Subject(s)
Brain Neoplasms/therapy , Neoplasms, Germ Cell and Embryonal/therapy , Pineal Gland , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Brain Neoplasms/blood , Brain Neoplasms/complications , Child , Humans , Male , Neoplasms, Germ Cell and Embryonal/blood , Neoplasms, Germ Cell and Embryonal/complications , Radiotherapy DosageABSTRACT
The pathogenesis of bronchopulmonary dysplasia is controversial. Oxygen toxicity, mechanical trauma to the lung secondary to respirator therapy, and congestive heart failure with a left to right shunt through a patent ductus arteriosus have all been implicated. Our data suggest that in addition to these three conditions, all of which are edemagenic, infants with bronchopulmonary dysplasia have a significantly greater mean fluid intake in the first five days of life when compared with infants with respiratory distress syndrome or patent ductus arteriosus alone. We suggest that the addition of a fluid load may potentiate the effects of other factors and increase the risk of bronchopulmonary dysplasia in infants with respiratory distress syndrome who require respiratory support.
Subject(s)
Bronchial Diseases/complications , Lung Diseases/complications , Pulmonary Edema/etiology , Respiratory Distress Syndrome, Newborn/complications , Bronchial Diseases/etiology , Ductus Arteriosus, Patent/complications , Heart Failure/complications , Humans , Infant, Newborn , Lung Diseases/etiology , Oxygen Inhalation Therapy/adverse effects , Respiratory Distress Syndrome, Newborn/therapy , Respiratory Therapy , Water-Electrolyte BalanceSubject(s)
Intermittent Positive-Pressure Breathing , Positive-Pressure Respiration , Adult , Aerosols , Bronchodilator Agents/administration & dosage , Child , Humans , Intermittent Positive-Pressure Breathing/adverse effects , Positive-Pressure Respiration/adverse effects , Pulmonary Atelectasis/therapy , Respiratory Function TestsABSTRACT
In monolayer cel cultures from late gestation (28-day) rabbit fetal lungs, cortisol (5.5 X 10(-6)M) enhances lecithin synthesis and reduced cellular growth. The addition of insulin (25-100 muU/ml) abolishes the stimulatory effect of cortisol on lecithin synthesis but does not affect its growth-inhibiting activity.