1.
Bioorg Med Chem Lett
; 11(7): 879-82, 2001 Apr 09.
Article
in English
| MEDLINE
| ID: mdl-11294382
ABSTRACT
A series of 1-phenylpyrazoles was evaluated for inhibitory activity against xanthine oxidase in vitro. Of the compounds prepared, 1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid (Y-700) had the most potent enzyme inhibition and displayed longer-lasting hypouricemic action than did allopurinol in a rat model of hyperuricemia induced by the uricase inhibitor potassium oxonate.
