ABSTRACT
INTRODUCTION: The aim of this study was to evaluate the association of breast cancer with thyroid diseases. Many authors have already studied the possible relationship between these two diseases, but the results are nowadays conflicting. MATERIALS AND METHODS: Our study examining 867 patients with breast cancer (862 women and 5 men, average age = 61 years old) of whom 141 also had thyroid disease evaluated the recurrence of thyroid diseases and their association with different types of breast cancer. Statistical analyses were performed using SPSS software for Windows; we used nonparametric tests (Chi-square and Mann-Whitney), and the level of significance was set at p < 0.05. RESULTS: We found a significant association between breast cancer diagnosed after menopause and thyroid disease (p < 0.003). Moreover, we analyzed the role of thyroid autoimmunity identifying an association between chronic autoimmune thyroiditis and breast cancer diagnosed before menopause (p < 0.05). Regarding receptor profile of breast carcinoma, we have found an increased expression of estrogen receptors in patients with autoimmune thyroiditis compared to patients with any other thyroid diseases (p < 0.03). Contrariwise, we do not have found any difference between the group with every thyroid disease and the group without thyroid disease (p < 1.00). We did not find other statistically significant associations with breast cancer's parameters like family history, tumor size, lymph node metastasis, distant metastasis, cancer clinical and pathological stage, differentiation grade and expression of Ki67, p53 and Her2 in the two main groups with or without thyroid disease. Likewise, we did not found other statistically significant association between hypothyroidism or hyperthyroidism and breast cancer.
Subject(s)
Breast Neoplasms/etiology , Carcinoma, Ductal, Breast/etiology , Carcinoma, Lobular/etiology , Thyroid Diseases/complications , Biomarkers, Tumor/metabolism , Breast Neoplasms/metabolism , Breast Neoplasms/pathology , Carcinoma, Ductal, Breast/metabolism , Carcinoma, Ductal, Breast/secondary , Carcinoma, Lobular/metabolism , Carcinoma, Lobular/secondary , Female , Follow-Up Studies , Humans , Lymphatic Metastasis , Male , Middle Aged , Neoplasm Grading , Prognosis , Receptors, Estrogen/metabolism , Receptors, Progesterone/metabolismABSTRACT
Monoclonal immunoglobulin deposition diseases are due to pathological protein deposition in various tissues and organs. Protein deposits may be found in a single tissue or systemically and the organs most frequently involved are kidney, heart, peripheral nerves and the liver. Depending on the pattern of the deposits and the type of immunoglobulin, these diseases are distinguished as primary amyloidosis, light chain deposition disease. Differential diagnosis is made in tissue specimens: microscopically by the identification of positive Congo red staining of the deposits, by immunohistochemical demonstration of proteins reacting with light chain (lambda or kappa) antisera or by recognition of fibrillar structures on electron microscopy. We report an unusual case of light chain deposition disease associated with amyloidosis, where hepatomegaly was the presenting manifestation and liver failure the cause of death, without any kidney involvement.
Subject(s)
Amyloidosis/complications , Hypergammaglobulinemia/complications , Immunoglobulin Light Chains , Liver Diseases/complications , Amyloidosis/diagnosis , Disease Progression , Fatal Outcome , Hepatomegaly/diagnosis , Hepatomegaly/etiology , Humans , Hypergammaglobulinemia/diagnosis , Liver/ultrastructure , Liver Diseases/diagnosis , Liver Failure, Acute/diagnosis , Liver Failure, Acute/etiology , Male , Microscopy, Electron , Middle AgedABSTRACT
The efficacy of cosmetic products and active substances have been investigated on human keratinocytes cell line on a pool of tests. The work aimed to study the possible modifications of the biological parameters tested (cytotoxicity and cytoskeleton morphology) related to the cellular adhesion function. The results have permitted to define different activities, for the different products, compared to the untreated culture and to their placebo.
Subject(s)
Cosmetics/toxicity , Keratinocytes/drug effects , Cell Survival/drug effects , Cells, Cultured , Culture Media, Serum-Free , Cytoskeleton/drug effects , HumansABSTRACT
Synopsis The aim of this work was to check if the specific microstructure of a water/oil nonionic microemulsion could induce a modification of the bioavailability of a probe (methyl nicotinate). The vasodilatory drug effects were recorded by laser doppler velocimetry in vivo, in man. The results show a quicker activity, and a better release of the drug in the microemulsion, than in the well-known kinetics of an aqueous solution.
