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1.
Protein Pept Lett ; 28(7): 761-768, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33302826

RESUMEN

BACKGROUND: The microbiome is now known for its important role in whole-body homeostasis. A dysbiosis of the normal microbiota is correlated with metabolic disorders. In this sense, the search for compounds able to modulate the microbiome is needed. Resveratrol, a natural compound found in grapes seems to be a promising candidate. OBJECTIVE: In this study, our motivation was to evaluate the effects of the association between Resveratrol and Lactococcus lactis, a probiotic, on the composition of the gastrointestinal microbiota and body weight of mice. METHODS: Twenty female mice were divided into 4 groups: (1) standard diet, (2) standard diet plus Lactococcus lactis, (3) standard diet plus resveratrol, and (4) standard diet plus Lactococcus lactis and resveratrol. At the end of the treatment period, samples of blood, mucus, stomach, and small and large intestines were collected for analysis. Total levels of Immunoglobulin A and Immunoglobulin E, Lac+ and Lac- bacteria and Lactobacillus were measured. RESULTS: The main results indicate that the association between resveratrol and probiotics was able to decrease mice body weight, as compared to the other groups, in addition to decrease the number of Lac- bacteria and increasing the number of Lac+ bacteria. The levels of secretory IgA were also decreased, compared to the animals treated with only probiotics or resveratrol. CONCLUSION: We observed potential synergism between Resveratrol and Lactococcus lactis mainly in modulating the stomach and intestinal microbiota.


Asunto(s)
Peso Corporal/efectos de los fármacos , Enterobacteriaceae/efectos de los fármacos , Microbioma Gastrointestinal/efectos de los fármacos , Lactococcus lactis/inmunología , Probióticos/administración & dosificación , Resveratrol/administración & dosificación , Animales , Peso Corporal/inmunología , Dieta/métodos , Enterobacteriaceae/crecimiento & desarrollo , Enterobacteriaceae/inmunología , Femenino , Microbioma Gastrointestinal/inmunología , Inmunoglobulina A/biosíntesis , Inmunoglobulina E/sangre , Intestino Grueso/efectos de los fármacos , Intestino Grueso/inmunología , Intestino Grueso/microbiología , Intestino Delgado/efectos de los fármacos , Intestino Delgado/inmunología , Intestino Delgado/microbiología , Ratones , Ratones Endogámicos C57BL , Estómago/efectos de los fármacos , Estómago/inmunología , Estómago/microbiología
2.
Nutr Clin Pract ; 32(1): 122-129, 2017 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-27329862

RESUMEN

This study evaluated the effect of an immune-modulatory diet on patients with gastric cancer and identified the parameters associated with postoperative outcomes. This was a single-arm prospective intervention study. At baseline, patients were assessed for nutrition (Patient-Generated Subjective Global Assessment), inflammatory markers (albumin, C-reactive protein, and interleukin 6 [IL-6]), and immune markers (percentage NK, CD4, CD8, and CD4:CD8 ratio); they also received nutrition counseling and high-calorie/protein supplement. A week before surgery, they were assessed for nutrition and inflammatory/immune markers and started on an immune-modulatory supplement until the day before surgery, when they were evaluated again. On the second postoperative day, patients were assessed for inflammatory/immune parameters, and a final nutrition evaluation was performed until the day of discharge. Complications were recorded daily and up to 30 days after discharge. Thirty-seven patients (60 ± 10 years old) were included, and 57% were classified as malnourished. Maintenance of nutrition and immune parameters occurred throughout the study period, but we found a preoperative increase in C-reactive protein (0.1-1.5 mg/dL) and IL-6 (2.0-14.2 pg/mL) and a postoperative increase in the CD4:CD8 ratio (2.3 ± 1.0). Complications and death were seen in 35%, especially patients with higher preoperative IL-6 (2.2-46 pg/mL), lower CD4:CD8 ratio (1.7 ± 0.5), and lower protein (1.2 ± 0.5 g/kg/d) and calorie intake (1552 ± 584 kcal/kg/d). The high-calorie/protein supplementation with the immune-modulating diet was able to maintain the nutrition and immune status of patients with gastric cancer.


Asunto(s)
Proteínas en la Dieta/uso terapéutico , Suplementos Dietéticos , Gastrectomía/efectos adversos , Inmunomodulación , Desnutrición/dietoterapia , Complicaciones Posoperatorias/prevención & control , Neoplasias Gástricas/cirugía , Anciano , Biomarcadores/sangre , Brasil/epidemiología , Instituciones Oncológicas , Ingestión de Energía , Femenino , Humanos , Mediadores de Inflamación/sangre , Masculino , Desnutrición/complicaciones , Desnutrición/epidemiología , Desnutrición/prevención & control , Persona de Mediana Edad , Estadificación de Neoplasias , Complicaciones Posoperatorias/sangre , Complicaciones Posoperatorias/epidemiología , Complicaciones Posoperatorias/inmunología , Prevalencia , Estudios Prospectivos , Riesgo , Estómago/inmunología , Estómago/patología , Estómago/cirugía , Neoplasias Gástricas/complicaciones , Neoplasias Gástricas/inmunología , Neoplasias Gástricas/patología
3.
Genet Mol Res ; 15(4)2016 Oct 24.
Artículo en Inglés | MEDLINE | ID: mdl-27813598

RESUMEN

Helicobacter pylori employs unique methods to colonize the stomach, which induces chronic inflammation. It is also able to avoid eradication by macrophages and other immune cells. Leukocyte cell-derived chemotaxin 2 (LECT2), a multi-functional cytokine involved in many pathological conditions, has recently been shown to activate macrophages via the CD209a receptor. Therefore, we aimed to investigate the effects of LECT2 on H. pylori-infected macrophages. Macrophages were treated with recombinant LECT2, and both their ability to kill H. pylori and produce nitric oxide were analyzed. Western blot was performed to determine nuclear translocation and protein phosphorylation of p65, a subunit of nuclear factor (NF)-κB. Transfection experiments were performed to analyze the signaling pathway of LECT2 in macrophages. We found that treatment with LECT2 enhanced H. pylori killing and nitric oxide production in macrophages. In addition, DNA-binding activity and nuclear translocation of p65 were up-regulated by LECT2 treatment. Furthermore, we found that NF-κB activation by LECT2 was mediated by Raf-1 in macrophages, and Raf-1 phosphorylation was specifically altered in response to LECT2. Moreover, LECT2 induced Ser28 phosphorylation in the intracellular domain of CD209a. CD209a Ser28 phosphorylation was required for LECT2-induced Raf-1 and NF-κB activation in RAW264.7 macrophages. Our study showed that the effects of LECT2 on H. pylori killing and nitric oxide production were dependent on CD209a phosphorylation, Raf-1, and NF-κB activation. Together, these results demonstrate for the first time that exposure to LECT2 can modulate specific intracellular mechanisms downstream of CD209a to enhance H. pylori killing and nitric oxide production in macrophages.


Asunto(s)
Infecciones por Helicobacter/genética , Péptidos y Proteínas de Señalización Intercelular/genética , Proteínas Recombinantes/genética , Factor de Transcripción ReIA/biosíntesis , Animales , Moléculas de Adhesión Celular/genética , Moléculas de Adhesión Celular/inmunología , Infecciones por Helicobacter/inmunología , Infecciones por Helicobacter/microbiología , Helicobacter pylori/inmunología , Helicobacter pylori/patogenicidad , Humanos , Péptidos y Proteínas de Señalización Intercelular/farmacología , Lectinas Tipo C/genética , Lectinas Tipo C/inmunología , Macrófagos/inmunología , Ratones , Óxido Nítrico/biosíntesis , Óxido Nítrico/genética , Fosforilación , Células RAW 264.7 , Receptores de Superficie Celular/genética , Receptores de Superficie Celular/inmunología , Proteínas Recombinantes/farmacología , Transducción de Señal/genética , Estómago/inmunología , Estómago/microbiología , Factor de Transcripción ReIA/genética , Activación Transcripcional/genética , Transfección
4.
Eur J Pharmacol ; 683(1-3): 260-9, 2012 May 15.
Artículo en Inglés | MEDLINE | ID: mdl-22426163

RESUMEN

This study investigates the gastroprotective effects of hecogenin, a steroid saponin isolated from Agave sisalana, on experimental models of gastric ulcer. Male Swiss mice were used in the models of ethanol- and indometacin-induced gastric ulcer. To clarify the hecogenin mechanism of action, the roles of nitric oxide (NO), sulfhydryls (GSH), K⁺(ATP) channels and prostaglandins were also investigated, and measurements of lipid peroxidation (TBARS assay) and nitrite levels in the stomach of hecogenin-treated and untreated animals were performed. Furthermore, the effects of hecogenin on myeloperoxidase (MPO) release from human neutrophils were assessed in vitro. Our results showed that hecogenin (3.1, 7.5, 15, 30, 60 and 90 mg/kg, p.o.) acutely administered, before ethanol or indomethacin, exhibited a potent gastroprotective effect. Although the pretreatments with L-NAME, an iNOS inhibitor, and capsazepine, a TRPV1 receptor agonist, were not able to reverse the hecogenin effect, this was reversed by glibenclamide, a K⁺(ATP) blocker, and indomethacin in the model of ethanol-induced gastric lesions. The hecogenin pretreatment normalized GSH levels and significantly reduced lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. The drug alone increased COX-2 expression and this effect was further enhanced in the presence of ethanol. It also decreased MPO release and significantly protected the gastric mucosa. In conclusion, we showed that hecogenin presents a significant gastroprotective effect that seems to be mediated by K⁺(ATP) channels opening and the COX-2/PG pathway. In addition, its antioxidant and anti-inflammatory properties may play a role in the gastroprotective drug effect.


Asunto(s)
Antiulcerosos/uso terapéutico , Modelos Animales de Enfermedad , Sapogeninas/uso terapéutico , Úlcera Gástrica/tratamiento farmacológico , Estómago/efectos de los fármacos , Animales , Antiinflamatorios/administración & dosificación , Antiinflamatorios/farmacología , Antiinflamatorios/uso terapéutico , Antiulcerosos/administración & dosificación , Antiulcerosos/farmacología , Antioxidantes/administración & dosificación , Antioxidantes/farmacología , Antioxidantes/uso terapéutico , Ciclooxigenasa 2/metabolismo , Relación Dosis-Respuesta a Droga , Etanol , Mucosa Gástrica/metabolismo , Glutatión/metabolismo , Humanos , Indometacina , Canales KATP/metabolismo , Peroxidación de Lípido/efectos de los fármacos , Masculino , Ratones , Activación Neutrófila/efectos de los fármacos , Óxido Nítrico/metabolismo , Prostaglandinas/metabolismo , Distribución Aleatoria , Sapogeninas/administración & dosificación , Sapogeninas/farmacología , Estómago/inmunología , Úlcera Gástrica/inmunología , Úlcera Gástrica/metabolismo
5.
J Fish Dis ; 34(2): 149-57, 2011 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-21241322

RESUMEN

We describe lesions associated with a seemingly intense infection of trypanorhynch plerocerci (Platyhelminthes: Cestoda: Trypanorhyncha) in the gastric wall of a female cownose ray, Rhinoptera bonasus (Myliobatiformes: Rhinopteridae) captured in the northern Gulf of Mexico. Grossly, the multitude of encapsulated, encysted plerocerci imparted a bumpy and cobbled appearance to the serosa of the stomach, and none was observed in any other tissue during routine parasitological necropsy. Histologically, the plerocerci were associated with severe intramural granulomatous gastritis, vascular ectasia and mesothelial polyposis with the exclusion of the mucosa. To our knowledge, this is the first published case study documenting platyhelminth-associated histopathological changes in the gastrointestinal tract of R. bonasus as well as that of the efficacy of immunocytochemical markers for smooth muscle actin, Factor VIII, S-100, and proliferating cell nuclear antigen in Myliobatiformes. It also may serve as a potential primer for much needed ecological investigations regarding the potential role of elasmobranchs as intermediate or 'paratenic' hosts in the life cycles of trypanorhynch cestodes.


Asunto(s)
Cestodos/anatomía & histología , Infecciones por Cestodos/veterinaria , Enfermedades de los Peces/parasitología , Rajidae/parasitología , Estómago/patología , Animales , Cestodos/clasificación , Infecciones por Cestodos/inmunología , Infecciones por Cestodos/parasitología , Femenino , Enfermedades de los Peces/inmunología , Interacciones Huésped-Parásitos , Mississippi , Rajidae/inmunología , Rajidae/fisiología , Estómago/inmunología , Estómago/parasitología
6.
J Agric Food Chem ; 57(12): 5571-7, 2009 Jun 24.
Artículo en Inglés | MEDLINE | ID: mdl-19469473

RESUMEN

An analysis of the peptides generated by hydrolysis of BLG by nonproliferating cells of the strain Lactobacillus acidophilus CRL 636 was carried out. The effect of polysaccharides (pectin, and two EPS synthesized by two Streptococcus thermophilus strains, EPS1190 and EPS804) on BLG digestibility using an in vitro gastric/pancreatic system was analyzed. Polysaccharides are commonly used in the dairy industry to improve food texture; these hydrocolloids may interact with proteins, affecting their digestibility. Nonproliferating cells of Lb. acidophilus CRL 636 were able to hydrolyze 52% of BLG. Twenty-six resulting peptides with molecular masses in the range 544-4119 Da were identified by LC-MS/MS. These peptides resulted mostly from the hydrolysis of the more accessible N-terminal part of BLG. Degradation of BLG by pepsin was poor (8%). When BLG was previously hydrolyzed by Lb. acidophilus CRL 636, peptic hydrolysis was of 54.8%, while when pectin and EPS1190 were added, hydrolysis was higher (58.2 and 57.2%, respectively). Peptides crossing 8 kDa dialysis membranes after trypsin/chymotrypsin hydrolysis were analyzed by HPSEC. The produced peptides were smaller when BLG was hydrolyzed previously by the Lb. acidophilus strain. Moreover, in the presence of pectin, the amount of the larger peptide (3.5 kDa) observed in the size exclusion chromatograms was considerably decreased. Our studies showed that prehydrolysis of BLG by Lb. acidophilus CRL 636 had a positive influence on BLG digestibility and that polysaccharides may change the peptide profile yielded by trypsin/chymotrypsin hydrolysis, releasing smaller size peptides, which are known to be less immune-reactive. Moreover, Lb. acidophilus CRL 636 was able to hydrolyze the main epitopes (41-60, 102-124, and 149-162) of BLG, reducing its allergenic content.


Asunto(s)
Lactobacillus acidophilus/metabolismo , Lactoglobulinas/metabolismo , Páncreas/fisiología , Polisacáridos Bacterianos/química , Estómago/fisiología , Secuencia de Aminoácidos , Animales , Digestión , Hidrólisis , Lactobacillus acidophilus/química , Lactoglobulinas/química , Lactoglobulinas/inmunología , Modelos Biológicos , Datos de Secuencia Molecular , Peso Molecular , Páncreas/inmunología , Estómago/inmunología
7.
Infect Immun ; 75(7): 3445-54, 2007 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-17438024

RESUMEN

Helicobacter pylori CagA is translocated into gastric epithelial cells by a type IV secretion system and interacts with the Src homology 2 phosphatase, altering cell morphology. Multiple EPIYA motifs in CagA are associated with increased activity in cells and with gastric cancer. The aim of this work was to study the heterogeneity in activity in cells of multiple H. pylori single colonies isolated from a single patient and its association with polymorphism in cagA. The presence of cagA, cagE, cagT, and cag10 was studied with 318 H. pylori isolates from the antra and corpora of 18 patients. AGS gastric epithelial cells were infected with 75 isolates, and interleukin-8 (IL-8) secretion, cytoskeletal changes, CagA translocation, and tyrosine phosphorylation were measured. The cagA 3'-variable region was sequenced for 30 isolates to determine the number and types of EPIYA motifs. Isolates from an individual stomach were usually genetically related and had quantitatively similar phenotypic effects on cells (IL-8 induction and cytoskeletal changes). However, strains from different patients with similar CagA EPIYA motif patterns varied widely in these phenotypes. Among isolates with an EPIYA-ABC pattern, the phenotype was variable: IL-8 induction ranged from 200 to 1,200 pg/ml, and morphological changes occurred in 20 to 70% of cells. In several cases, cagA sequence diversity appeared to explain the lack of CagA activity, as isolates with an EPIYA-ACC pattern or a modified B motif had reduced cell activity. cag pathogenicity island-positive H. pylori isolates displayed a high level of heterogeneity in the capacity to induce IL-8 secretion and morphological changes; an absent or modified B motif was associated with low activity.


Asunto(s)
Antígenos Bacterianos/genética , Proteínas Bacterianas/genética , Células Epiteliales/microbiología , Variación Genética , Helicobacter pylori/clasificación , Helicobacter pylori/patogenicidad , Estómago/citología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Secuencia de Aminoácidos , Antígenos Bacterianos/química , Antígenos Bacterianos/metabolismo , Proteínas Bacterianas/química , Proteínas Bacterianas/metabolismo , Línea Celular , Niño , Células Epiteliales/inmunología , Femenino , Infecciones por Helicobacter/microbiología , Helicobacter pylori/genética , Helicobacter pylori/aislamiento & purificación , Humanos , Interleucina-8/biosíntesis , Masculino , México , Persona de Mediana Edad , Datos de Secuencia Molecular , Fenotipo , Análisis de Secuencia de ADN , Estómago/inmunología
8.
J Pediatr ; 124(1): 57-62, 1994 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-8283376

RESUMEN

Lymphocytic gastritis is characterized by lymphocytic infiltration of the surface and pit epithelium. Its cause has not been established, but an association with Helicobacter pylori infection or celiac disease has been suggested. We evaluated the histologic features of both gastric and duodenal biopsy specimens from 245 consecutive children and adolescents, and found chronic gastritis in 60 children and celiac disease in 25. Chronic gastritis was associated with H. pylori infection in 36 children and with celiac disease in 15. Lymphocytic gastritis was found in nine children with celiac disease. Children with lymphocytic gastritis had a mean of 40.64 lymphocytes per 100 epithelial cells, compared with a mean of 3.92 lymphocytes per 100 epithelial cells in children with H. pylori-associated gastritis and 5.15 lymphocytes in normal control subjects. Immunohistochemical studies showed that the intraepithelial lymphocytes in lymphocytic gastritis were T cells. No child with lymphocytic gastritis had serologic evidence of past H. pylori infection. We conclude that lymphocytic gastritis in children is associated with celiac disease. Dyspeptic symptoms are frequent; the endoscopic appearance is not characteristic.


Asunto(s)
Enfermedad Celíaca/complicaciones , Gastritis/complicaciones , Infecciones por Helicobacter/complicaciones , Helicobacter pylori , Adolescente , Enfermedad Celíaca/patología , Niño , Preescolar , Enfermedad Crónica , Duodeno/patología , Endoscopía Gastrointestinal , Femenino , Gastritis/microbiología , Gastritis/patología , Humanos , Lactante , Linfocitos , Prevalencia , Estómago/inmunología , Estómago/patología
9.
Scand J Gastroenterol ; 28(11): 973-7, 1993 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-8284633

RESUMEN

Parietal cell antibodies were present in 12% of 272 Peruvians presenting for endoscopy. Gender, age, socioeconomic status, ethnic background (Peruvian versus Japanese), and altitude at which the patient lived were not associated with the presence of parietal cell antibodies. No significant relationship could be shown between the presence of parietal cell antibodies and either Helicobacter pylori infection or gastric lesions, including chronic atrophic gastritis. Loss of proper gastric glands was significantly more common in patients who had H. pylori infection than in those in whom no H. pylori was found on biopsy (78 of 114 (85%) versus 14 of 36 (39%); p = 0.002). Our data suggest that, although parietal cell antibodies are present in third-world populations, they are unrelated to H. pylori infection and that pathologic changes associated with this infection are not mediated by the action of parietal cell antibodies on the cells of the stomach.


Asunto(s)
Autoanticuerpos/análisis , Etnicidad , Gastritis/inmunología , Infecciones por Helicobacter/inmunología , Helicobacter pylori , Células Parietales Gástricas/inmunología , Neoplasias Gástricas/inmunología , Adulto , Anciano , Atrofia , Autoinmunidad , Biopsia , Femenino , Gastritis/patología , Infecciones por Helicobacter/etnología , Infecciones por Helicobacter/patología , Humanos , Intestinos/inmunología , Intestinos/patología , Japón/etnología , Masculino , Metaplasia , Persona de Mediana Edad , Perú/epidemiología , Prevalencia , Clase Social , Estómago/inmunología , Estómago/patología , Neoplasias Gástricas/etnología , Neoplasias Gástricas/patología
10.
Braz J Med Biol Res ; 23(2): 151-61, 1990.
Artículo en Inglés | MEDLINE | ID: mdl-2119837

RESUMEN

1. Indirect immunofluorescence was used to compare reticulin antibodies, endocardium-vessel-interstitium (EVI) antibodies and heterophilic antibodies in serum samples from patients with degenerative and inflammatory diseases, Chagas' disease, or paracoccidioidomycosis and from healthy blood donors. 2. The antigen substrates used were rat, mouse and human liver for reticulin antibodies, mouse and human heart and skeletal muscle for EVI factor, and rat heart and rat, mouse and human kidney and stomach for heterophilic antibodies. 3. The three antibodies produced extremely similar fluorescent patterns and were present simultaneously in a large proportion of reticulin-positive serum samples. 4. The three antibodies were significantly absorbed by heterophilic antigens such as sheep and rat red blood cells and guinea pig kidney, by Trypanosoma cruzi (an antigen associated with EVI factor) and by Paracoccidioides brasiliensis. However, they did not react with several human tissues. 5. These results suggest that reticulin and EVI antibodies can be considered to be heterophilic antibodies.


Asunto(s)
Anticuerpos/análisis , Enfermedad de Chagas/inmunología , Espacio Extracelular/inmunología , Paracoccidioidomicosis/inmunología , Reticulina/inmunología , Animales , Anticuerpos Heterófilos/análisis , Donantes de Sangre , Humanos , Riñón/inmunología , Ratones , Miocardio/inmunología , Ratas , Estómago/inmunología
11.
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;23(2): 151-61, 1990. tab, ilus
Artículo en Inglés | LILACS | ID: lil-85152

RESUMEN

Indirect immunofluorescence was used to compare reticulin antibodies, endocardium-vessel-interstitium (EVI) antibodies and heterophilic antibodies in serum samples from patients with degenerative and inflammatory diseases, Chagas' disease, or paracoccidioidomycosis and from healthy blood donors. The antigen substrates used were rat, mouse and human liver for reticulin antibodies, mouse and human heart and skeletal muscle for EVI factor, and rat heart and rat, mouse and human kidney and stomach for heterophilic antibodies. The three antibodies produced extremely similar fluorescent patterns and were present simultaneously in a large proportion of reticulin-positive serum samples. The three antibodies were significantly absorbed by heterophilic antigens such as sheep and rat red blood cells and guinea pig kidney, by Trypanosoma cruzi (an antigen associated with EVI factor) and by Paracoccidioides brasiliensis. However, they did not react with several human tissues. These results suggest that reticulin and EVI antibodies can be considered to be heterophilic antibodies


Asunto(s)
Anticuerpos/análisis , Enfermedad de Chagas/inmunología , Paracoccidioidomicosis/inmunología , Reticulina/inmunología , Anticuerpos Heterófilos/análisis , Donantes de Sangre , Espacio Extracelular/inmunología , Riñón/inmunología , Miocardio/inmunología , Estómago/inmunología
14.
s.l; s.n; 1972. 5 p. tab.
No convencional en Inglés | Sec. Est. Saúde SP, HANSEN, Hanseníase, SESSP-ILSLACERVO, Sec. Est. Saúde SP | ID: biblio-1240549

RESUMEN

Specimens of sera from 73 leprosy patients and from 20 controls were tested for rheumatoid factor, antinuclear factor, thyroglobulin antibody and for certain organ specific antibodies (gastric parietal cell, thyroid cytoplasmic, and mitochondrial antibodies). A significant proportion of the lepromatous leprosy patients showed positive reactions to rheumatoid factor, thyroglobulin, and antinuclear factor in low titre. The presence of non-organ specific autoantibodies bears no clinical significance to the disease. Organ specific autoantibodies were not common in leprosy sera.


Asunto(s)
Humanos , Anticuerpos Antinucleares , Autoanticuerpos/aislamiento & purificación , Estómago/inmunología , Factor Reumatoide , Glándula Tiroides/inmunología , Lepra/inmunología , Mitocondrias/inmunología , Pruebas de Fijación de Látex , Citoplasma , Técnica del Anticuerpo Fluorescente , Tiroglobulina
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