RESUMEN
A high-fat diet (HFD) induces inflammation in systemic organs including the hypothalamus, resulting in obesity and diabetes. The vagus nerve connects the visceral organs and central nervous system, and the gastric-derived orexigenic peptide ghrelin transmits its starvation signals to the hypothalamus via the vagal afferent nerve. Here we investigated the inflammatory response in vagal afferent neurons and the hypothalamus in mice following one day of HFD feeding. This treatment increased the number of macrophages/microglia in the nodose ganglion and hypothalamus. Furthermore, one-day HFD induced expression of Toll-like receptor 4 in the goblet cells of the colon and upregulated mRNA expressions of the proinflammatory biomarkers Emr1, Iba1, Il6, and Tnfα in the nodose ganglion and hypothalamus. Both subcutaneous administration of ghrelin and celiac vagotomy reduced HFD-induced inflammation in these tissues. HFD intake triggered inflammatory responses in the gut, nodose ganglion, and subsequently in the hypothalamus within 24 h. These findings suggest that the vagal afferent nerve may transfer gut-derived inflammatory signals to the hypothalamus via the nodose ganglion, and that ghrelin may protect against HFD-induced inflammation.
Asunto(s)
Dieta Alta en Grasa/efectos adversos , Encefalitis/inmunología , Ghrelina/inmunología , Hipotálamo/inmunología , Ganglio Nudoso/inmunología , Enfermedades del Nervio Vago/inmunología , Animales , Encefalitis/etiología , Encefalitis/patología , Hipotálamo/patología , Masculino , Ratones , Ratones Endogámicos C57BL , Ganglio Nudoso/patología , Enfermedades del Nervio Vago/etiología , Enfermedades del Nervio Vago/patologíaAsunto(s)
Enfermedades del Nervio Vago/diagnóstico por imagen , Enfermedades del Nervio Vago/inmunología , Autoanticuerpos/inmunología , Electrodiagnóstico , Gangliósidos/inmunología , Humanos , Hipertrofia/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Polirradiculoneuropatía Crónica Inflamatoria Desmielinizante/diagnóstico por imagen , UltrasonografíaRESUMEN
Chronic fatigue syndrome (CFS) is an often-debilitating condition of unknown origin. There is a general consensus among CFS researchers that the symptoms seem to reflect an ongoing immune response, perhaps due to viral infection. Thus, most CFS research has focused upon trying to uncover that putative immune system dysfunction or specific pathogenic agent. However, no single causative agent has been found. In this speculative article, I describe a new hypothesis for the etiology of CFS: infection of the vagus nerve. When immune cells of otherwise healthy individuals detect any peripheral infection, they release proinflammatory cytokines. Chemoreceptors of the sensory vagus nerve detect these localized proinflammatory cytokines, and send a signal to the brain to initiate sickness behavior. Sickness behavior is an involuntary response that includes fatigue, fever, myalgia, depression, and other symptoms that overlap with CFS. The vagus nerve infection hypothesis of CFS contends that CFS symptoms are a pathologically exaggerated version of normal sickness behavior that can occur when sensory vagal ganglia or paraganglia are themselves infected with any virus or bacteria. Drawing upon relevant findings from the neuropathic pain literature, I explain how pathogen-activated glial cells can bombard the sensory vagus nerve with proinflammatory cytokines and other neuroexcitatory substances, initiating an exaggerated and intractable sickness behavior signal. According to this hypothesis, any pathogenic infection of the vagus nerve can cause CFS, which resolves the ongoing controversy about finding a single pathogen. The vagus nerve infection hypothesis offers testable hypotheses for researchers, animal models, and specific treatment strategies.
Asunto(s)
Citocinas/inmunología , Síndrome de Fatiga Crónica/etiología , Síndrome de Fatiga Crónica/fisiopatología , Conducta de Enfermedad/fisiología , Enfermedades del Nervio Vago/complicaciones , Enfermedades del Nervio Vago/inmunología , Comunicación Celular/fisiología , Citocinas/metabolismo , Humanos , Modelos Biológicos , Enfermedades del Nervio Vago/microbiología , Enfermedades del Nervio Vago/virologíaAsunto(s)
Enfermedades del Sistema Nervioso Autónomo/inmunología , Bradicardia/inmunología , Síndrome de Miller Fisher/complicaciones , Síndrome de Miller Fisher/inmunología , Oftalmoplejía/complicaciones , Oftalmoplejía/inmunología , Enfermedad Aguda , Adulto , Autoanticuerpos/sangre , Enfermedades del Sistema Nervioso Autónomo/fisiopatología , Enfermedades del Sistema Nervioso Autónomo/virología , Blefaroptosis/inmunología , Blefaroptosis/fisiopatología , Bradicardia/fisiopatología , Bradicardia/virología , Enfermedades de los Nervios Craneales/complicaciones , Enfermedades de los Nervios Craneales/inmunología , Enfermedades de los Nervios Craneales/fisiopatología , Nervios Craneales/inmunología , Nervios Craneales/patología , Nervios Craneales/fisiopatología , Diplopía/inmunología , Diplopía/fisiopatología , Progresión de la Enfermedad , Diagnóstico Precoz , Gangliósidos/inmunología , Humanos , Inmunoglobulinas Intravenosas/uso terapéutico , Masculino , Síndrome de Miller Fisher/fisiopatología , Enfermedades del Nervio Oculomotor/complicaciones , Enfermedades del Nervio Oculomotor/inmunología , Enfermedades del Nervio Oculomotor/fisiopatología , Oftalmoplejía/virología , Infecciones del Sistema Respiratorio/complicaciones , Infecciones del Sistema Respiratorio/inmunología , Infecciones del Sistema Respiratorio/virología , Resultado del Tratamiento , Enfermedades del Nervio Vago/inmunología , Enfermedades del Nervio Vago/fisiopatología , Enfermedades del Nervio Vago/virología , Virosis/complicaciones , Virosis/inmunologíaRESUMEN
Vagal dysfunction is thought to be an early, primary and specific abnormality of chronic Chagas disease. However, chagasic patients with unequivocal evidence of heart disease, can have normal or abnormal vagal control of heart rate. A common explanation for these apparently discordant and contradictory results is proposed.