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1.
Vopr Onkol ; 34(8): 960-6, 1988.
Article in Russian | MEDLINE | ID: mdl-3420839

ABSTRACT

A microbiological model of two-stage experimental carcinogenesis is described. Induction of tumor-like growth in mycelial fungus Fusarium bulbigenum var. blasticola culture was shown to include: (1) initiation by carcinogenic mutagens and (2) promotion or reversible morpho-energy transformation of the cell.


Subject(s)
Fusarium/growth & development , Neoplasms, Experimental/etiology , Animals , Carcinogens/pharmacology , Cell Division/drug effects , Cell Transformation, Neoplastic/chemically induced , Energy Metabolism/drug effects , Fusarium/cytology , Fusarium/drug effects , Mutation , Mycology/methods , Phenotype , Precancerous Conditions/etiology , Time Factors
2.
Eksp Onkol ; 8(4): 68-70, 1986.
Article in Russian | MEDLINE | ID: mdl-3093186

ABSTRACT

The action of drugs of plant origin and of alkylating compounds (sarcolysine, prospidin) was accompanied by hormonal changes in rats with inoculated Pliss' lymphosarcoma. After the use of polyphenol plant drugs the secretion of pituitary FSH was inhibited, the blood concentration of testosterone was reduced and the cortisol secretion was substantially increased. The alkylating compounds stimulated the production of FSH, increased the secretion of testosterone, and clearly lowered the cortisol level.


Subject(s)
Antineoplastic Agents, Phytogenic/pharmacology , Flavonoids , Lymphoma, Non-Hodgkin/drug therapy , Phenols/pharmacology , Polymers/pharmacology , Animals , Follicle Stimulating Hormone/metabolism , Hydrocortisone/blood , Mice , Pituitary Gland/metabolism , Polyphenols , Rats , Testosterone/blood
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