors in their installation. Objective: to evaluate the relationship between deforming oral habits and transverse micrognathism. Method: a cross-sectional analytical observational study of case-control type was performed in patients admitted to the orthodontic clinic of the University Clinic of Stomatological Specialties Manuel Cedeño, between May and December 2017. The sample consisted of 55 patients between the ages of 7 to 12 years, who met the inclusion criteria. Results: mouth breathing, digital suction, tongue thrust and use of the bottle were factors of risk in the appearance of transversal micrognathism with p = 0.0079, p = 0.0029, p = 0.0000 and p = 0.0343; respectively. Conclusions: there is a relationship between mouth breathing, digital suction, tongue thrust and bottle feeding as etiological factors in the installation of transverse micrognathism(EU)

Micro-CT Imaging Reveals Mekk3 Heterozygosity Prevents Cerebral Cavernous Malformations in Ccm2-Deficient Mice.

Mutations in CCM1 (aka KRIT1), CCM2, or CCM3 (aka PDCD10) gene cause cerebral cavernous malformation in humans. Mouse models of CCM disease have been established by deleting Ccm genes in postnatal animals. These mouse models provide invaluable tools to investigate molecular mechanism and therapeutic approaches for CCM disease. However, the full value of these animal models is limited by the lack of an accurate and quantitative method to assess lesion burden and progression. In the present study we have established a refined and detailed contrast enhanced X-ray micro-CT method to measure CCM lesion burden in mouse brains. As this study utilized a voxel dimension of 9.5µm (leading to a minimum feature size of approximately 25µm), it is therefore sufficient to measure CCM lesion volume and number globally and accurately, and provide high-resolution 3-D mapping of CCM lesions in mouse brains. Using this method, we found loss of Ccm1 or Ccm2 in neonatal endothelium confers CCM lesions in the mouse hindbrain with similar total volume and number. This quantitative approach also demonstrated a rescue of CCM lesions with simultaneous deletion of one allele of Mekk3. This method would enhance the value of the established mouse models to study the molecular basis and potential therapies for CCM and other cerebrovascular diseases.