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1.
Pediatr Radiol ; 53(9): 1885-1893, 2023 08.
Article in English | MEDLINE | ID: mdl-37147428

ABSTRACT

PURPOSE: To evaluate the safety and efficacy of percutaneous interventional treatment of portal vein stenosis in children. MATERIAL AND METHODS: A retrospective analysis of all interventional treatments for portal vein stenosis in pediatric patients at a single institution from 2010 to 2021 was conducted. Platelet count, spleen size and portal vein flow velocity were assessed during the follow-up period. Primary and primary assisted patency time were determined. RESULTS: A total of ten children (median age 28.5 months, interquartile range (IQR): 2.75-52.5 months) with portal vein stenosis after Mesorex-Shunt (n = 4), liver transplantation (n = 3) and other etiologies (n = 3) underwent 15 interventional procedures. There were five reinterventions and one discontinued intervention. The technical success rate was 93.3% (14/15) and clinical success of treated patients was 100% (14/14). Median follow-up was 18 months (IQR: 13.5-81 months). The median primary patency time for stent placement was 70 months (IQR: 13.5-127.25 months). For balloon angioplasty, the median primary patency time was 9 months (IQR 7.25-11.5 months), while the median assisted primary patency time was 14 months (IQR: 12 to 15 months). Platelet count, spleen size and portal vein flow velocity reliably corresponded to recurrence of portal vein stenosis in asymptomatic patients during follow-up. CONCLUSION: Interventional treatment is a safe and efficient method to treat portal vein stenosis with long patency times, regardless of etiology. Primary stent placement shows a higher primary patency time than balloon angioplasty. Implementation of stent placement as the primary interventional method may improve patency times and reduce the need for repeat reinterventions in pediatric patients.


Subject(s)
Angioplasty, Balloon , Portal Vein , Child , Humans , Child, Preschool , Portal Vein/diagnostic imaging , Portal Vein/surgery , Treatment Outcome , Constriction, Pathologic/surgery , Retrospective Studies , Angioplasty, Balloon/adverse effects , Angioplasty, Balloon/methods , Stents
2.
Injury ; 54(2): 525-532, 2023 Feb.
Article in English | MEDLINE | ID: mdl-36503838

ABSTRACT

PURPOSE: Hip osteoarthritis (HOA) is known to have a multifactorial pathogenesis. Recent studies suggest that spinopelvic alignment may represent an important additional pathogenic abnormality resulting in HOA. This study aims to assess the correlation between spinopelvic parameters (pelvic incidence (PI), pelvic tilt (PT), sacral slope (SS) and lumbar lordosis (LL)) obtained in the supine position on MRI and HOA, lateral center edge (LCE) angle, and patient reported back pain. METHODS: Asymptomatic participants from the whole-body MRI cohort (FF4) from the cross-sectional case-control "Cooperative Health Research in the Region of Augsburg" study (KORA) were included. Whole-body MRI was performed in a standardized fashion in each case, on which hip osteoarthritis (HOA), anatomical spinopelvic parameters and lateral center edge angle were measured. Presence of back pain was assessed using a standardized questionnaire. Correlations were estimated by logistic regression models providing odds ratio. RESULTS: Among 340 subjects (mean age 56.3 ± 9.3 years; 56.5% male), HOA was present in 89.1% (male: 87.0%, female: 91.7%, p = 0.17). The LCE angle was 30.0° ± 5.5 (men: 29.8° ± 5.9; women: 30.1° ± 5.1; p = 0.696). Mean PI was 54.0° ± 11.3°, PT was 13.7° ± 5.9°, SS was 40.3° ± 8.8° (significantly smaller in women p<0.05) and LL was 36.4° ± 9.6° (significantly greater in women p<0.05). None of the spinopelvic parameters correlated significantly with hip osteoarthritis or LCE angle. HOA was not correlated with back pain. CONCLUSION: Spinopelvic parameters as measured in the supine position on MRI, do not correlate with hip osteoarthritis or lateral center edge angle.


Subject(s)
Lordosis , Osteoarthritis, Hip , Humans , Male , Female , Middle Aged , Aged , Osteoarthritis, Hip/diagnostic imaging , Osteoarthritis, Hip/surgery , Cross-Sectional Studies , Supine Position , Lordosis/diagnostic imaging , Magnetic Resonance Imaging , Lumbar Vertebrae/diagnostic imaging
3.
Rofo ; 195(5): 406-415, 2023 05.
Article in English | MEDLINE | ID: mdl-36261069

ABSTRACT

PURPOSE: To evaluate the safety and efficacy of rotational thrombectomy (RT) in a large single-center real-world cohort for total vascular occlusions of the lower extremity. MATERIALS AND METHODS: The clinical records and images of all patients between 2010 and 2020 treated via RT (Rotarex, BD) were assessed. Patient demographics, clinical data, procedural characteristics, and outcome parameters were documented. In total, 397 procedures in 293 patients were included (mean age 69.8 ±â€Š12.0 years; 64.8 % male). Occlusions were acute (47.5 %), subacute and acute-on-chronic (22.2 %), and chronic (30.3 %). The target lesions were the iliac artery (7.1 %), iliac/femoropopliteal (5.0 %), femoropopliteal (59.4 %), femoropopliteal/below-the-knee (27.0 %), below-the-knee (1.5 %), and after bypass surgery (14.9 %). Lesion length was > 20 cm in 61.5 % of cases. RESULTS: Clinically successful revascularization was achieved in 90.4 % of cases. Additional thrombolysis was necessary for 32.0 % of procedures. The arithmetic mean ankle-brachial index increased from 0.33 ±â€Š0.29 to 0.81 ±â€Š0.25 (p < 0.0001). Bypass grafts were less likely to be fully treatable and required additional lysis (p < 0.001). The overall primary patency (no clinically driven target lesion revascularization) was 93.2 %, 88.8 %, 79.1 %, and 72.4 % at 1, 3, 6, and 12 months, respectively. Adverse events occurred in 46.1 % of cases, of which peripheral embolization (22.4 %) was most frequent, requiring interventional treatment in 67.4 % of cases. RT was directly associated with 7.1 % (n = 28) of complications, which consisted of perforations 2.8 %, arteriovenous fistula 1.3 %, and dissections 2.0 %. CONCLUSION: Rotational thrombectomy is a safe and efficient method for the treatment of occlusions of the arterial circulation of the lower extremity with bypass occlusions having a higher propensity for residual thrombi requiring further lysis therapy. KEY POINTS: · Rotational thrombectomy was safe and efficacious for treating occlusions of the lower extremities.. · Rotational thrombectomy was associated with 7.1 % of complications.. · Distal embolization occurred in 22.4 % of cases with 67.4 % requiring interventional treatment.. · Primary patency was 93.2 %, 88.8 %, 79.1 %, 72.4 % after 1, 3, 6, and 12 months, respectively.. CITATION FORMAT: · Artzner C, Martin I, Hefferman G et al. Safety and Efficacy of Rotational Thrombectomy for Treatment of Arterial Occlusions of the Lower Extremities: A Large Single-Center Retrospective Study. Fortschr Röntgenstr 2023; 195: 406 - 415.


Subject(s)
Arterial Occlusive Diseases , Popliteal Artery , Humans , Male , Middle Aged , Aged , Aged, 80 and over , Female , Retrospective Studies , Popliteal Artery/surgery , Thrombectomy/methods , Femoral Artery/surgery , Arterial Occlusive Diseases/therapy , Arterial Occlusive Diseases/surgery , Lower Extremity , Treatment Outcome , Vascular Patency
4.
Diagnostics (Basel) ; 12(8)2022 Jul 23.
Article in English | MEDLINE | ID: mdl-35892500

ABSTRACT

The aim was to evaluate the accuracy of a prototypical artificial intelligence-based algorithm for automated segmentation and diameter measurement of the thoracic aorta (TA) using CT. One hundred twenty-two patients who underwent dual-source CT were retrospectively included. Ninety-three of these patients had been administered intravenous iodinated contrast. Images were evaluated using the prototypical algorithm, which segments the TA and determines the corresponding diameters at predefined anatomical locations based on the American Heart Association guidelines. The reference standard was established by two radiologists individually in a blinded, randomized fashion. Equivalency was tested and inter-reader agreement was assessed using intra-class correlation (ICC). In total, 99.2% of the parameters measured by the prototype were assessable. In nine patients, the prototype failed to determine one diameter along the vessel. Measurements along the TA did not differ between the algorithm and readers (p > 0.05), establishing equivalence. Inter-reader agreement between the algorithm and readers (ICC ≥ 0.961; 95% CI: 0.940−0.974), and between the readers was excellent (ICC ≥ 0.879; 95% CI: 0.818−0.92). The evaluated prototypical AI-based algorithm accurately measured TA diameters at each region of interest independent of the use of either contrast utilization or pathology. This indicates that the prototypical algorithm has substantial potential as a valuable tool in the rapid clinical evaluation of aortic pathology.

5.
Acta Radiol ; 63(6): 750-759, 2022 Jun.
Article in English | MEDLINE | ID: mdl-33878932

ABSTRACT

BACKGROUND: Little is known about the associations between cardiovascular risk factors (CRF) and disc degeneration (DD). PURPOSE: To evaluate the potential association between CRFs and intervertebral DD in a population-based sample. METHODS: A total of 400 participants from the community-based KORA-study were assessed in terms of CRFs, specifically obesity, hypertension, diabetes, elevated LDL-c, low HDL-c, elevated triglycerides, smoking status, and alcohol consumption. The patients additionally underwent whole-body magnetic resonance imaging (MRI) using T2-weighted single-shot fast-spin-echo and T1 dual-echo gradient-echo Dixon pulse sequences. Thoracic and lumbar DD were assessed using the Pfirrmann score and for the presence of disc bulging/protrusion. Cross-sectional associations between CRFs and MR-based Pfirrmann score were then analyzed. RESULTS: A total of 385 individuals (58.2% men; mean age 56.3 ± 9.2 years) were included. Prevalence of DD was 76.4%. Older age (ß = 0.18; 95% CI 0.12-0.25; P < 0.001) and higher body mass index (BMI) (ß = 0.19; 95% CI 0.06-0.30; P = 0.003) were significantly associated with DD of the thoracolumbar spine. Diabetes was significantly associated with DD at T7/8 (P = 0.029) and L3/4 (P = 0.017). Hypertension correlated significantly with DD in univariate analysis, but the association did not persist using multivariate analysis (ß = 0.53; 95% CI -0.74 to 1.81; P = 0.41). None of the other CRFs (P ≥ 0.11) were associated with advanced DD. Disc bulging was independently associated with hypertension (ß = 0.47; 95% CI 0.27-0.81; P = 0.01). CONCLUSION: A significant independent association exists between age, BMI, and intervertebral DD. In contrast, there is no significant association between cardiovascular risk factors and DD. Providing strong evidence that the pathologic process undergirding DD is mechanical, rather than microvascular, in nature.


Subject(s)
Cardiovascular Diseases , Hypertension , Intervertebral Disc Degeneration , Intervertebral Disc Displacement , Aged , Cardiovascular Diseases/diagnostic imaging , Cardiovascular Diseases/epidemiology , Cross-Sectional Studies , Female , Heart Disease Risk Factors , Humans , Hypertension/pathology , Intervertebral Disc Degeneration/diagnostic imaging , Intervertebral Disc Degeneration/epidemiology , Lumbar Vertebrae/diagnostic imaging , Magnetic Resonance Imaging/methods , Male , Middle Aged , Risk Factors , Whole Body Imaging/adverse effects
6.
Appl Opt ; 60(25): 7523-7529, 2021 Sep 01.
Article in English | MEDLINE | ID: mdl-34613217

ABSTRACT

This paper describes an integrated, accurate, and inexpensive semiconductor laser -based optical frequency domain reflectometry (OFDR) system design. The system utilizes the fiber under test for both sensing and frequency sweep linearization functions, allowing the system to mitigate and compensate for phase errors without the need for an auxiliary interferometer, as is the case for traditional OFDR systems. Benefiting from the unique and embedded design, this system reaches the minimal OFDR system with only one optical interferometer and its corresponding optic-electric components without sacrificing accuracy. In addition, conventional design requires an external auxiliary interferometer, which may experience different noises from the main measuring interferometer, deteriorating the overall performance. Experimental results demonstrate the enhanced performance of the compact design as compared with the former methods, as well as the reduced complexity and improved cost-effectiveness.

7.
PLoS One ; 16(6): e0252385, 2021.
Article in English | MEDLINE | ID: mdl-34106962

ABSTRACT

OBJECTIVE: This study aims to investigate the correlation between spinopelvic parameters in supine position (pelvic incidence (PI), sacral slope (SS), pelvic tilt (PT), lumbar lordosis (LL)), disc degeneration and herniation of the thoracolumbar spine, as well as cardiovascular risk factors and back pain in a southern German cohort from the general population. METHODS: This study is a cross-sectional, case-control study drawn from a prospective cohort of the "Cooperative Health Research in the Region of Augsburg/Kooperative Gesundheitsforschung in der Region Augsburg" study (KORA). In total, 374 participants (mean age 56.4 ± 9.2 years; 57.8% male) from the whole-body MRI cohort (FF4) were included. All participants underwent a standardized whole-body MRI on which disc degeneration of the thoracic and lumbar spine was evaluated using a sequence adapted Pfirrmann score. PI, PT, SS and LL were measured according to the description in the literature, using sagittal imaging. Furthermore, disc bulging and protrusion were assessed. Correlations were estimated by logistic regression models providing odds ratios. RESULTS: Mean PI was 54.0° ± 11.1°, PT 13.0° ± 5.8°, SS 40.2° ± 8.8° and LL 36.2° ± 9.6°. SS was greater in men (p<0.05) and lumbar lordosis in women (p<0.001). PT increased by 0.09° per age-year with rising age. Age was not associated with PI, SS and LL. Neither BMI, hypertension, cholesterol, lipid levels, nor physical activity were associated with PI, PT, SS or LL. Diabetes mellitus negatively correlated with SS (ß = -4.19; 95%CI -7.31-1.06, p<0.01). Smaller spinopelvic parameters (PI, SS and LL) where significantly (p<0.05) correlated with an increased frequency of disc bulging, as well as a local clustering in the lumbar, but not the thoracic spine. CONCLUSION: In conclusion, spinopelvic parameters, measured in supine position, are significantly correlated with disc bulging alone; there is no significant correlation between supine spinopelvic parameters and disc degeneration, back pain or cardiovascular risk factors.


Subject(s)
Intervertebral Disc Degeneration/diagnostic imaging , Lumbar Vertebrae/diagnostic imaging , Magnetic Resonance Imaging/methods , Pelvic Bones/diagnostic imaging , Thoracic Vertebrae/diagnostic imaging , Female , Heart Disease Risk Factors , Humans , Male , Middle Aged , Supine Position
8.
Emerg Radiol ; 28(5): 891-898, 2021 Oct.
Article in English | MEDLINE | ID: mdl-33866443

ABSTRACT

PURPOSE: The goal of this study was to determine whether the benefits of multiphase CTA (mCTA) over single-phase CTA (sCTA) for the detection of proximal cerebrovascular occlusions similarly extend to the distal cerebral vasculature. METHODS: Four attending radiologists, two neuroradiologists and two emergency radiologists, contributed as readers to this retrospective study. For each reader, two sessions were conducted, one using sCTA and one using mCTA. During each session, the reader interpreted the studies of 104 patients who underwent imaging for suspicion of acute ischemic stroke, resulting in a total of 832 interpretations. Changes in diagnostic accuracy, time to render final decision, and reported levels of reader confidence were quantitatively assessed. Further analysis comparing the effects for neuroradiologists versus emergency radiologists was additionally conducted. RESULTS: Using mCTA resulted in a significant 5.0% absolute increase in sensitivity (91.6% vs. 96.6%, p = .004) and an insignificant increase in specificity (99.5% vs. 99.7%, p = .39). A significant reduction in reading time (66.7 s vs. 59.6 s, p = .001) and an increase in diagnostic confidence (2.26 vs. 2.58, p < .001) were observed. Using sCTA, higher sensitivity was achieved by neuroradiologists than emergency radiologists (96.0% vs. 86.9%, p = .002); using mCTA resulted in an absolute increase in sensitivity of 0.9% (97.4%, p = .44) for neuroradiologists and 9.6% (96.5%, p < .001) for emergency radiologists, eliminating significant differences between the groups (p = 0.57). CONCLUSION: The use of mCTA results in increased sensitivity and negative predictive value, decreased reading time, increased diagnostic confidence, and the elimination of differences in accuracy between neuroradiologists and emergency radiologists.


Subject(s)
Brain Ischemia , Cerebrovascular Disorders , Stroke , Cerebral Angiography , Computed Tomography Angiography , Humans , Retrospective Studies
9.
Opt Lett ; 45(21): 6086-6089, 2020 Nov 01.
Article in English | MEDLINE | ID: mdl-33137075

ABSTRACT

As the security of optical fiber lines in data centers has attracted growing attention, it has become increasingly important to accurately characterize the fiber that is used. Optical frequency domain reflectometry (OFDR) has been demonstrated as a means of identifying specific segments of optical fiber; however, OFDR measurements are limited in length due to initial optical frequency (IOF) variations. This Letter describes a detailed analysis of IOF and introduces a method to mitigate it in an OFDR system constructed using a semiconductor laser (SCL). Additionally, an algorithm is described that minimizes the calculating density necessary for OFDR-based optical fiber verification, reducing the calculating time required by an order of magnitude relative to prior techniques. Experiments demonstrate that the described method can be effectively applied to a range of application areas, ranging from centimeter to meter lengths of optical fiber, with an error equal rate (EER) of less than 1%.

10.
Cancer Imaging ; 20(1): 37, 2020 May 27.
Article in English | MEDLINE | ID: mdl-32460898

ABSTRACT

BACKGROUND: Combination therapy using hepatic resection (HR) and intra-operative thermal ablation is a treatment approach for patients with technically unresectable liver malignancies. The aim of this study was to investigate safety, survival and local recurrence rates for patients with technically unresectable liver tumors undergoing HR and separate percutaneous MR-guided thermoablation procedure as an alternative approach. METHODS: Data from all patients with primary or secondary hepatic malignancies treated at a single institution between 2004 and 2018 with combined HR and MR-guided percutaneous thermoablation was collected and retrospectively analyzed. Complications, procedure related information and patient characteristics were collected from institutional records. Overall survival and disease-free survival were estimated using the Kaplan-Meier method. RESULTS: A total of 31 patients (age: 62.8 ± 9.1 years; 10 female) with hepatocellular carcinoma (HCC; n = 7) or hepatic metastases (n = 24) were treated for 98 hepatic tumors. Fifty-six tumors (mean diameter 28.7 ± 23.0 mm) were resected. Forty-two tumors (15.1 ± 7.6 mm) were treated with MR-guided percutaneous ablation with a technical success rate of 100%. Local recurrence at the ablation site occurred in 7 cases (22.6%); none of these was an isolated local recurrence. Six of 17 patients (35.3%) treated for colorectal liver metastases developed local recurrence. Five patients developed recurrence at the resection site (16.1%). Non-local hepatic recurrence was observed in 18 cases (58.1%) and extrahepatic recurrence in 11 cases (35.5%) during follow-up (43.1 ± 26.4 months). Ten patients (32.3%) developed complications after HR requiring pharmacological or interventional treatment. No complication requiring therapy was observed after ablation. Median survival time was 44.0 ± 7.5 months with 1-,3-, 5-year overall survival rates of 93.5, 68.7 and 31.9%, respectively. The 1-, 3- and 5-year disease-free survival rates were 38.7, 19.4 and 9.7%, respectively. CONCLUSION: The combination of HR and MR-guided thermoablation is a safe and effective approach in the treatment of technically unresectable hepatic tumors and can achieve long-term survival.


Subject(s)
Carcinoma, Hepatocellular/therapy , Catheter Ablation/methods , Liver Neoplasms/therapy , Magnetic Resonance Imaging/methods , Adult , Aged , Aged, 80 and over , Carcinoma, Hepatocellular/diagnostic imaging , Catheter Ablation/adverse effects , Disease-Free Survival , Female , Humans , Liver Neoplasms/diagnostic imaging , Male , Middle Aged
11.
Biomed Res Int ; 2020: 9526790, 2020.
Article in English | MEDLINE | ID: mdl-32190691

ABSTRACT

PURPOSE: The purpose of this study was to evaluate various objective, quantitative, time-resolved fluoroscopic imaging parameters for use in the peri-interventional evaluation of stenotic peripheral arterial disease lesions. Material and Methods. Ten patients (median age, 64; age range, 52 to 79; 8 males, 2 females) with high-grade stenoses of either the superficial femoral or popliteal arteries who underwent endovascular treatment were included. During each intervention, two series of intraprocedural fluoroscopic images were collected, one preintervention and one postintervention. For each imaging series, four regions of interest (ROIs) were defined within the vessel lumen, with two ROIs being proximal (ROIs 1 and 2) and two being distal (ROIs 3 and 4) to the stenosis. The time-density curve (TDC) at each ROI was measured, and the resulting area under the curve (AUC), full width at half maximum (FWHM), and time-to-peak (TTP) were then calculated. RESULTS: The analysis of the TDC-derived parameters demonstrated significant differences between pre- and postinterventional flow rates in the ROI placed most distal to the stenosis, ROI 4. The AUC at ROI 4 (reported as a relative percentage of the AUC measured at ROI 1 proximal to the lesion) demonstrated a significant increase in the total flow (mean 67.84% vs. 128.68%, p=0.003). A significant reduction in FWHM at ROI 4 (mean 2.93 s vs. 1.87 s, p=0.003). A significant reduction in FWHM at ROI 4 (mean 2.93 s vs. 1.87 s, p=0.003). A significant reduction in FWHM at ROI 4 (mean 2.93 s vs. 1.87 s. CONCLUSION: AUC, FWHM, and TTP are objective, reproducible, quantifiable tools for the peri-interventional fluoroscopic evaluation of vessel stenoses. When compared to the standard subjective interpretation of fluoroscopic imagery, AUC, FWHM, and TTP offer interventionalists the advantage of having an objective, complementary method of evaluating the success of a procedure, potentially allowing for more precisely targeted and quantitatively determined treatment goals and improved patient outcomes. This retrospective study was approved by the local ethics committee under the Number 372/2018BO2. The trial was registered at the German clinical trials register under the number DRKS00017813.


Subject(s)
Angiography, Digital Subtraction/methods , Fluoroscopy/methods , Peripheral Arterial Disease/physiopathology , Aged , Constriction, Pathologic/physiopathology , Feasibility Studies , Female , Femoral Artery/diagnostic imaging , Femoral Artery/physiopathology , Humans , Male , Middle Aged , Peripheral Arterial Disease/diagnostic imaging , Retrospective Studies
12.
Appl Opt ; 58(23): 6211-6216, 2019 Aug 10.
Article in English | MEDLINE | ID: mdl-31503761

ABSTRACT

This paper introduces an integrated fiber physical unclonable function (PUF) verification system based on a semiconductor laser source at substantially lower complexity and cost than existing alternatives. A source sub-section consisting of a linear frequency-swept semiconductor laser is used in combination with an optical frequency domain reflectometry (OFDR)/LiDAR-based measurement sub-section in order to conduct fiber identification via measurement of the unique Rayleigh reflection pattern of a section of optical fiber. When using these Rayleigh reflection patterns as PUFs, this technique results in a maximum equal error rate (EER) of 0.15% for a 5-cm section of optical fiber and an EER of less than 1% for a 4-cm section. These results demonstrate that the system can serve as a robust method fiber identification for device and communication verification applications.

13.
Cardiovasc Intervent Radiol ; 42(10): 1449-1458, 2019 Oct.
Article in English | MEDLINE | ID: mdl-31321481

ABSTRACT

OBJECTIVE: The objective of this study was to evaluate the potential benefit of a dedicated cone-beam-CT streak metal artifact removal technique (SMART) in terms of both image quality and diagnostic confidence in patients undergoing bronchial artery embolization. METHODS: A total of 17 patients were included in this retrospective study. The SMART algorithm was applied to images containing streak artifacts generated by a radiopaque intra-arterial catheter tip. Quantitative evaluation of artifact severity was performed via measurement of the Hounsfield units along a closed loop surrounding the catheter tip and was conducted in the frequency domain following the application of the discrete Fourier transform to the measured data. A high proportion of power in the low frequencies of the resulting spectrum indicated a high level of streak artifacts. Qualitative evaluation of diagnostic confidence was performed using a 4-point Likert scale. RESULTS: Both quantitative and qualitative evaluation demonstrated a significant reduction in artifact severity using the SMART algorithm. Quantitative evaluation demonstrated a mean artifact reduction of 22.5% using SMART compared to non-SMART images (p < 0.001). Qualitative evaluation demonstrated the greatest artifact reduction at the inner and outer aortic curvature, as well as immediately surrounding the tip of the catheter. In 6 of 17 cases, the use of the SMART algorithm yielded additional clinical information, increasing mean diagnostic confidence from 3.17 to 3.78 (p < 0.001). CONCLUSION: The SMART algorithm allows for efficient reduction of metal artifacts introduced by radiopaque catheter tips during cone-beam CT. Using this algorithm, diagnostic images of the aortic arch were significantly improved both quantitatively and qualitatively, yielding clinically relevant levels of enhanced diagnostic confidence. These results demonstrate that the SMART algorithm improves diagnostic and clinical characterization of the course of bronchial arteries on CBCT images, potentially improving the accuracy and clinical efficacy of bronchial artery embolization. LEVEL OF EVIDENCE: 3.


Subject(s)
Artifacts , Bronchial Arteries/diagnostic imaging , Bronchial Diseases/therapy , Cone-Beam Computed Tomography/methods , Embolization, Therapeutic/methods , Image Interpretation, Computer-Assisted/methods , Adult , Aged , Aged, 80 and over , Algorithms , Bronchial Arteries/pathology , Bronchial Diseases/diagnostic imaging , Bronchial Diseases/pathology , Evaluation Studies as Topic , Female , Humans , Male , Metals , Middle Aged , Retrospective Studies
14.
Cancer Imaging ; 19(1): 31, 2019 May 30.
Article in English | MEDLINE | ID: mdl-31146793

ABSTRACT

OBJECTIVE: To investigate the outcome and safety data of chemosaturation with percutaneous hepatic perfusion (CS-PHP) of melphalan in patients with liver-dominant metastatic uveal melanoma. MATERIAL AND METHODS: This is a HIPAA compliant, IRB approved, retrospective study. A total of 28 CS-PHPs were performed in 16 individual patients (six men and ten women, median age 63.1 years [range 49.1 to 78.7 years], one to six CS-PHP procedures per patient) for treatment of liver-dominant metastatic uveal melanoma between June, 2015 and December, 2018. All patients received cross-sectional imaging at baseline and during follow-up. CS-PHP was performed with the Hepatic CHEMOSAT® Delivery System (Delcath Systems, Inc., NY, USA) facilitating extracorporeal filtration of hepatic blood for melphalan removal. Ideal body weight-adjusted melphalan doses were administered into the hepatic arteries. Serious adverse events (SAE), progression-free survival based on response criteria in solid tumors, and overall survival were noted. Survival data were analyzed using Kaplan-Meier estimates. RESULTS: Partial response after first CS-PHP was observed in nine patients (60%), stable disease in five patients (33%) and progressive disease in one patient (7%). Median overall survival was 27.4 months (95% CI 4.1 to 35.4 month) after first CS-PHP. Median progression-free survival was 11.1 months after first CS-PHP (95% CI 4.9 to 23.6 months). SAEs were observed in the majority of patients with most SAEs limited to grades one and two. Thirteen SAEs of grades three and four were observed in seven individual patients. No grade five SAE was observed. CONCLUSION: CS-PHP is an efficacious and safe treatment for patients presenting with liver-dominant metastatic uveal melanoma.


Subject(s)
Antineoplastic Agents, Alkylating/administration & dosage , Chemotherapy, Cancer, Regional Perfusion/methods , Melanoma/therapy , Melphalan/administration & dosage , Uveal Neoplasms/therapy , Aged , Antineoplastic Agents, Alkylating/therapeutic use , Chemotherapy, Cancer, Regional Perfusion/adverse effects , Chemotherapy, Cancer, Regional Perfusion/instrumentation , Female , Humans , Liver Circulation , Male , Melanoma/pathology , Melphalan/therapeutic use , Middle Aged , Neoplasm Metastasis , Uveal Neoplasms/pathology
15.
Emerg Radiol ; 26(3): 295-299, 2019 Jun.
Article in English | MEDLINE | ID: mdl-30684063

ABSTRACT

PURPOSE: The purpose of this study is to detail the current state of the websites of each of the currently established emergency radiology fellowship programs within the USA, in terms of publicly available information. The goal of the project is to present data for emergency radiology fellowship programs to tailor that information to attract those most interested in the pursuit of an emergency radiology fellowship position. METHODS: Emergency radiology fellowship programs were identified using the American Society of Emergency Radiology website and recent published literature. The website for each program was evaluated for the presence or absence of 23 discrete areas of information. Additionally, information from a prior study evaluating radiology resident's opinions on desired information for interventional radiology fellowship websites was utilized and compared to the information currently available on emergency radiology fellowship websites. RESULTS: Eighteen emergency radiology fellowship programs were initially identified. One program website was inaccessible at the time of data collection. Of the remaining 17 program websites, contact information, application requirements, program description, stand-alone website, length of fellowship, research opportunities, salary, and other benefits were available for greater than 75% of programs, while listing of current fellows, moonlighting opportunities, social information, and alumni information were available at fewer than 25% of program websites. CONCLUSION: There is broad variability in the type and amount of data available to potential emergency radiology fellows across the surveyed program websites. Several key areas-specifically, listings of current fellows, rotation schedules, facility descriptions, and didactic information-present high-yield opportunities for improvement of desired accessible data.


Subject(s)
Access to Information , Emergency Medicine/education , Fellowships and Scholarships , Internet , Internship and Residency , Radiology/education , Education, Medical, Graduate , Humans , Quality Improvement
16.
Rev Sci Instrum ; 89(8): 085005, 2018 Aug.
Article in English | MEDLINE | ID: mdl-30184625

ABSTRACT

Distributed optical fiber sensors are an increasingly utilized method of gathering distributed strain and temperature data. However, the large amount of data they generate presents a challenge that limits their use in real-time, in situ applications. This article describes a parallel and pipelined computing architecture that accelerates the signal-processing speed of sub-terahertz fiber sensor arrays, maintaining high spatial resolution while allowing for expanded use of real-time sensing and control applications. The computing architecture described was successfully implemented in a field programmable gate array chip. The signal processing for the entire array takes only 12 system clock cycles. In addition, this design removes the necessity of storing any raw or intermediate data.

17.
Case Rep Gastrointest Med ; 2018: 5952315, 2018.
Article in English | MEDLINE | ID: mdl-29593916

ABSTRACT

Primary pancreatic lymphoma (PPL) is of very rare occurrence as an extra nodal site of Non-Hodgkin's lymphoma (NHL). It represents less than 1% of NHL. Out of which Burkitt lymphoma of pancreas is of a rare presentation. It usually occurs in children and presenting in adults is uncommon. The prevalence of pancreatic Burkitt lymphoma is not known as the incidence is significantly low. Clinical features of PPL are predominantly nonspecific and can become difficult with associated inflammation of pancreas. Differentiation of lymphoma to adenocarcinoma is important as chemotherapy is the main stay of treatment in lymphoma. We report a case of 68-year-old female who presented with nonspecific symptoms and was found to have obstructive jaundice secondary to pancreatic head neoplasm which was proved to be pancreatic Burkitt lymphoma which is a rare presentation.

18.
Rev Sci Instrum ; 88(7): 075104, 2017 Jul.
Article in English | MEDLINE | ID: mdl-28764506

ABSTRACT

This article details the generation of an extended-bandwidth frequency sweep using a single, communication grade distributed feedback (DFB) laser. The frequency sweep is generated using a two-step technique. In the first step, injection current modulation is employed as a means of varying the output frequency of a DFB laser over a bandwidth of 99.26 GHz. A digital optical phase lock loop is used to lock the frequency sweep speed during current modulation, resulting in a linear frequency chirp. In the second step, the temperature of the DFB laser is modulated, resulting in a shifted starting laser output frequency. A laser frequency chirp is again generated beginning at this shifted starting frequency, resulting in a frequency-shifted spectrum relative to the first recorded data. This process is then repeated across a range of starting temperatures, resulting in a series of partially overlapping, frequency-shifted spectra. These spectra are then aligned using cross-correlation and combined using averaging to form a single, broadband spectrum with a total bandwidth of 510.9 GHz. In order to investigate the utility of this technique, experimental testing was performed in which the approach was used as the swept-frequency source of a coherent optical frequency domain reflectometry system. This system was used to interrogate an optical fiber containing a 20 point, 1-mm pitch length fiber Bragg grating, corresponding to a period of 100 GHz. Using this technique, both the periodicity of the grating in the frequency domain and the individual reflector elements of the structure in the time domain were resolved, demonstrating the technique's potential as a method of extending the sweeping bandwidth of semiconductor lasers for frequency-based sensing applications.

19.
Opt Lett ; 42(5): 1007-1010, 2017 Mar 01.
Article in English | MEDLINE | ID: mdl-28248353

ABSTRACT

This Letter reports a sweep velocity-locked laser pulse generator controlled using a digital phase-locked loop (DPLL) circuit. This design is used for the interrogation of sub-terahertz-range fiber structures for sensing applications that require real-time data collection with millimeter-level spatial resolution. A distributed feedback laser was employed to generate chirped laser pulses via injection current modulation. A DPLL circuit was developed to lock the optical frequency sweep velocity. A high-quality linearly chirped laser pulse with a frequency excursion of 117.69 GHz at an optical communication band was demonstrated. The system was further adopted to interrogate a continuously distributed sub-terahertz-range fiber structure (sub-THz-fs) for sensing applications. A strain test was conducted in which the sub-THz-fs showed a linear response to longitudinal strain change with predicted sensitivity. Additionally, temperature testing was conducted in which a heat source was used to generate a temperature distribution along the fiber structure to demonstrate its distributed sensing capability. A Gaussian temperature profile was measured using the described system and tracked in real time, as the heat source was moved.

20.
Rev Sci Instrum ; 86(6): 065004, 2015 Jun.
Article in English | MEDLINE | ID: mdl-26133865

ABSTRACT

This letter reports a multiplexed optical displacement sensor using a thin core fiber (TCF) exciter. The TCF exciter is followed by a stripped single mode optical fiber. A small section of buffer is used as the movable component along the single mode fiber. Ultra-weak cladding mode reflection (< - 75 dB) was employed to probe the refractive index discontinuity between the air and buffer coating boundary. The position change of the movable buffer segment results in a delay change of the cladding mode reflection. Thus, it is a measure of the displacement of the buffer segment with respect to the glass fiber. The insertion loss of one sensor was measured to be less than 3 dB. A linear relationship was evaluated between the measurement position and absolute position of the moving actuator. Multiplexed capability was demonstrated and no cross talk was found between the sensors.


Subject(s)
Fiber Optic Technology/instrumentation , Equipment Design , Equipment Failure Analysis , Linear Models , Optical Fibers
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