RESUMEN
Encephalitis lethargica developed in epidemic from 1919 to 1926 in Europe and throughout the world. From the clinical point of view, the disturbances of consciousness and alertness and the possible outcomes of a postencephalitic Parkinsonism has attracted much attention. For a long time, it was thought that such a disease may still occur sporadically. In this review, the authors examined historical and current pictures of epidemics that may be related to Encephalitis lethargica. The previous Nona and Russian Influenza exhibited frequent neurological symptoms. The Spanish flu, formerly related to Encephalitis lethargica, would appear an epidemic that had its development in a partially overlapping period. The current pandemic linked to COVID-19 sometimes has aspects that can resemble Encephalitis lethargica. Based on historical analysis and the more recent immunological data, it could be suggested that Encephalitis lethargica was an autoimmune encephalitis that arose in a secondary form to the action of a viral agent. It cannot be ruled out that this agent was a coronavirus. From the nosological point of view, the term Encephalitis lethargica should be abolished in designating autoimmune encephalitis pictures that run sporadically.
Asunto(s)
Enfermedades Autoinmunes del Sistema Nervioso , COVID-19 , Influenza Pandémica, 1918-1919 , Gripe Humana , Enfermedad de Parkinson Posencefalítica , Historia del Siglo XX , Humanos , Enfermedad de Parkinson Posencefalítica/complicaciones , Enfermedad de Parkinson Posencefalítica/epidemiología , COVID-19/complicaciones , Enfermedades Autoinmunes del Sistema Nervioso/complicacionesRESUMEN
Postencephalitic parkinsonism is a characteristic chronic sequelae of encephalitis lethargica, a pandemic disorder which swept the whole world in 1917-1928. Based on his clinical experiences at the Mount Carmel hospital, Oliver Sacks published Awakenings in 1973, and an American drama film Awakenings was premiered in 1990. Success and setbacks of the levodopa trial in postencephalitic parkinsonism patients were chronologically described, and the mother's delight on her son's "return" was impressive; this scene can be shared by us neurologists, even if it was transient. Above all, the exemplary performances of the two distinguished actors, Robin Williams and Robert De Niro (especially the latter), enlivened the most excellent moments of the movie.
Asunto(s)
Enfermedad de Parkinson Posencefalítica , Humanos , Femenino , Estados Unidos , Enfermedad de Parkinson Posencefalítica/tratamiento farmacológico , Enfermedad de Parkinson Posencefalítica/complicaciones , Levodopa , NeurólogosRESUMEN
Immune-mediated extrapyramidal movement disorders typically occur in previously healthy children. Immune-mediated movement disorders may occur as a postinfectious, paraneoplastic, or idiopathic process. Sydenham chorea (SC) is the classical poststreptococcal movement and psychiatric disorder, and may be associated with other features of rheumatic fever. The outcome is typically good, although residual chorea, psychiatric disturbance, and relapses are possible. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) is a syndrome of streptococcal-induced tics and obsessive-compulsive disorder. Although a number of investigators have reported an association between streptococcal infection and neuropsychiatric syndromes, the PANDAS hypothesis is controversial. Encephalitis lethargica is an encephalitic illness with parkinsonism, dyskinesias, and psychiatric disturbance as dominant features. The exact disease mechanism is not understood, although an autoimmune process is suspected. NMDA-R encephalitis is a new entity characterized by encephalitis with dramatic psychiatric disturbance, dyskinesias, cognitive alteration, and seizures. Patients have autoantibodies against the NMDA-R that appear to be pathogenic: immune therapies appear warranted to minimize disability. Movement disorders are also described associated with systemic lupus erythematosus and antiphospholipid syndrome. The differential diagnosis and investigation approach of acute-onset movement disorders are also discussed.
Asunto(s)
Enfermedades de los Ganglios Basales/inmunología , Corea/inmunología , Enfermedad de Parkinson Posencefalítica/inmunología , Infecciones Estreptocócicas/inmunología , Enfermedades de los Ganglios Basales/etiología , Niño , Corea/etiología , Humanos , Enfermedad de Parkinson Posencefalítica/complicaciones , Infecciones Estreptocócicas/complicacionesRESUMEN
Postencephalitic parkinsonism has been considered unique among disorders with parkinsonian features because it is believed to have a unitary etiology associated with the virus that presumably caused encephalitis lethargica. Careful analysis of the historical record, however, suggests that this relationship is more complex than commonly perceived. In most cases, the diagnosis of acute encephalitis lethargica was made post hoc, and virtually any catarrh-like illness was considered to have represented encephalitis lethargica, often after an oral history-taking that was undoubtedly subject to patient recall and physician bias. Also, postencephalitic parkinsonism and oculogyric crises were not recognized as sequelae to encephalitis lethargica until well after other sequelae such as movement disorders and mental disturbances had been identified (see previous paper). We suggest here that the relationship between encephalitis lethargica and postencephalitic parkinsonism is not simplistic, i.e., encephalitis lethargica was not solely responsible for the etiology of postencephalitic parkinsonism, thus aligning the latter with most other parkinsonian disorders that are now believed to have multiple causes.
Asunto(s)
Encefalitis/complicaciones , Enfermedad de Parkinson Posencefalítica/complicaciones , Encefalitis/historia , Historia del Siglo XX , Humanos , Enfermedad de Parkinson Posencefalítica/historiaRESUMEN
This article and the subsequent one suggest that the currently accepted view of a simplistic (direct) relationship between encephalitis lethargica (EL) and postencephalitic Parkinsonism (PEP) is based on a incomplete evaluation of the epidemic period literature. In this article we provide a detailed analysis of the literature from the period that demonstrates that Parkinsonism was not initially part of acute EL symptomatology, that PEP was not typically the prevailing type of chronic EL and that oculogyric crises were never part of acute EL symptomatology and not initially associated with PEP. The second paper uses these finding, and also examines the clinical justifications for concluding that all patients with PEP had prior acute episodes of EL, to reevaluate the presumed direct etiologic relationship between EL and PEP.
Asunto(s)
Encefalitis/complicaciones , Medicina en la Literatura , Enfermedad de Parkinson Posencefalítica/complicaciones , Encefalitis/historia , Historia del Siglo XX , Humanos , Enfermedad de Parkinson Posencefalítica/historiaRESUMEN
Tauopathies with parkinsonism represent a spectrum of disease entities unified by the pathologic accumulation of hyperphosphorylated tau protein fragments within the central nervous system. These pathologic characteristics suggest shared pathogenetic pathways and possible molecular targets for disease-modifying therapeutic interventions. Natural history studies, for instance, in progressive supranuclear palsy, frontotemporal dementia with parkinsonism linked to chromosome 17, corticobasal degeneration, and Niemann-Pick disease type C as well as in amyotrophic lateral sclerosis/Parkinson-dementia complex permit clinical characterization of the disease phenotypes and are crucial to the development and validation of biological markers for differential diagnostics and disease monitoring, for example, by use of neuroimaging or proteomic approaches. The wide pathologic and clinical spectrum of the tauopathies with parkinsonism is reviewed in this article, and perspectives on future advances in the understanding of the pathogenesis are given, together with potential therapeutic strategies.
Asunto(s)
Trastornos Parkinsonianos/complicaciones , Tauopatías/complicaciones , Animales , Biomarcadores , Demencia/complicaciones , Demencia/genética , Demencia/fisiopatología , Diseño de Fármacos , Geografía , Humanos , Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina , Modelos Biológicos , Mutación , Enfermedad de Niemann-Pick Tipo C/complicaciones , Enfermedad de Niemann-Pick Tipo C/diagnóstico , Enfermedad de Niemann-Pick Tipo C/fisiopatología , Enfermedad de Parkinson Posencefalítica/complicaciones , Enfermedad de Parkinson Posencefalítica/fisiopatología , Trastornos Parkinsonianos/patología , Trastornos Parkinsonianos/fisiopatología , Trastornos Parkinsonianos/terapia , Enfermedad de Pick/complicaciones , Enfermedad de Pick/patología , Proteínas Serina-Treonina Quinasas/genética , Parálisis Supranuclear Progresiva/complicaciones , Parálisis Supranuclear Progresiva/diagnóstico , Parálisis Supranuclear Progresiva/fisiopatología , Tauopatías/patología , Tauopatías/fisiopatología , Tauopatías/terapia , Proteínas tau/genéticaRESUMEN
Since encephalitis lethargica's (EL) prevalence in the 1920s, epidemiologic and clinical debate has persisted over whether EL was caused by, potentiated by, or merely coincident with the Spanish influenza pandemic. Epidemiologic analyses generally suggest that the disorders were coincidental. Beginning in the 1970s, modern experiments on archival brain samples mainly failed to confirm a direct relationship between influenza and EL. These experimental studies have technical limitations, e.g., the appropriateness of antibodies, polymerase chain reaction (PCR) primers and controls, and the extreme paucity and age of available material. These factors render the case against influenza less decisive than currently perceived. Nevertheless, there is little direct evidence supporting influenza in the etiology of EL. Almost 100 years after the EL epidemic, its etiology remains enigmatic, raising the possibility of a recurrence of EL in a future influenza pandemic.
Asunto(s)
Brotes de Enfermedades , Gripe Humana/complicaciones , Enfermedad de Parkinson Posencefalítica/complicaciones , Salud Global , Humanos , Gripe Humana/epidemiología , Enfermedad de Parkinson Posencefalítica/epidemiologíaRESUMEN
Pergolide, an ergot-derived dopamine agonist prescribed since the late 1980's mainly in Parkinson's disease and restless leg syndrome has recognized fibrosis side effects, affecting the pleural, pericardial and retroperitoneal systems. Pergolide-induced valvulopathies were first reported in 2002. We present here the history of a patient developing an isolated pulmonary hypertension related to the intake of pergolide. The dyspnea related to the pulmonary hypertension as well as the echocardiographic abnormalities improved after treatment replacement. Valvulopathies and pulmonary hypertension were previously described under appetite-suppressant drugs after years of clinical use, in a similar way.
Asunto(s)
Antiparkinsonianos/efectos adversos , Hipertensión Pulmonar/inducido químicamente , Pergolida/efectos adversos , Antiparkinsonianos/uso terapéutico , Benserazida/uso terapéutico , Benzotiazoles/uso terapéutico , Presión Sanguínea , Catecoles/uso terapéutico , Disnea/inducido químicamente , Disnea/fisiopatología , Ecocardiografía , Humanos , Hipertensión Pulmonar/diagnóstico por imagen , Levodopa/uso terapéutico , Masculino , Persona de Mediana Edad , Nitrilos/uso terapéutico , Enfermedad de Parkinson Posencefalítica/complicaciones , Enfermedad de Parkinson Posencefalítica/tratamiento farmacológico , Pergolida/uso terapéutico , PramipexolRESUMEN
We report the case of a 16-year-old boy presented with a mild akinetic-rigid parkinsonism shortly after a post-streptococcal infection. After stopping corticoids, he had a rapid neurological deterioration to a fatal encephalitis lethargica-like syndrome. Serum analysis demonstrated consistently elevated anti-streptolysin-O. This case illustrates a new severe phenotype in the spectrum of the post-streptococcal disorders. This etiology should be considered in the differential diagnosis of a movement disorder with a rapid detrimental evolution.
Asunto(s)
Enfermedad de Parkinson Posencefalítica/etiología , Trastornos Parkinsonianos/etiología , Infecciones Estreptocócicas/complicaciones , Adolescente , Mutismo Acinético/complicaciones , Progresión de la Enfermedad , Humanos , Hipocinesia/etiología , Imagen por Resonancia Magnética , Masculino , Rigidez Muscular/etiología , Enfermedad de Parkinson Posencefalítica/complicaciones , Enfermedad de Parkinson Posencefalítica/patología , Trastornos Parkinsonianos/complicaciones , Trastornos Parkinsonianos/patología , FenotipoRESUMEN
Encephalitis lethargica (EL) syndrome was classically described by Von Economo and has somnolent-ophthalmoplegic, hyperkinetic, and amyostatic-akinetic forms. We describe 2 recent cases of EL characterized by an acute encephalitis with mixed movement disorders (dystonia-Parkinsonism plus stereotypy) and psychiatric disorders (agitated catatonia, coprolalia, and echo phenomena). Both patients suffered concurrent hyperkinetic and Parkinsonian features resulting in therapeutic challenges. Bradykinetic features responded to dopamine replacement therapy and both patients also had adverse affects to dopamine antagonists (oculogyric crises plus neuroleptic malignant syndrome). Investigation was unremarkable other than the presence of CSF lymphocytosis and oligoclonal bands. Despite prolonged in-patient stays and intensive care management, both patients have made complete recoveries. We believe these cases support the hypothesis that this syndrome is an inflammatory encephalitis that specifically effects dopamine neurotransmission.
Asunto(s)
Catatonia/diagnóstico , Distonía/diagnóstico , Enfermedad de Parkinson Posencefalítica/diagnóstico , Trastorno de Movimiento Estereotipado/diagnóstico , Adolescente , Catatonia/etiología , Catatonia/terapia , Niño , Cuidados Críticos , Dopamina/fisiología , Distonía/etiología , Distonía/terapia , Humanos , Masculino , Enfermedad de Parkinson Posencefalítica/complicaciones , Enfermedad de Parkinson Posencefalítica/terapia , Recuperación de la Función , Trastorno de Movimiento Estereotipado/etiología , Trastorno de Movimiento Estereotipado/terapiaRESUMEN
We report a 47-year-old man who is considered to have sporadic encephalitis lethargica (EL). He presented with hyperpyrexia, lethargy, akinetic mutism, and posture of decorticate rigidity following coma and respiratory failure. Intravenous methylprednisolone pulse therapy improved his condition rapidly and remarkably. Electroencephalography (EEG) showed severe diffuse slow waves of bilateral frontal dominancy, and paralleled the clinical course. Our patient fulfilled the diagnostic criteria for malignant catatonia, so we diagnosed secondary malignant catatonia due to EL syndrome. The effect of corticosteroid treatment remains controversial in encephalitis; however, some EL syndrome patients exhibit an excellent response to corticosteroid treatment. Therefore, EL syndrome may be secondary to autoimmunity against deep grey matter. It is important to distinguish secondary catatonia due to general medical conditions from psychiatric catatonia and to choose a treatment suitable for the medical condition.
Asunto(s)
Catatonia/etiología , Glucocorticoides/administración & dosificación , Metilprednisolona/administración & dosificación , Enfermedad de Parkinson Posencefalítica/complicaciones , Enfermedad de Parkinson Posencefalítica/tratamiento farmacológico , Catatonia/diagnóstico , Catatonia/terapia , Electroencefalografía , Humanos , Infusiones Intravenosas , Masculino , Persona de Mediana Edad , Enfermedad de Parkinson Posencefalítica/diagnóstico , Resultado del TratamientoRESUMEN
We describe six patients with clinicopathologically confirmed post-encephalitic parkinsonism (PEP) in whom oculomotor abnormalities developed several years after suffering the initial episode of encephalitis lethargica. Four of the cases had vertical supranuclear gaze palsy and two eyelid apraxia, features typically associated with progressive supranuclear palsy (PSP). Our findings indicate that the presence of gaze palsy alone may not be a reliable clinical discriminator between PEP and PSP. Involvement of the dorsal central gray nucleus, nucleus centralis pontis oralis, nucleus dorsal raphe interpositus, rostral interstitial nucleus of the medial longitudinal fasciculus (riMLF), nucleus interstitialis of Cajal, nucleus of the posterior commissure, pedunculopontine nuclei and frontal cortex was observed in several of our PEP cases and may contribute to the oculomotor abnormalities in this disorder. Whether the dorsal tegmental nucleus, caudal to the supratrochlear nucleus, severely affected in all our PEP cases, has a role in vertical gaze needs to be further studied.
Asunto(s)
Apraxias/etiología , Enfermedades de los Párpados/etiología , Enfermedad de Parkinson Posencefalítica/complicaciones , Parálisis Supranuclear Progresiva/complicaciones , Adulto , Anciano , Apraxias/patología , Apraxias/fisiopatología , Encéfalo/patología , Encéfalo/fisiopatología , Diagnóstico Diferencial , Femenino , Humanos , Masculino , Persona de Mediana Edad , Enfermedad de Parkinson Posencefalítica/diagnóstico , Enfermedad de Parkinson Posencefalítica/patología , Enfermedad de Parkinson Posencefalítica/fisiopatología , Parálisis Supranuclear Progresiva/diagnóstico , Parálisis Supranuclear Progresiva/patología , Parálisis Supranuclear Progresiva/fisiopatologíaAsunto(s)
Arterias Cerebrales/fisiopatología , Venas Cerebrales/fisiopatología , Circulación Cerebrovascular/fisiología , Trastornos Cerebrovasculares/complicaciones , Astenia Neurocirculatoria/fisiopatología , Trastornos Neurocognitivos/fisiopatología , Enfermedad de Parkinson Posencefalítica/complicaciones , Adulto , Trastornos Cerebrovasculares/psicología , Humanos , Persona de Mediana Edad , Astenia Neurocirculatoria/etiología , Trastornos Neurocognitivos/etiología , Enfermedad de Parkinson Posencefalítica/psicologíaAsunto(s)
Trastornos Mentales/complicaciones , Trastornos del Movimiento/psicología , Enfermedades de los Ganglios Basales/complicaciones , Enfermedades de los Ganglios Basales/psicología , Calcinosis/complicaciones , Discinesia Inducida por Medicamentos/fisiopatología , Degeneración Hepatolenticular/complicaciones , Humanos , Enfermedad de Huntington/complicaciones , Trastornos del Humor/complicaciones , Trastornos del Movimiento/complicaciones , Neuronas/patología , Trastorno Obsesivo Compulsivo/complicaciones , Trastorno Obsesivo Compulsivo/fisiopatología , Enfermedad de Parkinson/complicaciones , Enfermedad de Parkinson/patología , Enfermedad de Parkinson Posencefalítica/complicaciones , Trastornos Psicofisiológicos/psicología , Receptores Dopaminérgicos/fisiología , Esquizofrenia/complicaciones , Síndrome de Tourette/complicacionesAsunto(s)
Carbidopa/uso terapéutico , Hidrazinas/uso terapéutico , Levodopa/uso terapéutico , Trastornos del Movimiento/tratamiento farmacológico , Rigidez Muscular/tratamiento farmacológico , Anciano , Combinación de Medicamentos , Femenino , Humanos , Masculino , Enfermedad de Parkinson Posencefalítica/complicaciones , Trihexifenidilo/uso terapéuticoRESUMEN
The occurrence of dementia in patients with Parkinson's disease was studied in a Parkinsonian population consisting of all traceable patients residing in a defined area. The prevalence of dementia was found to be 29 per cent in 444 patients studied. The frequency of dementia increased with advancing age and the patients showing signs of clinical arteriosclerosis were more often demented than the patients without arteriosclerosis. There was, however, an evident association between the stage of the disease and the frequency of dementia. The most severely disabled patients displayed dementia more often than the mildly affected, both among the patients with and without arteriosclerosis. The demented patients showed significantly more severe rigidity and hypokinesia when compared with the non-demented. Increasing severity of rigidity and hypolinesia, in particular was found to have a positive correlation with the degree of dementia. The association between dementia and the degree of motor involvement is considered to suggest the role of subcortical structures in the patholophysiology of dementia in Parkinson's disease.
Asunto(s)
Trastornos Mentales/complicaciones , Enfermedad de Parkinson Posencefalítica/complicaciones , Enfermedad de Parkinson/complicaciones , Factores de Edad , Anciano , Arteriosclerosis/complicaciones , Femenino , Humanos , Masculino , Persona de Mediana Edad , Factores SexualesRESUMEN
Forty-five patients with parkinsonism were carefully matched for age and sex with 45 chronically disabled control patients with a significantly more severe grade of physical handicap. Depression was measured by the Hamilton Rating Scale, and it was found that the parkinsonian group was very significantly more depressed than the control group (p less than 0-0001). Depression scores in both groups were unaffected by the patients's sex or by the severity of the disability. Analysis of the individual ratings of the Hamilton Scale showed that parkinsonian patients had significantly higher scores on items relating to suicide, work and interests, retardation, psychic anxiety, general somatic symptoms, and loss of insight. It was concluded that patients with parkinsonism suffer a degree of depression which cannot be solely a reaction to the stress of physical disability. This finding is discussed with reference to the monoamine hypothesis of depressive illness.