ABSTRACT
This is the second article in a two-part series published in this journal, in which we examine the histopathological characteristics, as well as the differential diagnosis, of the main entities that present as cystic and pseudocystic structures in cutaneous biopsy. In this second article, we address ciliated cutaneous cysts, branchial cysts, Bartholin's cysts, omphalomesenteric cysts, thymic cysts, thyroglossal duct cysts, synovial cysts, and median raphe cysts, as well as mucocele, ganglion, and auricular and digital myxoid pseudocysts.
Subject(s)
Bartholin's Glands , Cysts , Female , Humans , Cysts/pathology , Diagnosis, Differential , Bartholin's Glands/pathologyABSTRACT
Cystic structures represent one of the most common findings in dermatopathology. These encompass both cystic tumors and pseudocysts resulting from the accumulation of certain substances, such as mucin. In a two-part series (of which this is the first part), we have reviewed the principal types of cysts and pseudocysts that may be observed in cutaneous biopsies, examining their histopathological features and primary differential diagnoses. This first part encompasses infundibular cysts, eruptive dermoid cysts, pigmented follicular cysts, pilonidal cysts, tricholemmal cysts, milium cysts, hybrid cysts, bronchogenic cysts, as well as steatocystoma, hydrocystoma, and comedones.
Subject(s)
Bronchogenic Cyst , Epidermal Cyst , Humans , Biopsy , Diagnosis, DifferentialABSTRACT
Nilotinib is a new multitargeted tyrosine kinase inhibitor, which is used to treat chronic myelogenous leukemia when intolerance or recurrence to imatinib occurs. We report the case of a 14-year-old patient being treated with nilotinib who developed a keratosis pilaris-like eruption. This cutaneous adverse effect is a rare but increasingly reported side effect of this therapy.
Subject(s)
Abnormalities, Multiple , Darier Disease , Eyebrows/abnormalities , Adolescent , Antineoplastic Agents , Fusion Proteins, bcr-abl , Humans , Protein Kinase Inhibitors/adverse effects , Pyrimidines/adverse effectsABSTRACT
High-frequency ultrasonography (HFUS) can help improve dermatofibrosarcoma protuberans (DFSP) recognition. We present three cases of DFSP in which a "jellyfish-like" sonographic pattern was a useful adjunct in formulating the diagnosis. In addition, we review all DFSP ultrasound images available in the literature.
Subject(s)
Dermatofibrosarcoma/diagnostic imaging , Skin Neoplasms/diagnostic imaging , Child , Dermatofibrosarcoma/pathology , Female , Humans , Male , Middle Aged , Skin Neoplasms/pathology , UltrasonographySubject(s)
Laser Therapy/methods , Skin Diseases, Genetic/pathology , Skin Diseases, Genetic/therapy , Adult , Biopsy, Needle , Cicatrix/diagnosis , Cicatrix/therapy , Diagnosis, Differential , Facial Dermatoses/diagnosis , Facial Dermatoses/therapy , Humans , Immunohistochemistry , Male , Rare Diseases , Skin Diseases, Genetic/diagnosis , Treatment OutcomeABSTRACT
High-frequency ultrasonography is a bedside tool increasingly used for the assessment of skin lesions, but there have been few reports about its importance in children with skin signs of hematologic disease. We present three cases to highlight the usefulness of high-frequency ultrasonography in assisting with the diagnosis of these skin lesions.
Subject(s)
Hematologic Neoplasms/pathology , Skin Neoplasms/diagnostic imaging , Ultrasonography/methods , Child , Female , Humans , Infant , Male , Skin/diagnostic imaging , Skin/pathology , Skin Neoplasms/pathologyABSTRACT
Follicular mucinosis can develop as a primary form or associated with other benign or malignant skin conditions. We present a case of primary follicular mucinosis in which complete clinical remission was achieved after treatment with topical imiquimod 5%. Primary follicular mucinosis (PFM), also called idiopathic alopecia mucinosa, is considered a distinct entity, the clinical course of which is usually benign, but its pathogenesis remains unclear. There is no standard treatment for PFM, and a wide variety of therapies have been described. There are no previous reports of treatment of PFM with imiquimod.
Subject(s)
Adjuvants, Immunologic/administration & dosage , Aminoquinolines/administration & dosage , Mucinosis, Follicular/drug therapy , Mucinosis, Follicular/pathology , Administration, Topical , Biopsy , Child , Humans , Imiquimod , Male , Treatment OutcomeABSTRACT
Acral erythema is a frequent cutaneous reaction related to chemotherapy. A patient presented herein developed acral erythema related to cytosine arabinoside treatment and then graft versus host disease (GVHD). Subsequently, worsening of palmar erythema and pain occurred with intravenous cyclosporin infusions.
Subject(s)
Cyclosporine/adverse effects , Cytarabine/therapeutic use , Erythema/chemically induced , Graft vs Host Disease/drug therapy , Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy , Adult , Antineoplastic Agents/therapeutic use , Drug Eruptions/etiology , Erythema/therapy , Humans , Infusions, Intravenous , Male , Methotrexate/therapeutic useABSTRACT
Circumscribed acral hypokeratosis (CAH) is a rare dermatosis that typically appears as well-dermarcated erythema with a scaly border on the palms or soles of middle-age patients. A pediatric case of CAH has been recently reported in a 10-year-old boy affecting the medial foot since birth. In this report we describe the second congenital case of CAH on the sole.
Subject(s)
Epidermis/pathology , Foot Dermatoses , Keratosis/diagnosis , Keratosis/pathology , Biopsy , Child, Preschool , Diagnosis, Differential , Foot Dermatoses/congenital , Foot Dermatoses/diagnosis , Foot Dermatoses/pathology , Humans , MaleABSTRACT
Severe combined immunodeficiency includes a group of diseases characterized by different inherited immunological defects. A 4-month-old girl diagnosed with Omenn syndrome, a subtype of severe combined immunodeficiency presenting with generalized erythroderma, was referred to our hospital for an allogeneic stem cell transplantation. Days before transplantation, she developed hyperpigmented macules that increased in number in the following months. As the erythroderma resolved after transplantation, diffuse hypopigmentation was simultaneously noted together with the expansion of hyperpigmented lesions. Cutaneous biopsy samples were taken at different moments, showing features of Omenn syndrome at first, and 2 months later changes consistent with hypopigmentation and repigmentation were observed. Although pigmentary disorders are rarely described in this context, these must be taken into account as a possible alternative diagnosis to graft-versus-host disease and toxicoderma in immunosuppressed patients.
Subject(s)
Pigmentation Disorders/complications , Pigmentation Disorders/pathology , Severe Combined Immunodeficiency/complications , Severe Combined Immunodeficiency/pathology , Female , Humans , Infant , Skin PigmentationABSTRACT
La cirugía oncológica dermatológica en la cara requiere unos conocimientos anatómicos y funcionales amplios y precisos. En la cara se encuentran estructuras con una función perfectamente delimitada, además de un componente estético muy importante. El colgajo de avance con triángulo de descarga o de Burow soluciona defectos de tamaños variables mediante una técnica sencilla con la que se obtienen resultados muy buenos. Las localizaciones ideales para el uso de este colgajo son el labio superior, la región preauricular y la región ciliar lateral. El uso del triángulo de descarga permite cerrar el defecto fácilmente sin tensión y evita la formación de orejas de perro. (AU)
Subject(s)
Aged , Female , Male , Middle Aged , Humans , Surgical Flaps/instrumentation , Surgical Flaps/methods , Surgical Flaps , Surgery, Plastic/methods , Skin Neoplasms/surgery , Skin/surgery , Surgical Procedures, Operative/methods , Surgery, Plastic/standards , Surgery, Plastic/trendsABSTRACT
La meningococemia crónica es una forma poco frecuente de infección meningocócica. Se ha descrito una mayor incidencia en pacientes con déficit del complemento. Presentamos un caso en un varón de 34 años, previamente sano y sin alteraciones del sistema inmune. El cuadro se complicó con una meningitis aguda (AU)
