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The low O2 activation ability at low temperatures and SO2 poisoning are challenges for metal oxide catalysts in the application of Hg0 removal in flue gas. A novel high-entropy fluorite oxide (MgAlMnCo)CeO2 (Co-HEO) with the second phase of spinel is synthesized by the microwave hydrothermal method for the first time. A high efficiency of Hg0 removal (close to 100%) is achieved by Co-HEO catalytic oxidation at temperatures as low as 100 °C and in the atmosphere of 145 µg m-3 Hg0 at a high GHSV (gas hourly space velocity) of 95,000 h-1. According to O2-TPD and in situ FT-IR, this extremely superior catalytic oxidation performance at low temperatures originates from the activation ability of Co-HEO to transform O2 into superoxide and peroxide, which is promoted by point defects induced from the spinel/fluorite heterointerfaces. Meanwhile, SO2 resistance of Co-HEO for Hg0 removal is also improved up to 2000 ppm due to the high-entropy-stabilized structure, construction of heterointerfaces, and synergistic effect of the multicomponents for inhibiting the oxidation of SO2 to surface sulfate. The design strategy of the dual-phase high-entropy material launches a new route for metal oxides in the application of catalytic oxidation and SO2 resistance.
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OBJECTIVE: To investigate the effects of acupoint catgut embedding for 3 weeks on lung tissue, blood immunoglobulin E (IgE) and interleutin-4 (IL-4), brain tissue microglia x-42 (OX-42) and toll-like receptor-2 (TLR-2) in rats with allergic rhinitis of lung deficiency type. METHODS: Forty-five female Sprague-Dawley rats were randomly divided for two times. The first time, they were randomly divided into model group and blank group (Group C) according to 2:1, and the second time, the model group were randomly divided into model control group (Group B) and intervention treatment group (Group A) according to 1:1. 15 in each group. For Group A and Group B, the lung deficiency model was made by "sulfur-moxa fumigation", and then the allergic rhinitis model was established by "ovalbumin (OVA) sensitization". Then catgut embedding was performed at acupoints in Group A and not in Group B. After 3 weeks, collect lung tissue samples for hematoxylin-eosin staining, then take blood to observe the concentration of IgE and IL-4, and finally take brain tissue to observe the results of OX-42 and TLR-2. RESULTS: IgE level (µg/mL) was (3.11 ± 0.20) in the Group A, (4.19 ± 0.44) in the Group B, and (2.29 ± 0.30) in the Group C (all < 0.001). IL-4 level (pg/mL) was (14.2 ± 0.7) in the Group A, (18.6 ± 2.4) in the Group B, and (11.4 ± 1.2) for the Group C (all < 0.001). The mean OD for OX-42 is (0.1728 ± 0.0016) in the Group A, (0.1810 ± 0.0046) in the Group B and (0.1674 ± 0.0025) in the Group C (all < 0.001). CONCLUSION: Although 3 weeks of acupoint catgut embedding already showed obvious efficacy on rats with allergic rhinitis, the allergic reaction in the body still continued. To achieve further treatment, prolonging the catgut embedding time is necessary.
Subject(s)
Rhinitis, Allergic , Toll-Like Receptor 2 , Female , Rats , Animals , Rats, Sprague-Dawley , Catgut , Interleukin-4 , Rhinitis, Allergic/therapy , Brain , Immunoglobulin E , LungABSTRACT
Due to the complex composition and similar structure, the extraction denitrification of aromatic rich oil is faced with the contradiction problem of denitrification efficiency and aromatic loss which cannot be efficiently solved by experiments. However, the complex interactions involved can be analyzed from the perspective of calculation, and the prediction criteria and methods are proposed. Based on rigorous density functional theory calculation data, Simple models based on electrostatic potential (ESP) and Van der Waals potential (VdWP)-based calculations were established and validated. The twofold model provided the best prediction for interactions between extractants and nitrogen compounds and between extractants and aromatics, which determines denitrification efficiency and aromatic loss, respectively, due to the most complete description of both electrostatic and VdW force. This provides a powerful tool for evaluating the non-covalent interactions and thence tuning the efficiency of the separation process. Thus, high denitrification efficiency (43.2~66.3 %) and moderate aromatic loss (1.7~4.4 %) were obtained using screened deep eutectic solvents (DESs). This ideal observation provided the potential for mild hydrodesulfurization and manufacture of high-grade carbon materials.
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Nuclear factor I B (NFIB) plays an important role in tumors. Our previous study found that NFIB can promote colorectal cancer (CRC) cell proliferation in acidic environments. However, its biological functions and the underlying mechanism in CRC are incompletely understood. Nicotinamide adenine dinucleotide (NAD+) effectively affects cancer cell proliferation. Nevertheless, the regulatory mechanism of NAD+ synthesis in cancer remains to be elucidated. Here we show NFIB promotes CRC proliferation in vitro and growth in vivo, and down-regulation of NFIB can reduce the level of NAD+. In addition, supplementation of NAD+ precursor NMN can recapture cell proliferation in CRC cells with NFIB knockdown. Mechanistically, we identified that NFIB promotes CRC cell proliferation by inhibiting miRNA-182-5p targeting and binding to NAMPT, the NAD+ salvage synthetic rate-limiting enzyme. Our results delineate a combination of high expression of NFIB and NAMPT predicted a clinical poorest prognosis. This work provides potential therapeutic targets for CRC treatment.
Subject(s)
Colorectal Neoplasms , MicroRNAs , Humans , NFI Transcription Factors/genetics , Down-Regulation , NAD/metabolism , MicroRNAs/genetics , MicroRNAs/metabolism , Colorectal Neoplasms/genetics , Colorectal Neoplasms/metabolismABSTRACT
Transition metal sulfides have exhibited remarkable advantages in gaseous elemental mercury (Hg0) capture under high SO2 atmosphere, whereas the weak thermal stability significantly inhibits their practical application. Herein, a novel N,N-dimethylformamide (DMF) insertion strategy via crystal growth engineering was developed to successfully enhance the Hg0 capture ability of MoS2 at an elevated temperature for the first time. The DMF-inserted MoS2 possesses an edge-enriched structure and an expanded interlayer spacing (9.8 Å) and can maintain structural stability at a temperature as high as 272 °C. The saturated Hg0 adsorption capacities of the DMF-inserted MoS2 were measured to be 46.91 mg·g-1 at 80 °C and 27.40 mg·g-1 at 160 °C under high SO2 atmosphere. The inserted DMF molecules chemically bond with MoS2, which prevents possible structural collapse at a high temperature. The strong interaction of DMF with MoS2 nanosheets facilitates the growth of abundant defects and edge sites and enhances the formation of Mo5+/Mo6+ and S22- species, thereby improving the Hg0 capture activity at a wide temperature range. Particularly, Mo atoms on the (100) plane represent the strongest active sites for Hg0 oxidation and adsorption. The molecule insertion strategy developed in this work provides new insights into the engineering of advanced environmental materials.
Subject(s)
Mercury , Molybdenum , Disulfides , SulfidesABSTRACT
With the rapid development of industrial society and humankind's prosperity, the growing demands of global energy, mainly based on the combustion of hydrocarbon fossil fuels, has become one of the most severe challenges all over the world. It is estimated that fossil fuel consumption continues to grow with an annual increase rate of 1.3%, which has seriously affected the natural environment through the emission of greenhouse gases, most notably carbon dioxide (CO2). Given these recognized environmental concerns, it is imperative to develop clean technologies for converting captured CO2 to high-valued chemicals, one of which is value-added hydrocarbons. In this article, environmental effects due to CO2 emission are discussed and various routes for CO2 hydrogenation to hydrocarbons including light olefins, fuel oils (gasoline and jet fuel), and aromatics are comprehensively elaborated. Our emphasis is on catalyst development. In addition, we present an outlook that summarizes the research challenges and opportunities associated with the hydrogenation of CO2 to hydrocarbon products.
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Copper sulfide (CuS) has received increasing attention as a promising material in gaseous elemental mercury (Hg0) capture, yet how to enhance its activity at elevated temperature remains a great challenge for practical application. Herein, simultaneous improvement in the activity and thermal stability of CuS toward Hg0 capture was successfully achieved for the first time by controlling the crystal growth. CuS with a moderate crystallinity degree of 68.8% showed a disordered structure yet high thermal stability up to 180 °C. Such disordered CuS can maintain its Hg0 capture activity stable during longtime test at a wide temperature range from 60 to 180 °C and displayed strong resistance to SO2 (6%) and H2O (8%). The significant improvement can be attributed to the synergistic effect of a moderately crystalline nature and a unique sulfur-rich interface. Moderate crystallinity guarantees the thermal stability of CuS and the presence of abundant defects, in which copper vacancy enhances significantly the Hg0 capture activity. The sulfur-rich interface enables CuS to provide plentiful highly active Sx2- sites for Hg0 adsorption. The interrelation between structure, reactivity, and thermal stability clarified in this work broadens the understanding toward Hg0 oxidation and adsorption over CuS and provides new insights into the rational design and engineering of advanced environmental materials.
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The morphological characteristics of Cd, Cr, Cu, Ni, Pb, and Zn in sediments were analyzed using an improved BCR extraction method in four water types of Baiyangdian Lake:watercourse, trench, lake surface, and fish pond. The potential ecological risk index, secondary and primary phases, and risk assessment codes were used to systematically assess the pollution level and ecological risk of heavy metals in surface sediments. The results showed that:â the mean contents of heavy metals Cd, Cu, and Zn in the sediments were 0.37, 28.49, and 83.08 mg·kg-1, respectively, 94.91%, 73.91%, and 46.39% of which exceeded the soil background value. â¡ Cd was dominated by the non-residual fraction (F1+F2+F3) with a fraction ranging from 54% to 97%, whereas Cr was dominated by the residual fraction (F4) with a mass fraction ranging from 87% to 99%. Cu, Ni, Pb, and Zn were mainly in the fraction of residual fraction. In the non-residual fraction, Cu and Ni were mainly in the oxidizable fraction (F3) state, whereas Pb and Zn were mainly in the reducible fraction (F2) state. ⢠The RAC risk assessment results showed that there were 68.97%, 39.89%, 54.84%, and 49.78% points in channel, trench, open water, and fish pond samples, respectively, of Cd at high risk. The Cu, Ni, and Pb were at low risk. In general, the overall heavy metal pollution level in Baiyangdian Lake was low, but Cd had ecological risk and high bioavailability in the Fuhe River of the Nanliuzhuang area and the Baigouyin River.
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Metals, Heavy , Water Pollutants, Chemical , Cadmium , Environmental Monitoring , Geologic Sediments , Lakes , Lead , Metals, Heavy/analysis , Water , Water Pollutants, Chemical/analysisABSTRACT
The presence of SO2 display significant effect on the mercury (Hg) adsorption ability of carbon-based sorbent. Yet the adsorption and oxidation of SO2 on carbon with oxygen group, as well as the roles of different sulfur oxide groups in Hg adsorption have heretofore been unclear. The formation of sulfur oxide groups by SO2 and their effects on Hg adsorption on carbon was detailed examined by the density functional theory. The results show that SO2 can be oxidized into SO3 by oxygen group on carbon surface. Both C-SO2 and C-SO3 can improve Hg adsorption on carbon site, while the promotive effect of C-SO2 is stronger than C-SO3. Electron density difference analyses reveal that sulfur oxide groups enhance the charge transfer ability of surface unsaturated carbon atom, thereby improving Hg adsorption. The experimental results confirm that surface active groups formed by SO2 adsorption is more active for Hg adsorption than the groups generated by SO3.
Subject(s)
Mercury , Adsorption , Carbon , Oxygen , Sulfur OxidesABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the COVID-19 pandemic, is rapidly evolving. Due to the limited efficacy of vaccination in prevention of SARS-CoV-2 transmission and continuous emergence of variants of concern (VOC), including the currently most prevalent Delta variant, orally bioavailable and broadly efficacious antiviral drugs are urgently needed. Previously we showed that adenosine analogue 69-0 (also known as GS-441524), possesses potent anti-SARS-CoV-2 activity. Herein, we report that esterification of the 5-hydroxyl moieties of 69-0 markedly improved the antiviral potency. The 5-hydroxyl-isobutyryl prodrug, ATV006, showed excellent oral bioavailability in rats and cynomolgus monkeys and potent antiviral efficacy against different VOCs of SARS-CoV-2 in cell culture and three mouse models. Oral administration of ATV006 significantly reduced viral loads, alleviated lung damage and rescued mice from death in the K18-hACE2 mouse model challenged with the Delta variant. Moreover, ATV006 showed broad antiviral efficacy against different mammal-infecting coronaviruses. These indicate that ATV006 represents a promising oral drug candidate against SARS-CoV-2 VOCs and other coronaviruses.
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Harmful algal blooms (HABs) is a worldwide water environmental problem. HABs usually happens in short time and is difficult to be controlled. Early warning of HABs using data-driven models is prospective in making time for taking precaution against HABs. High-frequency water quality monitoring data are necessary to improve the reliability of the model, but it is expensive. This research used environmental fluid dynamics code (EFDC) to extend one-point data obtained by only one instrument to the whole 249 ha water area instead of multi-instruments monitoring, followed by Long short-term memory (LSTM) to predict the HABs in the whole water body. Correlation analysis and principal component analysis were used to reduce the data dimension and improve model accuracy. Finally, the LSTM model was calibrated to predict chlorophyll-a (Chl-a) for the next 1 to 3 time steps. The Nash-Sutcliffe efficiency coefficient (NSE) and mean absolute percentage error (MAPE) of EFDC-LSTM were 0.797-0.991 and 2.74-13.16%, respectively, suggesting the promising utilization of this model in early warning systems for HABs. EFDC-LSTM achieves high-precision HABs forecasting in a cost-effective manner, providing a reliable way to detect HABs in advance.
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Harmful Algal Bloom , Hydrodynamics , Prospective Studies , Reproducibility of Results , Water QualityABSTRACT
Constructed wetlands (CWs) have been introduced to and developed in China for environmental engineering over the most prosperous three decades (1990-2020). To study the origin, development process, and future trend of CWs, this review summarized a wide range of literatures between 1990 and 2020 by Chinese authors. Firstly, the publication number over years, research highlights, and the author contributions with the most published papers in this field were conducted through bibliometric analysis. Secondly, the most principal components of CWs, substrates and macrophytes were summarized and analyzed. Thirdly, the typical application cases from traditional CWs, pond systems to combined pond-wetland systems were presented. In China, CWs were predominately distributed in the east of the so-called 'Hu Huanyong Line'. Therefore CWs were limited by the socio-economic level and climatic conditions. It is unquestionable that the overall level of China's CWs has improved significantly, and one of the most prominent features has started towards the plural pattern development. There has been a trend of large-scale or low-cost CW application in the recent years. However, lifecycle research and management are required for better strategies in the future.
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Waste Disposal, Fluid , Wetlands , China , Wastewater/analysisABSTRACT
In this study, a novel Co9S8 nanoparticles-embedded porous carbon (Co9S8-PC) was designed as an effective reusable sorbent for Hg0 capture from smelting flue gas. Some flue gas components can create more active sites on Co9S8-PC for Hg0 adsorption, but compete with Hg0 for the same sulfur sites over nano Co1-xS/Co3S4 (CoS) and Co1-xS/Co3S4 embedded porous carbon (CoS-PC), which can be ascribed to the difference in crystal structure between Co9S8 and Co1-xS/Co3S4. Therefore, Co9S8-PC shows much better Hg0 capture ability than CoS and CoS-PC under smelting flue gas. O2, SO2 and HCl improve Hg0 adsorption on Co9S8-PC mainly through creating Co3+ site, but H2O has neglectable effect on Hg0 capture. Co9S8-PC shows a remarkably large Hg0 adsorption capacity of 43.18 mg/g, which is greatly higher than the representative metal sulfides for Hg0 removal from smelting flue gas. During Hg0 adsorption, Co3+ is the primary site to directly interact with Hg0, and the adsorbed mercury exists as HgS. Co9S8-PC exhibits an excellent recyclability for capturing Hg0, which is mainly assigned to the replenishment of consumed Co3+ site by O2, SO2 and HCl. Therefore, Co9S8 nanoparticles-embedded porous carbon is an efficient, sustainable and highly recyclable sorbent for Hg0 recovery from smelting flue gas.
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Opioids, such as morphine, are clinic analgesics which induce euphoria. Morphine exposure modifies the excitability and functional interactions between neurons, while the underlying cellular and molecular mechanisms, especially how morphine assembles heterogeneous interneurons (INs) in prelimbic cortex (PrL) to mediate disinhibition and reward, are not clear. Using approaches of optogenetics, electrophysiology, and cell type-specific RNA-seq, we show that morphine attenuates the inhibitory synaptic transmission from parvalbumin+ (PV)-INs onto pyramidal neurons in PrL via µ-opioid receptor (MOR) in PV-INs. Meanwhile, morphine enhances the inhibitory inputs from somatostatin+ (SST)-INs onto PV-INs, and thus disinhibits pyramidal neurons via δ-opioid receptor (DOR)-dependent Rac1 upregulation in SST-INs. We show that MOR in PV-INs is required for morphine-induced behavioral sensitization, while DOR as well as Rac1 activity in SST-INs is required for morphine-induced conditioned place preference and hyper-locomotion. These results reveal that SST- and PV-INs, functioning in PrL as a disinhibitory architecture, are coordinated by morphine via different opioid receptors to disinhibit pyramidal neurons and enhance reward.
Subject(s)
Interneurons , Morphine , Morphine/pharmacology , Parvalbumins , Pyramidal Cells , RewardABSTRACT
The adsorption and diffusion characteristics of coal are important parameters for coalbed methane (CBM) extraction and mine gas control. However, the adsorption test can only obtain the apparent adsorption amount, and it cannot obtain the actual adsorption amount, which leads to a large error during the calculation of the coal diffusion coefficient. Taking the anthracite coal in the Jiulishan Mine as the research object, the micro-nanostructure and instantaneous apparent methane adsorption isotherms of the primary structure coal and tectonic coal were determined by low-temperature CO2 adsorption, mercury intrusion and methane diffusion kinetics tests, and the instantaneous apparent adsorption isotherms of methane were corrected to the instantaneous actual adsorption isotherm by the Langmuir model. The results demonstrate that the micro-nanopore, Density Function Theory (DFT) pore volume and specific surface area values below 1-2 nm in tectonic coal are larger than those in the primary structure coal, which is the fundamental reason why the ultimate adsorption capacity of tectonic coal is larger than that of the primary structure coal. The apparent adsorption amounts of the tectonic coal and the primary structure coal reach the maximum at 8 MPa and 10 MPa, respectively. Thereafter, the instantaneous isotherms of the apparent adsorption amount decrease with increasing of gas pressure. However, the instantaneous isotherms of the actual adsorption amount tend to be stable. The diffusion coefficient undergoes a rapid decay with time under low gas pressure, and undergoes a slow decay with under the high gas pressure.
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The outbreak of coronavirus disease 2019 (COVID-19) rapidly spreads across worldwide and becomes a global pandemic. Remdesivir is the only COVID-19 treatment approved by U.S. Food and Drug Administration (FDA); however, its effectiveness is still under questioning as raised by the results of a large WHO Solidarity Trial. Herein, we report that the parent nucleotide of remdesivir, GS-441524, potently inhibits the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero E6 and other cells. It exhibits good plasma distribution and longer half-life (t1/2=4.8h) in rat PK study. GS-441524 is highly efficacious against SARS-CoV-2 in AAV-hACE2 transduced mice and murine hepatitis virus (MHV) in mice, reducing the viral titers in CoV-attacked organs, without noticeable toxicity. Given that GS-441524 was the predominant metabolite of remdesivir in the plasma, the anti-COVID-19 effect of remdesivir may partly come from the effect of GS-441524. Our results also supported that GS-441524 as a promising and inexpensive drug candidate in the treatment of COVID-19 and future emerging CoVs diseases.
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In electrochemistry, the carbazole is generally coupled to dimer but not to polymer. This work has reported that organic electropolymerization (OEP) of 4,4',4â³-tri(N-carbazolyl)triphenylamine (TCTA) would form a high cross-linked carbazole polymer by its high activity/reversibility and a synchronous viscosity control. It has significantly improved the OEP film quality of both hole-transporting and electroluminescent layers in organic light-emitting diodes. As a result, the conductivity and power efficiency of the organic light-emitting diodes with TCTA are eight and four times of that without TCTA. A prototype display device with a 1.7 in. monochrome passive matrix of 58 ppi under the driving chip is successfully fabricated with accurate pixel size and uniform electroluminescence, which shows a great potential of OEP in the electroluminescent application.
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BACKGROUND: Postretrieval extinction attenuates the pathological memory associated with psychiatric states such as drug addiction in both humans and rodents. The extinction of a learned response requires gene transcription and protein synthesis after memory retrieval in a time-dependent manner, yet the precise physiological basis after retrieval to allow extinction to neutralize a learned behavior is not fully understood. METHODS: In a cocaine conditioned place preference paradigm, we used a ribosomal tagging strategy to measure the translational state of hippocampal pyramidal neurons after the retrieval of cocaine-associated context memory. Using approaches of electrophysiology, neuronal tracing, and a doxycycline-dependent robust activity marking system, we investigated the cellular and molecular basis of retrieval-induced plasticity that facilitated the extinction. RESULTS: Bioinformatics analysis discovered the specific translational regulation of signaling pathways by retrieval and revealed Nptx2 as the hub gene. Manipulating Nptx2 in dorsal hippocampus bidirectionally regulated the extinction of cocaine-associated context memory as well as the retrieval-driven synaptic remodeling. The pentraxin (PTX) domain of NPTX2 recruited GluA1-AMPA receptors and enhanced the extinction and excitatory synaptic transmission that was prevented by overexpressing carboxyl cytoplasmic tail of GluA1. Furthermore, Nptx2 in retrieval-activated neurons was required for the extinction. CONCLUSIONS: The retrieval-driven upregulation of Nptx2 contributes to the synaptic remodeling in dorsal hippocampus and facilitates the extinction of cocaine-associated context memory, indicating a potential target for the treatment of cue-induced cocaine seeking.
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Cocaine-Related Disorders , Cocaine , Extinction, Psychological , Hippocampus/metabolism , Humans , Memory , Receptors, AMPA/metabolismABSTRACT
Based on the formation of an autotetraploid fish line (4nAUT, 4n = 200; F2-F11) derived from the distant hybridization of female Carassius auratus red var. (RCC, 2n = 100) × male Megalobrama amblycephala (BSB, 2n = 48), we produced autotriploid hybrids (3nAUT) by crossing females of RCC with males of 4nAUT and allotriploid hybrids (3nALT) by crossing females of Cyprinus carpio (CC, 2n = 100) with males of 4nAUT. The aim of this study was to comparatively investigate the reproductive characteristics of 3nALT and 3nAUT. We investigated morphological traits, chromosomal numbers, DNA content and gonadal development in 3nAUT and 3nALT. The results indicated both 3nAUT and 3nALT possessed 150 chromosomes and were triploid hybrids. The females and males of 3nALT and males of 3nAUT had abnormal gonadal development and could not generate mature eggs or sperm, but the females of 3nAUT had normal gonadal development and generated mature eggs at 2 years old. The females of 3nAUT generated different sizes of eggs, which fertilized with haploid sperm from RCC and formed viable diploid, triploid, and tetraploid offspring. The formation of these two kinds of triploid hybrids provides an ideal model for studying the reproductive traits of triploid hybrids, which is of great value in animal genetics and reproductive biology.
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Nonferrous metal smelting produces a large amount of Hg0 in flue gas, which has caused serious damage to the environment and human health. In this work, amorphous cobalt sulfide was synthesized by a liquid-phase precipitation method and was used for capturing gaseous Hg0 from simulated smelting flue gas at low temperatures (50~150 °C). In the adsorption process, Hg0 can be transformed into the stable mercury compound, which is confirmed to be HgS by X-ray photoelectron spectroscopy (XPS) and temperature programmed desorption of Hg (Hg-TPD) analysis. Meanwhile, XPS results also demonstrate that S22- species on the surface of cobalt sulfide play an important role in Hg0 transformation. At the temperature of 50 °C (inlet Hg0 concentration of 214 µg·m-3), the Hg0 adsorption capacity of cobalt sulfide (penetration rate of 25%) is as high as 2.07 mg·g-1, which is much higher than that of popular adsorbents such as activated carbons and metal oxides. In addition, it was found that the Hg0 removal efficiency by cobalt sulfide in the flue gas with high concentration of SO2 (5%) remained more than 94%. The good adsorption and Hg0 removal performance guarantee cobalt sulfide the great superiority and application potential in the treatment of Hg0 in smelting flue gas with high concentration of SO2.