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Bioorg Med Chem Lett
; 19(16): 4733-9, 2009 Aug 15.
Article
in English
| MEDLINE
| ID: mdl-19586769
ABSTRACT
Two series of conformationally constrained analogs of the FXR agonist GW 4064 1 were prepared. Replacement of the metabolically labile stilbene with either benzothiophene or naphthalene rings led to the identification of potent full agonists 2a and 2g.