ABSTRACT
We describe a child with cystic fibrosis who was treated with high-dose pancreatic enzyme replacement therapy and who had a prominent ascending colon stricture with submucosal fibrosis. Unlike prior reported cases, this patient's disease was more extensive, involving the entire colon, and was associated with chylous ascites.
Subject(s)
Colon/pathology , Colonic Diseases/etiology , Cystic Fibrosis/complications , Intestinal Obstruction/etiology , Lipase/adverse effects , Pancreatic Extracts/adverse effects , Child, Preschool , Chronic Disease , Chylous Ascites/etiology , Cystic Fibrosis/drug therapy , Diarrhea/etiology , Fibrosis/etiology , Humans , Lipase/administration & dosage , Male , Pancreatic Extracts/administration & dosage , PancrelipaseABSTRACT
We compared the frequency of ovarian microcysts in girls with premature thelarche (n = 27) to that in age-matched control subjects (n = 24). There was an increased prevalence of detectable ovarian microcysts in girls with premature thelarche. The presence or absence of cysts did not correlate with basal gonadotropin or estradiol levels.
Subject(s)
Breast/growth & development , Ovarian Cysts/diagnostic imaging , Puberty, Precocious/complications , Child, Preschool , Estradiol/blood , Female , Follicle Stimulating Hormone/blood , Humans , Incidence , Infant , Luteinizing Hormone/blood , Ovarian Cysts/complications , Puberty, Precocious/blood , UltrasonographyABSTRACT
A distinctive form of necrotizing enterocolitis was observed in seven newborn infants in a 4 1/2-year period. Characteristically these patients had gross blood in the stools, but other local and systemic signs were mild or absent. Radiography mainly revealed submucosal intramural intestinal gas which was limited to the colon (pneumatosis coli). There was no evidence of small bowel involvement as judged by the absence of small intestinal pneumatosis or distension. This form of colonic disease should be recognized as a benign variety of neonatal necrotizing enterocolitis that carries a favorable prognosis and responds to medical management without sequelae.