Subject(s)
1-Naphthylamine/analogs & derivatives , Antidepressive Agents/therapeutic use , Delusions/drug therapy , Dermatitis/psychology , Ectoparasitic Infestations/psychology , Selective Serotonin Reuptake Inhibitors/therapeutic use , Self-Injurious Behavior/drug therapy , 1-Naphthylamine/therapeutic use , Dermatitis/drug therapy , Ectoparasitic Infestations/drug therapy , Humans , SertralineSubject(s)
1-Naphthylamine/analogs & derivatives , Antidepressive Agents/therapeutic use , Mental Disorders/complications , Selective Serotonin Reuptake Inhibitors/therapeutic use , Skin Diseases/drug therapy , Skin Diseases/psychology , 1-Naphthylamine/therapeutic use , Adult , Depressive Disorder/complications , Female , Humans , Male , Obsessive-Compulsive Disorder/complications , SertralineABSTRACT
We studied the effect of different time intervals between antibiotic administration and tourniquet inflation in 62 patients undergoing reconstructive surgery in the lower extremities. The in vivo concentrations in soft tissue and bone of 3 cephalosporins (ceftazidime, ceftriaxone and ceforanide) were determined. Our findings suggest that the highest tissue concentrations were achieved by administration 20 min before tourniquet inflation.
Subject(s)
Cephalosporins/administration & dosage , Cephalosporins/pharmacokinetics , Tourniquets , Adipose Tissue/metabolism , Adult , Aged , Bone and Bones/metabolism , Cefamandole/administration & dosage , Cefamandole/analogs & derivatives , Cefamandole/pharmacokinetics , Ceftazidime/administration & dosage , Ceftazidime/pharmacokinetics , Ceftriaxone/administration & dosage , Ceftriaxone/pharmacokinetics , Female , Humans , Knee Prosthesis , Male , Middle Aged , Muscle, Skeletal/metabolism , Prospective Studies , Skin/metabolism , Time Factors , Tissue DistributionABSTRACT
Prophylactic antibiotic administration for selected major orthopaedic procedures is feasible with wide-spectrum antibiotics that can achieve high tissue levels. We studied the influence of tourniquet on the in vivo concentrations of ceftazidime and ceftriaxone in soft tissue and bone. Our study group consisted of 47 patients undergoing reconstructive operations of lower extremities. The effect of different time intervals between antibiotic administration and tourniquet inflation was examined. Our data suggest that the time interval resulting in the highest tissue concentrations is approximately 20 min between administration and tourniquet inflation.
Subject(s)
Ceftazidime/pharmacokinetics , Ceftriaxone/pharmacokinetics , Knee Prosthesis , Premedication , Surgical Wound Infection/prevention & control , Tibia/surgery , Tourniquets , Aged , Ceftazidime/administration & dosage , Ceftriaxone/administration & dosage , Dose-Response Relationship, Drug , Female , Humans , Male , Metabolic Clearance Rate/physiology , Middle Aged , Surgical Wound Infection/blood , Tibia/metabolism , Tissue DistributionABSTRACT
Fifty patients with warts were treated with cryotherapy and given a 100-item questionnaire, The Tennessee Self-Concept Scale, to complete. Responses from 42 patients on whom follow-up data were available were subjected to computer analysis. The answers to eight of the questions differed significantly between treatment cures (23) and treatment failures (19). Further analysis of two of the eight questions showed that it may be possible to use them to predict cryosurgical treatment success or failure in up to 100% of cases.