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BACKGROUND: To describe the perinatal outcomes of fetoscopic urethral meatotomy (FUM) in fetuses with lower urinary tract obstruction (LUTO) by congenital megalourethra. STUDY DESIGN: Between 2012 and 2020, 226 cases with LUTO were referred to our fetal surgery center in Queretaro, Mexico. We report the perinatal outcome of cases with LUTO by congenital megalourethra that were selected for FUM in an attempt to release the penile urethral obstruction. RESULTS: Congenital megalourethra was diagnosed in 10 cases (4.4%) but only 3 cases (30%) with obstructive megalourethra and megacystis were selected for fetal surgery. Fetoscopic urethral metatotomy was successfully performed in all three cases at a median gestational age (GA) of 21.4 (18.0-26.7) weeks and with a median surgical time of 27 (12-43) min. A resolution of urethral dilatation and subsequent reduction of the penile length and normalization of both the bladder size and amniotic fluid were observed in all cases. The median GA at delivery was 35.2 (range: 30.6-38.0) weeks. There were no fetal deaths but one neonatal death (33%) secondary to renal failure and preterm delivery. CONCLUSION: In fetuses with LUTO by congenital obstructive megalourethra, FUM is feasible and is associated with good perinatal outcomes.
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Fetoscopía/métodos , Obstrucción Uretral/congénito , Femenino , Fetoscopía/tendencias , Edad Gestacional , Humanos , Lactante , Recién Nacido , Masculino , México/epidemiología , Pene/anomalías , Pene/cirugía , Embarazo , Ultrasonografía Prenatal/métodos , Ultrasonografía Prenatal/estadística & datos numéricos , Uretra/anomalías , Obstrucción Uretral/epidemiología , Obstrucción Uretral/cirugíaRESUMEN
BACKGROUND: Congenital obstructive uropathy (OU) is a leading cause of pediatric kidney failure, representing a unique mechanism of injury, in part from renal tubular stretch and ischemia. Tubular injury biomarkers have potential to improve OU-specific risk stratification. METHODS: Patients with OU were identified in the Chronic Kidney Disease in Children (CKiD) study. "Cases" were defined as individuals receiving any kidney replacement therapy (KRT), while "controls" were age- and time-on-study matched and KRT free at last study visit. Urine and plasma neutrophil gelatinase-associated lipocalin (NGAL), interleukin 18 (IL-18), and liver-type fatty acid-binding protein (L-FABP) levels were measured at enrollment and annually and compared between cases and controls. Urine values were normalized to urine creatinine. RESULTS: In total, 22 cases and 22 controls were identified, with median (interquartile range) ages of 10.5 (9.0-13.0) and 15.9 (13.9-16.9) years at baseline and outcome, respectively. At enrollment there were no differences noted between cases and controls for any urine (u) or plasma (p) biomarker measured. However, the mean pNGAL and uL-FABP/creatinine increased throughout the study period in cases (15.38 ng/ml per year and 0.20 ng/ml per mg/dl per year, respectively, p = 0.01 for both) but remained stable in controls. This remained constant after controlling for baseline glomerular filtration rate (GFR). CONCLUSIONS: In children with OU, pNGAL and uL-FABP levels increased over the 5 years preceding KRT; independent of baseline GFR. Future studies are necessary to identify optimal cutoff values and to determine if these markers outperform current clinical predictors.
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Proteínas de Unión a Ácidos Grasos/orina , Lipocalina 2/orina , Insuficiencia Renal Crónica/diagnóstico , Terapia de Reemplazo Renal/estadística & datos numéricos , Obstrucción Uretral/complicaciones , Adolescente , Biomarcadores/sangre , Biomarcadores/orina , Estudios de Casos y Controles , Niño , Creatinina/orina , Proteínas de Unión a Ácidos Grasos/sangre , Femenino , Estudios de Seguimiento , Tasa de Filtración Glomerular/fisiología , Humanos , Interleucina-18/sangre , Interleucina-18/orina , Riñón/fisiopatología , Lipocalina 2/sangre , Estudios Longitudinales , Masculino , Pronóstico , Estudios Prospectivos , Valores de Referencia , Insuficiencia Renal Crónica/etiología , Insuficiencia Renal Crónica/terapia , Insuficiencia Renal Crónica/orina , Medición de Riesgo/métodos , Obstrucción Uretral/sangre , Obstrucción Uretral/congénito , Obstrucción Uretral/orinaRESUMEN
OBJECTIVE: To determine postnatal neurodevelopmental (ND) outcomes for children with congenital lower urinary tract obstruction (LUTO) based on disease severity. METHODS: Twenty male infants with LUTO were classified prenatally as Stage 1 (normal amniotic fluid and renal function; n = 5), Stage 2 (signs of obstruction with preserved renal function; n = 13), and Stage 3 (signs of severe renal damage; n = 2). ND status was assessed using the Developmental Profile-3 test in 5 developmental domains (physical, adaptive behavior, social-emotional, cognitive, and communication). Each domain was considered to be delayed if standard scores were 2 or more SD below the mean. ND outcomes were compared between cases with an expected normal renal function (LUTO Stage 1) and those with impaired renal function (LUTO Stages 2 and 3). Results from cases with Stage 2 were also compared to those from Stage 3. ORs were calculated to predict risk for adverse ND outcome for each domain considering prenatal and postnatal factors. RESULTS: Gestational age (GA) at the diagnosis of LUTO was similar between both groups (Stage 1: 24.85 ± 7.87 vs. Stages 2 and 3: 21.4 ± 4.31 weeks; p = 0.24). Twelve of 15 cases with Stage 2 or 3 underwent vesicoamniotic shunt placement compared to none of Stage 1 fetuses (p < 0.01). No differences in GA at delivery were detected between the groups (37.9 ± 1.6 vs. 35.1 ± 3.6 weeks; p = 0.1). One of the infants in the Stage 2 and 3 groups received a kidney transplant during follow-up. One case (20%) from Stage 1 group required dialysis during the first 6 months of life, and 1 case from Stage 2 to 3 group required it during the first 6 months (p = 1.0), whereas 3 additional cases needed dialysis from 6 to 24 months (p = 0.6). Mean age at Developmental Profile 3 (DP-3) testing was 20.3 ± 12.3 months (Stage 1: 11.2 ± 8.6 vs. Stages 2 and 3: 23.4 ± 13.4 months; p = 0.07). Fifteen of the 20 patients (75%) had no ND delays. Of the 5 patients with ND delays, 4 received dialysis. No differences in ND outcomes between infants with LUTO Stage 1 and those with Stages 2 and 3 were detected except for a trend toward better physical development in Stage 1 (102.6 ± 11.6 vs. 80.7 ± 34.9; p = 0.05). Infants diagnosed with LUTO Stage 3 showed significantly lower adaptive scores than those diagnosed with Stage 2 (Stage 2: 101.9 ± 22.3 vs. Stage 3: 41.5 ± 30.4; p = 0.04) and a nonsignificant trend for lower results in physical (85.8 ± 33.0 vs. 47.5 ± 38.9; p = 0.1) and socio-emotional (94.7 ±17.9 vs. 73.5 ± 13.4; p = 0.1) domains. Infants who received dialysis showed 15-fold increased risk (95% CI 0.89-251) for delayed socio-emotional development (p = 0.06). Diagnosis of fetal renal failure increased the risk for delays in the adaptive domain 30-fold (95% CI 1.29-93.1; p = 0.03). Infants with abnormal renal function had 19 times (95% CI 1.95-292) increased risk for delays in the physical domain (p = 0.03). CONCLUSIONS: While most patients with LUTO do not exhibiting ND delays, our results support the importance of ND monitoring, especially in severe forms of LUTO, as increased severity of this condition may be associated with poorer ND outcomes.
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Riñón/diagnóstico por imagen , Malformaciones del Sistema Nervioso/diagnóstico por imagen , Obstrucción Uretral/congénito , Adolescente , Adulto , Líquido Amniótico , Femenino , Edad Gestacional , Humanos , Recién Nacido , Masculino , Embarazo , Estudios Retrospectivos , Índice de Severidad de la Enfermedad , Ultrasonografía Prenatal , Obstrucción Uretral/diagnóstico por imagen , Adulto JovenRESUMEN
Anterior urethral valves are a rare cause of obstructed voiding in adolescent children and are often unheard by adult urologists. In this case report, we discuss the management of two adolescent patients who were referred to us with obstructive voiding symptoms with a diagnosis of neurogenic bladder and posterior urethral valves respectively but on evaluation were found to have anterior urethral valves. This article highlights the need for considering anterior urethral valve as an important differential diagnosis in children and adolescents presenting with obstructive voiding symptoms so as to avoid delay in diagnosis and management in young boys.
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Cistoscopía/métodos , Errores Diagnósticos , Uretra , Obstrucción Uretral , Urodinámica , Niño , Errores Diagnósticos/clasificación , Errores Diagnósticos/prevención & control , Disección/métodos , Humanos , Hidronefrosis/diagnóstico , Hidronefrosis/etiología , Masculino , Enuresis Nocturna/diagnóstico , Enuresis Nocturna/etiología , Resultado del Tratamiento , Ultrasonografía/métodos , Procedimientos Innecesarios , Uretra/anomalías , Uretra/diagnóstico por imagen , Uretra/cirugía , Obstrucción Uretral/congénito , Obstrucción Uretral/diagnóstico , Obstrucción Uretral/fisiopatología , Obstrucción Uretral/cirugía , Infecciones Urinarias/diagnóstico , Infecciones Urinarias/etiologíaRESUMEN
OBJECTIVES: Anterior urethral anomalies (AUA) which present as anterior urethral valve, stenosis or atresia, are a rare cause for congenital urinary tract obstruction. We present our AUA prenatal diagnosis case series. METHODS: Fetuses presenting with prenatal findings suggestive for AUA according to postnatal reported clinical and imaging signs (urinary tract dilatation, dilated bladder, enlarged edematous fetal penis, dilatation of the fetal urethra and diverticula) were followed prospectively. RESULTS: Six fetuses were diagnosed with AUA. Diagnosis was confirmed upon examination of the neonate or the abortus. All cases presented with variable degrees of urinary tract dilatation. Four fetuses who presented with additional congenital anomalies of the kidneys and urinary tract (CAKUT) developed intra-uterine or early postnatal renal failure, while two isolated AUA cases have a normal renal outcome. CONCLUSIONS: AUA is a rare diagnosis. However, high index of suspicion and careful sonographic assessment of the male fetal urethra in cases referred for urinary tract dilatation may enable appropriate parent counseling, optimal prenatal surveillance and timed postnatal urological intervention. As in other lower urinary tract obstructions, future renal function seems to correlate with associated CAKUT, therefore close follow up throughout pregnancy and meticulous sonographic assessment is recommended.
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Dilatación Patológica/diagnóstico por imagen , Hidronefrosis/diagnóstico por imagen , Uretra/diagnóstico por imagen , Estrechez Uretral/diagnóstico por imagen , Anomalías Urogenitales/diagnóstico por imagen , Anomalías Múltiples/diagnóstico por imagen , Aborto Inducido , Adulto , Dilatación Patológica/etiología , Edema/diagnóstico por imagen , Femenino , Humanos , Hidronefrosis/congénito , Hidronefrosis/etiología , Recién Nacido , Riñón/diagnóstico por imagen , Masculino , Oligohidramnios/diagnóstico por imagen , Oligohidramnios/etiología , Pene/diagnóstico por imagen , Embarazo , Insuficiencia Renal/etiología , Ultrasonografía Prenatal , Uretra/anomalías , Obstrucción Uretral/complicaciones , Obstrucción Uretral/congénito , Obstrucción Uretral/diagnóstico por imagen , Estrechez Uretral/complicaciones , Estrechez Uretral/congénito , Vejiga Urinaria/diagnóstico por imagen , Sistema Urinario , Anomalías Urogenitales/complicaciones , Adulto JovenAsunto(s)
Anomalías Múltiples/diagnóstico , Ano Imperforado/diagnóstico , Enfermedades Pulmonares/diagnóstico , Pulmón/anomalías , Obstrucción Uretral/congénito , Anomalías Urogenitales/diagnóstico , Anomalías Múltiples/embriología , Femenino , Humanos , Recién Nacido , Pulmón/embriología , Enfermedades Pulmonares/embriología , Obstrucción Uretral/diagnósticoRESUMEN
INTRODUCTION: The diagnosis of renal function impairment and deterioration in congenital urinary tract obstruction (UTO) continues to be extremely challenging. The use of new renal biomarkers in this setting may favor early renal injury detection, allowing for a reliable choice of optimal therapeutic options and the prevention or minimization of definitive renal damage. OBJECTIVE: The aim of the study was to investigate a selection of promising biomarkers of renal injury with the intention of evaluating and comparing their profile with clinically based decisions for surgical intervention of infants with congenital obstructive uropathies. STUDY DESIGN: The first-year profile of renal biomarkers, serum creatinine (sCr), serum and urine cystatin C (CyC), neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), transforming growth factor beta-1 (TGF-ß1), retinol-binding protein (RBP), and microalbuminuria (µALB), was analyzed in a cohort of 37 infants with congenital UTO, divided into three subgroups, 14 cases with grade III unilateral hydro(uretero)nephrosis, 13 cases with grade III bilateral hydro(uretero)nephrosis, and 10 cases with low urinary tract obstruction (LUTO), compared with 24 healthy infants matched by gestational age and birth weight. Serum and urine samples were stored at -70 °C and thereafter analyzed by quantitative enzymatic immunoassay. RESULTS: Compared with the control group (Figure), all renal biomarker values were significantly increased in patients (P ≤ 0.02). In the unilateral hydronephrosis and LUTO group, RBP (P ≤ 0.043), NGAL (P ≤ 0.043), KIM-1 (P ≤ 0.03), and TGF-ß1 (P ≤ 0.034) values dropped significantly after surgery. Neutrophil gelatinase-associated lipocalin alone and in combination with urine and serum CyC demonstrated the best performance in determining the need for surgery (area under the curve, 0.801 and 0.881, respectively). Biomarker profile analysis was suggestive of surgical intervention in 55.4% (7/13) of non-operated cases, and most of the biomarker values were above the cutoff levels within at least 3 months before the clinically based surgical decision in 58% (14/24) of all operated patients. DISCUSSION: To the best of the authors' knowledge, this is the first study to present the clinical use of selected group of serum and urinary biomarkers in the setting of UTO to distinguish between patients who would benefit from surgery intervention. The most promising results were obtained using NGAL, RBP, TGF-ß1, and KIM-1, especially in the unilateral hydro(uretero)nephrosis and LUTO subgroups when compared with the control group. CONCLUSIONS: Urine biomarkers, alone and in combination, demonstrated high potential as a non-invasive diagnostic tool for identifying infants who may benefit from earlier surgical intervention.
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Toma de Decisiones Clínicas , Obstrucción Ureteral/metabolismo , Obstrucción Ureteral/cirugía , Obstrucción Uretral/metabolismo , Obstrucción Uretral/cirugía , Obstrucción del Cuello de la Vejiga Urinaria/metabolismo , Obstrucción del Cuello de la Vejiga Urinaria/cirugía , Biomarcadores/sangre , Femenino , Humanos , Lactante , Masculino , Valor Predictivo de las Pruebas , Obstrucción Ureteral/congénito , Obstrucción Uretral/congénito , Obstrucción del Cuello de la Vejiga Urinaria/congénito , Procedimientos Quirúrgicos UrológicosRESUMEN
OBJECTIVE: Congenital lower urinary tract obstruction (LUTO) is a rare condition with high perinatal mortality and morbidity when associated with severe oligohydramnios or anhydramnios in the second trimester of pregnancy. Severe pulmonary hypoplasia and end-stage renal disease are the underlying causes of poor neonatal outcome in these cases. However, little is known about the subset of fetal LUTO that is associated with a normal volume of amniotic fluid at midgestation. The objective of the current study was to describe the natural history, underlying causes, survival and postnatal renal function outcomes in pregnancies with fetal LUTO and normal amniotic fluid volume during the second trimester of pregnancy. METHODS: This was a retrospective study of all pregnancies with fetal LUTO and normal amniotic fluid volume in the second trimester that received prenatal and postnatal care at our quaternary care institution between 2013 and 2017. Data on demographic characteristics, fetal interventions, perinatal survival, need for neonatal respiratory support, postnatal renal function and need for dialysis at the age of 1 and 24 months were analyzed. RESULTS: Of the 18 fetuses that met the study criteria, 17 (94.4%) survived the perinatal period. Eleven (61.1%) pregnancies developed oligohydramnios in the third trimester, six of which were eligible for and underwent fetal intervention with vesicoamniotic shunt placement, which was performed successfully in all six cases. Two (11.1%) neonates required respiratory support owing to pulmonary hypoplasia. At the age of 2 years, 14 children had follow-up information available, two (14.3%) of whom had normal renal function, eight (57.1%) had developed some degree of chronic kidney disease (Stage 1-4) and four (28.6%) had developed end-stage renal disease (ESRD), including two who had already manifested ESRD in the neonatal period. CONCLUSIONS: Most fetuses diagnosed prenatally with LUTO that is associated with a normal volume of amniotic fluid at midgestation will have a favorable outcome in terms of perinatal survival and few will need long-term respiratory support. However, these children are still at increased risk for chronic renal disease, ESRD and need for renal replacement therapy. Larger multicenter studies are needed to characterize the prenatal factors associated with postnatal renal function, and to investigate the role of fetal intervention in the group of fetuses that present with late-onset oligohydramnios and evidence of preserved fetal renal function. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.
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Enfermedades Fetales/diagnóstico por imagen , Obstrucción Uretral/diagnóstico por imagen , Enfermedades Urológicas/diagnóstico por imagen , Adulto , Líquido Amniótico/diagnóstico por imagen , Preescolar , Femenino , Enfermedades Fetales/patología , Enfermedades Fetales/cirugía , Humanos , Lactante , Recién Nacido , Oligohidramnios/diagnóstico por imagen , Oligohidramnios/cirugía , Mortalidad Perinatal , Embarazo , Segundo Trimestre del Embarazo , Insuficiencia Renal Crónica/diagnóstico , Insuficiencia Renal Crónica/etiología , Insuficiencia Renal Crónica/terapia , Estudios Retrospectivos , Medición de Riesgo , Ultrasonografía/métodos , Obstrucción Uretral/congénito , Obstrucción Uretral/mortalidad , Enfermedades Urológicas/congénitoRESUMEN
OBJECTIVES: Cardiac remodeling due to renal dysfunction may have an impact on myocardial function (MF) of fetuses with lower urinary tract obstruction (LUTO). The aim was to identify possible differences in MF in LUTO fetuses compared with healthy controls and to look for interactions between urine biochemistry and MF indices. METHODS: This is a cohort study consisting of 31 LUTO fetuses and 45 healthy controls. Subgroups were generated according to intrauterine therapy (group 1: LUTO after therapy, group 2: LUTO without therapy at the time of examination, and group 3: controls). MF indices were measured using pulsed wave tissue Doppler imaging and M-mode. Furthermore, results of fetal urine biochemistry were gathered retrospectively. RESULTS: Among other findings, right ventricular (RV) e'/a' ratio was lower in group 1 compared with group 3 (p = .050). According to gestational age (GA) level-dependent analysis, RV isovolumetric relaxation time was significantly longer in group 2 compared with group 1 and group 3 at GA level 1 (19 wk of gestation). A significant positive correlation between RV e'/a' ratio and ß-2-microglobulin as well as α-1-microglobulin and potassium could be observed. CONCLUSION: We observed differences in MF and an association between ventricular filling pattern and renal protein secretion in LUTO fetuses. This can be interpreted as a sign of intrauterine cardiac remodeling.
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Enfermedades Fetales/fisiopatología , Feto/fisiología , Corazón/fisiología , Obstrucción Uretral/fisiopatología , Estudios de Casos y Controles , Estudios de Cohortes , Ecocardiografía Doppler , Femenino , Enfermedades Fetales/terapia , Enfermedades Fetales/orina , Fetoscopía , Edad Gestacional , Pruebas de Función Cardíaca , Humanos , Recién Nacido , Masculino , Embarazo , Estudios Retrospectivos , Ultrasonografía Prenatal , Obstrucción Uretral/congénito , Obstrucción Uretral/terapia , Obstrucción Uretral/orina , Anomalías Urogenitales/fisiopatología , Anomalías Urogenitales/terapia , Anomalías Urogenitales/orina , Función Ventricular Izquierda/fisiología , Remodelación Ventricular/fisiologíaRESUMEN
BACKGROUND: Posterior urethral valve (PUV) is the most serious form of congenital anomalies of kidney and urinary tract (CAKUT) in boys with significant risk of progression to chronic kidney disease (CKD). We present our long-term results in children with PUV. METHODS: Retrospective chart review of 113 children with PUV followed within the years of 1996-2018 was performed. Clinical, laboratory and epidemiologic parameters were analyzed for their impact on renal outcome. RESULTS: The median age of diagnosis was 1.00 month (1.00-132.00) and the median follow-up period was 70 months (60.00-216.00). Antenatal diagnosis was present in 33 patients (51.5%) mainly with bilateral hydronephrosis and oligohydramnios. The most common postnatal presentation was recurrent urinary tract infection (UTI) in 14 cases (21.9%) and incontinence in three cases (4.7%). Vesicoureteral-reflux (VUR) was present in 31 cases (48.4%). All patients had surgery and urinary diversion was needed in 18 (28.2%). Varying stages of chronic kidney disease (CKD) developed in 23 cases (35.9%) and rise in serum creatinine was especially prominent after the 4th year of follow-up. Of 23 CKD patients, seven (10.9%) were in ESRD and on dialysis. Mortality occurred in one (1.5%) patient. Hypertension, proteinuria and high initial serum creatinine (>1.28 mg/dL) were statistically significant risk factors for CKD, as expected. Surprisingly VUR and UTI did not show such a significant impact on CKD development. Antenatal detection was with significantly less risk for CKD. CONCLUSIONS: Our results confirm that PUV has a considerable risk for CKD development. Antenatal diagnosis, management of proteinuria and hypertension may modify this progression. But already injured kidneys still have a potential risk. The need for further research to evaluate the impact of any intervention on long term renal outcome is obvious.
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Uretra/anomalías , Uretra/cirugía , Obstrucción Uretral/congénito , Obstrucción Uretral/cirugía , Edad de Inicio , Niño , Preescolar , Femenino , Estudios de Seguimiento , Humanos , Hipertensión Renal/etiología , Hipertensión Renal/terapia , Lactante , Recién Nacido , Fallo Renal Crónico/etiología , Masculino , Embarazo , Diagnóstico Prenatal , Proteinuria/etiología , Proteinuria/terapia , Insuficiencia Renal Crónica/etiología , Estudios Retrospectivos , Factores de Riesgo , Resultado del Tratamiento , Obstrucción Uretral/diagnóstico , Derivación Urinaria/métodos , Procedimientos Quirúrgicos Urológicos , Reflujo VesicoureteralRESUMEN
BACKGROUND: Posterior urethral valves (PUVs) are associated with severe consequences to the urinary tract and are a common cause of chronic kidney disease (CKD). The aim of this study was to develop clinical predictive model of CKD in a cohort of patients with PUVs. METHODS: In this retrospective cohort study, 173 patients with PUVs were systematically followed up at a single tertiary unit. The primary endpoint was CKD ≥ stage 3. Survival analyses were performed by Cox regression proportional hazard models with time-fixed and time-dependent covariables. RESULTS: Mean follow-up time was 83 months (SD, 70 months). Sixty-five children (37.6%) developed CKD stage ≥ 3. After adjustment by the time-dependent Cox model, baseline creatinine, nadir creatinine, hypertension, and proteinuria remained as predictors of the endpoint. After adjustment by time-fixed model, three variables were predictors of CKD ≥ stage 3: baseline creatinine, nadir creatinine, and proteinuria. The prognostic risk score was divided into three categories: low-risk (69 children, 39.9%), medium-risk (45, 26%), and high-risk (59, 34.1%). The probability of CKD ≥ stage 3 at 10 years age was estimated as 6%, 40%, and 70% for patients assigned to the low-risk, medium-risk, and high-risk groups, respectively (P < 0.001). The main limitation was the preclusion of some relevant variables, especially bladder dysfunction, that might contribute to a more accurate prediction of renal outcome. CONCLUSION: The model accurately predicts the risk of CKD in PUVs patients. This model could be clinically useful in applying timely intervention and in preventing the impairment of renal function.
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Modelos Biológicos , Insuficiencia Renal Crónica/epidemiología , Uretra/anomalías , Obstrucción Uretral/complicaciones , Preescolar , Progresión de la Enfermedad , Estudios de Factibilidad , Femenino , Estudios de Seguimiento , Humanos , Lactante , Masculino , Modelos de Riesgos Proporcionales , Insuficiencia Renal Crónica/etiología , Estudios Retrospectivos , Medición de Riesgo/métodos , Factores de Riesgo , Análisis de Supervivencia , Obstrucción Uretral/congénito , Obstrucción Uretral/mortalidadRESUMEN
OBJECTIVE: To propose a staging system for congenital lower urinary tract obstruction (LUTO) capable of predicting the severity of the condition and its prognosis. METHODS: This was a national retrospective study carried out at the eight Academic Hospitals in The Netherlands. We collected prenatal and postnatal data of fetuses at high risk of isolated LUTO that were managed conservatively. Postnatal renal function was assessed by the estimated glomerular filtration rate (eGFR), calculated using the Schwartz formula, considering the length of the infant and the creatinine nadir in the first year after birth. Receiver-operating characteristics (ROC) curve analysis, univariate analysis and multivariate logistic regression analysis with stepwise backward elimination were performed in order to identify the best antenatal predictors of perinatal mortality and postnatal renal function. RESULTS: In total, 261 fetuses suspected of having LUTO and managed conservatively were included in the study. The pregnancy was terminated in 110 cases and perinatal death occurred in 35 cases. Gestational age at appearance of oligohydramnios showed excellent accuracy in predicting the risk of perinatal mortality with an area under the ROC curve of 0.95 (P < 0.001) and an optimal cut-off at 26 weeks' gestation. Fetuses with normal amniotic fluid (AF) volume at 26 weeks' gestation presented with low risk of poor outcome and were therefore defined as cases with mild LUTO. In fetuses referred before the 26th week of gestation, the urinary bladder volume (BV) was the best unique predictor of perinatal mortality. ROC curve analysis identified a BV of 5.4 cm3 and appearance of oligohydramnios at 20 weeks as the best threshold for predicting an adverse outcome. LUTO cases with a BV ≥ 5.4 cm3 or abnormal AF volume before 20 weeks' gestation were defined as severe and those with BV < 5.4 cm3 and normal AF volume at the 20 weeks' scan were defined as moderate. Risk of perinatal mortality significantly increased according to the stage of severity, from mild to moderate to severe stage, from 9% to 26% to 55%, respectively. Similarly, risk of severely impaired renal function increased from 11% to 31% to 44%, for mild, moderate and severe LUTO, respectively. CONCLUSIONS: Gestational age at appearance of oligo- or anhydramnios and BV at diagnosis can accurately predict mortality and morbidity in fetuses with LUTO. Our proposed staging system can triage reliably fetuses with LUTO and predict the severity of the condition and its prognosis. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.
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Enfermedades Fetales/diagnóstico , Oligohidramnios/diagnóstico por imagen , Obstrucción Uretral/diagnóstico , Vejiga Urinaria/diagnóstico por imagen , Tratamiento Conservador , Femenino , Edad Gestacional , Tasa de Filtración Glomerular , Humanos , Lactante , Recién Nacido , Modelos Logísticos , Mortalidad Perinatal , Valor Predictivo de las Pruebas , Embarazo , Curva ROC , Estudios Retrospectivos , Índice de Severidad de la Enfermedad , Ultrasonografía Prenatal , Obstrucción Uretral/clasificación , Obstrucción Uretral/congénito , Obstrucción Uretral/mortalidad , Vejiga Urinaria/anomalías , Vejiga Urinaria/embriologíaRESUMEN
OBJECTIVE: Because the literature on the predictive value of fetal urinalysis is controversial in fetuses with lower urinary tract obstruction, we determined the best model of fetal urine biochemical markers correlated with long-term postnatal renal function based on glomerular filtration rate (GFR). METHOD: This retrospective study concerned 89 fetuses with lower urinary tract obstruction and their renal function after 10 years of age. We correlated fetal urine biochemical markers (total protein, ß2-microglobulin, sodium, chloride, glucose, calcium, and phosphorus) with GFR at 10 to 30 years of age in 89 patients with posterior urethral valves. We defined five stages of chronic kidney disease (CKD). RESULTS: Of the 89 patients, 18 (20%) are 20 years old or over. Postnatal renal function was good in 67.4% (GFR > 60 mL/min/1.73 m2 ) and poor in 17% (GFR < 30 mL/min/1.73 m2 ). All fetal urine markers differed between CKD stage 1 + 2 and CKD stage 4 + 5 (P < 0.001). ß2-microblobulin showed an 87% sensitivity for a 72% specificity. A combination of ß2-microglobulin and chloride gave the best results (93% sensitivity and 71% specificity) versus amniotic fluid volume (80% sensitivity and 73% specificity). CONCLUSION: Fetal urine biochemistry predicts long-term (10-30 years) postnatal renal function.
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Enfermedades Fetales/orina , Insuficiencia Renal Crónica/fisiopatología , Insuficiencia Renal Crónica/orina , Obstrucción Uretral/orina , Microglobulina beta-2/orina , Biomarcadores/orina , Niño , Cloruros/orina , Femenino , Enfermedades Fetales/diagnóstico por imagen , Enfermedades Fetales/etiología , Tasa de Filtración Glomerular , Humanos , Masculino , Oligohidramnios/diagnóstico por imagen , Oligohidramnios/etiología , Valor Predictivo de las Pruebas , Embarazo , Pronóstico , Insuficiencia Renal Crónica/congénito , Insuficiencia Renal Crónica/etiología , Estudios Retrospectivos , Obstrucción Uretral/congénito , Obstrucción Uretral/diagnóstico por imagen , Obstrucción Uretral/etiología , UrinálisisRESUMEN
INTRODUCTION: Congenital Lower Urinary Tract Obstructions (LUTO) is a heterogeneous group of diseases in which urine elimination is obstructed at the level of bladder neck or urethra. The aim of the study is to evaluate the long-term renal outcome of patients suffering of congenital LUTO. PATIENTS AND METHOD: We retrospectively reviewed patients with congenital LUTO. All patients had at least 1 year follow-up. Data on surgery, renal imaging and Schwartz estimate creatinine clearance were collected. Incidence of Chronic Renal Disease (CRD) is presented with Kaplan-Meier method. RESULTS: 40 patients were included, 23 patients with Posterior Urethral Valve (PUVs) and 17 patients with other aetiologies: anterior urethral valve (2), urethral atresia (2), urethral stenosis (2), cloacal malformations (2), obstructive ureterocele (1), bladder trigone malformation (1) and neonatal bladder-sphincter dysfunction without neurological abnormalities (7). Incidence of CRD at age 10 years was 37% in congenital LUTO, 42% in PUVs and 30% in other aetiologies, and was significantly higher in PUVs (P=0.032). Renal prognosis was significantly worsened by discover of retentional bladder wall changes in initial cystoscopy, and by loss of parenchymal differentiation or cortical microcysts in first ultrasonography. The use of urinary diversion was significantly higher in LUTO of other aetiologies. CONCLUSION: A high incidence of CRD is observed in patients with congenital LUTO, significantly higher in patients with PUV. LUTO of other aetiologies require step by step surgical management and higher use of urinary diversion. Precise initial evaluation in cystoscopy and ultrasonography is required and participate to evaluate future renal outcome. LEVEL OF INCIDENCE: 4.
Asunto(s)
Riñón/fisiología , Enfermedades Uretrales/congénito , Enfermedades Uretrales/cirugía , Obstrucción del Cuello de la Vejiga Urinaria/congénito , Obstrucción del Cuello de la Vejiga Urinaria/cirugía , Anomalías Urogenitales/cirugía , Adolescente , Niño , Preescolar , Cistoscopía/rehabilitación , Femenino , Estudios de Seguimiento , Humanos , Lactante , Recién Nacido , Masculino , Recuperación de la Función , Estudios Retrospectivos , Factores de Tiempo , Resultado del Tratamiento , Enfermedades Uretrales/fisiopatología , Obstrucción Uretral/congénito , Obstrucción Uretral/fisiopatología , Obstrucción Uretral/cirugía , Obstrucción del Cuello de la Vejiga Urinaria/fisiopatología , Anomalías Urogenitales/fisiopatología , Adulto JovenRESUMEN
PURPOSE OF THE REVIEW: In this article, we explore the origins of intervention of fetal lower urinary tract obstruction, and we specifically discuss the background and recent outcomes of vesicoamniotic shunt placement and fetal cystoscopy. The article seeks to provide a comprehensive overview of the field while bringing the reader quickly up to speed on the pertinent literature and the critical data that are available to guide decision-making regarding intervention. RECENT FINDINGS: Appropriate patient selection for fetal intervention remains challenging despite advances in prenatal imaging. Both a randomized controlled trial and multiple systematic reviews show evidence of a perinatal survival benefit following fetal intervention but rates of renal morbidity remain very high. Despite 30 years of research, fetal lower urinary tract obstruction remains a difficulty entity to treat. Intervention may lead to survival, but physicians and caregivers must remain alert for the distinct possibility of long-term renal morbidity in survivors.
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Amnios/cirugía , Obstrucción Uretral/cirugía , Obstrucción del Cuello de la Vejiga Urinaria/cirugía , Vejiga Urinaria/cirugía , Anastomosis Quirúrgica , Cistoscopía , Femenino , Enfermedades Fetales/diagnóstico por imagen , Enfermedades Fetales/cirugía , Fetoscopía , Humanos , Hidronefrosis/congénito , Hidronefrosis/diagnóstico por imagen , Hidronefrosis/cirugía , Embarazo , Ultrasonografía Prenatal , Obstrucción Uretral/congénito , Obstrucción Uretral/diagnóstico por imagen , Obstrucción del Cuello de la Vejiga Urinaria/congénito , Obstrucción del Cuello de la Vejiga Urinaria/diagnóstico por imagenRESUMEN
A 34-year-old para V woman was referred to our centre at 35+1 weeks of gestation for an assumed fetal malformation with prenatal renal impairment and anhydramnios. Prenatal ultrasound demonstrated unilateral renal agenesis; the bladder was not detectable. The baby was born by caesarian section at 36+2 weeks of gestation because of placental insufficiency. Postnatal adaptation was uneventful, but the newborn presented external stigmas of trisomy 21 and progressive renal impairment with anuria. Nevertheless, the postnatal ultrasound showed two enlarged kidneys in loco typico with impaired perfusion but without signs of malformations. In the lower abdomen, a rosette-shaped structure of unknown origin was noted. Its origin could not be cleared by imaging including voiding cystourethrography and colon contrast radiography. Explorative laparotomy identified the structure as a persistent urachal cyst with secondary obstruction of the upper urinary tract. After removal of the urachus with reconstruction of the bladder dome, renal function recovered completely while urine was drained continuously via suprapubic catheter. A voiding cystourethrogram 3 weeks later showed a posterior urethral valve as an additional unexpected diagnosis. The valve was slit at the age of 6 months without complications, the renal function remained stable in the further course. In retrospect, the main cause for the renal failure remains unclear. It appears to be the obstruction due to the space-consuming character of the urachal cyst, especially because the megacystis typically associated with urethral valve was not viewable. Alternatively, the additional proximal stenosis may have only masked the typical findings of PUV.
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Lesión Renal Aguda/congénito , Enfermedades del Prematuro/diagnóstico , Quiste del Uraco/congénito , Obstrucción Ureteral/congénito , Lesión Renal Aguda/diagnóstico , Adulto , Diagnóstico Diferencial , Síndrome de Down/diagnóstico , Femenino , Humanos , Recién Nacido , Masculino , Embarazo , Ultrasonografía , Quiste del Uraco/diagnóstico , Obstrucción Ureteral/diagnóstico , Obstrucción Uretral/congénito , Obstrucción Uretral/diagnósticoRESUMEN
OBJECTIVE: To evaluate the effect on perinatal and postnatal survival of vesicoamniotic shunt (VAS) as treatment for fetal lower urinary tract obstruction (LUTO). METHODS: An electronic search of Ovid MEDLINE, Ovid EMBASE, Ovid Cochrane Central Register of Controlled Trials, Ovid Cochrane Database of Systematic Reviews and Scopus using relevant search terms was conducted from inception to June 2015 to identify studies comparing outcomes of VAS vs conservative management for treatment of LUTO. Cohort studies and clinical trials were considered eligible. Single-arm studies and studies that did not report survival were excluded. Sample size and language were not criteria for exclusion. Two reviewers extracted independently data in a standardized form, including study characteristics and results. Primary outcomes were perinatal and postnatal survival. Secondary outcome was postnatal renal function. Data on fetal survival were expressed as odds ratio (OR) and 95% CI. RESULTS: Of the 423 abstracts retrieved, nine studies were eligible for inclusion. These studies included 112 fetuses treated with VAS and 134 that were managed conservatively. There was heterogeneity in study design. Although the data demonstrated a difference in effect estimates between the study arms in terms of perinatal survival (OR, 2.54 (95% CI, 1.14-5.67)), there was no difference in 6-12-month survival (OR, 1.77 (95% CI, 0.25-12.71)) or 2-year survival (OR, 1.81 (95% CI, 0.09-38.03)). In addition, there was no difference in effect on postnatal renal function between fetuses that underwent intervention and those that did not (OR, 2.09 (95% CI, 0.74-5.94)). CONCLUSIONS: Available data seem to support an advantage for perinatal survival in fetuses treated with VAS compared with conservative management. However, 1-2-year survival and outcome of renal function after VAS procedure remain uncertain. Further studies are necessary to evaluate the effectiveness of fetal intervention for LUTO based on different severity of the disease, due to the very low quality of the studies according to GRADE guidelines. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.
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Obstrucción Uretral/diagnóstico por imagen , Anastomosis Quirúrgica , Cistoscopía , Femenino , Enfermedades Fetales/diagnóstico por imagen , Enfermedades Fetales/mortalidad , Enfermedades Fetales/cirugía , Terapias Fetales , Humanos , Embarazo , Análisis de Supervivencia , Ultrasonografía Prenatal , Obstrucción Uretral/congénito , Obstrucción Uretral/mortalidad , Obstrucción Uretral/cirugíaAsunto(s)
Sepsis/microbiología , Infecciones Estafilocócicas/microbiología , Obstrucción Uretral/microbiología , Infecciones Urinarias/microbiología , Reflujo Vesicoureteral/microbiología , Humanos , Lactante , Masculino , Síndrome , Uréter/anomalías , Uréter/microbiología , Obstrucción Uretral/congénitoAsunto(s)
Uretra/diagnóstico por imagen , Obstrucción Uretral/diagnóstico por imagen , Micción , Anomalías Urogenitales/diagnóstico por imagen , Endoscopía , Femenino , Humanos , Recién Nacido , Masculino , Embarazo , Sensibilidad y Especificidad , Ultrasonografía Prenatal , Uretra/anomalías , Uretra/fisiopatología , Obstrucción Uretral/congénito , Obstrucción Uretral/fisiopatología , Anomalías Urogenitales/fisiopatología , Procedimientos Quirúrgicos Urológicos MasculinosRESUMEN
Purpose This study aims to evaluate the endoscopic morphological features of congenital posterior urethral obstructions in boys with refractory daytime urinary incontinence and/or nocturnal enuresis. Patients and Methods A total of 54 consecutive patients underwent endoscopy and were diagnosed with a posterior urethral valve (PUV) (types 1-4). PUV type 1 was classified as severe, moderate, or mild. A transurethral incision (TUI) was mainly performed for anterior wall lesions of the PUV. Voiding cystourethrography and pressure flow studies (PFS) were performed before and 3 to 4 months after TUI. Clinical symptoms were evaluated 6 months after TUI, and outcomes were assessed according to PFS waveform pattern groups (synergic pattern [SP] and dyssynergic pattern [DP]). Results All patients had PUV type 1 and/or 3 (i.e., n = 34 type 1, 7 type 3, and 13 types 1 and 3). There were severe (n = 1), moderate (n = 21), and mild (n = 25) cases of PUV type 1. According to PFS, SP and DP were present in 43 and 11 patients, respectively. TUI was effective in the SP group and symptoms improved in 77.4 and 69.3% of patients with daytime incontinence and nocturnal enuresis, respectively. Almost no effect was observed in the DP group. A significant decrease in the detrusor pressure was observed at maximum flow rate using PFS in the SP group. Conclusions PUV type 1 encompassed lesions with a spectrum of obstructions ranging from severe to mild, with mild types whose main obstructive lesion existed at the anterior wall of urethra occurring most frequently in boys with refractory daytime urinary incontinence and/or nocturnal enuresis.