ABSTRACT
Understanding how free DNA might act as a signal between cells is important for knowing how DNA orchestrates immune responses and for optimizing the therapeutic of cancer, infection and immunologic diseases. This communication demonstrates that DNAs from different origins (bacteria, T. cruzi, HeLa cells) and synthetic oligonucleotide containing an unmethylated CpG motif are capable of inducing alterations in the protein profile of normal human leukocytes. As far as we know there have been no similar studies regarding the comparative effects of different free DNAs on early protein synthesis of human peripheral blood mononuclear cells.
Subject(s)
DNA/metabolism , DNA/pharmacology , Leukocytes, Mononuclear/metabolism , Protein Biosynthesis , CpG Islands , DNA, Bacterial/pharmacology , DNA, Protozoan/pharmacology , Humans , Leukocytes, Mononuclear/drug effects , Oligonucleotides/pharmacology , Proteins/drug effectsSubject(s)
Antibodies, Monoclonal , Chagas Cardiomyopathy/immunology , T-Lymphocytes/classification , Adult , Aged , Chronic Disease , Female , Heart Block/etiology , Humans , Immunity, Cellular , Male , Middle AgedABSTRACT
Uma revisao da atividade imunomoduladora de Bacillus Calmette Gerin (BCG), Propionibacterium spp. (Corynebacterium parvum), interferon, levamisole e timopoietina, como estabilizadores da homeostasia imunologica, quando injetados em mamiferos. Nao ha mecanismo comum de acao entre os imunoestimuladores, mas todos influenciam a ativacao de macrofagos. Levamisole e timopoietina revelam alguns efeitos similares nas imunorespostas celulares. O modelo do efeito da timopoietina pentapeptidio (TP5) em infeccoes experimentais por Babesia microti em hamsters foi destacado, revelando menor parasitemia durante a infeccao aguda