ABSTRACT
Rheumatoid arthritis is a chronic, systemic autoimmune disease predominantly based on joint lesions with an extremely high disability and deformity rate. Several drugs have been used for the treatment of rheumatoid arthritis, but their use is limited by suboptimal bioavailability, serious adverse effects, and nonnegligible first-pass effects. In contrast, transdermal drug delivery systems (TDDSs) can avoid these drawbacks and improve patient compliance, making them a promising option for the treatment of rheumatoid arthritis (RA). Of course, TDDSs also face unique challenges, as the physiological barrier of the skin makes drug delivery somewhat limited. To overcome this barrier and maximize drug delivery efficiency, TDDSs have evolved in terms of the principle of transdermal facilitation and transdermal facilitation technology, and different generations of TDDSs have been derived, which have significantly improved transdermal efficiency and even achieved individualized controlled drug delivery. In this review, we summarize the different generations of transdermal drug delivery systems, the corresponding transdermal strategies, and their applications in the treatment of RA.
ABSTRACT
Based on the pressure-state-response (PSR) model and entropy method, we analyzed the health status of land ecosystem and the temporal and spatial variations from 2009 to 2017 in ten cities and one district in Shaanxi Province. The driving factors affecting the health of the land ecosystem was examined. Results showed that during 2009-2017, the overall health of the land ecosystem in Shaanxi Province was improved, which was lower during 2009-2014 and being obviously improved after 2014. The health level of land ecosystems in Xi'an, Baoji, Weinan and Hanzhong was high and with substantial variation, while that in Yan'an, Yulin, and Ankang was low and stable, decreasing in order of South Shaanxi, Guanzhong region and North Shaanxi. Overall, the pressure, state and response indices of the land ecosystem in Shaanxi Province increased during 2014-2017 with a gentle growth, which were basically flat after 2014. Those results indicated that the land ecosystem in Shaanxi Province was at a stable and healthy state. Population growth, urbanization level, fertilizer load per unit of arable land, forest coverage rate, industrial wastewater discharge compliance rate and comprehensive utilization rate of industrial solid waste were the main driving factors for the health of land ecosystems in Shaanxi. Controlling the use of fertilizers and pesticides, optimizing the structure of land use and improving land use efficiency are necessary strategies to promote the construction of ecological civilization and implement the red line of ecological protection for Shaanxi Province.