Highly efficient iodine capture and ultrafast fluorescent detection of heavy metals using PANI/LDH@CNT nanocomposite.

Here, the hybrid material of polyaniline/layered double hydroxide@carbonnanotubes (PANI/LDH@CNT) is considered a multifunctional material. Instrumental methods, including FTIR, XRD, TEM, SEM, and TGA/DTA were utilized to characterize PANI/LDH@CNT. The polymerization method created PANI/LDH@CNT as an adsorbent to remove toxic iodine in hexane solution with a capture capacity of 303.20 mg g-1 during 9 h. It is 900 mg g-1 in the vapor phase within 24 h. After three cycles, the PANI/LDH@CNT could be regenerated while maintaining 91.90 % iodine adsorption efficiency. Due to the presence of free amine (-N) groups, OH-, CO2H, and π-π conjugated structures in the PANI/LDH@CNT, it is also explored for efficient iodine uptake. It was demonstrated that the pseudo-first-order (PFO) and Langmuir model had the optimum correlation with the kinetic and isotherm data, respectively. Moreover, the use of PANI/LDH@CNT is not only limited to iodine capture; it can also be utilized as a sensitive sensor that displays a fluorescence "turn-off" response for Mn7+ and Cr6+ ions and a fluorescence "turn-on" response in the case of Al3+ ions. The fluorescence intensity of the PANI/LDH@CNT was turned off in the presence of Mn7+ and Cr6+ because of the fluorescence inner filter effect (IFE) mechanism. In contrast, the fluorescence intensity was turned on in the case of Al3+, relying on the chelation-enhanced fluorescence (CHEF) effect mechanism. Under optimal conditions, the limit of detection (LOD) of 51, 59, and 81 nM for Mn7+, Cr6+, and Al3+, respectively. According to the literature, this is probably the first example based on PANI/LDH@CNT as a multifunctional hybrid material employed as an adsorbent for capturing radioactive iodine and as a chemosensor for detecting heavy metal ions in aqueous solutions.

Binding ability of roxatidine acetate and roxatidine acetate supported chitosan nanoparticles towards bovine serum albumin: characterization, spectroscopic and molecular docking studies.

The RxAc drug loaded on Tween80-chitosan-TPP nanoparticles (NRxAc) has been characterized and probed by UV-Vis, PXRD, FTIR, DLS and SEM technique. The physicochemical characteristics of NRxAc have been employed and evaluated for formulation of drug, particle size, external morphology, drug content and in vitro drug release. Multi-spectroscopic (i.e. fluorescence, UV-Vis, CD spectroscopy) and molecular docking techniques were also used to study the interaction of BSA with RxAc and NRxAc. RxAc and NRxAc quenched the fluorescence emission of BSA via a static quenching mechanism. The experimental data of Fluorescence demonstrated that the binding constant of RxAc and NRxAc were found around 104 L.mol-1, which suggests moderate binding affinity with BSA via hydrophobic forces. Through the site marker displacement experiments and molecular docking, the probable binding location of RxAc and NRxAc has been suggested in subdomain IB (site III) of BSA. Altogether, the results of present study can provide an important insight and a great deal of helpful information for future design of antiulcer drugs. Hence, The RxAc-loaded chitosan nanoparticles produced might be utilized as a successful tool for developing and using antiulcer drugs.Communicated by Ramaswamy H. Sarma.