Subject(s)
Lymphoma, B-Cell/diagnosis , Thyroid Neoplasms/diagnosis , Uterine Cervical Neoplasms/diagnosis , Aged , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Cyclophosphamide/administration & dosage , Diagnosis, Differential , Doxorubicin/administration & dosage , Fatal Outcome , Female , Humans , Lymphoma, B-Cell/complications , Lymphoma, B-Cell/drug therapy , Lymphoma, B-Cell/pathology , Lymphoma, B-Cell/surgery , Neoplasm Staging , Postmenopause , Prednisone/administration & dosage , Thyroid Neoplasms/complications , Thyroid Neoplasms/drug therapy , Thyroid Neoplasms/pathology , Uterine Cervical Neoplasms/complications , Uterine Cervical Neoplasms/drug therapy , Uterine Cervical Neoplasms/secondary , Uterine Cervical Neoplasms/surgery , Uterine Hemorrhage/etiology , Vincristine/administration & dosageABSTRACT
Cryosurgery is an alternative treatment option to surgical excision for lentigo maligna. Clinical evidence of recurrence is usually characterized by repigmentation at the treated site. We report two patients who developed amelanotic malignant melanoma following cryosurgery for a pigmented lentigo maligna. These cases illustrate the potential risk of treating lentigo maligna with cryosurgery.
Subject(s)
Cryosurgery/adverse effects , Ear Neoplasms/surgery , Facial Neoplasms/surgery , Hutchinson's Melanotic Freckle/surgery , Melanoma, Amelanotic/etiology , Skin Neoplasms/etiology , Aged , Cheek , Ear Neoplasms/pathology , Facial Neoplasms/pathology , Female , Humans , Hutchinson's Melanotic Freckle/pathology , Male , Melanoma, Amelanotic/pathology , Middle Aged , Neoplasm Recurrence, Local , Skin Neoplasms/pathologyABSTRACT
PURPOSE: To correlate the imaging and histological findings in diffuse neurofibroma. PATIENTS AND METHODS: Retrospective review of clinical, imaging and histological findings in two patients with diffuse neurofibroma. RESULTS: CT demonstrates diffuse infiltration of the deep and subcutaneous fat, isodense to muscle. Magnetic resonance imaging shows extensive infiltration of the subcutaneous and deep fat that envelops tendons and vessels but does not involve bone. Superficial masses enhance homogeneously after intravenous gadolinium. The reticular nature of the deep infiltration is seen on all sequences but is most conspicuous on post-gadolinium T1-weighted images which show tumour enhancement and non-enhancing hypointense soft tissue strands. Magnetic resonance angiography and Doppler ultrasound may show enlarged vessels, high blood flow and vascular pools. CONCLUSION: Diffuse neurofibroma has a characteristic appearance on magnetic resonance that is best shown on post-gadolinium T1-weighted images.
Subject(s)
Ankle , Neurofibroma/diagnosis , Soft Tissue Neoplasms/diagnosis , Adolescent , Adult , Female , Humans , Magnetic Resonance Imaging , Male , Retrospective Studies , Tomography, X-Ray Computed , Ultrasonography, DopplerABSTRACT
Sixty-seven patients with incompletely excised basal cell carcinomas are reviewed. No recurrences were seen in seven patients who had immediate supplementary treatment; 23 of 60 patients submitted to a "wait and see" regimen developed recurrent disease, Recurrence was commoner in those in whom both the lateral and deep margins were involved, and when the incomplete excision was for recurrent disease. The latter recurrences were more difficult to control in patients who had previously had radiotherapy, when the deep margin was involved and when a flap had been used to close the resulting defect. A case is made for immediate re-excision for all patients with incompletely excised basal cell carcinomas.