RESUMEN
The pathophysiology of syringomyelia remains poorly understood. Two prevailing challenges stand out: the need for a comprehensive understanding of its diverse types and the yet-to-be-explained mechanism of cerebrospinal fluid (CSF) retention in the syrinx despite its higher pressure than that in the adjacent subarachnoid space. Expanding on our previous proposal that direction-selective resistance to subarachnoid CSF flow drives syringomyelia genesis, this study uses a computer model to explore this mechanism further. We developed a computer simulation model to study spinal CSF dynamics, employing a lumped parameter approach with multiple compartments. This model replicated the to-and-fro movement of CSF in the spinal subarachnoid space and within an intraspinal channel. Subsequently, a direction-selective resistance-opposing only the caudal subarachnoid CSF flow-was introduced at a specific location within the subarachnoid space. Following the introduction of the direction-selective resistance, a consistent pressure increase was observed in the intraspinal channel downstream of the resistance. Importantly, this increase in pressure accumulated with every cycle of to-and-fro CSF flow. The accumulation results from the pressure drop across the resistance, and its effect on the spinal cord matrix creates a pumping action in the intraspinal channel. Our findings elucidate the mechanisms underlying our hypothesis that a direction-selective resistance to subarachnoid CSF flow causes syringomyelia. This comprehensively explains the various types of syringomyelia and resolves the puzzle of CSF retention in the syrinx despite a pressure gradient.
Asunto(s)
Siringomielia , Humanos , Siringomielia/etiología , Siringomielia/líquido cefalorraquídeo , Simulación por Computador , Presión del Líquido Cefalorraquídeo/fisiología , Espacio Subaracnoideo , Líquido Cefalorraquídeo/fisiología , Imagen por Resonancia MagnéticaRESUMEN
Anatomic MRI, MRI flow studies, and intraoperative ultrasonography demonstrate that the Chiari I malformation obstructs CSF pathways at the foramen magnum and prevents normal CSF movement through the foramen magnum. Impaired CSF displacement across the foramen magnum during the cardiac cycle increases pulsatile hindbrain motion, pressure transmission to the spinal subarachnoid space, and the amplitude of CSF subarachnoid pressure waves driving CSF into the spinal cord. Central canal septations in adults prevent syrinx formation by CSF directly transmitting its pressure wave from the fourth ventricle to the central canal.
Asunto(s)
Malformación de Arnold-Chiari , Siringomielia , Adulto , Humanos , Siringomielia/diagnóstico por imagen , Siringomielia/líquido cefalorraquídeo , Hidrodinámica , Malformación de Arnold-Chiari/complicaciones , Malformación de Arnold-Chiari/diagnóstico por imagen , Malformación de Arnold-Chiari/líquido cefalorraquídeo , Espacio Subaracnoideo/diagnóstico por imagen , Presión del Líquido Cefalorraquídeo/fisiologíaRESUMEN
BACKGROUND: Syringomyelia is a common spinal cord lesion. However, whether CSF blockage is linked to the formation and enlargement of syringomyelia is still controversial. The current model of syringomyelia needs modification to more closely mimic the clinical situation. METHODS: We placed cotton strips under the T13 lamina of 40 8-week-old rats and blocked CSF flow by extradural compression. After 4 and 8 weeks, MRI was performed to evaluate the morphology of syringomyelia and the ratio of spinal cord diameter to syrinx diameter calculated. Locomotor function was evaluated weekly. Spinal cord sections, staining and immunohistochemistry were performed 8 weeks after surgery, the ratio of the central canal to the spinal cord area was calculated, and ependymal cells were counted. In another experiment, we performed decompression surgery for 8 rats with induced syringomyelia at the 8th week after surgery. During the surgery, the cotton strip was completely removed without damaging the dura mater. Then, the rats received MRI imaging during the following weeks and were sacrificed for pathological examination at the end of the experiment. RESULTS: Syringomyelia formed in 82.5% (33/40) of rats at the 8-week follow-up. The Basso, Beattie and Bresnahan (BBB) scores of rats in the experimental group decreased from 21.0±0.0 to 18.0 ±3.9 in the first week after operation but returned to normal in later weeks. The BBB score indicated that the locomotor deficit caused by compression is temporary and can spontaneously recover. MRI showed that the syrinx is located in the center of the spinal cord, which is very similar to the most common syringomyelia in humans. The ratio of the central canal to the spinal cord area reached (2.9 ± 2.0) × 10-2, while that of the sham group was (5.4 ± 1.5) × 10-4. The number of ependymal cells lining the central canal was significantly increased (101.9 ± 39.6 vs 54.5 ± 3.4). There was no syrinx or proliferative inflammatory cells in the spinal cord parenchyma. After decompression, the syringomyelia size decreased in 50% (4/8) of the rats and increased in another 50% (4/8). CONCLUSION: Extradural blockade of CSF flow can induce syringomyelia in rats. Temporary locomotor deficit occurred in some rats. This reproducible rat model of syringomyelia, which mimics syringomyelia in humans, can provide a good model for the study of disease mechanisms and therapies.
Asunto(s)
Modelos Animales de Enfermedad , Compresión de la Médula Espinal/líquido cefalorraquídeo , Siringomielia/líquido cefalorraquídeo , Animales , Femenino , Locomoción , Ratas Sprague-Dawley , Médula Espinal/cirugía , Compresión de la Médula Espinal/complicaciones , Compresión de la Médula Espinal/patología , Siringomielia/etiología , Siringomielia/patologíaRESUMEN
In this paper, we introduce a one-dimensional model for analyzing the cerebrospinal fluid dynamics within the fourth ventricle and the spinal subarachnoid space (SSAS). The model has been derived starting from an original model of Linninger et al. and from the detailed mathematical analysis of two different reformulations. We show the steps of the modelization and the rigorous analysis of the first-order nonlinear hyperbolic system of equations which rules the new CSF model, whose conservative-law form and characteristic form are required for the boundary conditions treatment. By assuming sub-critical flows, for the particular dynamics we are dealing with, the most desirable option is to employ the nonreflecting boundary conditions, that allow the simple wave associated with the outgoing characteristic to exit the computational domain with no reflections. Finally, we carry out some numerical simulations related to different cerebral physiological conditions.
Asunto(s)
Líquido Cefalorraquídeo/fisiología , Cuarto Ventrículo/anatomía & histología , Cuarto Ventrículo/fisiología , Modelos Neurológicos , Presión del Líquido Cefalorraquídeo/fisiología , Biología Computacional , Simulación por Computador , Análisis de Elementos Finitos , Humanos , Hidrocefalia/líquido cefalorraquídeo , Hidrocefalia/patología , Hidrocefalia/fisiopatología , Hidrodinámica , Conceptos Matemáticos , Modelos Anatómicos , Dinámicas no Lineales , Espacio Subaracnoideo/anatomía & histología , Espacio Subaracnoideo/fisiología , Siringomielia/líquido cefalorraquídeo , Siringomielia/patología , Siringomielia/fisiopatologíaRESUMEN
OBJECTIVE: Syringogenesis in Chiari malformation type I (CM-I) is thought to occur secondary to impaction of the cerebellar tonsils within the foramen magnum (FM). However, the correlation between the CSF area and syringogenesis has yet to be elucidated. The authors sought to determine whether the diminution in subarachnoid space is associated with syringogenesis. Further, the authors sought to determine if syrinx resolution was associated with the degree of expansion of subarachnoid spaces after surgery. METHODS: The authors performed a retrospective review of all patients undergoing posterior fossa decompression for CM-I from 2004 to 2016 at the University of Virginia Health System. The subarachnoid spaces at the FM and at the level of the most severe stenosis were measured before and after surgery by manual delineation of the canal and neural tissue area on MRI and verified through automated CSF intensity measurements. Imaging and clinical outcomes were then compared. RESULTS: Of 68 patients, 26 had a syrinx at presentation. Syrinx patients had significantly less subarachnoid space at the FM (13% vs 19%, p = 0.0070) compared to those without syrinx. Following matching based on degree of tonsillar herniation and age, the subarachnoid space was significantly smaller in patients with a syrinx (12% vs 19%, p = 0.0015). Syrinx resolution was associated with an increase in patients' subarachnoid space after surgery compared with those patients without resolution (23% vs 10%, p = 0.0323). CONCLUSIONS: Syrinx development in CM-I patients is correlated with the degree to which the subarachnoid CSF spaces are diminished at the cranial outlet. Successful syrinx reduction is associated with the degree to which the subarachnoid spaces are increased following surgery.
Asunto(s)
Malformación de Arnold-Chiari/líquido cefalorraquídeo , Espacio Subaracnoideo/diagnóstico por imagen , Siringomielia/líquido cefalorraquídeo , Siringomielia/etiología , Adolescente , Adulto , Malformación de Arnold-Chiari/diagnóstico por imagen , Malformación de Arnold-Chiari/cirugía , Fosa Craneal Posterior/cirugía , Descompresión Quirúrgica , Encefalocele/cirugía , Femenino , Foramen Magno/cirugía , Humanos , Imagen por Resonancia Magnética , Masculino , Procedimientos Neuroquirúrgicos/métodos , Estudios Retrospectivos , Siringomielia/diagnóstico por imagen , Resultado del Tratamiento , Adulto JovenRESUMEN
BACKGROUND: Chiari malformations include a large spectrum of anomalies of hindbrain formation that appear at different stages of development of the central nervous system. Chiari described these malformations as congenital anomalies of the hindbrain characterized by downward elongation of the brain stem and cerebellum into the cervical portion of spinal cord. Much research regarding Chiari malformation I (CMI) has focused on the cerebrospinal fluid (CSF) dynamics rather than the anatomic relationships of the tonsils and brainstem. The aim of the present study was to measure the peak CSF velocity at the foramen magnum and record the changes after foramen magnum decompression in patients with CMI aged <18 years. METHODS: A total of 39 patients with CMI were included during a 2-year period and were analyzed for peak CSF flow velocity with respect to surgical intervention using predefined magnetic resonance imaging protocols and surgical technique. RESULTS: After foramen magnum decompression, the postoperative mean CSF peak flow velocity showed a statistically significant difference compared with the preoperative value. CONCLUSION: Decompression of the foramen magnum was associated with decreased CSF peak velocity in patients with CMI.
Asunto(s)
Malformación de Arnold-Chiari/cirugía , Líquido Cefalorraquídeo/citología , Foramen Magno/cirugía , Siringomielia/cirugía , Adolescente , Adulto , Cerebelo/cirugía , Niño , Descompresión Quirúrgica/métodos , Femenino , Humanos , Masculino , Procedimientos Neuroquirúrgicos/métodos , Rombencéfalo/cirugía , Siringomielia/líquido cefalorraquídeo , Resultado del TratamientoRESUMEN
BACKGROUND: The origin of syrinx fluid is controversial. OBJECTIVE: To elucidate the mechanisms of syringomyelia associated with cerebrospinal fluid pathway obstruction and with intramedullary tumors, contrast transport from the spinal subarachnoid space (SAS) to syrinx was evaluated in syringomyelia patients. METHODS: We prospectively studied patients with syringomyelia: 22 with Chiari I malformation and 16 with SAS obstruction-related syringomyelia before and 1 wk after surgery, and 9 with tumor-related syringomyelia before surgery only. Computed tomography-myelography quantified dye transport into the syrinx before and 0.5, 2, 4, 6, 8, 10, and 22 h after contrast injection by measuring contrast density in Hounsfield units (HU). RESULTS: Before surgery, more contrast passed into the syrinx in Chiari I malformation-related syringomyelia and spinal obstruction-related syringomyelia than in tumor-related syringomyelia, as measured by (1) maximum syrinx HU, (2) area under the syrinx concentration-time curve (HU AUC), (3) ratio of syrinx HU to subarachnoid cerebrospinal fluid (CSF; SAS) HU, and (4) AUC syrinx/AUC SAS. More contrast (AUC) accumulated in the syrinx and subarachnoid space before than after surgery. CONCLUSION: Transparenchymal bulk flow of CSF from the subarachnoid space to syrinx occurs in Chiari I malformation-related syringomyelia and spinal obstruction-related syringomyelia. Before surgery, more subarachnoid contrast entered syringes associated with CSF pathway obstruction than with tumor, consistent with syrinx fluid originating from the subarachnoid space in Chiari I malformation and spinal obstruction-related syringomyelia and not from the subarachnoid space in tumor-related syringomyelia. Decompressive surgery opened subarachnoid CSF pathways and reduced contrast entry into syringes associated with CSF pathway obstruction.
Asunto(s)
Líquido Cefalorraquídeo/diagnóstico por imagen , Siringomielia/líquido cefalorraquídeo , Siringomielia/diagnóstico por imagen , Siringomielia/patología , Adulto , Femenino , Humanos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Espacio Subaracnoideo/diagnóstico por imagen , Espacio Subaracnoideo/patologíaRESUMEN
BACKGROUND: Syringomyelia is a pathological condition in which fluid-filled cavities (syringes) form and expand in the spinal cord. Syringomyelia is often linked with obstruction of the craniocervical junction and a Chiari malformation, which is similar in both humans and animals. Some brachycephalic toy breed dogs such as Cavalier King Charles Spaniels (CKCS) are particularly predisposed. The exact mechanism of the formation of syringomyelia is undetermined and consequently with the lack of clinical explanation, engineers and mathematicians have resorted to computer models to identify possible physical mechanisms that can lead to syringes. We developed a computer model of the spinal cavity of a CKCS suffering from a large syrinx. The model was excited at the cranial end to simulate the movement of the cerebrospinal fluid (CSF) and the spinal cord due to the shift of blood volume in the cranium related to the cardiac cycle. To simulate the normal condition, the movement was prescribed to the CSF. To simulate the pathological condition, the movement of CSF was blocked. RESULTS: For normal conditions the pressure in the SAS was approximately 400 Pa and the same applied to all stress components in the spinal cord. The stress was uniformly distributed along the length of the spinal cord. When the blockage between the cranial and spinal CSF spaces forced the cord to move with the cardiac cycle, shear and axial normal stresses in the cord increased significantly. The sites where the elevated stress was most pronounced coincided with the axial locations where the syringes typically form, but they were at the perimeter rather than in the central portion of the cord. This elevated stress originated from the bending of the cord at the locations where its curvature was high. CONCLUSIONS: The results suggest that it is possible that repetitive stressing of the spinal cord caused by its exaggerated movement could be a cause for the formation of initial syringes. Further consideration of factors such as cord tethering and the difference in mechanical properties of white and grey matter is needed to fully explore this possibility.
Asunto(s)
Simulación por Computador , Enfermedades de los Perros/patología , Siringomielia/veterinaria , Animales , Enfermedades de los Perros/líquido cefalorraquídeo , Enfermedades de los Perros/etiología , Perros , Médula Espinal/patología , Siringomielia/líquido cefalorraquídeo , Siringomielia/etiología , Siringomielia/patologíaRESUMEN
Syringomyelia is associated with Chiari I malformation, although the mechanistic link is unclear. Studies have suggested that cerebrospinal fluid enters the spinal cord via the perivascular spaces, and that changes in the timing of the subarachnoid pressures may increase flow into the spinal cord. This study aims to determine how Chiari malformation and syringomyelia alter the subarachnoid space pressures and hence perivascular flow. Subject-specific models of healthy controls (Nâ¯=â¯9), Chiari patients with (Nâ¯=â¯7) and without (Nâ¯=â¯8) syringomyelia, were developed from magnetic resonance imaging (MRI), to simulate the subarachnoid pressures. These pressures were input to an idealised model of the perivascular space to evaluate potential differences in perivascular flow. Peak pressures in Chiari patients without a syrinx were higher than in controls (46% increase; pâ¯=â¯.029) and arrived earlier in the cardiac cycle than both controls (2.58% earlier; pâ¯=â¯.045) and syrinx patients (2.85% earlier; pâ¯=â¯.045). The perivascular model predicted Chiari patients without a syrinx would have the greatest flow into the cord (pâ¯<â¯.05) if the arterial pulse delay was between 4 and 10% of the cardiac cycle. Using phase-contrast MRI the mean arterial delay for all subjects was similar, and was estimated as 4.7⯱â¯0.2%. The perivascular pumping rate showed a strong positive correlation (RAdj2=0.85; pâ¯<â¯.0001) with extended periods of high pressure that arrived earlier in the cardiac cycle, suggesting these pressure characteristics may play a role in syrinx development.
Asunto(s)
Malformación de Arnold-Chiari/líquido cefalorraquídeo , Adulto , Malformación de Arnold-Chiari/diagnóstico por imagen , Arterias/fisiopatología , Estudios de Casos y Controles , Simulación por Computador , Femenino , Humanos , Presión Intracraneal , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Médula Espinal/metabolismo , Espacio Subaracnoideo/metabolismo , Siringomielia/líquido cefalorraquídeo , Siringomielia/diagnóstico por imagenRESUMEN
In the article, we describe a clinical case of syringomyelia associated with an Arnold-Chiari type 1 malformation, evaluate the efficacy of syringosubarachnoid shunting, and analyze the literature data of domestic and international researchers involved in investigation and treatment of the pathology. Application of syringosubarachnoid shunting in the described case resulted in a clinical improvement in the form of regression of paresis and hypoesthesia, which demonstrated the efficacy of the shunting technique for correction of the syringomyelia symptoms.
Asunto(s)
Derivaciones del Líquido Cefalorraquídeo/métodos , Procedimientos Neuroquirúrgicos/métodos , Siringomielia/cirugía , Adolescente , Femenino , Humanos , Siringomielia/líquido cefalorraquídeo , Siringomielia/diagnóstico , Resultado del TratamientoRESUMEN
BACKGROUND AND PURPOSE: The development of syringomyelia has been associated with changes in CSF flow dynamics in the spinal subarachnoid space. However, differences in CSF flow velocity between patients with posttraumatic syringomyelia and healthy participants remains unclear. The aim of this work was to define differences in CSF flow above and below a syrinx in participants with posttraumatic syringomyelia and compare the CSF flow with that in healthy controls. MATERIALS AND METHODS: Six participants with posttraumatic syringomyelia were recruited for this study. Phase-contrast MR imaging was used to measure CSF flow velocity at the base of the skull and above and below the syrinx. Velocity magnitudes and temporal features of the CSF velocity profile were compared with those in healthy controls. RESULTS: CSF flow velocity in the spinal subarachnoid space of participants with syringomyelia was similar at different locations despite differences in syrinx size and locations. Peak cranial and caudal velocities above and below the syrinx were not significantly different (peak cranial velocity, P = .9; peak caudal velocity, P = 1.0), but the peak velocities were significantly lower (P < .001, P = .007) in the participants with syringomyelia compared with matched controls. Most notably, the duration of caudal flow was significantly shorter (P = .003) in the participants with syringomyelia. CONCLUSIONS: CSF flow within the posttraumatic syringomyelia group was relatively uniform along the spinal canal, but there are differences in the timing of CSF flow compared with that in matched healthy controls. This finding supports the hypothesis that syrinx development may be associated with temporal changes in spinal CSF flow.
Asunto(s)
Traumatismos de la Médula Espinal/complicaciones , Siringomielia/líquido cefalorraquídeo , Adulto , Femenino , Humanos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Siringomielia/etiologíaRESUMEN
An existing axisymmetric fluid/structure-interaction (FSI) model of the spinal cord, pia mater, subarachnoid space, and dura mater in the presence of syringomyelia and subarachnoid-space stenosis was modified to include porous solids. This allowed investigation of a hypothesis for syrinx fluid ingress from cerebrospinal fluid (CSF). Gross model deformation was unchanged by the addition of porosity, but pressure oscillated more in the syrinx and the subarachnoid space below the stenosis. The poroelastic model still exhibited elevated mean pressure in the subarachnoid space below the stenosis and in the syrinx. With realistic cord permeability, there was slight oscillatory shunt flow bypassing the stenosis via the porous tissue over the syrinx. Weak steady streaming flow occurred in a circuit involving craniocaudal flow through the stenosis and back via the syrinx. Mean syrinx volume was scarcely altered when the adjacent stenosis bisected the syrinx, but increased slightly when the syrinx was predominantly located caudal to the stenosis. The fluid content of the tissues over the syrinx oscillated, absorbing most of the radial flow seeping from the subarachnoid space so that it did not reach the syrinx. To a lesser extent, this cyclic swelling in a boundary layer of cord tissue just below the pia occurred all along the cord, representing a mechanism for exchange of interstitial fluid (ISF) and cerebrospinal fluid which could explain recent tracer findings without invoking perivascular conduits. The model demonstrates that syrinx volume increase is possible when there is subarachnoid-space stenosis and the cord and pia are permeable.
Asunto(s)
Líquido Cefalorraquídeo , Modelos Biológicos , Médula Espinal/fisiopatología , Espacio Subaracnoideo/patología , Espacio Subaracnoideo/fisiopatología , Siringomielia/líquido cefalorraquídeo , Siringomielia/fisiopatología , Simulación por Computador , Constricción Patológica/patología , Constricción Patológica/fisiopatología , Módulo de Elasticidad , Humanos , Hidrodinámica , Porosidad , Reología/métodosRESUMEN
CONTEXT: We report a case of syringomyelia assessed by magnetic resonance imaging (MRI) with a time-spatial labeling inversion pulse (Time-SLIP), which is a non-contrast MRI technique that uses the cerebrospinal fluid (CSF) as an intrinsic tracer, thus removing the need to administer a contrast agent. Time-SLIP permits investigation of flow movement for over 3 seconds without any limitations associated with the cardiac phase, and it is a clinically accessible method for flow analysis. FINDINGS: We investigated an 85-year-old male experiencing progressive gait disturbance, with leg numbness and muscle weakness. Conventional MRI revealed syringomyelia from C7 to T12, with multiple webs of cavities. We then applied the Time-SLIP approach to characterize CSF flow in the syringomyelic cavities. Time-SLIP detected several unique CSF flow patterns that could not be observed by conventional imaging. The basic CSF flow pattern in the subarachnoid space was pulsatile and was harmonious with the heartbeat. Several unique flow patterns, such as bubbles, jumping, and fast flow, were observed within syringomyelic cavities by Time-SLIP imaging. These patterns likely reflect the complex flow paths through the septum and/or webs of cavities. CONCLUSION/CLINICAL RELEVANCE: Time-SLIP permits observation of CSF motion over a long period of time and detects patterns of flow velocity and direction. Thus, this novel approach to CSF flow analysis can be used to gain a more extensive understanding of spinal disease pathology and to optimize surgical access in the treatment of spinal lesions. Additionally, Time-SLIP has broad applicability in the field of spinal research.
Asunto(s)
Imagen por Resonancia Magnética/métodos , Siringomielia/diagnóstico por imagen , Anciano de 80 o más Años , Humanos , Masculino , Siringomielia/líquido cefalorraquídeoRESUMEN
A retrocerebellar arachnoid cyst causing syringomyelia is extremely rare without tonsillar herniation. The authors present a 44-year-old woman with symptoms of foramen magnum compression and syringomyelia. Magnetic resonance imaging demonstrated a large retrocerebellar arachnoid cyst with a large cervicothoracic syrinx but no signs of tonsillar herniation or hydrocephalus. The patient underwent a foramen magnum decompression with C1 laminectomy, microsurgical fenestration of the cyst, and duraplasty. After successful reconstruction of CSF flow, the patient experienced a relief of symptoms and a significant reduction of the syrinx. The intraoperative findings support the theory of a piston mechanism in the development of syringomyelia. Additional arachnoidal adhesions may also obstruct the CSF flow around the craniocervical junction. We recommend the surgical treatment should consist of an adequate decompression of the foramen magnum, wide microsurgical arachnoidal debridement, and duraplasty with autologous grafts sutured in a watertight way.
Asunto(s)
Quistes Aracnoideos/cirugía , Descompresión Quirúrgica , Encefalocele/diagnóstico , Foramen Magno/cirugía , Siringomielia/líquido cefalorraquídeo , Siringomielia/cirugía , Adulto , Quistes Aracnoideos/diagnóstico , Descompresión Quirúrgica/métodos , Femenino , Humanos , Imagen por Resonancia Magnética , Siringomielia/diagnóstico , Siringomielia/etiologíaRESUMEN
Surgical lysis of the thickened arachnoid membrane is the first choice of treatment in spinal arachnoid pathologies that cause flow disturbances or blockage of CSF. However, it is important to consider that while extensive lysis of the arachnoid may temporarily provide a wide pathway for CSF, an extensive lytic procedure may later cause secondary adhesion. Thus, it is ideal for the proper extent of the arachnoid lysis to be determined after careful analysis of regional CSF flow. The authors report their limited experience with intraoperative visualization of CSF flow in spinal arachnoid pathologies. Two patients with a dorsal arachnoid web (DAW) with cervical syringomyelia and 1 patient with focal adhesive arachnoiditis causing edema of the spinal cord were surgically treated at the authors' institution between 2007 and 2013. In all cases, the presence of a DAW or focal adhesive arachnoiditis was suspected from the findings on MRI, namely 1) an indentation on the upper thoracic spinal cord and 2) syringomyelia and/or edema of the spinal cord above the indentation. Exploratory surgery disclosed a transversely thickened arachnoid septum on the dorsal side of the indented cord. To prove blockage of the CSF by the septum and to decide on the extent of arachnoid lysis, regional CSF flow around the arachnoid septum was visualized by subarachnoid injection of gentian violet solution close to the web. Injected dye stagnated just close to the arachnoid septum in all cases, and these findings documented CSF blockage by the septum. In 2 cases, a 2-minute observation showed that the injected dye stayed close to the web without diffusion. The authors performed not only resection of the web itself but also lysis of the thickened arachnoid on both sides of the spinal cord to make a CSF pathway on the ventral side. In the third case, the dye stagnated close to the web at first but then diffused through the nerve root to the ventral CSF space. The lysis procedure was completed after exclusive removal of the dorsal web. Postoperative MR images confirmed reduction of the syrinx and/or improvement of the edema in all cases, suggesting that the extent of arachnoid lysis was optimal in each case. No adverse effect was observed after subarachnoid injection of gentian violet. The authors believe that their technique of visualizing regional CSF flow will be helpful to decide the optimal extent of lysis in some local arachnoid pathologies.
Asunto(s)
Aracnoides/patología , Aracnoides/cirugía , Aracnoiditis/líquido cefalorraquídeo , Aracnoiditis/cirugía , Colorantes , Violeta de Genciana , Siringomielia/líquido cefalorraquídeo , Siringomielia/cirugía , Adulto , Colorantes/administración & dosificación , Femenino , Violeta de Genciana/administración & dosificación , Humanos , Inyecciones , Laminectomía , Imagen por Resonancia Magnética , Masculino , Persona de Mediana EdadRESUMEN
It is unknown whether spinal cord motion has a significant effect on cerebrospinal fluid (CSF) pressure and therefore the importance of including fluid structure interaction (FSI) in computational fluid dynamics models (CFD) of the spinal subarachnoid space (SAS) is unclear. This study aims to determine the effects of FSI on CSF pressure and spinal cord motion in a normal and in a stenosis model of the SAS. A three-dimensional patient specific model of the SAS and spinal cord were constructed from MR anatomical images and CSF flow rate measurements obtained from a healthy human being. The area of SAS at spinal level T4 was constricted by 20% to represent the stenosis model. FSI simulations in both models were performed by running ANSYS CFX and ANSYS Mechanical in tandem. Results from this study show that the effect of FSI on CSF pressure is only about 1% in both the normal and stenosis models and therefore show that FSI has a negligible effect on CSF pressure.
Asunto(s)
Encéfalo/fisiopatología , Presión del Líquido Cefalorraquídeo , Médula Espinal/fisiopatología , Espacio Subaracnoideo/fisiología , Femenino , Humanos , Hidrodinámica , Modelos Biológicos , Canal Medular , Siringomielia/líquido cefalorraquídeo , Siringomielia/fisiopatología , Adulto JovenRESUMEN
Cerebrospinal fluid (CSF) dynamics in the spinal subarachnoid space (SSS) have been thought to play an important pathophysiological role in syringomyelia, Chiari I malformation (CM), and a role in intrathecal drug delivery. Yet, the impact that fine anatomical structures, including nerve roots and denticulate ligaments (NRDL), have on SSS CSF dynamics is not clear. In the present study we assessed the impact of NRDL on CSF dynamics in the cervical SSS. The 3D geometry of the cervical SSS was reconstructed based on manual segmentation of MRI images of a healthy volunteer and a patient with CM. Idealized NRDL were designed and added to each of the geometries based on in vivo measurments in the literature and confirmation by a neuroanatomist. CFD simulations were performed for the healthy and patient case with and without NRDL included. Our results showed that the NRDL had an important impact on CSF dynamics in terms of velocity field and flow patterns. However, pressure distribution was not altered greatly although the NRDL cases required a larger pressure gradient to maintain the same flow. Also, the NRDL did not alter CSF dynamics to a great degree in the SSS from the foramen magnum to the C1 level for the healthy subject and CM patient with mild tonsillar herniation (â¼ 6 mm). Overall, the NRDL increased fluid mixing phenomena and resulted in a more complex flow field. Comparison of the streamlines of CSF flow revealed that the presence of NRDL lead to the formation of vortical structures and remarkably increased the local mixing of the CSF throughout the SSS.
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Malformación de Arnold-Chiari , Líquido Cefalorraquídeo/diagnóstico por imagen , Médula Cervical , Ligamentos , Imagen por Resonancia Magnética , Raíces Nerviosas Espinales , Malformación de Arnold-Chiari/líquido cefalorraquídeo , Malformación de Arnold-Chiari/diagnóstico por imagen , Malformación de Arnold-Chiari/fisiopatología , Médula Cervical/diagnóstico por imagen , Médula Cervical/fisiopatología , Humanos , Ligamentos/diagnóstico por imagen , Ligamentos/fisiopatología , Masculino , Radiografía , Raíces Nerviosas Espinales/diagnóstico por imagen , Raíces Nerviosas Espinales/fisiopatología , Espacio Subaracnoideo/diagnóstico por imagen , Espacio Subaracnoideo/fisiopatología , Siringomielia/líquido cefalorraquídeo , Siringomielia/diagnóstico por imagen , Siringomielia/fisiopatologíaRESUMEN
The pathogenesis of syringomyelia in association with Chiari malformation (CM) is unclear. Studies of patients with CM have shown alterations in the CSF velocity profile and these could contribute to syrinx development or enlargement. Few studies have considered the fluid mechanics of CM patients with and without syringomyelia separately. Three subject-specific CFD models were developed for a normal participant, a CM patient with syringomyelia and a CM patient without syringomyelia. Model geometries, CSF flow rate data and CSF velocity validation data were collected from MRI scans of the 3 subjects. The predicted peak CSF pressure was compared for the 3 models. An extension of the study performed geometry and flow substitution to investigate the relative effects of anatomy and CSF flow profile on resulting spinal CSF pressure. Based on 50 monitoring locations for each of the models, the CM models had significantly higher magnitude (p<0.01) peak CSF pressure compared with normal. When using the same CSF input flow waveform, changing the upper spinal geometry changed the magnitude of the CSF pressure gradient, and when using the same upper spinal geometry, changing the input flow waveform changed the timing of the peak pressure. This study may assist in understanding syringomyelia mechanisms and relative effects of CSF velocity profile and spinal geometry on CSF pressure.
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Malformación de Arnold-Chiari/líquido cefalorraquídeo , Modelos Neurológicos , Siringomielia/líquido cefalorraquídeo , Malformación de Arnold-Chiari/patología , Malformación de Arnold-Chiari/fisiopatología , Fenómenos Biomecánicos , Estudios de Casos y Controles , Humanos , Hidrodinámica , Imagenología Tridimensional , Imagen por Resonancia Magnética , Persona de Mediana Edad , Siringomielia/patología , Siringomielia/fisiopatologíaRESUMEN
IMPORTANCE: The diagnosis of autoimmune and neurodegenerative conditions can be unclear. Treatments such as removing the associated tumor, if present, and immunosuppression can halt or often reverse the progression of autoimmune conditions, but there is no curative treatment for neurodegenerative conditions. The presence of autoantibodies can sometimes be misleading. This report illustrates potential difficulties in differentiating autoimmune encephalopathies from sporadic Creutzfeldt-Jakob disease. OBSERVATIONS: In a clinical follow-up of an older man with rapidly evolving encephalopathy at a neuroscience center, unsuccessful treatment with immunosuppression based on the incorrect presumptive diagnosis of Morvan syndrome was followed by the correct histological diagnosis of sporadic Creutzfeldt-Jakob disease. CONCLUSIONS AND RELEVANCE: Autoimmune encephalopathies raise important treatment options and potential for recovery. However, since neuronal antibodies may be positive in prion disease, interpretation can be complex and must be rooted in the clinical picture.
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Autoanticuerpos/líquido cefalorraquídeo , Encéfalo/patología , Síndrome de Creutzfeldt-Jakob/diagnóstico , Anciano , Atrofia/patología , Autoanticuerpos/biosíntesis , Encéfalo/fisiopatología , Síndrome de Creutzfeldt-Jakob/líquido cefalorraquídeo , Síndrome de Creutzfeldt-Jakob/inmunología , Diagnóstico Diferencial , Electroencefalografía , Electromiografía , Humanos , Masculino , Siringomielia/líquido cefalorraquídeo , Siringomielia/diagnóstico , Siringomielia/inmunología , Tomografía Computarizada por Rayos XRESUMEN
OBJECT: Phase contrast-cine MRI (PC-cine MRI) studies in patients with syringomyelia and Chiari malformation Type I (CM-I) have demonstrated abnormal CSF flow across the foramen magnum, which can revert to normal after craniocervical decompression with syrinx shrinkage. In order to investigate the mechanisms leading to postoperative syringomyelia shrinkage, the authors studied the hydrodynamic changes of CSF flow in the craniocervical junction and spinal canal in patients with scoliosis associated with syringomyelia after one-stage deformity correction by posterior vertebral column resection. METHODS: Preoperative and postoperative CSF flow dynamics at the levels of the foramen magnum, C-7, T-7 (or apex), and L-1 were assessed by electrocardiogram-synchronized cardiac-gated PC-cine MRI in 8 adolescent patients suffering from severe scoliosis with syringomyelia and CM-I (scoliosis group) and undergoing posterior vertebral column resection. An additional 8 patients with syringomyelia and CM-I without spinal deformity (syrinx group) and 8 healthy volunteers (control group) were also enrolled. Mean values were obtained for the following parameters: the duration of a CSF cycle, the duration of caudad CSF flow (CSF downflow [DF]) and cephalad CSF flow (CSF upflow [UF]), the ratio of DF duration to CSF cycle duration (DF%), and the ratio of UF duration to CSF cycle duration (UF%). The ratio of the stationary phase (SP) duration to CSF cycle duration was calculated (SP%). The maximum downflow velocities (VD max) and maximum upflow velocities (VU max) were measured. SPSS (version 14.0) was used for all statistical analysis. RESULTS: Patients in the scoliosis group underwent one-stage posterior vertebral column resection for deformity correction without suboccipital decompression. The mean preoperative coronal Cobb angle was 102.4° (range 76°-138°). The mean postoperative Cobb angle was 41.7° (range 12°-75°), with an average correction rate of 59.3%. During the follow-up, 1 patient with hypermyotonia experienced a significant decrease of muscle tension and 1 patient with reduced anal sphincter tone manifested recovery. A total of 5 patients demonstrated a significant decrease (> 30%) in syrinx size. With respect to changes in CSF flow dynamics, the syrinx group was characterized by slower and shorter downflow than the control group, and the difference was more significant at the foramen magnum and C-7 levels. In patients with scoliosis, CSF downflow at the foramen magnum level was significantly restricted, and a prolonged stationary phase indicated increased obstruction of CSF flow. After posterior vertebral column resection, the peak velocity of CSF flow at the foramen magnum increased, and the downflow phase duration was markedly prolonged. The parameters showed a return to almost normal CSF dynamics at the craniocervical region, and this improvement was maintained for 6-12 months of follow-up. CONCLUSIONS: There were distinct abnormalities of CSF flow at the craniocervical junction in patients with syringomyelia. Abnormal dynamics of downflow could be aggravated by associated severe spinal deformity and improved by correction via posterior vertebral column resection.