RESUMEN
BACKGROUND Cocaine abuse is a globally recognized problem with great socioeconomic and health impacts on society. We report a case of dissection of vertebral arteries and right renal artery after cocaine abuse that clinically presented as atypical headache and hypertension. CASE REPORT A 36-year-old male sought emergency care due to cervical pain after cocaine abuse. The pain was located to the right cervical side with irradiation to the homolateral temporal region. He had no previous comorbidities, except for cocaine abuse on a weekly basis. Angiotomography showed alterations compatible with recent arterial dissection of the right vertebral artery, confirmed on angioresonance. The patient received double anti-aggregation and antihypertensive drugs and was discharged. He was readmitted 5 days later due to hypertensive crisis and mild abdominal pain. Abdominal ultrasound with a Doppler of renal arteries showed signs right renal artery stenosis. Magnetic resonance angiography confirmed dissection of the same vessel. The patient underwent arteriography with stent implantation in the right renal artery. During outpatient follow-up, he progressed with gradual reduction of antihypertensive drugs. CONCLUSIONS There is only 1 case report correlating renal artery dissection with cocaine use and none with concomitant presentation of dissection in the vertebral and renal arterial beds. The scarcity of reports is a consequence of many problems. Therefore, young patients presenting with new-onset hypertension or abdominal pain and cocaine abuse history should raise suspicion for renal artery dissection.
Asunto(s)
Disección Aórtica/inducido químicamente , Cocaína/efectos adversos , Hipertensión Renovascular/inducido químicamente , Disección de la Arteria Vertebral/inducido químicamente , Adulto , Disección Aórtica/diagnóstico por imagen , Disección Aórtica/terapia , Angiografía por Tomografía Computarizada , Humanos , Hipertensión Renovascular/diagnóstico por imagen , Hipertensión Renovascular/terapia , Angiografía por Resonancia Magnética , Masculino , Arteria Renal/diagnóstico por imagen , Stents Metálicos Autoexpandibles , Disección de la Arteria Vertebral/diagnóstico por imagen , Disección de la Arteria Vertebral/terapiaRESUMEN
We report a case of multiple cervical artery dissections that occurred 4 days after a first course of alemtuzumab in a woman with relapsing-remitting multiple sclerosis and discuss its potential relationship and mechanisms of action. In particular, an arterial inflammatory process, secondary to cytokine release, could potentially lead to intimal thickening, luminal irregularities, stenosis, and ultimately occlusion. Occurrence of an unexpected serious adverse event, in our case, multiple cervical artery dissections, especially in a close time window after drug administration, questions a potential causal relationship with the drug or a simple coincidence.
Asunto(s)
Alemtuzumab/efectos adversos , Disección de la Arteria Carótida Interna/inducido químicamente , Factores Inmunológicos/efectos adversos , Esclerosis Múltiple Recurrente-Remitente/tratamiento farmacológico , Disección de la Arteria Vertebral/inducido químicamente , Adulto , Disección de la Arteria Carótida Interna/diagnóstico por imagen , Femenino , Humanos , Imagen por Resonancia Magnética , Disección de la Arteria Vertebral/diagnóstico por imagenRESUMEN
BACKGROUND AND PURPOSE: Because of their potential to alter the integrity of collagen and other components of the extracellular matrix, fluoroquinolone antibiotics might be involved in the pathogenesis of spontaneous cervical artery dissection (sCeAD). METHODS: In the setting of a single-centre case-control study, whether fluoroquinolone use in the 30-day period before the index event is associated with sCeAD (cases) in comparison with a group of age- and sex-matched patients who suffered a first-ever acute cerebral infarction from a cause other than CeAD (non-CeAD IS, controls) was assessed. RESULTS: Overall, 284 cases (mean age 43.2 ± 10.4 years; 58.5% men) and 568 controls qualified for the analysis. Thirty (10.6%) patients in the sCeAD group and 16 (2.8%) in the non-CeAD IS group were fluoroquinolone users (P ≤ 0.001). The use of these antibiotics was associated with a more than two-fold increased risk of sCeAD [odds ratio (OR) 2.31; 95% confidence interval (CI) 1.00-5.30] after adjusting for confounders. The risk was more substantial in the subgroup of patients with dissection involving the carotid artery (OR 2.78; 95% CI 1.14-6.78), in females (OR 4.58; 95% CI 1.04-20.1) and compared to that conferred by other antibiotics (OR 2.42; 95% CI 1.02-5.75). CONCLUSIONS: Fluoroquinolones may represent a novel contributing factor involved in the pathogenesis of sCeAD.
Asunto(s)
Antibacterianos/efectos adversos , Isquemia Encefálica/inducido químicamente , Fluoroquinolonas/efectos adversos , Accidente Cerebrovascular/inducido químicamente , Disección de la Arteria Vertebral/inducido químicamente , Adulto , Estudios de Casos y Controles , Femenino , Humanos , Masculino , Persona de Mediana Edad , Factores de RiesgoRESUMEN
This case report describes a transient ischaemic attack secondary to vertebral artery dissection (VAD) in a young male body builder. This occurred following weight training with weights across the back and shoulders. The patient was also known to take multiple performance enhancing agents including anabolic steroids, slimming agents, stimulants and human growth hormone. Cases of VAD have been described with cervical manipulation in the past and an association between the use of anabolic steroids and embolic strokes has been described. To the authors knowledge, this is the first case describing a link between VAD, weight training and anabolic steroids.
Asunto(s)
Sustancias para Mejorar el Rendimiento/efectos adversos , Disección de la Arteria Vertebral/inducido químicamente , Levantamiento de Peso , Humanos , Masculino , Persona de Mediana EdadRESUMEN
A 37-year-old woman presented with cerebral venous and sinus thrombosis (CVST). During the period of anticoagulation she developed asymptomatic dissection of the intracranial segments of both vertebral arteries with an enlarging false aneurysm on the right side. Endovascular occlusion of the pathological segment of the right vertebral artery including the dissecting aneurysm and conservative management of the other side resulted in complete recovery without neurological complications.