Multifocal giant cell tumor of the tendon sheath occuring at different localizations of the same tendon of a finger: a case report and review of the literature.

The giant cell tumor of the tendon sheath is regarded as one of the most common neoplasms of the hand. This tumor usually manifests itself as a localized, solitary, painless and palpable subcutaneous nodule on the palmar aspect of a digit. A multifocal origin of the tumor has rarely been reported in the literature before. In this article we present a case of a giant cell tumor of the tendon sheath, in which two separate lesions developed simultaneously on the same tendon (flexor digitorum superficialis) of the little finger of the right hand together with a literature review about multifocal cases.

Phototherapy in childhood.

BACKGROUND: Little data exist about the efficacy of phototherapy in childhood dermatoses. OBJECTIVE: To report our experience with pediatric patients treated with phototherapy. METHODS: The study included children

Basal cell carcinoma arising in nevus sebaceous during childhood.

Nevus sebaceous usually occurs as a solitary lesion located mostly on the scalp and the face. The potential for nevus sebaceous to develop malignancy is well recognized, though it is generally thought that this transformation occurs only postpubertally or later. However, few cases of basal cell carcinoma arising in nevus sebaceous before puberty were reported. Herein, we report a case of basal cell carcinoma arising in a nevus sebaceous on the scalp of a 10-year-old boy, and a review of the literature on prepubertal cases and the need for prophylactic surgery.

Multiple endocrine neoplasia type 2b associated with lichen nitidus.

Multiple endocrine neoplasia (MEN) type 2B syndrome is an autosomal dominantly inherited endocrine disorder with rare skin manifestations. We report the case of a 19-year-old Turkish girl who presented with skin-colored flat papules scattered all over the trunk and extremities. Additionally, she had marfanoid habitus, thick lips, and multiple flesh-colored papules over the inner eyelids and oral mucosa. Histopathological examination of one of the trunk lesions was consistent with lichen nitidus. Her past medical history was significant for medullary thyroid carcinoma. Genetic testing showed a point mutation in exon 16 at codon 918 (M918T) in the RET proto-oncogene. Based on all these findings, MEN type 2B was diagnosed. To the best of our knowledge we report the first case of MEN type 2B associated with lichen nitidus.

Interstitial granulomatous dermatitis with arthritis.

Interstitial granulomatous dermatitis with arthritis is an uncommon disorder. In its original description, the presence of linear inflammatory indurations on the lateral aspects of the trunk (the rope sign) in association with arthritis were considered the pathognomonic clinical features. Later cases presenting with plaques and papules have been reported. Herein we describe a case of interstitial granulomatous dermatitis with arthritis without the rope sign. The present case supports the idea that interstitial granulomatous dermatitis with arthritis may have variable clinical appearances.

Reversible sclerotic changes of lumbar spine and femur due to long-term oral isotretinoin therapy.

We present a rare case of retinoid-induced sclerotic changes of lumbar spine and femur demonstrated by dual energy x-ray absorptiometrie (DEXA). The patient had flowing ossification along thoracic spine resembling diffuse idiopathic skeletal hyperostosis (DISH), but there was no ligament calcification in the lumbar spine or pelvis. After discontinuation of the treatment, gradual decline of bone mineral density at lumbar and femoral sites was detected with serial DEXA measurements. To the best of our knowledge, although various abnormalities of bone due to retinoids have been described before, reversible sclerotic changes have not been reported.