RESUMEN
OBJECTIVE: To describe the surgical technique and clinical outcome of minimally invasive parathyroidectomy for primary hyperparathyroidism (PHPT) in the dog. ANIMALS: Fifty client-owned dogs with PHPT that underwent minimally invasive parathyroidectomy. STUDY DESIGN: Retrospective cohort study. METHODS: An ultrasound-guided mini lateral approach was made via a plane established between the sternocephalicus muscle and sternohyoideus muscles to expose the thyroid gland and enlarged parathyroid gland. Abnormal parathyroid glands were removed en bloc via partial thyroidectomy. The technique for bilateral disease was similar, the skin incision was made on midline and moved laterally to develop the above-mentioned plane of dissection. Age, sex, breed, bodyweight, ultrasound findings, histopathological diagnosis, surgical time, preoperative clinical signs, and clinical outcome were extracted from the records for descriptive statistics. RESULTS: A total of 62 glands were surgically removed, including 17 hyperplastic glands (17/62, 27.4%), 34 adenomas (34/62, 54.8%), and two carcinomas (2/62, 3.2%). Hypercalcemia resolved shortly after surgery in 44 dogs (44/45, 97.8%). One dog had recurrent hypercalcemia (1/45, 2.2%), one dog had persistent hypercalcemia (1/45, 2.2%), two dogs had permanent hypocalcemia requiring life-long calcitriol supplementation (2/45, 4.4%), and one dog died from clinical hypocalcemia (1/45, 2.2%). CONCLUSION: Minimally invasive parathyroidectomy was associated with a low morbidity and led to favorable outcomes in 44/45 dogs in this series. CLINICAL SIGNIFICANCE: The results of this study supports the use of minimally invasive parathyroidectomy to treat PHPT in dogs.
Asunto(s)
Enfermedades de los Perros , Hipercalcemia , Hiperparatiroidismo Primario , Hipocalcemia , Neoplasias de las Paratiroides , Perros , Animales , Paratiroidectomía/veterinaria , Hiperparatiroidismo Primario/cirugía , Hiperparatiroidismo Primario/veterinaria , Hipocalcemia/complicaciones , Hipocalcemia/cirugía , Hipocalcemia/veterinaria , Hipercalcemia/complicaciones , Hipercalcemia/cirugía , Hipercalcemia/veterinaria , Estudios Retrospectivos , Neoplasias de las Paratiroides/diagnóstico por imagen , Neoplasias de las Paratiroides/cirugía , Neoplasias de las Paratiroides/veterinaria , Procedimientos Quirúrgicos Mínimamente Invasivos/veterinaria , Procedimientos Quirúrgicos Mínimamente Invasivos/métodos , Ultrasonografía Intervencional/veterinaria , Enfermedades de los Perros/diagnóstico por imagen , Enfermedades de los Perros/cirugíaRESUMEN
A 10 yr old female spayed domestic shorthair was referred for an 11mo history of persistent total hypercalcemia and elevated ionized calcium with intermittent episodes of lethargy, vomiting, and diarrhea with a history of recurrent urinary tract infections and intermittently elevated kidney values. An abdominal ultrasound, thoracic radiographs, cervical ultrasound, and ionized calcium level, parathyroid hormone (PTH), and PTH-related peptide (PTHrp) levels were assessed. Results were consistent with chronic kidney disease, splenomegaly, diffuse thickening of small intestines, nodular lesions noted in the left thyroid and right parathyroid, and elevated ionized calcium, PTH, and elevated PTHrp levels. A left thyroidectomy and right cranial parathyroidectomy were performed. Hypocalcemia and anemia developed postoperatively, which were managed with calcium carbonate, calcitriol, and calcium gluconate and benign neglect of anemia. Histopathology was consistent with a left thyroid carcinoma and right cranial parathyroid adenoma. Thyroid carcinoma and parathyroid adenomas have not previously been reported to occur concurrently in domestic felines and should be considered when ionized calcium is elevated with both PTH and PTHrp levels increased in addition to ultrasonographic lesions.
Asunto(s)
Enfermedades de los Gatos , Hipercalcemia , Neoplasias de las Paratiroides , Neoplasias de la Tiroides , Gatos , Animales , Femenino , Proteína Relacionada con la Hormona Paratiroidea , Neoplasias de las Paratiroides/complicaciones , Neoplasias de las Paratiroides/diagnóstico , Neoplasias de las Paratiroides/cirugía , Neoplasias de las Paratiroides/veterinaria , Calcio , Hormona Paratiroidea , Hipercalcemia/veterinaria , Neoplasias de la Tiroides/complicaciones , Neoplasias de la Tiroides/diagnóstico , Neoplasias de la Tiroides/cirugía , Neoplasias de la Tiroides/veterinaria , Enfermedades de los Gatos/diagnóstico , Enfermedades de los Gatos/cirugíaRESUMEN
A 15-year-old Miniature Horse mare with persistently increased plasma calcium (total and ionized) and serum parathyroid hormone concentrations was presented for suspected primary hyperparathyroidism. Ultrasonography of the thyroid region identified an enlarged heterogeneous mass axial to the right thyroid lobe suggestive of an enlarged parathyroid gland, which was further confirmed using sestamibi nuclear scintigraphy and 3-phase computed tomography. Percutaneous ultrasound-guided ethanol ablation of the mass, a method not previously described in the horse, was performed under general anesthesia resulting in rapid normalization of plasma ionized calcium and serum parathyroid hormone concentrations. Ablation of abnormal parathyroid gland tissue may be a suitable alternative to surgical resection in certain cases of primary hyperparathyroidism in the horse.
Asunto(s)
Adenoma , Enfermedades de los Caballos , Hiperparatiroidismo Primario , Neoplasias de las Paratiroides , Adenoma/veterinaria , Animales , Femenino , Enfermedades de los Caballos/diagnóstico por imagen , Enfermedades de los Caballos/cirugía , Caballos , Hiperparatiroidismo Primario/veterinaria , Glándulas Paratiroides/diagnóstico por imagen , Glándulas Paratiroides/cirugía , Hormona Paratiroidea , Neoplasias de las Paratiroides/diagnóstico por imagen , Neoplasias de las Paratiroides/cirugía , Neoplasias de las Paratiroides/veterinaria , Tecnecio Tc 99m Sestamibi , Tomografía Computarizada por Rayos X/veterinaria , UltrasonografíaRESUMEN
This article provides a review with a focus on clinical updates in treating patients with surgical parathyroid or thyroid disease. Primary hyperparathyroidism is a common cause of hypercalcemia. Patients are older and often asymptomatic, and urinary stones and urinary tract infection are common. Surgical treatment is recommended with an excellent prognosis. Thyroid tumors in dogs are the most common endocrine neoplasm. Functional thyroid testing, laryngeal examinations, and regional lymphadenectomy should be considered during surgery, along with use of vessel-sealing devices to mitigate hemorrhage. Long-term outcomes for dogs with advanced disease can be reached, so surgical resection should be an option.
Asunto(s)
Enfermedades de los Perros , Hipercalcemia , Hiperparatiroidismo , Neoplasias de las Paratiroides , Animales , Enfermedades de los Perros/cirugía , Perros , Hipercalcemia/etiología , Hipercalcemia/veterinaria , Hiperparatiroidismo/etiología , Hiperparatiroidismo/cirugía , Hiperparatiroidismo/veterinaria , Neoplasias de las Paratiroides/complicaciones , Neoplasias de las Paratiroides/patología , Neoplasias de las Paratiroides/cirugía , Neoplasias de las Paratiroides/veterinaria , Paratiroidectomía/efectos adversos , Paratiroidectomía/veterinaria , Glándula Tiroides/patologíaRESUMEN
OBJECTIVE: To evaluate outcomes of dogs with parathyroid carcinoma (PTC) treated by surgical excision and to describe the incidence of postoperative hypocalcemia, degree of hypocalcemia, duration of hospitalization, duration of calcium supplementation, and survival time. ANIMALS: 100 client-owned dogs with PTC admitted to academic, referral veterinary institutions. PROCEDURES: In a retrospective multi-institutional study, medical records of dogs undergoing surgical excision of PTC between 2010 to 2019 were reviewed. Signalment, relevant medical history, clinical signs, clinicopathologic testing, imaging, surgical findings, intraoperative complications, histologic examination, and survival time were recorded. RESULTS: 100 dogs with PTC were included, and 96 dogs had clinical or incidental hypercalcemia. Common clinical signs included polyuria (44%), polydipsia (43%), hind limb paresis (22%), lethargy (21%), and hyporexia (20%). Cervical ultrasonography detected a parathyroid nodule in 91 of 91 dogs, with a single nodule in 70.3% (64/91), 2 nodules in 25.3% (23/91), and ≥ 3 nodules in 4 (4/91)% of dogs. Hypercalcemia resolved in 89 of 96 dogs within 7 days after surgery. Thirty-four percent of dogs developed hypocalcemia, on the basis of individual analyzer ranges, within 1 week after surgery. One dog had metastatic PTC to the prescapular lymph node, and 3 dogs were euthanized for refractory postoperative hypocalcemia. Estimated 1-, 2-, and 3-year survival rates were 84%, 65%, and 51% respectively, with a median survival time of 2 years. CONCLUSIONS AND CLINICAL RELEVANCE: Excision of PTC results in resolution of hypercalcemia and excellent long-term tumor control. Surgical excision of PTC is recommended because of resolution of hypercalcemia and a good long-term prognosis. Future prospective studies and long-term follow-up are needed to further assess primary tumor recurrence, metastasis, and incidence of postoperative hypocalcemia.
Asunto(s)
Enfermedades de los Perros , Neoplasias de las Paratiroides , Animales , Enfermedades de los Perros/patología , Perros , Incidencia , Neoplasias de las Paratiroides/cirugía , Neoplasias de las Paratiroides/veterinaria , Estudios Prospectivos , Estudios RetrospectivosRESUMEN
Primary hyperparathyroidism is rare in large animal species, and little is known regarding its pathophysiology, endocrine and electrolyte derangements, diagnosis, medical management, and prognosis. This report describes the clinicopathologic diagnosis of a parathyroid (PT) gland chief cell adenoma in a 12-year-old Quarter Horse mare, including PT hormone (PTH) and electrolyte disarrangements associated with the neoplasia, the surgical removal of the adenoma, and medical management of the case. This report also describes for the first time the use PTH immunohistochemistry to confirm the nature of this neoplasia in a horse.
Asunto(s)
Adenoma , Enfermedades de los Caballos , Hipercalcemia , Hiperparatiroidismo Primario , Neoplasias de las Paratiroides , Adenoma/complicaciones , Adenoma/veterinaria , Animales , Femenino , Enfermedades de los Caballos/diagnóstico , Caballos , Hipercalcemia/veterinaria , Hiperparatiroidismo Primario/diagnóstico , Hiperparatiroidismo Primario/veterinaria , Hormona Paratiroidea , Neoplasias de las Paratiroides/complicaciones , Neoplasias de las Paratiroides/veterinariaRESUMEN
BACKGROUND: Primary hyperparathyroidism is uncommon in equids. OBJECTIVES: To describe the diagnostic findings and efficacy of treatment in equids with primary hyperparathyroidism. STUDY DESIGN: Retrospective case series describing 16 horses and one mule. METHODS: Cases were identified by retrospective review of records at Cornell University and via an ACVIM listserv query. Inclusion criteria were an equid with hypercalcemia, normal renal function and high parathyroid hormone (PTH) or histopathological diagnosis of a parathyroid adenoma. Equids with normal PTH and PTH-related protein (PTHrP) in the face of hypercalcemia were included as suspect cases. RESULTS: The most common presenting complaints were weight loss (12/17) and hypercalcemia (10/17). PTH was above reference range in 12/17 cases. Suspected parathyroid tumours were localised in 12/14 equids imaged using ultrasonography alone (2/3), technetium 99m Tc sestamibi scintigraphy alone (1/1) or both modalities (9/10). Three horses did not have imaging performed. Surgical exploration successfully excised tumours in six of 10 cases. Five were located at the thoracic inlet, and surgery resulted in complete cure. One tumour was excised from the thyroid lobe, and the horse remained hypercalcemic. Four other cases explored surgically, four treated medically and three that were not treated also remained hypercalcemic. MAIN LIMITATIONS: The small study size prohibited statistical analysis. CONCLUSIONS: Parathyroid adenomas in equids can be successfully localised with ultrasonography and scintigraphy. Surgical excision appears more likely to be successful for single gland disease at the thoracic inlet.
Asunto(s)
Adenoma/veterinaria , Equidae , Hiperparatiroidismo/veterinaria , Neoplasias de las Paratiroides/veterinaria , Adenoma/diagnóstico , Adenoma/cirugía , Animales , Calcio/sangre , Hiperparatiroidismo/diagnóstico , Hiperparatiroidismo/cirugía , Neoplasias de las Paratiroides/diagnóstico , Neoplasias de las Paratiroides/cirugía , Estudios RetrospectivosRESUMEN
A 15-year-old neutered female domestic shorthair cat was presented for weight loss, polydipsia/polyuria, and lethargy. A large fluctuant mass was palpated in the ventral right cervical region. Biochemistry results were consistent with primary hyperparathyroidism. Parathyroid hormone level in the fluid was higher to that observed in the plasma, consistent with a cystic parathyroid lesion. Right parathyroidectomy and thyroidectomy were performed without complications. Ionized calcium normalized within a few hours. Histopathology yielded a diagnosis of cystic parathyroid adenoma. Follow-up showed complete recovery of clinical signs and normalization of ionized calcium. This case shows an uncommon presentation of feline primary hyperparathyroidism secondary to a cystic parathyroid adenoma and is, to our knowledge, the first case presented with a large palpable mass in which parathyroid hormone concentration was measured. This report highlights the value of selective hormonal analyses of the cystic fluid to confirm the origin of the cystic lesion pre-operatively.
Asunto(s)
Adenoma/veterinaria , Enfermedades de los Gatos/cirugía , Hiperparatiroidismo Primario/veterinaria , Neoplasias de las Paratiroides/veterinaria , Adenoma/diagnóstico , Adenoma/patología , Adenoma/cirugía , Animales , Enfermedades de los Gatos/diagnóstico , Enfermedades de los Gatos/patología , Gatos , Femenino , Hiperparatiroidismo Primario/diagnóstico , Hiperparatiroidismo Primario/patología , Hiperparatiroidismo Primario/cirugía , Cuello/patología , Neoplasias de las Paratiroides/diagnóstico , Neoplasias de las Paratiroides/patología , Neoplasias de las Paratiroides/cirugía , Paratiroidectomía/veterinaria , Tiroidectomía/veterinaria , Resultado del TratamientoRESUMEN
Accurate ultrasonographic differentiation of normal versus abnormal parathyroid glands is important for clinical workup and presurgical screening in dogs with hypercalcemia. In previous published studies, size has been the only ultrasonographic criterion correlated with histologic diagnoses of abnormal parathyroid glands. In this retrospective, cross-sectional study, the medical records of dogs with ultrasonographic examinations of the parathyroid glands and histologic diagnoses of parathyroid gland hyperplasia, adenoma, and adenocarcinoma were evaluated. Ultrasonographic characteristics were recorded for each gland and compared among histologic diagnosis groups. A total of 49 dogs and 59 parathyroid glands were sampled and assigned to the following groups for analyses: adenoma (n = 24), hyperplastic (n = 20), and adenocarcinoma (n = 15). There were no associations with dog age, sex, weight, breed; or gland laterality, location, ultrasonographic shape, or echogenicity among histologic diagnosis groups (P > .05). Parathyroid gland adenocarcinomas were found to be less likely to have a homogeneous echotexture on ultrasonographic evaluation, with hyperplastic glands being smaller (P = .022) and adenocarcinomas being larger (P = .042). While 3 mm was the optimum cutoff for differentiating hyperplastic and neoplastic parathyroid glands in this sample of dogs, values varied widely within groups and there were overlapping values between groups. Therefore, authors caution against using ultrasonographic size as a sole criterion for differentiating hyperplasia from neoplasia and normal versus abnormal parathyroid glands.
Asunto(s)
Enfermedades de los Perros/diagnóstico por imagen , Hipercalcemia/veterinaria , Enfermedades de las Paratiroides/veterinaria , Adenocarcinoma/diagnóstico por imagen , Adenocarcinoma/veterinaria , Adenoma/diagnóstico por imagen , Adenoma/veterinaria , Animales , Estudios Transversales , Enfermedades de los Perros/patología , Perros , Femenino , Hipercalcemia/diagnóstico por imagen , Masculino , Enfermedades de las Paratiroides/diagnóstico por imagen , Neoplasias de las Paratiroides/diagnóstico por imagen , Neoplasias de las Paratiroides/veterinaria , Estudios Retrospectivos , Ultrasonografía/veterinariaRESUMEN
Based on microscopic and immunohistochemical characterization, we documented spontaneous proliferative and neoplastic lesions in the thyroid and parathyroid glands of nondomestic felids. Ten animals (4 leopards, 3 tigers, and 3 cougars), all with a previous diagnosis of thyroid neoplasia were identified from the University of Tennessee College of Veterinary Medicine database. The mean age of affected animals was 15.9 y. Twelve neoplasms were identified; 2 animals had 2 concurrent neoplasms. After immunohistochemical characterization using a panel of chromogranin A, thyroglobulin, and calcitonin, 7 of the former thyroid neoplasms were diagnosed as thyroid adenomas, 1 was diagnosed as a thyroid carcinoma, and 4 were diagnosed as parathyroid adenomas. No thyroid medullary neoplasms (C-cell tumors) were diagnosed in the current study. Most of the diagnosed neoplasms were benign (11 of 12), and metastasis was not documented in the single carcinoma. Only 2 animals were suspected to have functional neoplasms (1 thyroid adenoma and 1 parathyroid adenoma), based on associated tissue lesions or serum biochemistry. Other documented lesions in the thyroid and parathyroid glands included thyroid nodular hyperplasia ( n = 7), parathyroid hyperplasia associated with chronic renal disease ( n = 2), a thyroid abscess, and a branchial cyst. Parathyroid adenomas were more commonly diagnosed than expected in comparison with domestic cats. We demonstrated that an immunohistochemistry panel for thyroglobulin, calcitonin, and chromogranin A can be used to differentiate neoplasms of thyroid from parathyroid origin in nondomestic felids.
Asunto(s)
Adenoma/veterinaria , Carcinoma Neuroendocrino/veterinaria , Enfermedades de los Gatos/diagnóstico , Neoplasias de las Paratiroides/veterinaria , Neoplasias de la Tiroides/veterinaria , Adenoma/diagnóstico , Animales , Animales Salvajes , Carcinoma Neuroendocrino/diagnóstico , Enfermedades de los Gatos/patología , Gatos , Bases de Datos Factuales , Femenino , Inmunohistoquímica/veterinaria , Masculino , Neoplasias de las Paratiroides/diagnóstico , Tennessee , Neoplasias de la Tiroides/diagnósticoRESUMEN
OBJECTIVE: To describe outcomes for dogs with primary hyperparathyroidism following treatment with percutaneous ultrasound-guided ethanol ablation of presumed functional parathyroid nodules. DESIGN: Retrospective case series. ANIMALS: 24 dogs with primary hyperparathyroidism that underwent 27 ultrasound-guided ethanol ablation procedures of presumed functional parathyroid nodules identified by cervical ultrasonography. PROCEDURES: Dogs were anesthetized for each procedure. For each nodule, 95% ethanol was injected into the center with ultrasound guidance (volume injected calculated on the basis of ultrasonographic measurements). The interval from treatment to resolution of hypercalcemia, complications, and follow-up clinicopathologic data were recorded. RESULTS: 5 procedures involved simultaneous treatment of 2 nodules. Three dogs underwent a second treatment because of initial treatment failure or development of another nodule. Hypercalcemia resolved after 23 of 27 (85%) procedures. In those 23 treatments, 22 (96%) had resolution of hypercalcemia within 72 hours after treatment. Hypocalcemia was detected in 6 different dogs at 2 (1 dog), 7 (3 dogs), 14 (1 dog), and 21 (1 dog) days after treatment; 5 of these dogs had mild transient hypocalcemia and 1 developed clinical signs requiring calcium supplementation. Although there were no periprocedural adverse effects, 2 dogs had delayed adverse effects; the overall rate of complications (including delayed adverse events and clinical hypocalcemia) was 11.1%. Long-term follow-up data indicated sustained normocalcemia in 17 of 19 dogs. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that percutaneous ultrasound-guided ethanol ablation of functional parathyroid nodules may be an effective treatment for primary hyperparathyroidism of dogs, with short duration of anesthesia, minimal complications, and low risk for hypocalcemia.
Asunto(s)
Técnicas de Ablación/veterinaria , Enfermedades de los Perros/terapia , Etanol/farmacología , Hiperparatiroidismo/veterinaria , Neoplasias de las Paratiroides/veterinaria , Animales , Perros , Femenino , Hiperparatiroidismo/terapia , Inyecciones Intralesiones/veterinaria , Masculino , Neoplasias de las Paratiroides/terapia , Estudios Retrospectivos , Resultado del TratamientoRESUMEN
A 12-year-old dachshund dog was presented for persistent hypercalcemia and hyperparathyroidism despite bilateral parathyroidectomy. Magnetic resonance imaging of the head, neck, and cranial mediastinum identified an increased number of cranial mediastinal lymph nodes with heterogeneous signal intensity. Hypercalcemia and hyperparathyroidism resolved after surgery to remove multiple cranial mediastinal lymph nodes, one of which contained presumed metastatic parathyroid tissue.
Adénocarcinome parathyroïdien métastatique fonctionnel chez un chien. Un chien Dachsund âgé de 12 ans a été présenté pour de l'hypercalcémie et de l'hyperparathyroïdie persistantes malgré une parathyroïdectomie bilatérale. Une imagerie par résonance magnétique de la tête, du cou et du médiastin crânien a identifié un nombre accru de ganglions lymphatiques médiastinaux avec une intensité hétérogène du signal. L'hypercalcémie et l'hyperparathyroïdie se sont résorbées après la chirurgie pour enlever les nombreux ganglions lymphatiques médiastinaux crâniens, dont l'un contenait du tissu parathyroïdien métastatique présumé.(Traduit par Isabelle Vallières).
Asunto(s)
Adenocarcinoma/veterinaria , Enfermedades de los Perros/patología , Ganglios Linfáticos/patología , Neoplasias de las Paratiroides/veterinaria , Adenocarcinoma/patología , Animales , Perros , Hipercalcemia/etiología , Hipercalcemia/veterinaria , Hiperparatiroidismo/etiología , Hiperparatiroidismo/veterinaria , Ganglios Linfáticos/cirugía , Metástasis Linfática , Masculino , Neoplasias de las Paratiroides/patologíaRESUMEN
A 16-year-old domestic shorthaired cat with chronic kidney disease was presented with a subacute history of weakness and anorexia. Severe hypercalcaemia was identified and attributed to a cervical mass, diagnosed as a parathyroid carcinoma after surgery. Renal function, as evaluated by plasma creatinine, initially worsened during hypercalcaemia but fully returned to previously documented values two months post-operatively.
Asunto(s)
Enfermedades de los Gatos/cirugía , Hipercalcemia/veterinaria , Hiperparatiroidismo Primario/veterinaria , Neoplasias de las Paratiroides/veterinaria , Animales , Enfermedades de los Gatos/etiología , Gatos , Hipercalcemia/complicaciones , Hipercalcemia/cirugía , Hiperparatiroidismo Primario/etiología , Hiperparatiroidismo Primario/cirugía , Masculino , Neoplasias de las Paratiroides/complicaciones , Neoplasias de las Paratiroides/cirugía , Insuficiencia Renal Crónica/etiología , Insuficiencia Renal Crónica/veterinaria , Resultado del TratamientoAsunto(s)
Adenoma/veterinaria , Enfermedades de los Caballos/diagnóstico por imagen , Neoplasias de las Paratiroides/veterinaria , Adenoma/diagnóstico por imagen , Adenoma/cirugía , Animales , Enfermedades de los Caballos/cirugía , Caballos , Masculino , Glándulas Paratiroides/cirugía , Neoplasias de las Paratiroides/diagnóstico por imagen , Neoplasias de las Paratiroides/cirugía , Paratiroidectomía/veterinaria , Tecnecio Tc 99m Sestamibi , Tomografía Computarizada de Emisión/métodos , Tomografía Computarizada de Emisión/veterinariaRESUMEN
A 7½-yr-old male cougar (Puma concolor) was presented with a 2-wk history of progressive hindlimb abnormalities. An abdominal mass was palpated on physical examination. Computed tomography of the abdomen showed a mass surrounding the left ureter. A postmortem diagnosis of paraganglioma was established.
Asunto(s)
Neoplasias Renales/veterinaria , Neoplasia Endocrina Múltiple/veterinaria , Paraganglioma Extraadrenal/veterinaria , Neoplasias de las Paratiroides/veterinaria , Puma , Animales , Animales de Zoológico , Neoplasias Renales/diagnóstico , Neoplasias Renales/patología , Masculino , Neoplasia Endocrina Múltiple/diagnóstico , Neoplasia Endocrina Múltiple/patología , Paraganglioma Extraadrenal/diagnóstico , Paraganglioma Extraadrenal/patología , Neoplasias de las Paratiroides/diagnóstico , Neoplasias de las Paratiroides/patologíaRESUMEN
Parathyroid carcinoma (PTC) is rare in dogs and there is little information documenting its treatment and prognosis. The objective of this study was to describe the outcome of dogs with PTC treated with surgical excision. Medical records of 19 dogs undergoing surgical excision of PTC between 1990 and 2010 were reviewed retrospectively. Dogs were presented for clinical hypercalcaemia or incidental hypercalcaemia noted by referring veterinarians on routine serum chemistry profiles. A parathyroid nodule was identified with cervical ultrasound in 17/17 dogs. Hypercalcaemia resolved in 18/19 dogs within 4 days postoperatively. Nine developed hypocalcaemia. None were confirmed to develop recurrent or metastatic PTC. The only death associated with PTC was a dog that was euthanized for intractable hypocalcaemia 9 days after surgery. Estimated 1-, 2- and 3-year survival rates were 72, 37 and 30%, respectively. Excision of PTC results in resolution of hypercalcaemia and excellent tumour control.
Asunto(s)
Carcinoma/veterinaria , Enfermedades de los Perros/cirugía , Neoplasias de las Paratiroides/veterinaria , Animales , Carcinoma/patología , Carcinoma/cirugía , Enfermedades de los Perros/patología , Perros , Femenino , Hipercalcemia/complicaciones , Hipercalcemia/veterinaria , Masculino , Neoplasias de las Paratiroides/complicaciones , Neoplasias de las Paratiroides/patología , Neoplasias de las Paratiroides/cirugía , Estudios Retrospectivos , Análisis de Supervivencia , Resultado del Tratamiento , Estados UnidosRESUMEN
OBJECTIVE: Retrospective evaluation of diagnosis and outcome in 20 dogs with primary hyperparathyroidism. MATERIAL AND METHODS: In 20 dogs primary hyperparathyroidism was diagnosed and 19 patients were treated via parathyroidectomy, 10 additionally with partial thyroidectomy. Medical records of the dogs were reviewed for signalment, clinical features, laboratory findings and results of histopathologic examination. In some cases postsurgical rehabilitation of calcium metabolism required substitution with calcium and vitamin D preparations. RESULTS: Mean age of the dogs was 11.5 years. The most common clinical signs comprised polydipsia, polyuria, reduced activity, and stiff gait. Laboratory findings were moderate to extensive hypercalcaemia, low or low-normal serum phosphorus concentrations and normal or increased serum parathyroid hormone concentrations. None of the dogs had an elevated parathyroid hormone-related polypeptide level. Histological examination revealed 11 adenomas, six carcinomas and two glandular hyperplasias. Postsurgical management of calcium homeostasis was challenging in some cases. CONCLUSION: Tumours of the parathyroid gland can be easily treated by parathyroidectomy and usually have a good prognosis. CLINICAL RELEVANCE: With careful interpretation of laboratory findings of a patient presenting with hypercalcaemia and ruling out other causes of hypercalcaemia diagnosis of primary hyperparathyroidism can be easily achieved and successfully treated byparathyroidectomy.
Asunto(s)
Enfermedades de los Perros/diagnóstico , Enfermedades de los Perros/terapia , Hiperparatiroidismo Primario/veterinaria , Cuidados Posoperatorios/veterinaria , Complicaciones Posoperatorias/veterinaria , Animales , Calcio/administración & dosificación , Calcio/metabolismo , Enfermedades de los Perros/cirugía , Perros , Femenino , Hipercalcemia/etiología , Hipercalcemia/veterinaria , Hiperparatiroidismo Primario/diagnóstico , Hiperparatiroidismo Primario/terapia , Masculino , Neoplasias de las Paratiroides/complicaciones , Neoplasias de las Paratiroides/cirugía , Neoplasias de las Paratiroides/veterinaria , Paratiroidectomía/veterinaria , Complicaciones Posoperatorias/terapia , Pronóstico , Estudios Retrospectivos , Tiroidectomía/veterinaria , Resultado del Tratamiento , Vitamina D/administración & dosificación , Vitaminas/administración & dosificaciónRESUMEN
An 18-yr-old male bobcat (Lynx rufus) presented with chronic moderate weight loss and acute onset of anorexia and lethargy. Hypercalcemia and azotemia were present on the serum chemistry panel. Abdominal ultrasound revealed hyperechoic renal cortices, but no evidence of neoplasia. Ionized calcium and 25-hydroxyvitamin D were mildly elevated, intact parathyroid hormone was severely elevated, and parathormone-related protein was undetected, suggesting primary hyperparathyroidism with possible renal dysfunction. Azotemia lessened in severity following diuresis, but hypercalcemia persisted; thus primary hyperparathyroidism was considered the most probable differential diagnosis. A second ultrasound including the cervical region revealed a solitary intraparenchymal left thyroid nodule. The nodule was surgically excised; histopathology confirmed a parathyroid adenoma. Although primary hyperparathyroidism was suspected, diagnosis was not achieved from serum chemistry values alone. This case emphasizes the importance of diagnostic imaging and histopathology in the investigation of persistently abnormal laboratory values.
Asunto(s)
Hiperparatiroidismo/veterinaria , Lynx , Adenoma/diagnóstico , Adenoma/cirugía , Adenoma/veterinaria , Animales , Hipercalcemia/sangre , Hipercalcemia/etiología , Hipercalcemia/veterinaria , Hiperparatiroidismo/complicaciones , Hiperparatiroidismo/diagnóstico , Hiperparatiroidismo/terapia , Masculino , Neoplasias de las Paratiroides/diagnóstico , Neoplasias de las Paratiroides/cirugía , Neoplasias de las Paratiroides/veterinariaRESUMEN
The purpose of this study is to characterize the sonographic appearance of canine parathyroid glands using high-resolution ultrasonography. Ten cadaver dogs were studied after euthanasia for reasons not relating to the parathyroid. The cervical region was examined using a 13-5 MHz linear transducer in right and left recumbency. Ultrasonographic features of the parathyroid and thyroid glands were compared with the gross and histopathologic findings. Thirty-five structures were identified sonographically as parathyroid glands but only 26 of 35 glands (74% positive predictive value) were proven to be normal parathyroid glands histopathologically. Of the nine false positives, five (14%) were proven to be lobular thyroid tissue. The remaining four (11%) structures were visible grossly or found histopathologically. There were no statistical differences between ultrasonographic and gross measurements of the parathyroid glands. The average size as seen sonographically was 3.3 x 2.2 x 1.7 mm and the average gross size was 3.7 x 2.6 x 1.6 mm (length, width, height). The average size of the thyroid lobules assessed sonographically was 2.3 x1.6 x 0.8 mm (length, width, height). Normal parathyroid glands can be identified using high-resolution ultrasonography. But some thyroid lobules will be misinterpreted as parathyroid glands; this will result in false positives when identifying parathyroid glands with ultrasonography.
Asunto(s)
Enfermedades de los Perros/diagnóstico por imagen , Glándulas Paratiroides/diagnóstico por imagen , Neoplasias de las Paratiroides/veterinaria , Glándula Tiroides/diagnóstico por imagen , Neoplasias de la Tiroides/veterinaria , Ultrasonografía/veterinaria , Animales , Artefactos , Nitrógeno de la Urea Sanguínea , Cadáver , Perros , Femenino , Hiperparatiroidismo/diagnóstico por imagen , Hiperparatiroidismo/patología , Hiperparatiroidismo/veterinaria , Masculino , Ovariectomía , Glándulas Paratiroides/anatomía & histología , Glándulas Paratiroides/patología , Neoplasias de las Paratiroides/diagnóstico por imagen , Glándula Tiroides/anatomía & histología , Glándula Tiroides/patología , Neoplasias de la Tiroides/diagnóstico por imagen , Ultrasonografía/métodosRESUMEN
A 13-year-old spayed Labrador Retriever cross dog presented for polyuria and polydipsia. Serum total calcium, free calcium, and intact parathyroid hormone concentrations were elevated. Surgical exploration of the ventral neck revealed a grossly enlarged right external parathyroid gland. The histopathological diagnosis for the excised right parathyroid gland was an incompletely resected parathyroid carcinoma. Parathyroid carcinoma in the dog is an infrequent cause of hypercalcemia and primary hyperparathyroidism.