Muscle endurance, neuromuscular fatigability, and cognitive control during prolonged dual-task in people with chronic obstructive pulmonary disease: a case-control study.

PURPOSE: Recent studies suggest that, compared to healthy individuals, people with chronic obstructive pulmonary disease (pwCOPD) present a reduced capacity to perform cognitive-motor dual-task (CMDT). However, these studies were focused on short-duration CMDT offering limited insight to prolonged CMDT inducing fatigue, which can be encountered in daily life. The present study aimed to explore the effect of adding a cognitive task during repeated muscle contractions on muscle endurance, neuromuscular fatigability, and cognitive control in pwCOPD compared to healthy participants. METHODS: Thirteen pwCOPD and thirteen age- and sex-matched healthy participants performed submaximal isometric contractions of the knee extensors until exhaustion in two experimental sessions: (1) without cognitive task and (2) with a concurrent working memory task (i.e., 1-back task). Neuromuscular fatigability (as well as central and peripheral components measured by peripheral magnetic stimulation), cognitive performance, and perceived muscle fatigue were assessed throughout the fatiguing tasks. RESULTS: Independently to the experimental condition, pwCOPD exhibited lower muscle endurance compared to healthy participants (p = 0.039), mainly explained by earlier peripheral fatigue and faster attainment of higher perceived muscle fatigue (p < 0.05). However, neither effect of cognitive task (p = 0.223) nor interaction effect (group × condition; p = 0.136) was revealed for muscle endurance. Interestingly, cognitive control was significantly reduced only in pwCOPD at the end of CMDT (p < 0.015), suggesting greater difficulty for patients with dual tasking under fatigue. CONCLUSION: These findings provide novel insights into how and why fatigue develops in COPD in dual-task context, offering a rationale for including such tasks in rehabilitation programs.

The Effects of Different Modalities of an Acute Energy Deficit on Sleep and Next Morning Appetitive and Compensatory Behavior in Healthy Young Adults: The EDIES Protocol.

Sleep is bi-directionally linked to energy balance. This crossover study design will evaluate the acute effect of a moderate energy deficit (500 kcal) induced by diet, exercise, or mixed (-250 kcal by diet and 250 kcal by exercise) on sleep and the next morning's appetitive responses. The study sample comprises 24 healthy young adults. The experimental measurements will be conducted in a naturalistic, momentary manner and partly assessed by the participants. The participants will undergo a run-in period in order to stabilize their sleep schedules and provide them with training on the study protocol and measurements. Indirect calorimetry will be used to determine their resting metabolic rate and peak oxygen consumption (VO2 peak). Then, they will take part in a control session (CTL), followed by three energy deficit sessions in random order: a diet-induced energy deficit session (DED), an exercise-induced energy deficit session (EED), and a mixed energy deficit session (MED). All experimental sessions will be separated by a one-week washout. The participants' sleep will be monitored by ambulatory polysomnography, and the next morning's appetitive response will be evaluated via ad libitum food intake, appetite sensations, and food reward, measured by a food liking and wanting computerized test.

Effects of Nonstationarity on Muscle Force Signals Regularity During a Fatiguing Motor Task.

Physiological signals present fluctuations that can be assessed from their temporal structure, also termed complexity. The complexity of a physiological signal is usually quantified using entropy estimators, such as Sample Entropy. Recent studies have shown a loss of force signal complexity with the development of neuromuscular fatigue. However, these studies did not consider the stationarity of the force signals which is an important prerequisite of Sample Entropy measurements. Here, we investigated the effect of the potential nonstationarity of force signals on the kinetics of neuromuscular fatigue-induced change in force signal's complexity. Eleven men performed submaximal intermittent isometric contractions of knee extensors until exhaustion. Neuromuscular fatigue was assessed from changes in voluntary and electrically evoked contractions. Sample Entropy values were computed from submaximal force signals throughout the fatiguing task. The Dickey-Fuller test was used to statistically investigate the stationarity of force signals and the Empirical Mode Decomposition was applied to detrend these signals. Maximal voluntary force, central voluntary activation and muscle twitch decreased throughout the task (all ), indicating the development of global, central and peripheral fatigue, respectively. We found an increase in Sample Entropy with fatigue ( p = 0.024 ) when not considering the nonstationarity of force signals (i.e., 43% of nonstationary signals). After applying the Empirical Mode Decomposition, we found a decrease in Sample Entropy with fatigue ( p = 0.002 ). These findings confirm the presence of nonstationarity in force signals during submaximal isometric contractions which influences the kinetics of Sample Entropy with neuromuscular fatigue.

Influence of cognitive load on the dynamics of neurophysiological adjustments during fatiguing exercise.

We aimed to determine the neurophysiological mechanisms associated with reduced endurance performance during cognitive-motor dual task at different levels of cognitive load, compared to a motor task alone. Eighteen healthy men performed isometric quadriceps contractions at 15% of maximal voluntary contraction (blocks of 170 s interspaced by neuromuscular evaluations) until exhaustion. This task was performed on three separate days: (a) in the absence of concomitant cognitive task, (b) with concomitant 1-back task, and (c) with concomitant 2-back task. Autonomic nervous system activity, perceived exertion, and cognitive performance were continuously monitored. Peripheral and central determinants of neuromuscular function were assessed at rest, between each block, and at task failure using femoral nerve stimulation. Endurance time was shorter during 2-back (982 ± 545 s) and 1-back (1,128 ± 592 s) conditions, compared with control (1,306 ± 836 s). Voluntary activation level was lower in 2-back (87.1%; p < 0.001) and 1-back (88.6%; p = 0.04) conditions compared to control (91.2%) at isotime (100% of the shortest test duration). Sympathetic activity showed a greater increase in 2-back condition compared to control. Perceived muscular exertion was higher during 2-back than during control. Cognitive performance decreased similarly with time during both cognitive-motor dual task but was always lower during 2-back condition. Motor performance is reduced when adding a concomitant demanding memory task to a prolonged isometric exercise. This can be explained by the interaction of various psychological and neurophysiological factors including higher perceived exertion, greater perturbations of autonomic nervous system activity, and cerebral impairments leading to earlier onset of central fatigue.