Effectiveness of Lactoferrin in the Treatment of Anemia in Chronic Kidney Disease: A Single-Center Pilot Study.

Background: Anemia occurs in majority of patients with chronic kidney disease despite adequate dialysis and iron replete status. This study was done to evaluate the effects of lactoferrin with or without iron supplementation for the treatment of anemia in patients with chronic kidney disease (CKD). Materials and Methods: In this prospective, observational, single-center, single-arm pilot study, adult patients aged >18 years, having stage 5 CKD (estimated glomerular filtration rate [eGFR] <15 ml/min/1.73 m2), and who had anemia (hemoglobin [Hb] <10 g/dl; transferrin saturation [Tsat] >20%) were included. Patients were treated with 100 mg of oral lactoferrin twice a day for one month with or without iron supplementation. Patients had been on stable erythropoietin doses for ≥1 month prior to inclusion in the study. We report on the improvement in Hb levels and effect on inflammatory markers from baseline at four weeks. Results: A total of 46 CKD patients having anemia were included. Patients had a mean age of 39.3 years, and a majority were men (69.6%). Improvement in the mean (SD) Hb level (g/dl) was observed from baseline (8.18 [1.19]) to Week 2 (8.54 [1.57]), which attained significance at Week 4 (8.96 [1.93]; P < 0.001; mean difference: -0.76; 95% confidence interval [CI]: -1.291 to - 0.2383). The improvement in Hb was higher in women than in men (P = 0.48) and in patients receiving lactoferrin with iron supplementation than in those receiving lactoferrin alone (P = 0.14). There was a non-significant decrease in the erythrocyte sedimentation rate (P = 0.14) and a non-significant increase in C-reactive protein (P = 0.54) level. Conclusion: Oral lactoferrin therapy was effective in improving hemoglobin levels in patients with advanced CKD and anemia. The effects of lactoferrin therapy on inflammatory markers remain uncertain.

The influence of contextual factors on the subjective value of control.

The propensity to perceive and exert control in our environment contributes to both our adaptive behavior and general well-being. Prior studies have shown that humans have an inherent behavioral bias toward control-conferring environments and that this bias translates into greater subjective affect and is protective of our well-being. As such, it is vital to understand contextual factors that can alter our preference for control. In our previous work, we demonstrated that the behavioral bias toward control can be captured experimentally as the subjective value of control using a novel Value of Control task. We adapted this task in two experiments to study whether one's subjective value of control is (a) tied to overestimation of success probability or outcome magnitude (Experiment 1) and (b) affected by the contextual valence of a decision (e.g., gain, loss; Experiment 2). Using a within-subjects design (Experiment 1), we found that participants showed similar behavioral bias toward control regardless of whether probability or magnitude was manipulated, suggesting that the perception of control can increase both how much a reward is subjectively worth and the probability estimation for obtaining the given reward. Using a between-subjects design (Experiment 2), we showed that when the outcome was framed as a potential loss, participants significantly lowered their subjective value of control, suggesting that outcome valence plays a role in shaping how much perceived control influences our behavior. Collectively, these findings offer further insight into the malleability of an individual's perception of control and drive to perform control-seeking behaviors. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Laparoscopic ureteroneocystostomy with psoas hitch.

BACKGROUND AND PURPOSE: Laparoscopic extravesical ureteroneocystostomy is an infrequently described technique. Our aim is to describe five cases where we used the intracorporeal freehand suturing technique successfully for performing laparoscopic extravesical transperitoneal ureteral reimplantation with psoas hitch. We describe the preliminary results of these cases. PATIENTS AND METHODS: We performed this surgery in five female patients. Two patients had a low ureterovaginal fistula after total laparoscopic hysterectomy. The other three patients had undergone laparoscopic radical hysterectomy. RESULTS: The average surgical time was 220 minutes. The average blood loss was 150 mL. The average stay was 3 days, and the average time to starting oral intake was 12 hours. No intraoperative or postoperative complications occurred. The urinary catheter was removed after 3 weeks and the double j stent after 6 weeks. Follow-up urography showed good clearance of the kidney and ureter. There was no reflux on the postoperative cystogram. CONCLUSION: Laparoscopic extravesical ureteroneocystostomy with intracorporeal freehand suturing technique and psoas hitch is a feasible procedure in females for managing ureterovaginal fistulas after laparoscopic gynecologic surgeries. The patients need not be subjected to open surgery because this complication can be repaired laparoscopically, thus minimizing the morbidity.