Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 6 de 6
Filtrar
1.
Rev. med. Chile ; 150(10): 1396-1400, oct. 2022. ilus, tab
Artículo en Español | LILACS | ID: biblio-1431859

RESUMEN

Clostridioides difficile infection (CDI) is a major public health problem and responsible for significant morbidity and mortality. Eighty percent of CDIs occur in adults older than 65 years of age due to a decreased gastrointestinal microbial diversity, immunosenescence and frailty. Thus, the most reported risk factor for recurrent CDI is older age since nearly 60% of cases occur in individuals aged ≥ 65 years. Fecal microbiota transplantation (FMT) is a highly cost-effective alternative to antibiotic treatment for patients with recurrent CDI. We report a 75-year-old male with recurrent CDI, who received a FMT after several unsuccessful antimicrobial treatments. He had a satisfactory evolution after the procedure and remained without diarrhea during the ensuing five months.


Asunto(s)
Humanos , Masculino , Anciano , Clostridioides difficile , Infecciones por Clostridium/terapia , Trasplante de Microbiota Fecal , Reinfección/terapia , Resultado del Tratamiento
2.
Rev Med Chil ; 150(10): 1396-1400, 2022 Oct.
Artículo en Español | MEDLINE | ID: mdl-37358099

RESUMEN

Clostridioides difficile infection (CDI) is a major public health problem and responsible for significant morbidity and mortality. Eighty percent of CDIs occur in adults older than 65 years of age due to a decreased gastrointestinal microbial diversity, immunosenescence and frailty. Thus, the most reported risk factor for recurrent CDI is older age since nearly 60% of cases occur in individuals aged ≥ 65 years. Fecal microbiota transplantation (FMT) is a highly cost-effective alternative to antibiotic treatment for patients with recurrent CDI. We report a 75-year-old male with recurrent CDI, who received a FMT after several unsuccessful antimicrobial treatments. He had a satisfactory evolution after the procedure and remained without diarrhea during the ensuing five months.


Asunto(s)
Clostridioides difficile , Infecciones por Clostridium , Trasplante de Microbiota Fecal , Reinfección , Anciano , Humanos , Masculino , Infecciones por Clostridium/terapia , Reinfección/terapia , Resultado del Tratamiento
3.
Femina ; 50(9): 572-576, 2022.
Artículo en Portugués | LILACS | ID: biblio-1397895

RESUMEN

A infecção do trato urinário (ITU) é a doença bacteriana mais comum no sexo feminino, e cerca de 25% a 30% das mulheres apresentam ITUs recorrentes ao longo da vida. Os antibióticos são muito utilizados para o tratamento e prevenção dessas infecções. Entretanto, o uso excessivo e indevido desses medicamentos, além dos efeitos adversos, está relacionado ao surgimento de uropatógenos multirresistentes. Há um interesse crescente na comunidade científica para encontrar alternativas ao uso de antibióticos para tratamento e/ou prevenção das infecções bacterianas. Esta revisão tem por objetivo discutir algumas dessas alternativas.(AU)


Urinary tract infection (UTI) is the most common bacterial disease in females, and about 25% to 30% of women experience recurrent UTIs throughout their lives. Antibiotics are widely used standard for treating and preventing these infections. However, the excessive and improper use of these drugs, in addition to the adverse effects, is related to the emergence of multidrug-resistant uropathogens. There is a growing interest in the scientific community to find alternatives to the use of antibiotics for the treatment and/or prevention of bacterial infections. This review aims to discuss some of these alternatives.(AU)


Asunto(s)
Humanos , Femenino , Infecciones Urinarias/tratamiento farmacológico , Infecciones Urinarias/terapia , Terapias Complementarias , Reinfección/terapia , Adyuvantes Inmunológicos , Probióticos/uso terapéutico , Vaccinium macrocarpon , Ingestión de Líquidos , Estrógenos/uso terapéutico , Fluidoterapia , Antibacterianos/uso terapéutico
4.
Emerg Infect Dis ; 27(6): 1737-1740, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33871331

RESUMEN

We documented 4 cases of severe acute respiratory syndrome coronavirus 2 reinfection by non-variant of concern strains among healthcare workers in Campinas, Brazil. We isolated infectious particles from nasopharyngeal secretions during both infection episodes. Improved and continued protection measures are necessary to mitigate the risk for reinfection among healthcare workers.


Asunto(s)
COVID-19/diagnóstico , Personal de Salud , Reinfección/diagnóstico , Reinfección/virología , SARS-CoV-2/aislamiento & purificación , Esparcimiento de Virus , Adulto , Brasil/epidemiología , COVID-19/epidemiología , Femenino , Humanos , Persona de Mediana Edad , Reinfección/terapia
5.
Public Health ; 193: 113-115, 2021 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-33774512

RESUMEN

OBJECTIVE: The aim of the study was to evaluate factors predicting severe symptomatic laboratory-confirmed (via Reverse transcription polymerase chain reaction, RT-PCR polymerase chain reaction) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection. STUDY DESIGN: This is a nationwide retrospective cohort study that was conducted in Mexico. METHODS: Data from 258 reinfection cases (at least 28 days between both episodes onset) were analyzed. We used risk ratios (RRs) and 95% confidence intervals (CIs) to evaluate predictors of severe (dyspnea requiring hospital admission) secondary SARS-CoV-2 infection. RESULTS: The risk of severe disease was 14.7%, and the observed overall fatality rate was 4.3%. Patients with more serious primary disease were more likely to develop severe symptoms (39.5% vs. 5.5%, P < 0.001) during reinfection. In multiple analysis, factors associated with an increased risk of severe symptomatic SARS-CoV-2 reinfection were increasing age (RRper year = 1.007, 95% CI = 1.003-1.010), comorbidities (namely, obesity [RR = 1.12, 95% CI = 1.01-1.24], asthma [RR = 1.26, 95% CI = 1.06-1.50], type 2 diabetes mellitus [RR = 1.22, 95% CI = 1.07-1.38]), and previous severe laboratory-confirmed coronavirus disease 2019 (RR = 1.20, 95% CI = 1.03-1.39). CONCLUSIONS: To the best of our knowledge, this is the first study evaluating disease outcomes in a large set of laboratory-positive cases of symptomatic SARS-CoV-2 reinfection, and factors associated with illness severity were characterized. Our results may contribute to the current knowledge of SARS-CoV-2 pathogenicity and to identify populations at increased risk of a poorer outcome after reinfection.


Asunto(s)
COVID-19/diagnóstico , Reinfección/diagnóstico , SARS-CoV-2/aislamiento & purificación , Índice de Severidad de la Enfermedad , Adulto , Anciano , COVID-19/epidemiología , COVID-19/terapia , Prueba de Ácido Nucleico para COVID-19 , Comorbilidad , Femenino , Hospitalización , Humanos , Laboratorios , Masculino , México/epidemiología , Persona de Mediana Edad , Reinfección/terapia , Estudios Retrospectivos , Factores de Riesgo , Evaluación de Síntomas , Resultado del Tratamiento , Adulto Joven
6.
Actual. SIDA. infectol ; 28(104): 134-140, 2020 dic. tab
Artículo en Español | LILACS, BINACIS | ID: biblio-1349063

RESUMEN

Con el avance de la pandemia por COVID-19, la aparición de pacientes con un segundo episodio confirmado por reacción en cadena de la polimerasa, con transcripción inversa (rt-PCR) compatible con reinfección, puso de manifiesto la falta de recomendaciones para su abordaje.Presentamos un estudio descriptivo multicéntrico retro-prospectivo de una serie de doce casos atendidos entre el 01/06/2020 y el 20/10/2020. En la misma, diez casos presentaron el segundo episodio en un período de tiempo menor a 90 días.Por su complejidad, la confirmación de una reinfección no está al alcance en la práctica diaria. Esto requiere de estudios que incluyan comparaciones genómicas de cepas virales involucradas en ambos episodios, determinación de la infectividad del ARN por cultivo viral y análisis molecular.Es necesario establecer definiciones operativas y algoritmos clínicos para la atención de los segundos episodios


As COVID-19 pandemic progresses, patients with a second confirmed episode by reverse transcription-polymerase chain reaction (RT PCR) compatible with reinfection reveals the lack of recommendations for its approach.A multicenter retro-prospective descriptive work was done of a series of 12 cases evaluated between June 1, 2020 and October 20, 2020. In this study, 10 out of 12 cases presented the second episode occurred in less than 90 days.Due to the diagnosing reinfection complexity, its confirmation is not available in the daily practice, this requires studies, which include viral strains genomic comparisons involved in both episodes, ARN determination infectivity by viral culture and molecular analysis.It is necessary to establish operational and clinical algorithms definitions to assist second episodes


Asunto(s)
Humanos , Adulto , Persona de Mediana Edad , Anciano , Epidemiología Descriptiva , Estudios Retrospectivos , Estudio Multicéntrico , Esparcimiento de Virus , Toma de Decisiones , Atención Ambulatoria , Reinfección/terapia , ARN Polimerasa Dependiente de ARN de Coronavirus/inmunología , Hospitalización
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA