ABSTRACT
Background: Neonatal early onset sepsis (NEOS) is a serious and potentially life-threatening condition affecting newborns within the first few days of life. While the diagnosis of NEOS was based on clinical signs and symptoms in the past, recent years have seen growing interest in identifying specific diagnostic factors and optimizing therapy outcomes. This study aims to investigate the diagnostic and risk factors and therapy outcomes of neonatal EOS in ICU patients in Saudi Arabia, with the goal of improving the management of neonatal EOS in the country. Methods: This method outlines the protocol development, search strategy, study selection, and data collection process for a systematic review on neonatal early onset sepsis in Saudi Arabian ICU patients, following the PRISMA 2020 guidelines. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) is a well-established guideline that provides a framework for conducting systematic reviews and meta-analyses in a transparent and standardized manner. It aims to improve the quality and reporting of such research by ensuring clear and comprehensive reporting of study methods, results, and interpretations. The search strategy included electronic databases (PubMed, Embase, Google Scholar, Science Direct, and the Cochrane Library) and manual search of relevant studies, and data were extracted using a standardized form. Results: The systematic review included 21 studies on neonatal sepsis in Saudi Arabia, with varying study designs, sample sizes, and prevalence rates of sepsis. Group B streptococcus and E. coli were the most commonly isolated pathogens. Various diagnostic factors and risk factors were reported, including hematological parameters, biomarkers, and blood cultures. The quality of the included studies was assessed using the Newcastle-Ottawa Scale and Joanna Briggs Institute critical checklist. Conclusions: The review identified a number of risk and diagnostic factors and therapy outcomes for neonatal sepsis. However, most of the studies were having small scale cohort groups. Further research with controlled study designs is needed to develop effective prevention and management strategies for neonatal sepsis in Saudi Arabia.
ABSTRACT
BACKGROUND: The knowledge that teachers have about epilepsy affects their attitudes and practices towards students with the disorder. This study aimed to explore teachers' knowledge, attitudes, and practices (KAP) toward epilepsy in the Aseer region. METHODS: This online cross-sectional survey targeted teachers aged 18 years and above, encompassing both males and females residing in the Aseer region with internet access. Teachers included in this study were recruited using snowball and convenience non-random sampling methods. Descriptive statistics and Pearson's chi-square test in Statistical Package for the Social Sciences (SPSS) version 27 were employed, with a significance level of 0.05 (IBM Corp., Armonk, NY). RESULTS: A total of 62 teachers were included in this study: 62.90% were aged 35-49, 93.55% were females, 90.32% were married, 80.65% worked in the governmental sector, 51.61% earned between 5,000 and 10,000 SAR, and 93.55% held a university education. Regarding knowledge, 36.6% of the teachers studied had very bad knowledge, 29% had poor knowledge, 35.5% had intermediate knowledge, and 4.8% had good knowledge. While 1.9% had a detrimental attitude about epilepsy, 58.1% had an incorrect attitude, 30.6% had an approximate attitude, and 1.6% had a correct attitude. Concerning teacher practice, 4.8% of the studied sample had detrimental practice, 56.5% had inadequate practice, and 4.8% had average practice. CONCLUSIONS: The study highlights the need for targeted educational interventions to improve teachers' knowledge about epilepsy. The positive attitudes observed provide a foundation for fostering inclusivity in educational settings. Strategies that address misconceptions and improve first aid preparedness can contribute to a more supportive environment for students with epilepsy.
