RESUMEN
A white, lobular mass was found in the right ovary of a pregnant Risso's dolphin (Grampus griseus) at necropsy. The mass was unilateral and occupied most of the pre-existing ovarian tissue. Histologically, the mass was composed of diffuse sheets of polyhedral cells with abundant eosinophilic cytoplasm and oval nuclei, separated by fibrous connective tissue. Only a few ovarian follicles were observed at the periphery of the mass. Immunohistochemically, the large eosinophilic cells were positive for vimentin and negative for pan-cytokeratins. Based on the histopathological features, the present case was diagnosed as luteoma. In human medicine, luteoma of pregnancy, a tumor-like proliferative lesion occurring in pregnant women, is well described. In veterinary medicine, luteoma associated with pregnancy has never been described. The present study would provide useful information for understanding the characteristics of luteoma in animals.
Asunto(s)
Luteoma/veterinaria , Neoplasias Ováricas/veterinaria , Complicaciones Neoplásicas del Embarazo/veterinaria , Animales , Delfines , Femenino , Luteoma/patología , Neoplasias Ováricas/patología , Embarazo , Complicaciones Neoplásicas del Embarazo/patología , Edema Pulmonar/mortalidad , Edema Pulmonar/veterinaria , Vimentina/análisisRESUMEN
A subcutaneous pale brown-colored mass was observed macroscopically in the ventral neck of a 16-week-old Wistar rat on day 18 of gestation. The mass was well demarcated from the adjacent tissues with partial invasion into connective tissues. Necrosis and hemorrhage were evident throughout the mass. The mass comprised a diffuse sheet and a nest-like structure of epithelial cells with prominent squamous metaplasia. The neoplastic cells tested immunopositive for keratin, vimentin, glial fibrillary acidic protein and p63. A portion of the neoplastic cells exhibited a similar immunoreaction of prominin-1 to the ductal and acinar cells in normal submandibular and parotid glands. Collectively, the tumor was diagnosed as a poorly differentiated carcinoma derived from epithelial/myoepithelial lineages in the submandibular and/or parotid glands.
Asunto(s)
Carcinoma/veterinaria , Complicaciones Neoplásicas del Embarazo/veterinaria , Neoplasias de las Glándulas Salivales/veterinaria , Animales , Carcinoma/complicaciones , Carcinoma/patología , Femenino , Embarazo , Complicaciones Neoplásicas del Embarazo/patología , Ratas , Ratas Wistar , Neoplasias de las Glándulas Salivales/complicaciones , Neoplasias de las Glándulas Salivales/patología , Glándulas Salivales/patologíaRESUMEN
The case report describes a narrowing of the spinal canal in the lumbar and sacroiliac regions with entailing acute recumbency in a nearterm 17-year-old Welsh B Pony mare. The reason for recumbency was metastases of a malignant melanoma in the spinal canal of the lumbo-sacral region, where the tumour had invaded the dura mater and applied severe pression on the spinal cord over a length of 10 cm. Clinical findings, laboratory diagnostics, pathological-anatomical and histopathological findings are presented.
Asunto(s)
Enfermedades de los Caballos/patología , Melanoma/veterinaria , Complicaciones Neoplásicas del Embarazo/veterinaria , Compresión de la Médula Espinal/veterinaria , Médula Espinal/patología , Neoplasias de la Columna Vertebral/veterinaria , Animales , Femenino , Enfermedades de los Caballos/diagnóstico , Enfermedades de los Caballos/etiología , Caballos , Melanoma/complicaciones , Melanoma/diagnóstico , Melanoma/patología , Postura , Embarazo , Complicaciones Neoplásicas del Embarazo/diagnóstico , Complicaciones Neoplásicas del Embarazo/patología , Radiografía , Médula Espinal/diagnóstico por imagen , Compresión de la Médula Espinal/diagnóstico , Compresión de la Médula Espinal/etiología , Compresión de la Médula Espinal/patología , Neoplasias de la Columna Vertebral/complicaciones , Neoplasias de la Columna Vertebral/diagnóstico , Neoplasias de la Columna Vertebral/patologíaRESUMEN
Papillomaviruses (PVs) are believed to be highly epitheliotropic as they usually establish productive infections within stratified epithelia. In vitro, various PVs appear to complete their entire life-cycle in different trophoblastic cell lines. In this study, infection by and protein expression of bovine papillomavirus type 2 (BPV-2) in the uterine and chorionic epithelium of the placenta has been described in four cows suffering from naturally occurring papillomavirus-associated urothelial bladder tumors. E5 oncoprotein was detected both by Western blot analysis and immunohistochemically. It appears to be complexed and perfectly co-localized with the activated platelet-derived growth factor ß receptor (PDGFßR) by laser scanning confocal microscopy. The activated PDGFßR might be involved in organogenesis and neo-angiogenesis rather than in cell transformation during pregnancy. The major capsid protein, L1, believed to be only expressed in productive papillomavirus infection has been detected by Western blot analysis. Immunohistochemical investigations confirmed the presence of L1 protein both in the cytoplasm and nuclei of cells of the uterine and chorionic epithelium. Trophoblastic cells appear to be the major target for L1 protein expression. Finally, the early protein E2, required for viral DNA replication and known to be expressed during a productive infection, has been detected by Western blot and immunohistochemically. Electron microscopic investigations detected viral particles in nuclei of uterine and chorionic epithelium. This study shows that both active and productive infections by BPV-2 in the placenta of pregnant cows can occur in vivo.
Asunto(s)
Papillomavirus Bovino 1 , Enfermedades de los Bovinos/virología , Infecciones por Papillomavirus/veterinaria , Placenta/virología , Complicaciones Infecciosas del Embarazo/veterinaria , Complicaciones Neoplásicas del Embarazo/veterinaria , Neoplasias de la Vejiga Urinaria/veterinaria , Animales , Papillomavirus Bovino 1/genética , Papillomavirus Bovino 1/metabolismo , Carcinoma Papilar/metabolismo , Carcinoma Papilar/veterinaria , Carcinoma Papilar/virología , Bovinos , Enfermedades de los Bovinos/genética , Enfermedades de los Bovinos/metabolismo , Femenino , Infecciones por Papillomavirus/metabolismo , Infecciones por Papillomavirus/virología , Placenta/metabolismo , Embarazo , Complicaciones Infecciosas del Embarazo/metabolismo , Complicaciones Infecciosas del Embarazo/virología , Complicaciones Neoplásicas del Embarazo/metabolismo , Complicaciones Neoplásicas del Embarazo/virología , Unión Proteica , Transporte de Proteínas , Receptor beta de Factor de Crecimiento Derivado de Plaquetas/genética , Receptor beta de Factor de Crecimiento Derivado de Plaquetas/metabolismo , Neoplasias de la Vejiga Urinaria/metabolismo , Neoplasias de la Vejiga Urinaria/virología , Proteínas Virales/metabolismoRESUMEN
CASE HISTORY: A 14-year-old Thoroughbred mare was presented for evaluation of a rapidly enlarging ovary at 73 days gestation. The mare's owner reported behavioural changes in the mare since she returned from stud, notably aggression towards other horses. CLINICAL FINDINGS: Transrectal palpation and ultrasonography of the reproductive tract revealed a viable pregnancy, an enlarged, multiloculated right ovary, and a normal-sized left ovary with a corpus luteum present. Concentrations of inhibin and testosterone in serum were 13.8 ng/mL and 1,150 pg/mL, respectively, being markedly higher than reference ranges. Concentration of progesterone was 4.5 ng/mL, consistent with the presence of functional luteal tissue. A presumptive diagnosis of a granulosa theca cell tumour (GTCT) was made, and the ovary was surgically removed. Histopathological examination of the removed ovary confirmed a benign GTCT. At 31 days after surgery concentrations of inhibin in serum had decreased 18-fold, and testosterone had decreased 10-fold. Pregnancy was reconfirmed at 115 days gestation by rectal palpation and transrectal ultrasonography. DIAGNOSIS: Granulosa theca cell tumour associated with elevated concentrations of inhibin and testosterone in serum. CLINICAL RELEVANCE: While ovarian enlargement and aggressive behaviour may be considered normal in some pregnant mares, a GTCT should be included as a differential diagnosis. Measurement of concentrations of inhibin and testosterone in serum are useful to support a presumptive diagnosis of GTCT in mares.
Asunto(s)
Tumor de Células de la Granulosa/veterinaria , Enfermedades de los Caballos , Inhibinas/sangre , Neoplasias Ováricas/veterinaria , Complicaciones Neoplásicas del Embarazo/veterinaria , Testosterona/sangre , Animales , Femenino , Tumor de Células de la Granulosa/sangre , Tumor de Células de la Granulosa/patología , Tumor de Células de la Granulosa/cirugía , Enfermedades de los Caballos/sangre , Enfermedades de los Caballos/patología , Enfermedades de los Caballos/cirugía , Caballos , Neoplasias Ováricas/sangre , Neoplasias Ováricas/patología , Neoplasias Ováricas/cirugía , Embarazo , Complicaciones Neoplásicas del Embarazo/sangre , Complicaciones Neoplásicas del Embarazo/patología , Complicaciones Neoplásicas del Embarazo/cirugíaRESUMEN
A 10-year-old Swiss Braunvieh cow near term was referred to our clinic because of severe abdominal distension, which caused loss of demarcation between the udder and ventral abdominal wall. Ultrasonographic examination revealed marked ascites and multiple echogenic nodules in the greater omentum. Based on the findings, non-inflammatory ascites attributable to neoplasia was diagnosed. Rupture of the prepubic tendon from the pubic symphysis was also suspected. Because of a grave prognosis, parturition was induced and a live calf was delivered. The cow was euthanized and a postmortem examination was carried out. The abdominal cavity contained 248.5 litres of clear fluid. The greater omentum was thickened and oedematous and regionally contained fluid-filled cystic structures, which varied in size with a maximum diameter of 10 centimetres. Based on the histological, immunohistochemical and electron microscopical findings, biphasic mesothelioma with cyst formation affecting the entire abdominal cavity was diagnosed.
Asunto(s)
Cavidad Abdominal/patología , Neoplasias Abdominales/veterinaria , Enfermedades de los Bovinos/patología , Mesotelioma/veterinaria , Complicaciones Neoplásicas del Embarazo/veterinaria , Neoplasias Abdominales/patología , Animales , Ascitis/diagnóstico por imagen , Ascitis/veterinaria , Bovinos , Eutanasia Animal , Resultado Fatal , Femenino , Mesotelioma/patología , Embarazo , Complicaciones Neoplásicas del Embarazo/patología , Resultado del Embarazo/veterinaria , Pronóstico , UltrasonografíaRESUMEN
A mass in the pelvic canal of a 4-year-old pregnant alpaca hembra diagnosed as leiomyosarcoma of the urogenital tract was confirmed by biopsy. Following a tube cystotomy, the alpaca was presented 33 d later, 2 d after the tube cystotomy had been dislodged. A dead cria was delivered by caesarean section.
Asunto(s)
Camélidos del Nuevo Mundo , Leiomiosarcoma/veterinaria , Complicaciones Neoplásicas del Embarazo/veterinaria , Neoplasias Uterinas/veterinaria , Animales , Femenino , Muerte Fetal/veterinaria , Leiomiosarcoma/complicaciones , Leiomiosarcoma/diagnóstico , Embarazo , Complicaciones Neoplásicas del Embarazo/diagnóstico , Neoplasias Uterinas/complicaciones , Neoplasias Uterinas/diagnósticoRESUMEN
Fibroleiomyomas of the ovary are rare. This smooth muscle tumour may develop and increase in size during pregnancy. Diagnosis is based on histological and immunohistochemical analyses. Histologically, the ovarian fibroleiomyoma consists of non-invasive bundles of smooth muscle cells that synthesize collagen-like extracellular matrix. This case report describes an ovarian fibroleiomyoma in a pregnant multiparous broodmare with a history of intermittent signs of colic.
Asunto(s)
Enfermedades de los Caballos/patología , Leiomioma/veterinaria , Neoplasias Ováricas/veterinaria , Complicaciones Neoplásicas del Embarazo/veterinaria , Animales , Femenino , Enfermedades de los Caballos/cirugía , Caballos , Leiomioma/patología , Leiomioma/cirugía , Neoplasias Ováricas/patología , Neoplasias Ováricas/cirugía , EmbarazoRESUMEN
This case report describes a placental tumor from a stillborn East African bongo fetus. On gross examination, the tumor was reminiscent of a chorangioma; however, based on histomorphology, histochemical and immunophenotypic characterization, comparison to 21 human cases of chorangioma, and embryogenesis, this tumor is hypothesized to be a placental stem cell tumor. Histologically, the tumor had 2, often commingled, morphologies with one area having dense cellularity and scant vascularity and a second area having scant cellularity and prominent vascularity. Pleomorphic mesenchymal cells were arranged in intersecting fascicles, often whorled around, or were contiguous with vascular channels and had features of skeletal muscle, smooth muscle, pericyte, endothelial, fibrous, and undifferentiated mesenchymal cells. Phosphotungstic acid-hematoxylin outlined cross-striations in some cells. Cells variably were immunoreactive for vimentin, CD31, von Willebrand factor VIII, desmin, muscle specific actin, alpha-smooth muscle actin, and skeletal myosin and negative for cytokeratin antigens. The relationship of this tumor to the presence of fetal musculoskeletal and omental anomalies is discussed.
Asunto(s)
Antílopes , Enfermedades Fetales/veterinaria , Placenta/patología , Complicaciones Neoplásicas del Embarazo/veterinaria , Animales , Antílopes/embriología , Femenino , Enfermedades Fetales/patología , Embarazo , Células Madre/patologíaRESUMEN
ANIMAL STUDIED: A 6-year-old, pregnant female llama experienced a 6-month history of epiphora, buphthalmos, and acute loss of vision in the left eye. The condition was unresponsive to topical antimicrobial and anti-inflammatory therapy and progressed to corneal rupture. PROCEDURES: Transpalpebral enucleation was performed and an intraorbital silicone prosthesis was implanted. The eye was fixed in formalin and processed according to routine paraffin technique. Sections of a mass were immunohistochemically prepared routinely and stained for glial fibrillary acidic protein (GFAP), S-antigen, and rhodopsin. RESULTS: Gross, histopathologic, and immunohistochemical analysis revealed a retinal tumor consistent with a retinoblastoma. The neoplastic tissue formed Flexner-Wintersteiner and Homer-Wright rosettes, originated from the retina, and demonstrated photoreceptor differentiation with S-antigen and rhodopsin expression. Neoplastic cells were negative for GFAP. Four years after enucleation, the llama showed no signs of recurrent neoplasia. CONCLUSIONS: This report describes the diagnosis and successful treatment of the first known retinoblastoma in a llama.
Asunto(s)
Camélidos del Nuevo Mundo , Complicaciones Neoplásicas del Embarazo/veterinaria , Neoplasias de la Retina/veterinaria , Retinoblastoma/veterinaria , Animales , Diagnóstico Diferencial , Femenino , Inmunohistoquímica , Embarazo , Complicaciones Neoplásicas del Embarazo/diagnóstico , Complicaciones Neoplásicas del Embarazo/patología , Complicaciones Neoplásicas del Embarazo/cirugía , Neoplasias de la Retina/diagnóstico , Neoplasias de la Retina/patología , Neoplasias de la Retina/cirugía , Retinoblastoma/diagnóstico , Retinoblastoma/patología , Retinoblastoma/cirugíaAsunto(s)
Enfermedades de los Bovinos/diagnóstico , Condrosarcoma/veterinaria , Neoplasias de los Músculos/veterinaria , Complicaciones Neoplásicas del Embarazo/veterinaria , Animales , Bovinos , Enfermedades de los Bovinos/patología , Condrosarcoma/diagnóstico , Diagnóstico Diferencial , Femenino , Inmunohistoquímica , Neoplasias de los Músculos/diagnóstico , Embarazo , Complicaciones Neoplásicas del Embarazo/diagnósticoRESUMEN
Uterine leiomyomas occurred in three eastern bongo (Tragelaphus eurycerus isaaci) 10, 15, and 16 yr of age at three separate zoological institutions. Two animals were nulliparous, and one had given birth to 14 calves over its lifetime. Two of the leiomyomas originated in the cervix. The third originated in the uterine wall and incorporated the body of the uterus and both uterine horns. The tumors in the two animals that had never calved were large and nonresectable. They were associated with gastrointestinal clinical signs including diarrhea, anorexia, and the inability to defecate. The tumor in the animal that had calved was an incidental finding at necropsy. Uterine leiomyomas have not been previously documented in the literature on eastern bongo.
Asunto(s)
Antílopes , Leiomioma/veterinaria , Complicaciones Neoplásicas del Embarazo/veterinaria , Neoplasias Uterinas/veterinaria , Animales , Animales de Zoológico , Resultado Fatal , Femenino , Leiomioma/diagnóstico , Leiomioma/patología , Embarazo , Complicaciones Neoplásicas del Embarazo/diagnóstico , Complicaciones Neoplásicas del Embarazo/patología , Neoplasias Uterinas/diagnóstico , Neoplasias Uterinas/patologíaRESUMEN
An 11-year-old Quarterhorse mare developed a paranasal sinus osteoma that extended into the right orbit and led to ipsilateral exophthalmia. Although the tumor was radiographically evident in the paranasal sinuses, ultrasonography was used to demonstrate extension of the tumor into the retrobulbar space, and endoscopy was used to identify its extension into the nasopharynx. Biopsies were obtained using both fine-needle aspiration and paranasal sinus trephination. Despite numerous antemortem diagnostic tests, only postmortem histologic analysis of the mass afforded the diagnosis of osteoma.
Asunto(s)
Exoftalmia/veterinaria , Enfermedades de los Caballos/patología , Osteoma/veterinaria , Neoplasias de los Senos Paranasales/veterinaria , Complicaciones Neoplásicas del Embarazo/veterinaria , Animales , Biopsia con Aguja Fina/veterinaria , Endoscopía/veterinaria , Exoftalmia/etiología , Exoftalmia/patología , Resultado Fatal , Femenino , Histocitoquímica/veterinaria , Caballos , Osteoma/patología , Neoplasias de los Senos Paranasales/patología , Embarazo , Complicaciones Neoplásicas del Embarazo/patologíaRESUMEN
A teratocarcinoma was diagnosed in the amnion of a 5-year-old Arabian mare that delivered a healthy, full-term foal. The foal died at 2.5 months of age as a result of metastasis of an undifferentiated component of the mass. This case is unique because it is the first reported case of placental teratocarcinoma in animals and the malignant component apparently metastasized to the foal resulting in its death.
Asunto(s)
Enfermedades de los Caballos/patología , Neoplasias Peritoneales/veterinaria , Enfermedades Placentarias/veterinaria , Complicaciones Neoplásicas del Embarazo/veterinaria , Teratocarcinoma/veterinaria , Animales , Animales Recién Nacidos , Resultado Fatal , Femenino , Histocitoquímica/veterinaria , Caballos , Neoplasias Peritoneales/secundario , Enfermedades Placentarias/patología , Embarazo , Complicaciones Neoplásicas del Embarazo/patología , Teratocarcinoma/secundarioAsunto(s)
Enfermedades de los Perros/patología , Glándulas Mamarias Animales/patología , Neoplasias Mamarias Animales/patología , Complicaciones Neoplásicas del Embarazo/veterinaria , Seudoembarazo/veterinaria , Animales , Perros , Femenino , Hiperplasia , Ovariectomía , Embarazo , Complicaciones Neoplásicas del Embarazo/patología , Seudoembarazo/patologíaRESUMEN
The literature on congenital tumours and tumour-like lesions in horses was reviewed. Included were embryonic tumours and teratomas. Special attention was paid to the ubiquitous adenomatous hyperplasia of the placenta. It appears that temporal teratomas, interstitial hamartomas and placental adenomatous hyperplasia are unique in the horse. Benign teratoma of the undescended testis is far more frequent in the horse than in other species. In horses, as in calves and pigs, congenital skin tumours were of papillomatous, vascular and melanocytic types. The sporadic occurrence of congenital tumours in the horse did not provide an etiologic or pathogenetic clue. The possibility of oncogenic viruses in cases of congenital skin papilloma or malignant lymphoma could neither be proven, nor be excluded. Hereditary tumours were not encountered.