ABSTRACT
Two 1D coordination polymers (CPs) with general formula [M(L)(H2O)(AcO)]n, (M = Co (1) or Cd (2), AcO = acetate anion and L denotes l-phenylalanine based ligand), were synthesized and fully characterized by various spectroscopies (UV-vis, FTIR, and NMR), thermal techniques, magnetic measurements (for 1), and single-crystal and powder X-ray diffraction studies. They can be described as "ribbon-like" 1D polymers constructed through a zigzag arrangement. The polymeric structure is developed due to the coordination mode adopted by the amino acid ligand, classified as µ3-N1O1:O1:O2, which simultaneously links three metal centers. This moiety also plays an important role as a magnetic coupler between metal centers in the cobalt system, which shows a weak antiferromagnetic interaction. Both CPs have also been used in the catalytic oxidation of cyclohexene with molecular oxygen (O2) as an oxidant. Under mild conditions, both compounds demonstrated remarkable catalytic activity, with the cobalt system being more efficient than the cadmium analogue (conversion: 73 and 58% and selectivity for the major product, 2-cyclohexanone: 63 and 55%, for 1 and 2, respectively). Leaching experiments and the results obtained using a radical quencher are consistent with a radical-mediated mechanism for the Co compound. The presence of the superoxide radical was also confirmed using EPR spectroscopy and DMPO as a spin trap, which was further validated by DFT calculations. The activity observed for the Cd analogue is attributed to the organic scaffold assisted by the templating effect of the metal ion.
ABSTRACT
Fibromyalgia is a widespread chronic condition characterized by pain and fatigue. Among the long list of physiological disturbances linked to this syndrome, mitochondrial imbalance and oxidative stress stand out. Recently, the crosstalk between mitochondria and intestinal microbiota has caught the attention of biomedical researchers, who have found connections between this axis and several inflammatory and pain-related conditions. Hence, this pilot descriptive study focused on characterizing the mitochondrial mass/mitophagy ratio and total antioxidant capacity in PBMCs, as well as some microbiota components in feces, from a Peruvian cohort of 19 females and 7 males with FM. Through Western blotting, electrochemical oxidation, ELISA, and real-time qPCR, we determined VDAC1 and MALPLC3B protein levels; total antioxidant capacity; secretory immunoglobulin A (sIgA) levels; and Firmicutes/Bacteroidetes, Bacteroides/Prevotella, and Roseburia/Eubacterium ratios; as well as Ruminococcus spp., Pseudomonas spp., and Akkermansia muciniphila levels, respectively. We found statistically significant differences in Ruminococcus spp. and Pseudomonas spp. levels between females and males, as well as a marked polarization in mitochondrial mass in both groups. Taken together, our results point to a mitochondrial imbalance in FM patients, as well as a sex-dependent difference in intestinal microbiota composition.
ABSTRACT
La endomiocardiofibrosis es una miocardiopatía restrictiva causada por formación de tejido fibroso en el subendocardio. Es una enfermedad de etiología desconocida, que puede afectar uno o ambos ventrículos, comprometer músculos papilares y causar insuficiencia valvular auriculoventricular del ventrículo correspondiente. Es endémica de los países tropicales de África y puede hallarse en Europa y en países de clima templado como Brasil, Colombia e India. El diagnóstico se hace mediante hallazgos clínicos, ecocardiográficos y angiográficos típicos. El tratamiento, después de la aparición de los síntomas, es eminentemente quirúrgico. Se describe un caso de endomiocardiofibrosis biventricular en una paciente desnutrida y en fase avanzada de la enfermedad.
Endomyocardial fibrosis is a restrictive cardiomyopathy caused by the deposit of fibrotic tissue in the subendocardium. The etiology remains unknown. It can affect one or both ventricles, alter the papillary muscles and produce insufficiency of the auriculoventricular valve of the corresponding ventricle. It is endemic in the tropical countries of Africa, but can also be found in Europe and countries with mild temperatures such as Brazil, Colombia and India. Diagnosis is made by typical clinical, echocardiographic and angiographic findings. Once symptoms are established, the treatment is eminently surgical. This article describes a case of biventricular endomyocardial fibrosis in a malnourished patient with an advanced stage of the disease.
Subject(s)
Humans , Female , Adult , Endomyocardial Fibrosis , Cardiomyopathy, Restrictive , EchocardiographyABSTRACT
Objetivo: Comparar las estrategias tradicionales del análisis ácido-básico con la teoría de Stewart en pacientes pediátricos con disfunción multiorgánica en postoperatorio de cirugía cardiaca. Materiales y métodos: Estudio observacional analítico de cohorte concurrente, realizado en 66 pacientes pediátricos sometidos a circulación extracorporea (CEC) con una técnica estándar. En el postoperatorio inmediato se tomo muestra arterial para realizar el análisis ácido-básico tradicional y según Stewart; se aplicó diariamente la escala SOFA de disfunción orgánica durante tres días y se obtuvieron los valores mas altos. Los pacientes se dividieron en dos grupos de acuerdo a quienes presentaron falla orgánica (SOFA > 7; 20 pacientes) y sin falla orgánica (SOFA < 7; 46 pacientes). Resultados y conclusiones: El análisis tradicional en los pacientes que no desarrollaron falla mostró acidosis metabólica (pH 7.36 +/- 0.08, HCO3 16.6 +/- 2.6, BE -6.03 +/- 3.5). Los pacientes que desarrollaron falla mostraron resultados normales (pH 7.39 +/-0.08, HCO3 17.9+/-2.1, BE-4.8+/-2.6). El análisis de Stewart evidenció una mayor aparición de aniones anormales en los pacientes que desarrollaron falla (-4.2 vs -2.6), además sugiere que la acidosis evidenciada en los pacientes sin falla se explica por los cambios en la concentración de cloro y sodio producidos por la CEC
