ABSTRACT
No disponible
Subject(s)
Humans , Female , Uterine Cervical Neoplasms/pathology , Papanicolaou Test , Cytological Techniques , Professional Training , Mass Screening , Early Detection of Cancer/methodsABSTRACT
No disponible
Subject(s)
Humans , Female , Mass Screening/methods , Uterine Cervical Neoplasms/pathology , Papillomavirus Infections/pathology , Uterine Cervical Neoplasms/prevention & control , Early Detection of Cancer/methods , Specimen Handling/standards , Age FactorsABSTRACT
No disponible
Subject(s)
Early Detection of Cancer/methods , Uterine Cervical Neoplasms/diagnosis , Papillomavirus Infections/diagnosis , Mass Screening/methods , Mandatory Testing , Vaginal Smears/methods , Papanicolaou Test/methods , Age Factors , Papillomaviridae/pathogenicity , Cost-Benefit AnalysisABSTRACT
OBJECTIVE: To determine the clinical importance of repeating the Hybrid Capture 2 (HC2) high-risk human papillomavirus (HPV) test when the result obtained falls between 2.7 and 0.8 pg/mL, the so-called "grey zone." STUDY DESIGN: Repeat testing was performed on 139 thin-layer liquid-based cytology cervicovaginal samples that were found to fall in the grey zone. The samples represented a variety of cytological diagnoses. The results of both HPV HC2 tests were analyzed related to the cytological diagnosis of both the previous and the follow-up cytological samples. RESULTS: The change of the HPV HC2 result from positive (2.7-1 pg/mL) to negative (< 1 pg/mL) when repeating the test is not related with the diagnosis obtained in the cytological follow-up of the patient. CONCLUSION: The HC2 test should not be repeated when the result falls between 2.7 and 0.8 pg/mL. In these cases the result of the cytology is more relevant and should be used in the clinical assessment of the patient.
Subject(s)
Cytodiagnosis , Papillomaviridae/isolation & purification , Uterine Cervical Dysplasia/diagnosis , Uterine Cervical Dysplasia/virology , Adult , Animals , DNA, Viral/isolation & purification , Female , Humans , Middle Aged , Papillomaviridae/genetics , Pregnancy , Risk Factors , Vaginal Smears , Uterine Cervical Dysplasia/genetics , Uterine Cervical Dysplasia/pathologyABSTRACT
La automatización de la citología ginecológica es ya un hecho en progresivo aumento en los servicios de anatomía patológica. Entre otros cambios, permite focalizar la atención del citotécnico y del citopatólogo en algunos datos de la extensión a analizar lo que permite mejorar la interpretación y por tanto, el diagnóstico. Hemos realizado un estudio comparativo de un total de 53.311 muestras correspondientes a otras tantas mujeres de distintos distritos de Barcelona, comparando el rendimiento de la citología convencional, de la citología liquida (ThinPrep Pap Test®, TPPT, Hologic, Malborough, Massachussets) con lectura manual y de la citología liquida (ThinPrep Pap Test®) con lectura automatizada (Imager®, Hologic, Malborough Massachussets), en 2 aspectos, uno el rendimiento global comparativo y 2 el rendimiento en relación al seguimiento de las pacientes. Concluimos que la lectura automatizada aumenta en nuestra serie el diagnóstico de ASCUS y LSIL, manteniendo en términos comparativos el diagnóstico de HSIL. Sin embargo, en el seguimiento de las pacientes observamos que se detectan más casos de HSIL en diagnósticos previos de ASCUS y LSIL con lectura automatizada y que los casos diagnosticados de HSIL muestran una correlación con la biopsia significativamente superior. Concluimos que la lectura automatizada de citología ginecológica incrementa la sensibilidad para diagnóstico de ASCUS y LSIL e incrementa la especificidad para el diagnóstico de HSIL(AU)
The use of automated technologies in gynaecological cytology is increasing in many departments of pathology. Amongst other things, it allows the cytotechnician and the cytologist to focus on specific areas of the slide which enhances identification and therefore improves diagnosis. We have carried out a comparative study of 53.311 samples taken from the same number of women resident in Barcelona. We compared the efficiency of conventional cytology, liquid cytology (ThinPrep Pap Test®, TPPT, Hologic, Malborough, Massachussets) with manual reading and liquid cytology (ThinPrep Pap Test) with automated reading (Imager®, Hologic, Malborough Massachussets). Two aspects were evaluated: comparative global performance and performance in relation to patient follow-up. We found that automated readings increased the diagnosis of ASCUS and LSIL whilst the frequency of HSIL diagnosis remained similar. However, in patient follow-ups, we observed that more cases of HSIL were detected in women with previous diagnoses of ASCUS and LSIL when automated reading was used and that there was a significantly greater correlation between the cytological diagnosis and the findings on biopsy. We concluded that there is greater sensitivity for the diagnosis of ASCUS and LSIL as well as an increased specificity for the diagnosis of HSIL when automated readings of gynaecological cytology are used(AU)
Subject(s)
Humans , Female , Cytological Techniques/trends , Cytological Techniques , /methods , Quality Control , Cytological Techniques/instrumentation , Cytological Techniques/methodsABSTRACT
Aportamos un caso de mesotelioma maligno en unamujer de 37 años con antecedentes de laparoscopia por leiomiomasuterinos. El diagnostico de mesotelioma se estableciópor autopsia. El estudio inmunohistoquímico del tumormesotelial, reveló intensa positividad para CD10, y ausenciade inmunoreactividad para receptores de estrógenos y deprogesterona y calretinina. En nuestra serie de mesoteliomasobservamos que alrededor del 30% de ellos expresabanCD10. En la revisión de la Literatura se observó que aproximadamenteel 40% de los mesoteliomas, mostraban inmunoreactividadpara CD10. En conslusión nuestras observacionesmuestran que CD10 puede expresarse de formaextensa en los mesoteliomas, dato que puede ayudar al establecerun diagnóstico diferencial en estos casos
We report a case of malignant mesothelioma in a 37year-old woman treated for uterine leiomyomas. The diagnosisof mesothelioma was stablished based on autopsystudy. The immunohistochemical study of mesothelialtumor showed strong CD10 immunoreactivity. Our series ofmesotheliomas was also retrospectively studied with anti-CD10 and around 30% of them expressed CD10. Around40% of mestohelioma cases reported in the Literatureexpress CD10. We conclude that CD10 could be expressedin some mesothelial tumors, and may help to stablish a differentialdiagnosis in some cases