[Heart injury caused by air shock wave trauma]. / Obrazenia serca spowodowane przez bezposrednie dzialanie powietrznej fali underzeniowej.

The aim of the study was the estimation of heart muscle in response to air shock wave trauma. The animals were divided into four groups according to the time between trauma and the examination (3, 24, 48 and 120 hours). In all groups of animals ecg was performed and plasma level of creatinine kinase (CK), cardiac isoenzymes (CK-MB), lactic dehydrogenase (LDH) and its isoenzymes (LDH1-2) and alpha hydroxybutyrate dehydrogenase (HBDH) were determined. CK-MB activity as a percent of CK activity and rate of LDH isoenzymes activity were calculated. Morphologic estimation of heart injury based on macroscopic observation, histology and coronarography of heart specimens was performed. It was revealed that pathologic changes in ecg indicating intracardial conduction disturbances occur most intensively in first ten minutes after trauma. Plasma CPK, LDH and LDH1-2 activity increased significantly after 120 hrs following trauma. Morphologic manifestation of heart damage was multifocal injury of heart muscle.

[Therapeutic management of massive hemorrhage caused by gastroduodenal ulcer]. / Conduite thérapeutique dans l'hémorragie massive de l'ulcére gastro-duodénal.

Based on 103 patients the authors discussed policy of therapeutic management in gastric and duodenal ulcer disease complicated by massive hemorrhage. In the surgical treatment of such patients the authors prefer resection procedures aimed at simultaneous control of bleeding, prevention of its relapse and radical treatment of peptic ulcer disease.

[Lung injuries caused by explosion in rabbits. 3. The behavior of the lung after injury]. / Untersuchungen über Lungentraumen bei Kaninchen durch Luftstosswellen. Teil 3: Das Verhalten der Lungenaktivität nach der Verletzung.

The behaviour of the pulmonary activity was investigated in 30 rabbits after a blast. The estimation was carried out by the results of volumetric, gasometric, and radio-isotopic researches. The results show a considerable disturbance of the pulmonary activity which leads to respiratory insufficiency in rabbits after a blast of medium strength. The restriction type was dominant in the disturbance of the ventilation. An impairment of the gas diffusion is the consequence and leads to hypoxia and to a compensated respiratory acidosis.

[Lung injuries caused by explosion in rabbits. 1. The experimental model of the injury]. / Untersuchungen über Lungentraumen durch Luftstosswellen bei Kaninchen. Teil 1: Das Versuchsmodell der Verletzung.

A model for producing blasts of medium strength was developed. The injuries lead to the death of 25 to 50% of the experimental rabbits. The injuries were tested physically by direct measurements. The explosion of 225 g TNT in the air in 110 cm distance killed 35% of the rabbits. The corpus of the rabbit absorbed 67% of the energy of the blast in 0.46 ms in average. The average of the maximum positive pressure in the blast was 25.4 +/- 3.1 bar.

[Lung injuries caused by explosion in rabbits. 2. Pathogenetic mechanisms in lung injury (a hypothesis)]. / Untersuchungen über Lungentraumen bei Kaninchen durch Luftstosswellen. Teil 2: Der Pathomechanismus der Entstehung der Lungentraumen (Hypothese).

A hypothesis of the pathogenetic mechanism of the pulmonary changes after the injury is introduced. Basis are the results of the morphologic estimation of the lung traumas by blast with known energy in rabbits. The reason is the lung deformation by the sudden pressure increasing in the thoracic cavity and the volume reduction of the thorax. The deformed lungs were pressed against the thorax wall in the region of the smallest deformation.

[Role of leukocytes in the healing process in surgical wounds]. / Untersuchungen über die Rolle der Leukozyten im Heilprozess chirurgischer Verletzungen.

In the last period of time there has been stated that in human lysosomes of neutrophilic leukocytes an in ones of some experimental animals occur, which stimulate the growth of lymphocytes and fibroblasts in the study in vitro. With regard to this it was assumed that similar stimulating processes may take place in the surgical wounds. The experiments were carried out on guinea pigs which were wounded and afterwards the wounds were sutured and the allogenic proteins preparations were introduced into its in dose of 100 microgram as follows: lysosomal proteins of granulocytes, mixed and separated on the the DEAE-cellulose columns; lysosomal proteins of macrophages, the proteins isolated from plasma and nuclei both the granulocytes and macrophages. The evaluation of healing was based on the measurement of mechanical resistance of wounds adhesions and was completed with the pathomorphological examinations. It has been shown that the mixture of lysosomal proteins of granulocytes, intruduced into the wounds, caused the acceleration of the healing processes. After giving into the wounds some fractions of proteins which were separated on the colums with DEAE-cellulose, the stimulating processes of healing were seen, while after adding the other ones-the inhibiting processes. The protein with similar evidences were not show inside other structures studied of granulocytes and macrophages. The results obtained seem to support the supposition that in lysosomes of neutrophilic granulocytes there are the factors which regulate the repair processes in wounds.