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1.
Arch Endocrinol Metab ; 66(2): 229-236, 2022 Apr 28.
Article in English | MEDLINE | ID: mdl-35420265

ABSTRACT

Objective: Evaluate the celiac disease (CD) markers, within the scope of its screening, in a pediatric population with diagnosis of type 1 diabetes (T1D) at Hospital de Braga (HB) and determine the prevalence of CD in the sample. Reflect on CD screening algorithm applied in this pediatric population. Methods: Retrospective observational study with 94 patients diagnosed with T1D at age 10 years or younger, followed up at the HB Outpatient Diabetology Consultation, including those referred from other hospitals. Record of clinical information, IgA anti-transglutaminase and anti-endomysium and HLA DQ2/DQ8 haplotypes. Results: We obtained positive serological test for CD in 4 patients. This test had 100% sensitivity and specificity. The prevalence of CD was 4.3% (n = 4). Positive HLA screening in 84.6% of patients, with both sensitivity and negative predictive value of 100% and specificity of 16.67%. Diagnosis of CD was made on average 3.40 ± 3.32 years after the diagnosis of TD1. All cases of CD registered non-gastrointestinal manifestations, none had gastrointestinal symptoms. Conclusion: This study proved that there is a higher prevalence of CD in pediatric population with TD1, when compared to general population, and clarified the importance of CD screening. Furthermore, it was observed that serological screening for CD antibodies is an excellent screening test and HLA typing, although not the most suitable first line test, can be useful in excluding the possibility of patients with T1D developing CD.


Subject(s)
Autoantibodies , Celiac Disease , Diabetes Mellitus, Type 1 , HLA-DQ Antigens , Celiac Disease/diagnosis , Celiac Disease/genetics , Child , Diabetes Mellitus, Type 1/diagnosis , Diabetes Mellitus, Type 1/genetics , Genetic Predisposition to Disease , HLA-DQ Antigens/genetics , Haplotypes , Humans , Retrospective Studies , Transglutaminases/immunology
2.
Arch. endocrinol. metab. (Online) ; 66(2): 229-236, Apr. 2022. tab
Article in English | LILACS-Express | LILACS | ID: biblio-1374276

ABSTRACT

ABSTRACT Objectives: Evaluate the celiac disease (CD) markers, within the scope of its screening, in a pediatric population with diagnosis of type 1 diabetes (T1D) at Hospital de Braga (HB) and determine the prevalence of CD in the sample. Reflect on CD screening algorithm applied in this pediatric population. Subjects and methods: Retrospective observational study with 94 patients diagnosed with T1D at age 10 years or younger, followed up at the HB Outpatient Diabetology Consultation, including those referred from other hospitals. Record of clinical information, IgA anti-transglutaminase and anti-endomysium and HLA DQ2/DQ8 haplotypes. Results: We obtained positive serological test for CD in 4 patients. This test had 100% sensitivity and specificity. The prevalence of CD was 4.3% (n = 4). Positive HLA screening in 84.6% of patients, with both sensitivity and negative predictive value of 100% and specificity of 16.67%. Diagnosis of CD was made on average 3.40 ± 3.32 years after the diagnosis of TD1. All cases of CD registered non-gastrointestinal manifestations, none had gastrointestinal symptoms. Conclusion: This study proved that there is a higher prevalence of CD in pediatric population with TD1, when compared to general population, and clarified the importance of CD screening. Furthermore, it was observed that serological screening for CD antibodies is an excellent screening test and HLA typing, although not the most suitable first line test, can be useful in excluding the possibility of patients with T1D developing CD.

3.
Rev. bras. crescimento desenvolv. hum ; 22(2): 179-186, 2012. tab
Article in English | LILACS | ID: lil-647551

ABSTRACT

A obesidade acarreta consequências para além das meramente relacionadas com a saúde física, sendo também de salientar os aspetos psicossociais. Com o objetivo de avaliar as diferenças ao nível da qualidade de vida, morbilidade psicológica e imagem pessoal (autoconceito) foram avaliadas 267 crianças divididas em três grupos: um grupo de crianças da comunidade com peso normal (N = 147), um grupo de crianças da comunidade com excesso de peso/obesidade (N = 89) e um grupo de crianças com excesso de peso/obesidade em tratamento (grupo clínico) (N = 31). Os resultados mostraram que as crianças com excesso de peso/obesidade em tratamento são as que têm uma percepção mais negativa da sua saúde física e da saúde escolar, quando comparadas com as restantes crianças. Relativamente ao auto-conceito o grupo de crianças com excesso de peso/obesidade do grupo clínico perceciona-se como menos competente no domínio escolar, atlético, aparência física, aceitação social, comportamento e auto-estima. As crianças do grupo clínico com excesso de peso/obesidade apresentam ainda mais sintomatologia depressiva quando comparadas com as crianças da comunidade com peso normal e com as crianças do grupo clínico. Não foram encontradas diferenças significativas ao nível da sintomatologia ansiosa nas três amostras estudadas. Em suma, as diferenças entre os grupos avaliados podem refletir diferentes características das crianças com excesso de peso/obesidade que procuram tratamento.


Subject(s)
Humans , Male , Female , Child , Body Image , Child , Cost of Illness , Obesity , Prejudice , Quality of Life , Self Concept , Social Desirability
4.
Rev. bras. crescimento desenvolv. hum ; 22(2): 179-186, 2012. tab
Article in English | Index Psychology - journals | ID: psi-55050

ABSTRACT

Obesity is a complex disease with not only physical consequences but also psychological. The aim of the present work was to analyze differences between community children with normal weight versus community overweight children versus children with overweight in clinical setting, at the level of quality of life, psychological morbidity and self-concept . The study sample has 267 children represented in three groups: group of community children with normal weight (N = 147), group of community overweight children (N = 89) and a group of overweight children in treatment (N = 31). The results from this study showed differences on quality of life, for the total scale and on the dimension of physical health and school health, in which overweight children in the clinical sample are the ones who presented more negative perception of physical health and school health, when compared with community children with normal weight vs community overweight children. For the rest of the dimensions of quality of life, no significant differences were found between the three groups. Regarding the self-concept on the group of children with a clinical diagnosis of obesity they perceived themselves as less competent relative to school competency, athletic competency, physical appearance, social acceptance, behavior and self-esteem. Regarding the variable depression this study suggests that community overweight children present more depressive symptomatology when compared with the other groups. No significant differences were found regarding anxiety symptomatology. To summarize, results from this empirical study demonstrated the importance of psychological variables when in the presence of obesity.(AU)


A obesidade acarreta consequências para além das meramente relacionadas com a saúde física, sendo também de salientar os aspetos psicossociais. Com o objetivo de avaliar as diferenças ao nível da qualidade de vida, morbilidade psicológica e imagem pessoal (autoconceito) foram avaliadas 267 crianças divididas em três grupos: um grupo de crianças da comunidade com peso normal (N = 147), um grupo de crianças da comunidade com excesso de peso/obesidade (N = 89) e um grupo de crianças com excesso de peso/obesidade em tratamento (grupo clínico) (N = 31). Os resultados mostraram que as crianças com excesso de peso/obesidade em tratamento são as que têm uma percepção mais negativa da sua saúde física e da saúde escolar, quando comparadas com as restantes crianças. Relativamente ao auto-conceito o grupo de crianças com excesso de peso/obesidade do grupo clínico perceciona-se como menos competente no domínio escolar, atlético, aparência física, aceitação social, comportamento e auto-estima. As crianças do grupo clínico com excesso de peso/obesidade apresentam ainda mais sintomatologia depressiva quando comparadas com as crianças da comunidade com peso normal e com as crianças do grupo clínico. Não foram encontradas diferenças significativas ao nível da sintomatologia ansiosa nas três amostras estudadas. Em suma, as diferenças entre os grupos avaliados podem refletir diferentes características das crianças com excesso de peso/obesidade que procuram tratamento.(AU)


Subject(s)
Obesity/psychology , Psychosocial Impact , Feeding and Eating Disorders of Childhood/psychology
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