ABSTRACT
The synthesis of new furo-salicylanilides and their heterocyclic derivatives is described. Twenty-three compounds were screened for their molluscicidal activity against Biomphalaria alexandrina snails, the intermediate host of Schistosoma mansoni. Five of the tested compounds showed no activity, while eighteen compounds showed strong to moderate activity using bayluscide as a reference.
Subject(s)
Furans/chemical synthesis , Molluscacides/chemical synthesis , Molluscacides/toxicity , Salicylanilides/chemical synthesis , Animals , Biomphalaria/drug effects , Biomphalaria/growth & development , Dose-Response Relationship, Drug , Furans/toxicity , Molecular Structure , Niclosamide/standards , Niclosamide/toxicity , Salicylanilides/toxicity , Schistosoma mansoni/drug effects , Schistosoma mansoni/growth & development , Solubility , Structure-Activity Relationship , Toxicity Tests/methodsABSTRACT
New derivatives related to floctafenine were synthesized and representative examples were screened for their anti-inflammatory and analgesic activities. All compounds tested were found to exhibit anti-inflammatory and analgesic activities and some were more potent than the references, floctafenine and indomethacin, in carragenan-induced rat's paw edema. None of the tested compounds showed an ulcerogenic effect on the p-benzoquinone-induced writhing test in mice.