RESUMEN
Adoption of electronic health record systems offers an opportunity to collate massive volumes of complex information about patient care. Healthcare data can inform performance management, enable predictive analytics and enhance strategic decision making. A data-driven approach to improving patient care is vital to address the growing burden of morbidity and mortality associated with major surgery. We describe our methodology for transforming and utilising process of care data in an electronic health record system to develop a registry for quality improvement purposes in patients undergoing major surgery at a single UK hospital. We highlight development of our data-driven vision, technical aspects of processing raw data into metrics relevant to clinical decision making, alongside challenges encountered. Finally, we outline how our data infrastructure supports clinical governance, quality improvement and research. In sharing our experiences, we hope to enable others to embed and access the transformative clinical insights that healthcare data can yield.
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Registros Electrónicos de Salud , Mejoramiento de la Calidad , Centros de Atención Terciaria , Humanos , Centros de Atención Terciaria/organización & administración , Londres , Medicina Perioperatoria/métodos , Sistema de RegistrosRESUMEN
Failure, ubiquitous in life and medical practice, offers myriad opportunities for learning and growth alongside challenges to overall well-being. In this article, we explore the nature of failure, it's sources and impacts in perioperative medicine, and the specific challenges it brings to trainee well-being. With a deeper understanding of the societal, psychological and cognitive determinants and effects of failure, we propose solutions in order to harness the opportunities inherent in failures to create brave and supportive learning environments conducive to both education and well-being.
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Anestesiología , Aprendizaje , Medicina Perioperatoria , Humanos , Anestesiología/educación , Medicina Perioperatoria/métodosRESUMEN
Over time, the focus of evidence-based acute pain medicine has shifted, from a focus on drugs and interventions (characterized by numbers needed to treat), to an appreciation of procedure-specific factors (characterized by guidelines and meta-analyses), and now anesthesiologists face the challenge to integrate our current approach with the concept of precision medicine. Psychometric and biopsychosocial markers can potentially guide clinicians on who may need more aggressive perioperative pain management, or who would respond particularly well to a given analgesic intervention. The challenge will be to identify an easily assessable set of parameters that will guide perioperative physicians in tailoring the analgesic strategy to procedure and patient.
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Medicina Basada en la Evidencia , Manejo del Dolor , Dolor Postoperatorio , Atención Perioperativa , Humanos , Manejo del Dolor/métodos , Dolor Postoperatorio/tratamiento farmacológico , Dolor Postoperatorio/prevención & control , Dolor Postoperatorio/diagnóstico , Atención Perioperativa/métodos , Analgésicos/uso terapéutico , Analgésicos/administración & dosificación , Medicina Perioperatoria/métodosAsunto(s)
Humanos , Femenino , Procedimientos Quirúrgicos Ginecológicos/métodos , Recuperación Mejorada Después de la Cirugía/normas , Medicina Perioperatoria/métodos , Medicina Perioperatoria/normas , Dolor Postoperatorio/prevención & control , Complicaciones Posoperatorias/prevención & control , Regulación de la Temperatura Corporal , Drenaje/normas , Ayuno , Guía de Práctica Clínica , Medicina Basada en la Evidencia/métodos , Náusea y Vómito Posoperatorios/prevención & control , Deshidratación/prevención & control , Dietoterapia , Enfermedades del Íleon/prevención & control , Anestesia/normasRESUMEN
OBJECTIVE: We aimed to review recommendations for the postoperative resumption of direct oral anticoagulants (DOACs) and report complications 30 days postoperatively. METHODS: We retrospectively reviewed patients receiving DOAC therapy who underwent preoperative evaluations from January 1, 2015 through May 30, 2018. We noted days that DOAC therapy was withheld, postoperative time until resumption of the DOAC, and complications within 30 postoperative days. RESULTS: A total of 317 patients were included. Ten had complications. Complication rates among patients stratified by time to resumption were not significantly different, except for the deep vein thrombosis rate when DOACs were resumed after 72 hours (n = 2 [4.17%]; P = 0.02). The total time without DOACs did not affect the complication rates. CONCLUSIONS: We suggest withholding DOACs for 48 to 72 hours before surgery and resuming them 48 to 72 hours after surgery, if safe. The interruption of therapy was not associated with an increase in thrombotic events for patients who resumed DOACs within 72 hours postoperatively. Patients who resumed DOACs after 72 hours postoperatively had a low rate of thrombotic complications.
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Inhibidores del Factor Xa/administración & dosificación , Inhibidores del Factor Xa/efectos adversos , Medicina Perioperatoria/normas , Anciano , Anciano de 80 o más Años , Inhibidores del Factor Xa/farmacología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Medicina Perioperatoria/métodos , Medicina Perioperatoria/estadística & datos numéricos , Estudios RetrospectivosAsunto(s)
Líneas Directas , Hepatopatías , Trasplante de Hígado , Medicina Perioperatoria , Consulta Remota , COVID-19/epidemiología , COVID-19/prevención & control , Femenino , Accesibilidad a los Servicios de Salud , Líneas Directas/métodos , Líneas Directas/organización & administración , Líneas Directas/estadística & datos numéricos , Humanos , Control de Infecciones , Israel/epidemiología , Hepatopatías/epidemiología , Hepatopatías/terapia , Masculino , Persona de Mediana Edad , Innovación Organizacional , Aceptación de la Atención de Salud/estadística & datos numéricos , Medicina Perioperatoria/métodos , Medicina Perioperatoria/organización & administración , Consulta Remota/métodos , Consulta Remota/estadística & datos numéricos , SARS-CoV-2RESUMEN
Introducción: Múltiples son los artículos publicados que abordan el tema de la ciencia abierta y su importancia para la sociedad, especialmente para la comunidad de investigadores. Esta constituye, ineludiblemente, el presente y futuro de las revistas científicas como método de expandir las investigaciones con alta calidad y credibilidad. La ciencia abierta como movimiento, tiene varios componentes y dentro de ellos, la gestión de citas y referencias de datos, códigos y materiales, que fundamentan la necesidad de que los autores tengan disponibles los contenidos subyacentes a los artículos que se publican y que constituyen la base de los resultados obtenidos en cada investigación. Objetivo: Evaluación de la eficacia de los protocolos de recuperación mejorada en cirugía cardiaca. Métodos: El protocolo que se propone fue elaborado por la investigadora principal (registro público cubano de ensayos clínicos RPCEC00000304) y se describe acorde a las recomendaciones de la lista internacional de chequeo para ensayos clínicos (SPIRIT). Conclusiones: Estarían en relación a si se puede demostrar, después de terminada la investigación, si el protocolo motivo de la Intervención, es mejor, igual o peor que el protocolo de control(AU)
Introduction: There are multiple articles published that address the subject of open science and its importance for society, especially for the research community. This constitutes, inevitably, the present and future of scientific journals as a method of expanding research with high quality and credibility. Open science, as a movement, has several components including the management of citations and references of data, codes and materials, which support the need for authors to have available the underlying content of the articles published and constituting the base for the results obtained in each investigation. Objective: Assessment of the efficacy of improved recovery protocols in cardiac surgery. Methods: The proposed protocol was prepared by the main researcher (Cuban public registry of clinical trials: RPCEC00000304) and is described according to the recommendations of the international checklist for clinical trials (SPIRIT). Conclusions: They would be related to whether it can be demonstrated, after the end of the investigation, if the protocol reason for the intervention is better, equal to, or worse than the control protocol(AU)
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Humanos , Masculino , Femenino , Isquemia Miocárdica/epidemiología , Recuperación Mejorada Después de la Cirugía/normas , Atención Perioperativa/normas , Medicina Perioperatoria/métodosRESUMEN
Systematic reviews and meta-analyses (SRMAs) are increasing in popularity, but should they be used to inform clinical decision-making in anaesthesia? We present evidence that the certainty of evidence from SRMAs in anaesthesia (and in general) may be unacceptably low because of risks of bias exaggerating treatment effects, unexplained heterogeneity reducing certainty in estimates, random errors, and widespread prevalence of publication bias. We also present the latest methodological advances to help improve the certainty of evidence from SRMAs. The target audience includes both review authors and practising clinicians to help with SRMA appraisal. Issues discussed include minimising risks of bias from included trials, trial sequential analysis to reduce random error, updated methods for presenting effect estimates, and novel publication bias tests for commonly used outcome measures. These methods can help to reduce spurious conclusions on clinical significance, explain statistical heterogeneity, and reduce false positives when evaluating small-study effects. By reducing concerns in these domains of Grading of Recommendations, Assessment, Development and Evaluation, it should help improve the certainty of evidence from SRMAs used for decision-making in anaesthesia, pain, and perioperative medicine.
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Anestesia/métodos , Metaanálisis como Asunto , Medicina Perioperatoria/métodos , Ensayos Clínicos Controlados Aleatorios como Asunto/métodos , Revisiones Sistemáticas como Asunto/métodos , HumanosRESUMEN
BACKGROUND: Adverse cardiovascular events are a leading cause of perioperative morbidity and mortality. The definitions of perioperative cardiovascular adverse events are heterogeneous. As part of the international Standardized Endpoints in Perioperative Medicine initiative, this study aimed to find consensus amongst clinical trialists on a set of standardised and valid cardiovascular outcomes for use in future perioperative clinical trials. METHODS: We identified currently used perioperative cardiovascular outcomes by a systematic review of the anaesthesia and perioperative medicine literature (PubMed/Ovid, Embase, and Cochrane Library). We performed a three-stage Delphi consensus-gaining process that involved 55 clinician researchers worldwide. Cardiovascular outcomes were first shortlisted and the most suitable definitions determined. These cardiovascular outcomes were then assessed for validity, reliability, feasibility, and clarity. RESULTS: We identified 18 cardiovascular outcomes. Participation in the three Delphi rounds was 100% (n=19), 71% (n=55), and 89% (n=17), respectively. A final list of nine cardiovascular outcomes was elicited from the consensus: myocardial infarction, myocardial injury, cardiovascular death, non-fatal cardiac arrest, coronary revascularisation, major adverse cardiac events, pulmonary embolism, deep vein thrombosis, and atrial fibrillation. These nine cardiovascular outcomes were rated by the majority of experts as valid, reliable, feasible, and clearly defined. CONCLUSIONS: These nine consensus cardiovascular outcomes can be confidently used as endpoints in clinical trials designed to evaluate perioperative interventions with the goal of improving perioperative outcomes.
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Enfermedades Cardiovasculares/diagnóstico , Determinación de Punto Final/métodos , Atención Perioperativa/métodos , Medicina Perioperatoria/métodos , Complicaciones Posoperatorias/diagnóstico , Ensayos Clínicos como Asunto , Consenso , Técnica Delphi , Humanos , Proyectos de InvestigaciónRESUMEN
Pharmacogenomics is the study of how genetic differences between individuals affect pharmacokinetics and pharmacodynamics. These differences are apparent to clinicians when taking into account the wide range of responses to medications given in clinical practice. A review of literature involving pharmacogenomics and pain management was performed. The implementation of preoperative pharmacogenomics will allow us to better care for our patients by delivering personalized, safer medicine. This review describes the current state of pharmacogenomics as it relates to many aspects of clinical practice and how clinicians can use these tools to improve patient outcomes.
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Manejo del Dolor/tendencias , Dolor Postoperatorio/genética , Dolor Postoperatorio/terapia , Atención Perioperativa/tendencias , Medicina Perioperatoria/tendencias , Farmacogenética/tendencias , Predicción , Humanos , Manejo del Dolor/métodos , Dolor Postoperatorio/fisiopatología , Atención Perioperativa/métodos , Medicina Perioperatoria/métodos , Farmacogenética/métodosRESUMEN
Graphical models have emerged as a tool to map out the interplay between multiple measured and unmeasured variables, and can help strengthen the case for a causal association between exposures and outcomes in observational studies. In Part 1 of this methods series, we will introduce the reader to graphical models for causal inference in perioperative medicine, and set the framework for Part 2 of the series involving advanced methods for causal inference.
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Investigación Biomédica/métodos , Modelos Estadísticos , Estudios Observacionales como Asunto/métodos , Medicina Perioperatoria/métodos , Investigación Biomédica/estadística & datos numéricos , Humanos , Estudios Observacionales como Asunto/estadística & datos numéricos , Medicina Perioperatoria/estadística & datos numéricosRESUMEN
Although RCTs represent the gold standard in clinical research, most clinical questions cannot be answered using this technique, because of ethical considerations, time, and cost. The goal of observational research in clinical medicine is to gain insight into the relationship between a clinical exposure and patient outcome, in the absence of evidence from RCTs. Observational research offers additional benefit when compared with data from RCTs: the conclusions are often more generalisable to a heterogenous population, which may be of greater value to everyday clinical practice. In Part 2 of this methods series, we will introduce the reader to several advanced methods for supporting the case for causality between an exposure and outcome, including: mediation analysis, natural experiments, and joint effects methods.