Parche hemático como tratamiento de cefalea por hipotensión de líquido cefalorraquídeo espontánea / Blood patch as treatment of headache due to spontaneous hypotension of cerebrospinal fluid

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Low CSF met-enkephalin levels in cluster headache are elevated by acupuncture.

Significantly lower met-enkephalin levels were found in CSF from cluster headache sufferers as compared to age-matched healthy volunteers, whereas it was not possible to demonstrate any clear-cut difference for beta-endorphin. CSF opioid levels may rise following manual or electroacupuncture. It was studied whether traditional Chinese (manual) acupuncture affected CSF levels of met-enkephalin or beta-endorphin in these patients, and to what extent this treatment would be beneficial for the headache. A significant rise in lumbar CSF met-enkephalin levels was found, whereas no clear change in beta-endorphin levels was obtained. The treatment was, however, of little value in preventing the headache.

[Cerebrospinal fluid signalization in chronic inflammatory diseases of the central nervous system]. / Sinalização do líquido cefalorraqueano em doenças inflamatórias crônicas do sistema nervoso central.

Dynamics of cerebrospinal fluid (CSF) cyto-proteic dual obeys to different models when central nervous system (CNS) inflammatory diseases are considered. In order to evaluate these models data pertinent to multiple sclerosis (20 cases), neurosyphilis (20 cases), neurocysticercosis (20 cases), subacute sclerosing panencephalitis (20 cases), neuroschistosomiasis (18 cases) and neuro-cryptococcosis (20 cases) are compared in report to a control group: chronic vascular headache (50 cases). CSF data on cytology and proteins were considered. Cytology was evaluated as to the total cell count (cumm); the cytomorphological profile (%) and as to lymphocytes subpopulations (B, T, T-active, T-sensitized, and T-avid for T-total and for T-active). Proteins were evaluated as to the total content (mg/dl) and protein fractions (agar gel electrophoresis). Antibodies determinations were studied for comparative purposes and diagnosis. Results were analyzed according to the groups considered and comparatively. Analyses support conclusions on cells and proteins dual interaction. This interaction is expressed by phenomena that obey similar parameters. These parameters permit to consider two models of chronic inflammatory signalization: the continuous model and the repetitive model. Neurosyphilis and subacute sclerosing panencephalitis obey the chronic continuous inflammatory model. Neurocysticercosis and multiple sclerosis obey the repetitive model.

Sinalizaçäo do líquido cefalorraqueano em doenças inflamatórias crônicas do sistema nervoso central / Cerebrospinal fluid signalization in chronic inflammatory diseases of the central nervous system

Foi estudado o comportamento do dual citoproteico do LCR em processos inflamatórios do sistema nervoso central (SNC). Do ponto de vista neuroimunológico e levando em conta a sinalizaçäo observada mediante o estudo do líquido cefalorraqueano (LCR) podem ser considerados três grupos de modelos: o agudo, o crônico e o intermediário. Cada um deles pode apresentar subtipos. Foram avaliadas as características de comportamento do dual em dois modelos do tipo intermediário (criptococose do SNC e esquistossomose do SNC) e em 4 crônicos: dois de tipo contínuo (neurossífilis e panencefalite esclerosante subaguda) e dois de tipo repetitivo (neurocisticercose e esclerose múltipla). Os dados analisados permitem visäo quanto ao comportamento do dual citoproteico do LCR (número de células, perfil citomorfológico, subpopulaçöes linfocitárias, estudo proteico, fraçöes proteicas e suas relaçöes) nos modelos inflamatórios considerados. As diferenças observadas entre os modelos intermediários e os crônicos, tanto o contínuo como o repetitivo, säo evidentes independentemente do agente etiológico considerado

[Cerebrospinal fluid cAMP and cGMP in various peripheral and central nervous system diseases. Preliminary report]. / cAMP i cGMP w plynie mózgowo-rdzeniowym w niektórych schorzeniach obwodowego i osrodkowego ukladu nerwowego. Doniesienie wstepne.

In a group of 51 patients the concentrations of cAMP and cGMP and their ratio were determined in the cerebrospinal fluid in certain neurological diseases. Statistically significant differences were found in the values of the concentrations of the above metabolites in selected groups of neurological diseases. Generally speaking, apart from a group of multiple sclerosis cases the values of cAMP concentration were higher in central nervous system diseases than in peripheral nervous system diseases. The highest values of the cAMP/cGMP ratio were observed in the group of patients with inflammatory conditions of the central nervous system. This method of cerebrospinal fluid examination may have an important role in the diagnosis of neurological diseases, particularly in multiple sclerosis.