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Biol Neonate ; 33(1-2): 62-5, 1978.
Article in English | MEDLINE | ID: mdl-656522

ABSTRACT

Malnourished rat pups were supplemented with orotic acid. RNA-synthesizing activity of isolated brain cell nuclei and microsomal protein synthesis was measured in vitro. A marked increase was found in the activity of nuclear RNA synthesis but not in microsomal protein synthesis after orotic acid treatment for 7 days.


Subject(s)
Brain/cytology , Cell Nucleus/metabolism , Microsomes/metabolism , Nerve Tissue Proteins/biosynthesis , Nutrition Disorders/drug therapy , Orotic Acid/therapeutic use , RNA/biosynthesis , Animals , Animals, Newborn , Brain/metabolism , Female , Pregnancy , Rats
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