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1.
J Trauma Nurs ; 31(2): 82-89, 2024.
Article En | MEDLINE | ID: mdl-38484163

BACKGROUND: Approximately 90% of adults endorse psychological trauma exposure. However, barriers to assessment of psychological trauma and sequelae include limited access to care, lack of standardized assessments in nonpsychiatric settings, and comorbid diagnoses, such as traumatic brain injury (TBI), that may mimic psychiatric syndromes. OBJECTIVES: This study aims to assess the prevalence rates of psychological trauma exposure and TBI to understand the relationship of these experiences with current psychiatric symptoms. METHODS: This is a cross-sectional study of a convenience sample of adult patients (age 18 years and older) referred for outpatient evaluation at a neuropsychology clinic in the Western United States between September 2021 and October 2022. Patients completed a clinical interview to assess their history of psychological trauma, TBI, and current psychiatric symptoms. RESULTS: A total of 118 patients met inclusion criteria. Patients in the TBI group (n = 83) endorsed significantly higher rates of childhood trauma and prior physical, emotional, and sexual abuse compared with the No TBI group (n = 35). Psychological trauma exposure and TBI significantly predicted current anxiety and depressive symptoms, but there was no interaction between these experiences in predicting current psychiatric symptoms. CONCLUSIONS: Individuals with prior TBI experienced psychological trauma, particularly childhood trauma, at a significantly higher rate than those without TBI. Psychological trauma exposure and TBI independently predicted anxious and depressive symptoms, suggesting both may be viable treatment targets. Evaluation of prior psychological trauma exposure during evaluation of TBI may provide opportunities for trauma-informed care and may allow for improved outpatient treatment planning.


Brain Injuries, Traumatic , Psychological Trauma , Stress Disorders, Post-Traumatic , Adult , Humans , Adolescent , Depression/diagnosis , Depression/epidemiology , Depression/etiology , Cross-Sectional Studies , Brain Injuries, Traumatic/diagnosis , Brain Injuries, Traumatic/epidemiology , Brain Injuries, Traumatic/complications , Psychological Trauma/complications , Anxiety/diagnosis , Anxiety/epidemiology , Stress Disorders, Post-Traumatic/psychology
3.
Dig Dis Sci ; 69(3): 870-875, 2024 Mar.
Article En | MEDLINE | ID: mdl-38112834

BACKGROUND: There is frequent overlap between and the connective tissue diseases Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome (JHS/EDS) and disorders of the gut-brain interaction (DGBIs). AIMS: Because not all JHS/EDS patients develop DGBIs, we sought to determine whether secondary environmental triggers may lead to development of irritable bowel syndrome (IBS) and functional dyspepsia (FD) in patients with JHS/EDS. METHODS: We sent electronic surveys to 253 patients from a JHS/EDS support group, with responses collected over one year. IBS and FD were diagnosed by the Rome IV criteria, with additional validated assessments of adverse childhood experiences (ACEs) and traumatic stressors according to DSM-V criteria. We compared clinical and psychological characteristics of JHS/EDS patients with and without DGBIs using univariable and multivariable analyses. RESULTS: We enrolled 193 JHS/EDS patients, of whom 67.9% met Rome IV criteria for IBS. The IBS and JHS/EDS overlap group reported significantly more traumatic exposures (P < 0.001) and were more likely to have experienced greater than 3 ACEs (P < 0.001) than JHS/EDS patients without IBS. FD was found in 35.2% of patients and was associated with significantly more traumatic exposures (P < 0.001) and were more likely to have experienced greater than 3 ACEs (P < 0.001) than JHS/EDS patients without FD. CONCLUSIONS: We found that JHS/EDS patients with IBS and FD overlap reported significantly more traumatic exposures and ACEs compared to JHS/EDS patients without overlapping IBS or FD. JHS/EDS patients may have increased susceptibility to DGBIs, with traumatic life experiences and/or ACEs acting a secondary environmental trigger driving the subsequent development of DGBIs.


Dyspepsia , Ehlers-Danlos Syndrome , Irritable Bowel Syndrome , Joint Instability , Joint Instability/congenital , Psychological Trauma , Humans , Irritable Bowel Syndrome/diagnosis , Irritable Bowel Syndrome/epidemiology , Irritable Bowel Syndrome/complications , Dyspepsia/diagnosis , Dyspepsia/epidemiology , Joint Instability/complications , Joint Instability/diagnosis , Ehlers-Danlos Syndrome/complications , Ehlers-Danlos Syndrome/diagnosis , Ehlers-Danlos Syndrome/epidemiology , Psychological Trauma/complications
4.
Int J Gynaecol Obstet ; 161(2): 568-573, 2023 May.
Article En | MEDLINE | ID: mdl-36700371

OBJECTIVE: The aim of the present study was three-fold. One, to assess the prevalence of medical traumatization in outpatients of a gynecologic department; two, to analyze the relationship of medical traumatization with adverse childhood events; and three, to investigate the extent to which medical traumatization affects the health outcomes of woman. METHODS: Between January and September 2022, a prospective cross-sectional study recruited patients of a gynecologic outpatient clinic at St. Gallen Cantonal Hospital in Switzerland. Medical trauma was a self-reported item. The presence of adverse childhood events was assessed using the Childhood Trauma Questionnaire. The severity of post-traumatic stress was evaluated using the Impact of Event Scale Revised questionnaire. RESULTS: In total, 227 patients were recruited. Medical trauma was reported by 20% of the interviewees and it was strongly associated with obesity (A = 0.005). Undergoing surgery was most commonly the source of psychological distress (5.7%) followed by delivery (4.8%), pregnancy loss (4.8%), and cancer diagnosis (4.0%). Yet, fewer than 1% of the patients reached the threshold suggesting post-traumatic stress disorder. CONCLUSIONS: We found no relationship between the medical trauma, adverse childhood events, cardiovascular disease, or substance abuse. The presence of medical trauma was associated with the patient's body mass index (calculated as weight in kilograms divided by the square of height in meters).


Psychological Trauma , Stress Disorders, Post-Traumatic , Pregnancy , Humans , Female , Prevalence , Cross-Sectional Studies , Prospective Studies , Psychological Trauma/complications , Stress Disorders, Post-Traumatic/epidemiology , Stress Disorders, Post-Traumatic/complications , Stress Disorders, Post-Traumatic/psychology , Women's Health , Stress, Psychological/epidemiology
5.
J Sleep Res ; 32(2): e13639, 2023 04.
Article En | MEDLINE | ID: mdl-35644523

Nightmares are a core feature of posttraumatic stress disorder, are poorly understood, and are associated with serious negative outcomes. Their biology has been difficult to study, and the feasibility of capturing them in the naturalistic home environment has been poor. This said, the published research and dominant scientific model has focused on nightmares as a manifestation of noradrenergic hyperarousal during rapid eye movement sleep. The current study used at-home, participant-applied devices to measure nightmare physiology in posttraumatic stress disorder treatment-seeking veterans, by examining heartrate measures as indicators of noradrenergic tone, and sleep-stage characteristics and stability in the sleep preceding time-stamped nightmare awakenings. Our data indicate the high feasibility of participant-administered, at-home measurement, and showed an unexpected stability of -rapid eye movement sleep along with no evidence of heartrate elevations in sleep preceding nightmare awakenings. Altogether, these data highlight new opportunities for the study of nightmares while questioning the sufficiency of dominant models, which to date are largely theoretically based.


Psychological Trauma , Sleep Wake Disorders , Stress Disorders, Post-Traumatic , Veterans , Humans , Dreams/psychology , Veterans/psychology , Home Environment , Sleep , Psychological Trauma/complications , Stress Disorders, Post-Traumatic/psychology , Electroencephalography , Sleep Wake Disorders/complications
6.
Article En | MEDLINE | ID: mdl-35451296

Traumatic childbirth is an international public health problem because it is supposed that currently up to 45% of new mothers have reported such an experience. International rates of PTSD due to birth trauma range between 1.5 and 9 percent of all births. Birth trauma is defined as an event occurring during the labour and delivery process that involves actual or threatened serious injury or death of the mother or her infant. A traumatic event or situation creates psychological trauma when it overwhelms the individual's ability to cope, and leaves that person fearing death, annihilation, mutilation, or psychosis. The individual may feel emotionally, cognitively, and physically overwhelmed. The aim of this article is to present a review of published data for childbirth trauma over various periods of time, as well as in different regions of the world. Studies were identified through a comprehensive search of PubMed, PsycInfo, ProQuest and PILOTS (Published International Literature of Traumatic Stress) over the last 20 years. More than 8000 articles were found. In this article we present and discuss some important findings.


Psychological Trauma , Stress Disorders, Post-Traumatic , Delivery, Obstetric/adverse effects , Female , Humans , Infant , Mothers/psychology , Parturition/psychology , Pregnancy , Psychological Trauma/complications , Stress Disorders, Post-Traumatic/epidemiology , Stress Disorders, Post-Traumatic/etiology , Stress Disorders, Post-Traumatic/psychology
7.
Psychol Trauma ; 14(7): 1175-1183, 2022 Oct.
Article En | MEDLINE | ID: mdl-31789533

OBJECTIVE: Interpersonal trauma is a nonspecific risk factor for disordered eating (DE). Studies have begun to examine mechanisms that explain the relationship; however, few have tested comprehensive theoretical models. The Model of Psychological Adaptation (McCann, Sakheim, & Abrahamson, 1988) posits that trauma exposure results in core schema disruptions that are associated with varying psychological response patterns, or psychological adaptations, that are also established predictors of DE, such as interpersonal and affective problems. The model has been successfully applied to symptoms of other psychological disorders, such as PTSD and depression, but has not previously been extended to predict DE. The current study addressed this gap in the literature by assessing an extension of the Model of Psychological Adaptation to DE. METHOD: A sample of 371 undergraduate women completed an online survey. RESULTS: Using structural equation modeling, the results of the current study demonstrated positive fit for a model that represents the extension of the Model of Psychological Adaptation to DE. CONCLUSION: These findings corroborate the link between interpersonal trauma and DE, thus demonstrating the potential importance of assessing for DE symptoms among clients who have survived interpersonal trauma and attending to trauma history among clients who have DE. In addition, it highlights mechanisms that may be relevant to the conceptualization and treatment of DE among survivors of interpersonal trauma. (PsycInfo Database Record (c) 2022 APA, all rights reserved).


Feeding and Eating Disorders , Psychological Trauma , Stress Disorders, Post-Traumatic , Adaptation, Psychological , Female , Humans , Psychological Trauma/complications , Stress Disorders, Post-Traumatic/psychology , Surveys and Questionnaires , Survivors
8.
Psychol Trauma ; 14(4): 545-557, 2022 May.
Article En | MEDLINE | ID: mdl-34498897

BACKGROUND: Military personnel are at a heightened risk of being exposed to potentially traumatic incidents in the line of duty. Evidence would suggest that the risk of developing psychological trauma and/or PTSD after a traumatic event is predicted by the interaction of pre-trauma, peri-trauma and post-trauma risk and protective factors. OBJECTIVE: This research will explore military personnels' experience of potentially traumatic events while deployed. In particular, the research aims to gain an understanding of both protective and risk factors which influence personnels' experience of potentially traumatic events. METHOD: One to one, semi-structured interviews were conducted with 12 members of the Irish Defence Forces. We conducted a thematic analysis in line with the recommendations provided by Braun & Clarke 2006. RESULTS: There was a wide variety of potentially traumatic events experienced by participants, ranging from stressful naval migrant rescues to armed standoffs. Aside from more pointed events, chronic stress was reported to negatively affect personal resilience while factors such as positive mindset and a belief in the mission had a galvanizing effect. Both the family back home and the "military family" were reported to provide sources of comfort and support, while at times being a source of significant stress. The organisational context of the military, including training and formal psychological supports was viewed with mixed opinions by our participants. CONCLUSIONS: The findings of this research illuminate the unique stress and strains faced by Irish military personnel at pre, peri and post deployment. The results highlight the need for effective predeployment resilience building programmes to equip personnel with the tools to deal with traumatic events. This foundational work provides the basis for further research into the military peacekeeper and humanitarian domain. (PsycInfo Database Record (c) 2022 APA, all rights reserved).


Military Personnel , Psychological Trauma , Resilience, Psychological , Stress Disorders, Post-Traumatic , Humans , Military Personnel/psychology , Psychological Trauma/complications , Risk Factors , Stress Disorders, Post-Traumatic/psychology
9.
Eur J Psychotraumatol ; 12(1): 2009271, 2021.
Article En | MEDLINE | ID: mdl-34900125

Background: Numerous studies found robust associations between psychosis and posttraumatic stress disorder (PTSD), but few have examined the relationships between psychosis and recently formulated ICD-11 Complex PTSD (CPTSD). Further, no known study has examined the effects of different traumatic life events on CPTSD and psychotic-like symptoms in a manner that permits gender-specific effects to be identified. Objective: Using a nationally representative sample of 1,020 Irish adults, we examined gender-differences in (a) psychotic-like symptoms, CPTSD, and exposure to 21 different traumatic life events, and (b) the unique associations between different traumas with CPTSD and Psychosis. Method: Bivariate analyses and structural equation modelling were performed. Results: Consistent with the literature, no gender differences were observed in psychotic-like symptoms. Females reported slightly higher levels of CPTSD and were more likely to be exposed to sexual and emotional abuse, whereas men reported greater exposure to physical violence, accidents, and disasters. Psychosis symptoms were explained by trauma exposure to a considerate degree and at a level similar to CPTSD; a moderate correlation was also found between CPTSD and Psychosis. Physical/emotional neglect was the only traumatic life event that significantly and most strongly predicted both conditions. Two gender-specific associations between different traumatic life events and CPTSD and Psychosis were identified out of the 42 possible effects modelled. Conclusions: The present investigation provides initial evidence that psychotic-like symptoms and CPTSD are moderately correlated constructs in the general population. Results also highlight the importance of conducting a detailed assessment of trauma history for all clients presenting with symptoms of CPTSD, psychosis, or both.


Antecedentes: Numerosos estudios han encontrado asociaciones robustas entre la psicosis y el trastorno de estrés postraumático (TEPT), pero pocos han examinado la relación entre la psicosis y el recientemente formulado TEPT Complejo (TEPT-C). Es más, no existe algún estudio conocido que haya examinado los efectos de diferentes eventos vitales traumáticos en el TEPT-C y los síntomas psicóticos de una forma que permita identificar efectos específicos por género.Objetivo: Usando una muestra representativa a nivel nacional de 1.020 adultos irlandeses, examinamos las diferencias de género en (a) los síntomas psicóticos, el TEPT-C, y exposición a 21 eventos vitales traumáticos diferentes, y (b) las asociaciones únicas entre los diferentes traumas con el TEPT-C y la Psicosis.Método: Se llevaron a cabo análisis bivariados y modelamiento de ecuaciones estructurales.Resultados: Consistente con la literatura, no se observaron diferencias de género en los síntomas psicóticos. Las mujeres reportaron niveles levemente más altos del TEPT-C y fueron más propensas a estar expuestas a abuso sexual y emocional, mientras que los hombres reportaron mayor exposición a la violencia física, accidentes, y desastres. Los síntomas de la psicosis fueron explicados por la exposición a trauma en un grado considerable y en un nivel similar al TEPT-C; se encontró también una correlación moderada entre el TEPT-C y la Psicosis. La negligencia física/emocional fue el único evento vital traumático que predijo significativamente y más fuertemente ambas condiciones. De los 42 posibles efectos modelados, se identificaron dos asociaciones específicas al género entre eventos vitales traumáticos y el TEPT-C y la Psicosis.Conclusiones: La presente investigación proporciona evidencia inicial que los síntomas psicóticos y TEPT-C son constructos correlacionados moderadamente en la población general. Los resultados también subrayan la importancia de conducir una evaluación detallada de la historia de trauma de todos los clientes presentando síntomas de TEPT-C, psicosis, o ambos.


Psychological Trauma/complications , Psychotic Disorders/etiology , Stress Disorders, Post-Traumatic/etiology , Adolescent , Adult , Aged , Aged, 80 and over , Female , Humans , International Classification of Diseases , Male , Middle Aged , Risk Factors , Young Adult
10.
Eur J Psychotraumatol ; 12(1): 1-14, 2021.
Article En | MEDLINE | ID: mdl-34912501

Background: Prolonged grief disorder (PGD) is newly included in the text revision of the DSM-5 (DSM-5-TR). So far, it is unknown if DSM-5-TR PGD is distinguishable from bereavement-related posttraumatic stress disorder (PTSD). Prior research examining the distinctiveness of PTSD and pathological grief focused on non-traumatic loss samples, used outdated conceptualizations of grief disorders, and has provided mixed results. Objective: In a large sample of traumatically bereaved people, we first evaluated the factor structure of PTSD and PGD separately and then evaluated the factor structure when combining PTSD and PGD symptoms to examine the distinctiveness between the two syndromes. Methods: Self-reported data were used from 468 people bereaved due to the MH17 plane disaster (N = 200) or a traffic accident (N = 268). The 10 DSM-5-TR PGD symptoms were assessed with the Traumatic Grief Inventory-Self Report Plus (TGI-SR+). The 20-item Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5) was used to tap PTSD symptoms. Confirmatory factor analyses were conducted. Results: For PTSD, a seven factor, so-called 'Hybrid' model yielded the best fit. For PGD, a univariate factor model fits the data well. A combined model with PGD items loading on one factor and PTSD items on seven factors (associations between PGD and PTSD subscales r ≥ .50 and ≤.71), plus a higher-order factor (i.e. PTSD factors on a higher-order PTSD factor) (association between higher-order PTSD factor and PGD factor r = .82) exhibited a better fit than a model with all PGD and PTSD symptom loading on a single factor or two factors (i.e. one for PGD and one for PTSD). Conclusions: This is the first study examining the factor structure of DSM-5-TR PGD and DSM-5 PTSD in people confronted with a traumatic loss. The findings provide support that PGD constitutes a syndrome distinguishable from, yet related with, PTSD.


Antecedentes: El trastorno de duelo prolongado (PGD en su sigla en inglés) se incluyó recientemente en la revisión del texto del DSM-5 (DSM-5-TR). Hasta ahora, se desconoce si el PGD del DSM-5-TR se puede distinguir del trastorno de estrés postraumático (TEPT) relacionado con el duelo. Investigaciones anteriores que examinaron el carácter distintivo del trastorno de estrés postraumático y el duelo patológico se centraron en muestras con pérdidas no traumáticas, utilizaron conceptualizaciones obsoletas de los trastornos del duelo y arrojaron resultados mixtos.Objetivo: En una muestra grande de personas en duelo traumático, primero evaluamos la estructura factorial de TEPT y PGD por separado y luego evaluamos la estructura factorial al combinar los síntomas de TEPT y PGD para examinar la distinción entre los dos síndromes.Métodos: Se utilizaron datos autoreportados de 468 personas en duelo debido al desastre del avión MH17 (N = 200) o un accidente de tráfico (N = 268). Los 10 síntomas de PGD del DSM-5-TR se evaluaron con el Inventario de Autoreporte de Duelo Traumático Plus (TGI-SR +). Se utilizó la lista de chequeo de 20 ítems para el trastorno de estrés postraumático para el DSM-5 (PCL-5) para examinar los síntomas del TEPT. Se realizaron análisis factoriales confirmatorios.Resultados: Para el TEPT, un modelo de siete factores, llamado modelo 'híbrido', produjo el mejor ajuste. Para el PGD, un modelo de factor univariado se ajusta bien a los datos. Un modelo combinado con elementos de PGD que cargan en un factor y elementos de TEPT en siete factores (asociaciones entre las subescalas de PGD y TEPT r ≥ 50 y ≤ .71), más un factor de orden superior (es decir, factores de TEPT en un factor de TEPT de orden superior)) (asociación entre el factor TEPT de orden superior y el factor PGD r = .82) mostró un mejor ajuste que un modelo con toda la carga de síntomas de PGD y TEPT en un solo factor o dos factores (es decir, uno para PGD y otro para TEPT).Conclusiones: Este es el primer estudio que examina la estructura factorial del PGD según DSM-5-TR y el TEPT según DSM-5 en personas que enfrentan una pérdida traumática. Los hallazgos respaldan que el PGD constituye un síndrome que se distingue del TEPT, pero que está relacionado con él.


Prolonged Grief Disorder , Psychological Trauma , Stress Disorders, Post-Traumatic , Adult , Aged , Diagnostic and Statistical Manual of Mental Disorders , Factor Analysis, Statistical , Female , Humans , Male , Middle Aged , Psychological Trauma/classification , Psychological Trauma/complications , Psychological Trauma/physiopathology , Stress Disorders, Post-Traumatic/classification , Stress Disorders, Post-Traumatic/etiology , Stress Disorders, Post-Traumatic/physiopathology
11.
JAMA Psychiatry ; 78(11): 1228-1237, 2021 11 01.
Article En | MEDLINE | ID: mdl-34468741

Importance: A substantial proportion of the 40 million people in the US who present to emergency departments (EDs) each year after traumatic events develop posttraumatic stress disorder (PTSD) or major depressive episode (MDE). Accurately identifying patients at high risk in the ED would facilitate the targeting of preventive interventions. Objectives: To develop and validate a prediction tool based on ED reports after a motor vehicle collision to predict PTSD or MDE 3 months later. Design, Setting, and Participants: The Advancing Understanding of Recovery After Trauma (AURORA) study is a longitudinal study that examined adverse posttraumatic neuropsychiatric sequalae among patients who presented to 28 US urban EDs in the immediate aftermath of a traumatic experience. Enrollment began on September 25, 2017. The 1003 patients considered in this diagnostic/prognostic report completed 3-month assessments by January 31, 2020. Each patient received a baseline ED assessment along with follow-up self-report surveys 2 weeks, 8 weeks, and 3 months later. An ensemble machine learning method was used to predict 3-month PTSD or MDE from baseline information. Data analysis was performed from November 1, 2020, to May 31, 2021. Main Outcomes and Measures: The PTSD Checklist for DSM-5 was used to assess PTSD and the Patient Reported Outcomes Measurement Information System Depression Short-Form 8b to assess MDE. Results: A total of 1003 patients (median [interquartile range] age, 34.5 [24-43] years; 715 [weighted 67.9%] female; 100 [weighted 10.7%] Hispanic, 537 [weighted 52.7%] non-Hispanic Black, 324 [weighted 32.2%] non-Hispanic White, and 42 [weighted 4.4%] of non-Hispanic other race or ethnicity were included in this study. A total of 274 patients (weighted 26.6%) met criteria for 3-month PTSD or MDE. An ensemble machine learning model restricted to 30 predictors estimated in a training sample (patients from the Northeast or Midwest) had good prediction accuracy (mean [SE] area under the curve [AUC], 0.815 [0.031]) and calibration (mean [SE] integrated calibration index, 0.040 [0.002]; mean [SE] expected calibration error, 0.039 [0.002]) in an independent test sample (patients from the South). Patients in the top 30% of predicted risk accounted for 65% of all 3-month PTSD or MDE, with a mean (SE) positive predictive value of 58.2% (6.4%) among these patients at high risk. The model had good consistency across regions of the country in terms of both AUC (mean [SE], 0.789 [0.025] using the Northeast as the test sample and 0.809 [0.023] using the Midwest as the test sample) and calibration (mean [SE] integrated calibration index, 0.048 [0.003] using the Northeast as the test sample and 0.024 [0.001] using the Midwest as the test sample; mean [SE] expected calibration error, 0.034 [0.003] using the Northeast as the test sample and 0.025 [0.001] using the Midwest as the test sample). The most important predictors in terms of Shapley Additive Explanations values were symptoms of anxiety sensitivity and depressive disposition, psychological distress in the 30 days before motor vehicle collision, and peritraumatic psychosomatic symptoms. Conclusions and Relevance: The results of this study suggest that a short set of questions feasible to administer in an ED can predict 3-month PTSD or MDE with good AUC, calibration, and geographic consistency. Patients at high risk can be identified in the ED for targeting if cost-effective preventive interventions are developed.


Accidents, Traffic , Depressive Disorder, Major/diagnosis , Emergency Service, Hospital , Models, Theoretical , Psychological Trauma/complications , Psychometrics/standards , Stress Disorders, Post-Traumatic/diagnosis , Wounds and Injuries/psychology , Adolescent , Adult , Aged , Female , Humans , Longitudinal Studies , Machine Learning , Male , Middle Aged , Prognosis , Psychometrics/instrumentation , Risk Assessment , Young Adult
12.
Psychoneuroendocrinology ; 133: 105398, 2021 11.
Article En | MEDLINE | ID: mdl-34479104

BACKGROUND: Evidence supports raised circulating levels of inflammatory mediators, such as interleukin-6 (IL-6) and tumor necrosis factor (TNFα), among clinically depressed adults, although preliminary findings in adolescents are mixed. Independently, meta-analyses identify correlations between childhood trauma and elevated cytokine levels in adulthood. Here, we examine the possible role of individual differences in exposure to childhood trauma in contributing to variability in cytokine levels in depressed adolescents. METHODS: 52 depressed adolescents and 20 healthy adolescents completed measures of childhood trauma and provided blood for the assessment of plasma IL-6 and TNFα. Cross-sectional associations of childhood trauma and cytokine measures were assessed in both depressed and healthy adolescents, along with exploratory analysis of childhood trauma subtypes. Longitudinal relationships between childhood trauma and cytokine measures were also studied in an exploratory fashion within a subset of depressed participants (n = 36). RESULTS: Higher childhood trauma (particularly emotional abuse) was positively associated with TNFα in depressed adolescents. Childhood trauma was not linked to longitudinal changes in cytokine levels. DISCUSSION: In depressed adolescents, childhood trauma may relate to higher levels of the proinflammatory cytokine TNFα and contribute to heterogeneity in cytokine elevation among depressed adolescents. Such findings may ultimately help guide more effective individualized treatments for adolescents with depression.


Adverse Childhood Experiences , Cytokines/blood , Depression/blood , Depression/complications , Psychological Trauma/blood , Psychological Trauma/complications , Adolescent , Case-Control Studies , Cross-Sectional Studies , Female , Humans , Interleukin-6/blood , Male , Tumor Necrosis Factor-alpha/blood
13.
Medicine (Baltimore) ; 100(31): e26836, 2021 Aug 06.
Article En | MEDLINE | ID: mdl-34397850

BACKGROUND: Endometrial tissue plays an important role in the regulation of female fertility and there is evidence that endometrial pathology (including endometriosis) is closely related to endocrine disorders. On the other hand, various neuroendocrine changes can be significantly affected by psychosocial stress. In connection with these findings, we tested the relationship between neuroendocrine changes, sexual dysfunction, psychosocial/traumatic stress, and dissociative symptoms in women with endometriosis. METHODS: A total of 65 patients with endometriosis were included in the study. Clinical examinations were focused on the biochemical analysis of neuroendocrine markers of endometriosis (cancer antigen 125 [CA 125] and cancer antigen 19-9 [CA 19-9]), estradiol, psychometric evaluation of sexual dysfunction, psychosocial/traumatic stress, and dissociative symptoms. RESULTS: The results showed significant Spearman correlations between the values of the revised range of sexual difficulties for sexual dysfunction (Revised Female Sexual Distress Scale), psychosocial/traumatic stress (Trauma Symptoms Checklist) (R = 0.31), and dissociative symptoms (Somatoform Dissociation Questionnaire) (R = 0.33). Positive correlations were also found between CA 125 and CA 19-9 (R = 0.63), and between CA 125 and the results of the values of the revised scale of sexual difficulties for sexual dysfunction (Revised Female Sexual Distress Scale) (R = 0.29). Also psychosocial/traumatic stress (Trauma Symptoms Checklist) significantly correlated with CA 125 (R = 0.38) and with CA 19-9 (R = 0.33). CONCLUSION: These results represent the first findings regarding the relationship of the neuroendocrine markers CA 125 and CA 19-9 and sexual dysfunction with trauma/stress-related symptoms and dissociative symptoms in women with endometriosis.


CA-125 Antigen/blood , CA-19-9 Antigen/blood , Endometriosis , Psychological Trauma , Sexual Dysfunction, Physiological , Somatoform Disorders , Adult , Correlation of Data , Dissociative Disorders/diagnosis , Dissociative Disorders/psychology , Endometriosis/blood , Endometriosis/complications , Endometriosis/psychology , Female , Humans , Neurosecretory Systems/metabolism , Psychological Techniques , Psychological Trauma/complications , Psychological Trauma/diagnosis , Psychological Trauma/physiopathology , Psychology , Sexual Dysfunction, Physiological/blood , Sexual Dysfunction, Physiological/psychology , Somatoform Disorders/diagnosis , Somatoform Disorders/physiopathology , Somatoform Disorders/psychology
14.
J Am Geriatr Soc ; 69(4): 1019-1026, 2021 04.
Article En | MEDLINE | ID: mdl-33399223

BACKGROUND/OBJECTIVES: Trauma survivors with chronic post-traumatic stress disorder (PTSD) have been found to have cognitive impairment. But little is known about these outcomes among Latino and Asians who comprise more than 80% of the U.S. immigrant population. They also experience disparities in PTSD and dementia care albeit increased exposure to trauma. This study aimed to (1) examine the association between trauma exposures and PTSD with cognitive impairment in a sample of Latino and Asian older adults; and (2) assess whether sleep quality attenuated the PTSD-cognitive impairment association. DESIGN: Cross-sectional secondary analysis of baseline data from the Positive Minds-Strong Bodies randomized controlled trial on disability prevention. SETTING: Community-based organizations serving minority or immigrant older adults in Massachusetts, New York, Florida, or Puerto Rico. PARTICIPANTS: Hispanic/Latino and Asian/Pacific Islander adults aged 60 or older eligible per randomized controlled trial screening for elevated mood symptoms and minor-to-moderate physical dysfunction (n = 134 and n = 86, respectively). MEASUREMENTS: Neuropsychiatric measures were cognitive impairment (Mini Montreal Cognitive Assessment (MoCA)), PTSD (Posttraumatic Stress Disorder Checklist for Diagnostic and Statistical Manual-5), trauma exposure (Brief Trauma Questionnaire), depression (Patient Health Questionnaire-9), generalized anxiety (Generalized Anxiety Disorder Scale-7), and daytime sleepiness (Epworth Sleepiness Scale). RESULTS: Mean age was 72.8 years and 77.5 years for the Latino and Asian groups, respectively. The Asian group was 100% immigrant, whereas 70.2% (n = 92) of the Latino group was foreign-born. In unadjusted models, higher Posttraumatic Stress Disorder Checklist for Diagnostic and Statistical Manual-5 scores were associated with decreased odds of normal cognitive functioning (MoCA ≥25) in the Asian group (odds ratio (95% confidence interval) = .93 (.87, .99)), but not the Latino group (odds ratio (95% confidence interval) = .99 (.95, 1.05)). This association remained significant after adjusting for covariates. Daytime sleepiness did not moderate the association between PTSD and cognitive functioning in the Asian group. CONCLUSION: Higher PTSD symptoms were associated with cognitive impairment in Asian, but not Latino, older adults. Clinicians serving older Asians should integrate trauma and cognitive screening to ensure this growing, underserved population receives appropriate evidence-based treatments.


Asian People , Cognitive Dysfunction , Disorders of Excessive Somnolence , Mood Disorders , Psychological Trauma/complications , Stress Disorders, Post-Traumatic , Aged , Asian People/psychology , Asian People/statistics & numerical data , Cognitive Dysfunction/diagnosis , Cognitive Dysfunction/ethnology , Cross-Cultural Comparison , Disorders of Excessive Somnolence/diagnosis , Disorders of Excessive Somnolence/ethnology , Disorders of Excessive Somnolence/etiology , Emigrants and Immigrants/psychology , Emigrants and Immigrants/statistics & numerical data , Female , Health Services Needs and Demand , Healthcare Disparities/ethnology , Healthcare Disparities/standards , Hispanic or Latino/psychology , Hispanic or Latino/statistics & numerical data , Humans , Male , Mood Disorders/diagnosis , Mood Disorders/ethnology , Mood Disorders/etiology , Neuropsychological Tests , Stress Disorders, Post-Traumatic/diagnosis , Stress Disorders, Post-Traumatic/etiology , Stress Disorders, Post-Traumatic/psychology , United States/epidemiology
15.
Eur J Psychotraumatol ; 12(1): 1863580, 2021.
Article En | MEDLINE | ID: mdl-34992746

Background: Psychological trauma has only recently been considered a traumatic event. Therefore, research on Posttraumatic Stress Disorder (PTSD) and Complex-PTSD following exposure to psychological violence, is less studied compared with physical and sexual violence. Objectives: This study aimed to establish the prevalence of PTSD and C-PTSD of among female victims of partner violence (IPV) and examine the unique association between different subtypes of IPV (i.e. physical, psychological and sexual IPV) and the traumatic response. Methods: The study includes a shelter-based sample of female victims of IPV (N = 147). Validated measures were used to estimate IPV exposure and mental health outcomes. Partial Correlation and Hierarchical Regression was used to examine the association between IPV and PTSD and C-PTSD, respectively. Results: The study found a high prevalence of both PTSD (56.5%) and C-PTSD (21.1%) in the sample. Overall, when controlling for the other types of violence, psychological violence correlated with PTSD, C-PTSD, negative affect and somatization. When controlling for psychological violence, neither physical nor sexual violence correlated with any of the mental health outcomes. Hierarchical regression models helped explain 23.5% and 29.7% of the variance in symptoms of PTSD and C-PTSD, respectively. Conclusion: A relatively large subgroup of the women had symptoms of C-PTSD, which demonstrate a potentially unmet need for trauma-informed treatment services in Danish Women Shelters. Psychological violence was found to be the strongest risk factor for all mental health outcomes and thus, it is important to acknowledge the severity of this IPV subtype.


Antecedentes: El trauma psicológico sólo recientemente ha sido considerado un evento traumático. Por lo tanto, la investigación sobre el Trastorno de Estrés Postraumático (TEPT) y el TEPT Complejo tras la exposición a la violencia psicológica, está menos estudiada en comparación con la violencia física y sexual.Objetivos: El objetivo de este estudio fue establecer la prevalencia del TEPT y el TEP-C entre las mujeres víctimas de la violencia de pareja (IVP, en siglas en inglés) y examinar la asociación distintiva entre los diferentes subtipos de IVP (es decir, IVP físico, psicológico y sexual) y la respuesta traumática.Métodos: El estudio incluye una muestra basada en refugios para mujeres víctimas de IVP (N = 147). Se utilizaron medidas validadas para estimar la exposición a la IVP y los resultados de salud mental. Se utilizó la correlación parcial y la regresión jerárquica para examinar la asociación entre la IVP y el TEPT y el TEPT-C, respectivamente.Resultados: El estudio encontró una alta prevalencia tanto de TEPT (56,5%) como de TEPC (21,1%) en la muestra. En general, al controlar los otros tipos de violencia, la violencia psicológica se correlacionó con el TEPT, el TEPT-C, el afecto negativo y la somatización. Al controlar la violencia psicológica, ni la violencia física ni la sexual se correlacionaron con ninguno de los resultados de salud mental. Los modelos de regresión jerárquica ayudaron a explicar el 23,5% y el 29,7% de la variación en los síntomas del TEPT y el TEPT-C, respectivamente.Conclusión: Un subgrupo relativamente grande de mujeres tenía síntomas de TEPTC, lo que demuestra una necesidad potencialmente no cubierta de servicios de tratamiento con información en traumas en los refugios de mujeres danesas. Se comprobó que la violencia psicológica era el factor de riesgo más fuerte para todos los resultados de salud mental y, por lo tanto, es importante reconocer la gravedad de este subtipo de IVP.


Exposure to Violence/statistics & numerical data , Intimate Partner Violence/statistics & numerical data , Psychological Trauma/epidemiology , Stress Disorders, Post-Traumatic/epidemiology , Adult , Cross-Sectional Studies , Denmark , Female , Humans , Intimate Partner Violence/classification , Middle Aged , Psychological Trauma/complications , Stress Disorders, Post-Traumatic/etiology , Young Adult
16.
Psychol Trauma ; 13(2): 202-205, 2021 Feb.
Article En | MEDLINE | ID: mdl-32940521

Objective: Extensive research supports the contention that trauma exposure is a nonspecific risk factor for the development of eating disorders (EDs). Limited research has investigated the relative association of diverse types of traumatic events with EDs in the same statistical model. In a recent exception, Breland et al. (2018) found that only sexual trauma predicted ED pathology among female veterans when both sexual trauma and combat exposure were examined simultaneously, even though combat exposure alone had been previously identified as an ED risk factor. Given the current replication crisis in psychology, it is important to investigate if this finding replicates in different populations. This study investigated whether results from Breland et al. (2018) would (a) replicate in a distinct population (i.e., participants living with food insecurity) and (b) hold when 3 additional traumatic events were included in the statistical model. Method: We hypothesized that self-reported sexual trauma would be uniquely associated with ED pathology as compared to combat exposure, wreck/crash/accident, serious body-related accident, and life-threatening illness or injury. Results: Using a cross-sectional logistic regression model, sexual trauma was the only independent predictor of EDs in the model, thus replicating the findings of Breland et al. (2018) in a different population. Conclusion: Findings highlight the importance of (a) investigating multiple traumatic events in the same statistical models and (b) careful screening of traumatic events in patients presenting with EDs. (PsycInfo Database Record (c) 2021 APA, all rights reserved).


Feeding and Eating Disorders/etiology , Food Insecurity , Poverty , Psychological Trauma/complications , Sexual Trauma/complications , Adult , Aged , Cross-Sectional Studies , Female , Humans , Male , Middle Aged , Poverty/psychology
17.
Psychiatr Q ; 92(1): 217-227, 2021 03.
Article En | MEDLINE | ID: mdl-32562150

The definition of adjustment disorder (AjD) was recently revised by the 11th version of the International Classification of Diseases. Thus far, only two studies explored stressors associated with symptoms of AjD according to the new definition, revealing that there might be a difference in associations with daily stressors compared to traumatic events. The present study aims at examining the associations of AjD with both types of stressors as well as the mediating role of psychological well-being that was previously suggested as a buffer against mental illness. Four hundred and 19 participants completed questionnaires assessing the prevalence of daily stressors and traumatic events experienced in the last 2 years, psychological well-being and the diagnostic criteria of AjD. Results revealed a direct effect of the prevalence of daily stressors on the diagnosis of AjD as well as the mediating effect of psychological well-being of this association. However, no effect was found for traumatic events on AjD or psychological well-being. Given these findings, psychological well-being should be regarded as a means to reduce the prevalence of AjD among individuals coping with multiple and continuous daily stressors.


Adjustment Disorders/psychology , Psychological Trauma/psychology , Stress, Psychological/psychology , Adjustment Disorders/etiology , Adolescent , Adult , Aged , Female , Humans , International Classification of Diseases , Male , Middle Aged , Prevalence , Psychological Trauma/complications , Stress, Psychological/complications , Surveys and Questionnaires , Young Adult
18.
Behav Sleep Med ; 19(5): 672-688, 2021.
Article En | MEDLINE | ID: mdl-33251855

OBJECTIVE/BACKGROUND: The current study describes insomnia precipitating events reported by women Veterans and examines differences in sleep and psychological distress variables in those who endorsed traumatic, nontraumatic, or no insomnia precipitating events. PARTICIPANTS: Baseline data were collected from 347 women Veterans enrolled in a behavioral sleep intervention study (NCT02076165). METHODS: Participants completed self-report measures of insomnia symptoms, sleep quality, sleep efficiency (SE), nightmare frequency, and depression and posttraumatic stress disorder (PTSD) symptoms; SE was also assessed by wrist actigraphy. Participants responded to 2 open-ended questions assessing stressful life events and health changes that coincided with insomnia symptom onset. Responses were coded as traumatic, nontraumatic, and no events. Analyses of covariance examined the effect of insomnia precipitating event type on sleep and psychological symptom variables after controlling for sociodemographic factors. RESULTS: Overall, 25.80% of participants endorsed traumatic events, 65.80% endorsed only nontraumatic events, and 8.41% endorsed no events. Participants who endorsed traumatic events reported more severe insomnia (p = .003), PTSD (p = .001), and depression symptoms (p = .012), and poorer quality of sleep (p = .042) than participants who endorsed no events. Participants who endorsed traumatic events reported more severe PTSD symptoms (p = .004), a longer duration of sleep problems (p = .001), and poorer quality of sleep (p = .039) than participants who endorsed nontraumatic events. Participants who endorsed nontraumatic events reported more severe insomnia (p = .029) and PTSD (p = .049) symptoms than participants who endorsed no events. CONCLUSIONS: Trauma as a precipitant for insomnia may be related to higher symptom severity in women Veterans. Implications for treatment engagement and effectiveness remain unstudied.


Mental Health , Psychological Trauma/complications , Psychological Trauma/psychology , Sleep Initiation and Maintenance Disorders/complications , Sleep Initiation and Maintenance Disorders/psychology , Sleep , Veterans/psychology , Depression/complications , Depression/psychology , Female , Humans , Middle Aged , Severity of Illness Index , Stress Disorders, Post-Traumatic/complications , Stress Disorders, Post-Traumatic/psychology
19.
Psychol Trauma ; 13(2): 240-248, 2021 Feb.
Article En | MEDLINE | ID: mdl-33271048

Objective: Memory problems are a frequent complaint in neuropsychological settings, particularly among individuals in mid-to-late adulthood and those who have experienced neurological insult (e.g., head trauma; Bay et al., 2012; Lezak et al., 2004; Wammes et al., 2017). Neuropsychiatric comorbidities that influence cognitive functioning (e.g., depression, anxiety, posttraumatic stress) are also common among neuropsychological patients, which can challenge interpreting etiology and predicting prognosis (Campbell et al., 2009; Reischies & Neu, 2000). Prolonged trauma exposure is associated with brain abnormalities in regions that subserve memory and executive functions (Daniels et al., 2016; Woon et al., 2010). Furthermore, a subgroup of individuals with trauma exposure experience dissociative symptoms, which can also interfere with memory and performing goal-directed behaviors (Bergouignan et al., 2014; Brewin et al., 2013; Özdemir et al., 2015). Method: In this article, we focus on symptoms that are consistent with dissociation and present three case studies of trauma-exposed women who were referred for neuropsychological testing following complaints of memory decline. Results: Formal neuropsychological testing did not fully support the degree of amnestic symptoms reported. Based upon the complex pattern of results, we propose a potential hypothesis for consideration: the dissociative interference hypothesis. Conclusions: For all three women presented, dissociation was a common symptom that may have contributed to an exacerbation of memory failures and amnestic experiences. Thus, interventions targeted at increasing awareness, rather than withdrawal, during times of stress may lead to a reduction in their memory complaints. (PsycInfo Database Record (c) 2021 APA, all rights reserved).


Dissociative Disorders/complications , Memory Disorders/diagnosis , Memory Disorders/etiology , Psychological Trauma/complications , Stress Disorders, Post-Traumatic/complications , Adult , Female , Humans , Middle Aged , Neuropsychological Tests
20.
Am J Clin Hypn ; 63(2): 78-94, 2020 Oct.
Article En | MEDLINE | ID: mdl-33118880

In considering the applicability of hypnosis to treating Complex PTSD (C-PTSD) we examine the relationship between trauma, hypnosis, and dissociation, the latter being a common response to traumatization that is particularly salient in C-PTSD. We then provide an overview of the nature of C-PTSD, which research is beginning to demonstrate is considerably more prevalent than the more circumscribed PTSD syndrome depicted in the DSM. Building on this foundation, we discuss the reasons why hypnotically structured treatment is particularly well suited for C-PTSD, explaining how each of the major aspects of this syndrome can be addressed within a hypnotic framework.


Dissociative Disorders/therapy , Hypnosis , Psychological Trauma/therapy , Stress Disorders, Post-Traumatic/therapy , Dissociative Disorders/etiology , Dissociative Disorders/physiopathology , Humans , Hypnosis/methods , Psychological Trauma/complications , Psychological Trauma/physiopathology , Stress Disorders, Post-Traumatic/etiology , Stress Disorders, Post-Traumatic/physiopathology
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