[The effect of metronidazole on the radiosensitivity of cancer of the uterine cervix]. / Vliianie metronidazola na radiochuvstvitel'nost' raka sheiki matki.

A comparative study of the effect of rectal administration of metronidazole on radiosensitivity of cervical cancer with relation to tumor sizes and a Hb level was conducted. The effect of a direct tumor reaction on survival was investigated. Rectal administration of metronidazole proved to be effective in large tumor sizes and a low Hb level. The use of metronidazole resulted in an increase in the number of patients with complete tumor regression and an increase in their survival. A low Hb level is an independent prognostic factor in radiation therapy of cervical cancer leading to an increase in tumor radiosensitivity.

[Hemoglobin level--a prognostic factor of the effectiveness of metronidazole in radiotherapy of cancer of the cervix uteri]. / Gemoglobin krovi--prognosticheskii faktor éffektivnosti metronidazola pri luchevoi terapii raka sheiki matka.

A clinical trial was performed in 339 patients with Stages IIB, IIIB cervical carcinoma to test the effect of radiotherapy in combination with metronidazole. When the overall material was evaluated, no significant difference in the local clearance rate of tumors in metronidazole-treated and untreated patients was revealed. However, when the case material was subdivided into a group of anemic patients (hemoglobin less than 120 g/l) and a group of patients with normal hemoglobin levels (hemoglobin greater than 120 g/l) the data indicated that metronidazole therapy improved significantly the results in the anemic patients. The results in the non-anemic patients were not influenced, to any significant extent, by the drug.

[Dynamic fractionation of the radiation treatment of lung cancer with different rates of tumor growth]. / Dinamicheskoe fraktsionirovanie luchevogo lecheniia raka legkogo pri razlichnoi skorosti rosta opukholi.

The paper is concerned with the results of radiotherapy of inoperable lung cancer patients. The efficacy of dynamic and conventional fractionation regimens was evaluated in relation to the tumor growth rate and size. The tumor growth rate was shown to be of importance for a local radiation effect: the higher growth rate was, the more pronounced tumor lesion and resorption were. A close relationship between the regression intensity and patients' survival was shown.