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Sci Rep ; 14(1): 11120, 2024 05 15.
Article in English | MEDLINE | ID: mdl-38750131

ABSTRACT

Very High Energy Electron (VHEE) beams are a promising alternative to conventional radiotherapy due to their highly penetrating nature and their applicability as a modality for FLASH (ultra-high dose-rate) radiotherapy. The dose distributions due to VHEE need to be optimised; one option is through the use of quadrupole magnets to focus the beam, reducing the dose to healthy tissue and allowing for targeted dose delivery at conventional or FLASH dose-rates. This paper presents an in depth exploration of the focusing achievable at the current CLEAR (CERN Linear Electron Accelerator for Research) facility, for beam energies >200 MeV. A shorter, more optimal quadrupole setup was also investigated using the TOPAS code in Monte Carlo simulations, with dimensions and beam parameters more appropriate to a clinical situation. This work provides insight into how a focused VHEE radiotherapy beam delivery system might be achieved.


Subject(s)
Electrons , Monte Carlo Method , Radiotherapy Dosage , Humans , Particle Accelerators/instrumentation , Radiotherapy Planning, Computer-Assisted/methods , Radiotherapy/methods , Radiotherapy, High-Energy/methods , Radiotherapy, High-Energy/instrumentation
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