Purpose: To analyze binocular vision of individuals aged 18 to 35 years diagnosed with keratoconus, utilizing spectacles and rigid gas-permeable (RGP) contact lenses. Research was led by the Universidad Autónoma de Aguascalientes, México and Fundación Universitaria del Área Andina Pereira, Colombia. Methods: A single center, prospective non-randomized, comparative, interventional, open-label study, in which the differences in binocular vision performance with both spectacles and RGP contact lenses was carried out from December 2018 to December 2019. Sampling was performed according to consecutive cases with keratoconus that met the inclusion criteria until the proposed sample size was reached. Results: Rigid gas-permeable (RGP) contact lenses notably enhanced distance and near visual acuity in keratoconus patients compared to spectacles. Visual alignment analysis shows exophoria at both distances and is slightly higher with RGP contact lenses. The difference was statistically significant (p<0.05), with 82.5 % presenting compensated phoria with spectacles and pnly 42.50% with RGP contact lenses. Stereoscopic vision improved while wearing RGP contact lenses (42.59 %), although accommodation and accommodative flexibility remained within normal ranges. Conclusions: Patients with keratoconus fitted with RGP contact lenses have improved binocular vision skills such as visual acuity, stereopsis, and accommodative flexibility. However, even when the vergence and motor system is decompensated with respect to normal ranges, the range between break and recovery points for both fusional reserves and the near point of convergence (NPC) improves with the use of RGP contact lenses, giving indications of an adaptive condition of the motor system from the medium to the long term.(AU)
Humans , Male , Female , Adolescent , Young Adult , Keratoconus , Eyeglasses , Contact Lenses , Vision, Binocular , Vision Tests , Colombia , Mexico , Ophthalmology , Prospective Studies
PURPOSE: To analyze binocular vision of individuals aged 18 to 35 years diagnosed with keratoconus, utilizing spectacles and rigid gas-permeable (RGP) contact lenses. Research was led by the Universidad Autónoma de Aguascalientes, México and Fundación Universitaria del Área Andina Pereira, Colombia. METHODS: A single center, prospective non-randomized, comparative, interventional, open-label study, in which the differences in binocular vision performance with both spectacles and RGP contact lenses was carried out from December 2018 to December 2019. Sampling was performed according to consecutive cases with keratoconus that met the inclusion criteria until the proposed sample size was reached. RESULTS: Rigid gas-permeable (RGP) contact lenses notably enhanced distance and near visual acuity in keratoconus patients compared to spectacles. Visual alignment analysis shows exophoria at both distances and is slightly higher with RGP contact lenses. The difference was statistically significant (p<0.05), with 82.5 % presenting compensated phoria with spectacles and pnly 42.50% with RGP contact lenses. Stereoscopic vision improved while wearing RGP contact lenses (42.59 %), although accommodation and accommodative flexibility remained within normal ranges. CONCLUSIONS: Patients with keratoconus fitted with RGP contact lenses have improved binocular vision skills such as visual acuity, stereopsis, and accommodative flexibility. However, even when the vergence and motor system is decompensated with respect to normal ranges, the range between break and recovery points for both fusional reserves and the near point of convergence (NPC) improves with the use of RGP contact lenses, giving indications of an adaptive condition of the motor system from the medium to the long term.
Acanthamoeba griffini is known to cause amoebic keratitis (AK); its main causes are inadequate hygiene when contact lenses are handled and/or its prolonged use at night, as well as the use of contact lenses during underwater activities. The most used treatment for AK is the combination of propamidine isethionate combined with polyhexamethylene biguanide, which disrupts the cytoplasmic membrane, and damages cellular components and respiratory enzymes. We proposed an immunoconjugate treatment obtained from Acanthamoeba immunized rabbit serum combined with propamidine isethionate; the corneas of hamsters inoculated with A. griffini (MYP2004) were treated with the combined, at 1, 2, and 3 weeks. Propamidine isethionate is frequently used for AK treatment, in vivo study we are found IL-1ß and IL-10 expression and caspase 3 activity is significantly increased with respect to the group that was inoculated with the amoeba without receiving any treatment, suggesting that it may be an effect of the toxicity of this drug on the corneal tissue. Application of the immunoconjugate showed enhanced amoebicidal and anti-inflammatory activities, with comparison to propamidine isethionate only. The aim of this study is to evaluate the effect of the immunoconjugate of propamidine isethionate and polyclonal antibodies as a treatment of AK in golden hamsters (Mesocricetus auratus).
PURPOSE: Subjective measurement of the oculomotor deviation at both distance and near is a standard test in optometric practice. A number of procedures are available to the practitioner, and previous studies have demonstrated differences in the repeatability of many of the techniques. However, it is unclear whether testing the subject through a phoropter or in free space (trial frame) will alter the oculomotor deviation. METHODS: Distance and near heterophoria was measured in 60 visually normal subjects between 20 and 34 years of age using the Von Graefe (VG), Maddox Rod (MR), and Modified Thorington (MT) procedures. The deviation was assessed for viewing distances of 6 m and 0.40 m using both a phoropter and trial frame. To examine the repeatability of each technique, the deviation was measured on two separate occasions for each procedure, with the two sessions being separated by at least 24 hours. RESULTS: The mean vertical deviations at both distance and near were extremely close to orthophoria, and only minimal variation was observed. However, the MR procedure, when used with a trial frame, gave the best repeatability for measuring vertical deviations both at distance and near. Regarding horizontal deviations, the repeatability was better for all three procedures when using a trial frame compared with the phoropter. The best repeatability at distance and near was observed when the MT and MR techniques, respectively, were used with the trial frame. Consistent with previous reports, the VG procedure had poor repeatability, especially when used with the phoropter, and the mean findings showed a greater exo deviation when compared with the other two techniques. CONCLUSIONS: Testing oculomotor deviations in free space provides a more repeatable response than when using a phoropter. Accordingly, we recommend that subjective measurements of heterophoria in the clinical setting can best be quantified using either the MR or MT techniques in free space.
Accommodation, Ocular/physiology , Oculomotor Muscles/physiopathology , Optometry/instrumentation , Strabismus/diagnosis , Adult , Humans , Reference Values , Strabismus/physiopathology , Vision Disparity
