Vía de finalización en inducciones de embarazos postérmino, según score de Bishop / Induction of postterm pregnancies according to Bishop score

Objetivo: Determinar la vía de finalización en embarazos pos término de mujeres que fueron internadas para inducción al trabajo de parto y establecer la relación entre la vía de finalización y Bishop de comienzo. Pacientes y métodos: Estudio Observacional, Descriptivo, Transversal, de 2013 a 2014. La población se identificó del SIP de aquellas pacientes con embarazo mayor a 41 semanas internadas para inducción. Test de Fisher exacto o Chi cuadrado para evaluar la siginficancia estadística p=0.05. Resultados: De 197 pacientes, la media fue de 24 años. El 21% comenzó la inducción con Bishop entre 0 y 3 puntos, 59.5% entre 4 y 6 puntos. 13 pacientes recibieron una segunda inducción tras la primera fallida. El 67.5% de las inducciones finalizaron por parto vaginal, 32.5% cesárea. De las mujeres con score 0-3 puntos el 61,5% finalizaron por cesárea, para el segundo grupo (Bishop 4-6) el 71.8% de las inducciones finalizó por parto vaginal, encontrándose una significancia estadística en estas relaciones, test de Fisher=0.000. Conclusiones: Podríamos relacionar el score de Bishop de comienzo de inducción con la vía de finalización y si bien se han encontrado gran porcentaje de partos vaginal con score de 4 en adelante, el 61.5% de las mujeres que pertenecían al grupo de 0-3 finalizaron por la vía quirúrgica por lo que podría recomendarse la maduración cervical previa inducción en este grupo de como estatregia para la reducción de la tasa de cesáreas en inducciones por 41 semanas.

The aim of this report was to present an evaluation of induction of postterm pregnancies according to the ´Bishop score in women admitted for labor induction. Labor induction is an intervention in order to iniciate artificially the uterine contractions to produce the effacement and the dilatation of the uterine cervix and to end with a birth. At present we have three main methods for induction, oxytocin, prostaglandins and amniotomy. The pregnancy chronologically prolongued refers to that simple gestation that reaches or overcomes the 294 days since the date of the last menstruation. It is known that the pregnancies chronologically prolongued are associated with a rise of the maternal and perinatal morbimortality, and therefore, since they are diagnosed. It is mandatory the management toward a minimization of the risks. For these reasons, it is recommended, in the case of a prolonged pregnancy, to consider beneficial to begin the parturition for security reasons for the mother and the fetus. ´These considerations are referred in the article

Prenatal prochloraz treatment significantly increases pregnancy length and reduces offspring weight but does not affect social-olfactory memory in rats.

Metabolites of the commonly used imidazole fungicide prochloraz are androgen receptor antagonists. They have been shown to block androgen-driven development and compromise reproductive function. We tested the effect of prochloraz on cognitive behavior following exposure to this fungicide during the perinatal period. Pregnant Wistar rats were administered a 200 mg/kg dose of prochloraz on gestational day (GD) 7, GD11, and GD15. The social recognition test (SRT) was performed on 7-week-old male rat offspring. We found an increase in pregnancy length and a significantly reduced pup weight on PND15 and PND40 but no effect of prenatal prochloraz exposure on social investigation or acquisition of social-olfactory memory.

Effects of progesterone on iNOS, COX-2, and collagen expression in the cervix.

This study examines the relationship between inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the control of cervical ripening and parturition under normal (normal term pregnancy) and abnormal (preterm labor and prolongation of pregnancy) conditions by (a) measuring changes in the collagen both visually and quantitatively, (b) localizing and characterizing iNOS and COX-2 under normal conditions, and (c) characterizing the changes in iNOS and COX-2 under abnormal conditions. Cervices are obtained from estrus and timed pregnant Sprague-Dawley rats (n=4-10 per group). Preterm labor is induced with Onapristone (3 mg/rat; progesterone antagonist) and the prolongation of pregnancy with progesterone (2.5 mg, twice daily). Collagen changes are measured and visualized with the picrosirius polarization method. RT-PCR is used to characterize the mRNA expression (p<0.05), and immunohistochemistry is used to localize the protein expression for iNOS and COX-2. The organization and birefringence of the collagen during pregnancy decreased and is supported by changes in the luminosity (p<0.001). The iNOS and COX-2 enzymes were localized in cervical smooth muscle, vascular smooth muscle, and epithelium. Under normal conditions, iNOS mRNA levels decreased as COX-2 mRNA levels increased demonstrating an inverse correlation (Spearman r = -0.497; p=0.00295). Onapristone stimulated preterm labor, increasing the iNOS and COX-2 mRNA (p<0.05). The increase demonstrated a positive correlation (Spearman r = 0.456; p=0.03). Progesterone prolonged pregnancy, decreasing the iNOS and COX-2 mRNA (p=0.036). In conclusion, there may be an interaction between the nitric oxide and prostaglandin pathways in cervical ripening and parturition.