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Bioorg Med Chem Lett
; 21(5): 1354-8, 2011 Mar 01.
Article
in English
| MEDLINE
| ID: mdl-21310610
ABSTRACT
We sought to design dual pharmacology bronchodilators targeting both the M(3) muscarinic acetylcholine and beta-2 adrenergic (ß(2)) receptors by applying our multivalent approach to drug discovery. Herein, we describe our initial discovery and the SAR of the first such compounds with matched potencies at both receptors.