RESUMEN
AbstractThe etiologic agent of yaws, Treponema pallidum subsp. pertenue, causes a multistage infection transmitted by nonsexual contact with the exudates from active lesions. Bone lesions in the form of osteoperiostitis are common and occur in numerous bones simultaneously in early stages. Although a multinational eradication campaign with mass administration of intramuscular benzathine benzylpenicillin in the 1950s greatly reduced its global incidence, a resurgence of yaws has occurred since around 2000 in western and central Africa and the Pacific Islands. The finding that a single oral dose of azithromycin (30 mg/kg) was as effective as benzathine benzylpenicillin prompted renewed interest by World Health Organization in 2012 toward eradication of this infection by 2020. We previously reported the excellent response to benzathine benzylpenicillin therapy for yaws osteoperiostitis. Herein, we document a confirmed case of yaws with osteoperiostitis successfully treated with single-dose azithromycin and discuss the pathology of yaws periostitis and comment on the implications of this in light of the new campaign toward yaws eradication.
Asunto(s)
Antibacterianos/uso terapéutico , Azitromicina/uso terapéutico , ADN Bacteriano/aislamiento & purificación , Periostitis/tratamiento farmacológico , Treponema pallidum/efectos de los fármacos , Buba/tratamiento farmacológico , Preescolar , Humanos , Pierna/diagnóstico por imagen , Pierna/microbiología , Pierna/patología , Masculino , Periostio/diagnóstico por imagen , Periostio/efectos de los fármacos , Periostio/microbiología , Periostio/patología , Periostitis/diagnóstico por imagen , Periostitis/microbiología , Periostitis/patología , Tomografía Computarizada por Rayos X , Resultado del Tratamiento , Treponema pallidum/genética , Treponema pallidum/aislamiento & purificación , Muñeca/diagnóstico por imagen , Muñeca/microbiología , Muñeca/patología , Buba/diagnóstico por imagen , Buba/microbiología , Buba/patologíaRESUMEN
Bone and joint localizations of treponematosis vary greatly although there are many common features. Osteal and periosteal lesions are common. We report radiographic descriptions of bone and joint treponematosis, which must not go unrecognized due to the increasing incidence of these diseases.
Asunto(s)
Enfermedades Óseas Infecciosas/diagnóstico por imagen , Sífilis Congénita/diagnóstico por imagen , Sífilis/diagnóstico por imagen , Buba/diagnóstico por imagen , Huesos/diagnóstico por imagen , Diagnóstico Diferencial , Humanos , RadiografíaRESUMEN
We describe the case of a 16-year old male patient from African presenting tertiary yaws at the distal tibia. Clinical signs, biochemical results and the different diagnostic imaging methods are demonstrated. Differential diagnosis and therapy are described.
Asunto(s)
Enfermedades Óseas/diagnóstico , Tibia/patología , Buba/diagnóstico , Adolescente , Enfermedades Óseas/diagnóstico por imagen , Humanos , Imagen por Resonancia Magnética , Masculino , Tibia/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Buba/diagnóstico por imagenRESUMEN
Two children suffering from early yaws in Indonesia are presented. Apart from skin lesions and a positive treponemal serology in both patients, involvement of tubular bones, particularly of the hands, was revealed by radiological examination. In one patient involvement of a distal phalanx was remarkable. Early diagnosis and treatment of yaws is important since a delay in treatment may result in severe and irreversible bone deformities of the late stage of the disease. This report illustrates that radiological changes, although rare, can still be detected in the early stage of yaws in areas where yaws is resurgent nowadays.
Asunto(s)
Huesos/diagnóstico por imagen , Piel/patología , Buba/diagnóstico por imagen , Adolescente , Niño , Femenino , Dedos/patología , Humanos , Indonesia , Masculino , Penicilina G Benzatina/uso terapéutico , Radiografía , Buba/tratamiento farmacológico , Buba/patologíaRESUMEN
A case of tertiary yaws in an immigrant from the Solomon Islands is presented. The report highlights the atypical features and diagnostic difficulties of late-stage treponemal infection.
Asunto(s)
Enfermedades Óseas/diagnóstico , Articulación de la Rodilla , Buba/diagnóstico , Adulto , Australia , Enfermedades Óseas/diagnóstico por imagen , Enfermedades Óseas/etiología , Enfermedades Óseas/terapia , Terapia Combinada , Diagnóstico Diferencial , Femenino , Estudios de Seguimiento , Humanos , Ilion/trasplante , Melanesia/etnología , Radiografía , Tibia/cirugía , Prueba de Inmovilización del Treponema , Buba/clasificación , Buba/complicaciones , Buba/diagnóstico por imagen , Buba/terapiaRESUMEN
Yaws is a treponematosis which is rare in Europe. Tertiary stages may present with tumor-like lesions predominantly in the face. These manifestations are called rhinopharyngitis mutilans and goundou. A 40-year-old woman with goundou is presented.
Asunto(s)
Seno Maxilar/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Buba/diagnóstico por imagen , Adulto , Diagnóstico Diferencial , Femenino , Humanos , Neoplasias del Seno Maxilar/diagnóstico por imagenRESUMEN
Yaws, a spirochetal infection that is endemic in certain tropical countries, including Malaysia, may present with various orthopedic problems. As the condition is relatively unknown, diagnosis is often missed, which leads to poor management. There are initial, early, and late phases of the disease process. By involving skin, bone, and joints, yaws can produce deep ulcerations, joint deformities, and bone destruction. Within a ten-year period in Malaysia, 14 cases of serologically proven yaws have been treated for chronic ulcers, gross joint deformities, and pathologic fractures.