RESUMEN
Herbal agents are increasingly used for medicinal purposes, but there is a lack of knowledge about the content of these agents. Indiscriminate use of herbal agents may cause severe side effects and also death. We report a newborn who developed convulsions and respiratory arrest after oral intake of an opium poppy preparation containing papaverine for its antitussive effect. The infant experienced a good outcome with supportive treatment. To the best of our knowledge, this is the first time a newborn with papaverine intoxication has been described. Parents should avoid self-medication of their children, and the possibility of exposure to foreign products should be kept in mind in any seizure of a newborn with unexplained origin.
Asunto(s)
Papaverina/envenenamiento , Convulsiones/inducido químicamente , Electroencefalografía , Femenino , Humanos , Recién Nacido , Convulsiones/diagnóstico , Vasodilatadores/envenenamientoRESUMEN
OBJECTIVE: To observe the expression of Bcl-2 and Bax proteins in rat's myocardial cells after Macleaya cordata alkaloids poisoning, and to provide certain molecular biology references for the detection of Macleaya cordata alkaloids poisoning. METHODS: Experimental model of Macleaya cordata alkaloids poisoning was established, the expression levels of Bcl-2 and Bax proteins in these cells were detected by immunohistochemistry, and the results were analyzed by computer image system. RESULTS: The expression levels of Bcl-2 and Bax proteins in myocardial cells in poisoning groups were much greater than those in the control groups (P<0.05). CONCLUSION: If the clinical symptoms may not be obvious, the detection of Bcl-2 and Bax proteins level by immunohistochemistry still could be ancillary method.
Asunto(s)
Miocardio/patología , Miocitos Cardíacos/metabolismo , Papaveraceae/química , Papaverina/envenenamiento , Proteínas Proto-Oncogénicas c-bcl-2/metabolismo , Proteína X Asociada a bcl-2/metabolismo , Animales , Modelos Animales de Enfermedad , Femenino , Inmunohistoquímica , Masculino , Miocardio/metabolismo , Miocitos Cardíacos/patología , Papaverina/administración & dosificación , Ratas , Ratas Sprague-Dawley , Coloración y Etiquetado , Factores de TiempoRESUMEN
OBJECTIVE@#To observe the expression of Bcl-2 and Bax proteins in rat's myocardial cells after Macleaya cordata alkaloids poisoning, and to provide certain molecular biology references for the detection of Macleaya cordata alkaloids poisoning.@*METHODS@#Experimental model of Macleaya cordata alkaloids poisoning was established, the expression levels of Bcl-2 and Bax proteins in these cells were detected by immunohistochemistry, and the results were analyzed by computer image system.@*RESULTS@#The expression levels of Bcl-2 and Bax proteins in myocardial cells in poisoning groups were much greater than those in the control groups (P<0.05).@*CONCLUSION@#If the clinical symptoms may not be obvious, the detection of Bcl-2 and Bax proteins level by immunohistochemistry still could be ancillary method.
Asunto(s)
Animales , Femenino , Masculino , Ratas , Modelos Animales de Enfermedad , Inmunohistoquímica , Miocardio/patología , Miocitos Cardíacos/patología , Papaveraceae/química , Papaverina/envenenamiento , Proteínas Proto-Oncogénicas c-bcl-2/metabolismo , Ratas Sprague-Dawley , Coloración y Etiquetado , Factores de Tiempo , Proteína X Asociada a bcl-2/metabolismoRESUMEN
OBJECTIVE: To observe pathological changes and apoptosis in rats myocardial cells after Macleaya cordata total alkaloids poisoning, and to provide some references for Macleaya cordata total alkaloids poisoning detection. METHODS: An experimental model of Macleaya cordata total alkaloids poisoning was established, and the technology of TUNEL staining was used.The results were analyzed by computer image analysis competitive system. RESULTS: Quantities of apoptosis in myocardial cells in poisoning groups were much more than those in the control groups at different tages (P<0.01). In addition the quantities of apoptosis were different after different poisoning duration. CONCLUSION: Although clinical symptoms was not obvious and could not be detected by poison analysis. Pathological changes induced by Macleaya cordata total alkaloids could be found through the apoptosis detection.
Asunto(s)
Apoptosis/efectos de los fármacos , Miocardio/patología , Miocitos Cardíacos/efectos de los fármacos , Papaveraceae/química , Papaverina/envenenamiento , Enfermedad Aguda , Animales , Recuento de Células , Modelos Animales de Enfermedad , Femenino , Inmunohistoquímica , Etiquetado Corte-Fin in Situ , Masculino , Papaverina/administración & dosificación , Distribución Aleatoria , Ratas , Ratas Sprague-Dawley , Coloración y Etiquetado , Factores de TiempoRESUMEN
OBJECTIVE@#To observe pathological changes and apoptosis in rats myocardial cells after Macleaya cordata total alkaloids poisoning, and to provide some references for Macleaya cordata total alkaloids poisoning detection.@*METHODS@#An experimental model of Macleaya cordata total alkaloids poisoning was established, and the technology of TUNEL staining was used.The results were analyzed by computer image analysis competitive system.@*RESULTS@#Quantities of apoptosis in myocardial cells in poisoning groups were much more than those in the control groups at different tages (P<0.01). In addition the quantities of apoptosis were different after different poisoning duration.@*CONCLUSION@#Although clinical symptoms was not obvious and could not be detected by poison analysis. Pathological changes induced by Macleaya cordata total alkaloids could be found through the apoptosis detection.
Asunto(s)
Animales , Femenino , Masculino , Ratas , Enfermedad Aguda , Apoptosis/efectos de los fármacos , Recuento de Células , Modelos Animales de Enfermedad , Inmunohistoquímica , Etiquetado Corte-Fin in Situ , Miocardio/patología , Miocitos Cardíacos/efectos de los fármacos , Papaveraceae/química , Papaverina/envenenamiento , Distribución Aleatoria , Ratas Sprague-Dawley , Coloración y Etiquetado , Factores de TiempoAsunto(s)
Bronquiolitis Obliterante/etiología , Intoxicación por Plantas/etiología , Verduras/efectos adversos , Relación Ventilacion-Perfusión , Adulto , Bronquiolitis Obliterante/diagnóstico , Bronquiolitis Obliterante/fisiopatología , Femenino , Humanos , Pulmón/diagnóstico por imagen , Papaverina/envenenamiento , Intoxicación por Plantas/diagnóstico , Intoxicación por Plantas/fisiopatología , Cintigrafía , Agregado de Albúmina Marcado con Tecnecio Tc 99m , Pentetato de Tecnecio Tc 99m , Pérdida de PesoAsunto(s)
Antiinfecciosos/análisis , Medicina Legal/métodos , Nitrofurazona/análisis , Papaverina/análogos & derivados , Parasimpatolíticos/análisis , Antiinfecciosos/envenenamiento , Cadáver , Cromatografía en Capa Delgada/métodos , Humanos , Nitrofurazona/envenenamiento , Papaverina/análisis , Papaverina/envenenamiento , Parasimpatolíticos/envenenamiento , Intoxicación/diagnóstico , Espectrofotometría Ultravioleta/métodos , ComprimidosAsunto(s)
Hernia Inguinal/tratamiento farmacológico , Papaverina/envenenamiento , Enfermedad Crónica , Humanos , Lactante , Sulfato de Magnesio/administración & dosificación , Sulfato de Magnesio/envenenamiento , Masculino , Relajantes Musculares Centrales/envenenamiento , Papaverina/administración & dosificación , SupositoriosRESUMEN
A 61-year-old female developed severe lactic acidosis after ingesting approximately 15 g of papaverine. This was associated with intense respiratory alkalosis, elevated plasma pyruvate, mild hyperglycemia, and hypokalemia. Severe lactic acidosis with elevated plasma pyruvate level and profound respiratory drive observed in this patient can be explained by the inhibition of mitochondrial oxidative reactions by papaverine. The clinical and biochemical features of papaverine-induced acid-base disturbance closely resemble those caused by salicylates, another known mitochondrial toxin.