1.
J Org Chem
; 76(20): 8262-9, 2011 Oct 21.
Article
in English
| MEDLINE
| ID: mdl-21899258
ABSTRACT
A POCl(3)-mediated, direct amination reaction of heterocyclic amides/ureas with NH-heterocycles or N-substituted anilines is described. Compared to the existing methods, this operationally simple protocol provides unique reactivity and functional group compatibility because of the metal-free, acidic reaction conditions. The yields are generally excellent.