An in vitro evaluation of the fatigue behavior of resin composite materials as part of a translational research cycle.

PURPOSE: This study aimed to reproduce and translate clinical presentations in an in vitro set-up and evaluate laboratory outcomes of mechanical properties (flexural strength, fatigue resistance, wear resistance) and link them to the clinical outcomes of the employed materials in the Radboud Tooth Wear Project (RTWP). MATERIALS AND METHODS: Four dental resin composites were selected. 30 discs (Ø12.0 mm, 1.2 mm thick) were fabricated for each of Clearfil TM AP-X (AP), Filtek TM Supreme XTE (FS), Estenia TM C&B (ES), and Lava Ultimate (LU). Cyclic loading (200 N, 2 Hz frequency) was applied concentrically to 15 specimens per group with a spherical steatite indenter (r = 3.18 mm) in water in a contact-load-slide-liftoff motion (105 cycles). The wear scar was analysed using profilometry and the volume loss was digitally computed. Finally, all specimens were loaded (fatigued specimens with their worn surface loaded in tension) until fracture in a biaxial flexure apparatus. The differences in volume loss and flexural strength were determined using regression analysis. RESULTS: Compared to AP and FS, ES and LU showed a significantly lower volume loss (p < 0.05). Non-fatigued ES specimens had a similar flexural strength compared to nonfatigued AP, while non-fatigued FS and LU specimens had a lower flexural strength (p < 0.001; 95 %CI: -80.0 - 51.8). The fatigue test resulted in a significant decrease of the flexural strength of ES specimens, only (p < 0.001; 95 %CI: -96.1 - -54.6). CLINICAL RELEVANCE: These outcomes concur with the outcomes of clinical studies on the longevity of these composites in patients with tooth wear. Therefore, the employed laboratory test seems to have the potential to test materials in a clinically relevant way.

[Restorative treatment of generalized tooth wear]. / Restauratieve behandeling van gegeneraliseerde gebitsslijtage.

A 24-year-old patient with generalized tooth wear was referred to the Radboud Tooth Wear Project. The tooth wear had a chemical aetiology, caused by gastro-oesophageal reflux and resulting in functional problems of the masticatory system and a reduced quality of life. The treatment of the patient was minimally invasive, with directly applied composite restorations on all teeth, by means of which an increase of vertical dimension of occlusion was introduced. The restorative treatment was not preceded by testing of the new vertical dimension of occlusion. The patient was able to function well again after restorative treatment.

[Measuring tooth wear with regular intra-oral 3D scanners: for still in the future, or is it already possible?] / Serie: Innovatieve technieken en ontwikkelingen in de mondzorg. Meten van gebitsslijtage met reguliere 3D-scanners: toekomstmuziek, of al mogelijk?

Quantitative tooth wear measurement is a method of increasing importance when measuring tooth wear progression. The Radboud university medical center has developed a protocol that measures height and volumetric differences on regular 3D-scans. Intra-oral scans were made on patients with tooth wear and superimposed. To assess reliability the precision , as well as intra- and inter-rater precision of the protocol was tested. T-tests were performed to determine the structural and random error. Our findings indicate that the method is precise enough to measure height differences in patients with severe tooth wear progression, or tooth wear with an interval longer than 1 year. The method is not precise enough to measure volumetric changes.

Randomized controlled trial on the performance of direct and indirect composite restorations in patients with severe tooth wear.

OBJECTIVE: The study aimed to evaluate survival and failure behavior of Direct Composite Restorations (DRC) and Indirect Composite Restorations (ICR) on molars and anterior teeth, in a Randomized Controlled Trial (RCT). METHODS: Patients with generalized severe tooth wear were included, and randomly assigned to one of 2 protocols: (1) DCR: All teeth were restored with directly applied micro-hybrid composite restorations (Clearfil AP-X, Kuraray) for load bearing areas and nano-hybrid composite restorations (IPS Empress Direct, Ivoclar Vivadent) for buccal veneers; (2) ICR: First molars were restored with indirect composite 'tabletop' restorations and maxillary anterior teeth were restored with indirect palatal veneer restorations (Clearfil Estenia C&B, cemented with Panavia F, Kuraray). Remaining teeth were restored directly. Restorations were evaluated after 3 years, focusing on clinical acceptability. Statistical analysis was performed using Kaplan Meier curves, Annual Failure Rates (AFRs), and univariate Cox regression analyses (p < 0.05). RESULTS: 41 patients (age: 36.6 ± 6.6y) were evaluated after 3 years (40.0 ± 2.2 m). 408 restorations on first molars and palatal veneers on maxillary anterior teeth were part of this RCT, with 220 DCRs and 188 ICRs. No differences in survival between treatment modality for palatal veneers for any failure criteria were found. Tabletop restorations on first molars showed a considerable higher failure rate for ICR compared to DCR (p = 0.026, HR: 3.37, 95%CI = 1.16-9.81). SIGNIFICANCE: In this RCT, directly applied composite restorations showed superior behavior compared to the indirect composite restorations, when used in the molar region.

An investigation into the impact of tooth wear on the oral health related quality of life amongst adult dental patients in the United Kingdom, Malta and Australia.

OBJECTIVE: To investigate the relationship between levels of tooth wear scored using the Basic Erosive Wear Examination (BEWE) and the impact on the quality of life of adult dental patients. METHODS: BEWE assessments were performed on 319 new dentate adult patients attending the practices of 5 trained recruiters based in primary care in Malta (120), Australia (118) or the UK (81). Oral impacts on the quality of life were measured using a shortened form of the Oral Health Impact Profile (OHIP-26). Regression analysis were performed, adjusted for age, to estimate the relationship between the variables. Data were expressed as Confidence Intervals (95 % CI), p-values (values <0.05 were considered statistically significant) and adjusted R2 values. RESULTS: Overall, the sample had a mean age of 42.6 ±â€¯17.1 (range, 18-93 years), a mean cumulative BEWE score of 6.7 ±â€¯4.4 and a mean total OHIP-26 score of 1.84 ±â€¯0.59. For the cumulative sextant BEWE scores, 68.0 % of the participants scored ≤ 8, 24.5 % between 9 and 13 and 7.5 %, ≥ 14. A significant association was found between increasing BEWE score and the overall OHIP-26 total score (effect = 0.028; p = 0.002), implying a higher BEWE to be associated with a larger impact of oral conditions on daily life. CONCLUSION: Higher levels of tooth wear were significantly associated with a deteriorating oral-health related quality of life amongst the participants. CLINICAL RELEVANCE: When treatment planning for patients with tooth wear, it is appropriate to consider the psycho-social impact of the condition alongside other clinical findings.

[Cup-shaped tooth wear defects: more than erosive challenges?] / Komvormige defecten in occlusale vlakken van molaren: meer dan alleen erosieve belasting?

The underlying mechanism of the development of cups and grooves on occlusal tooth surfaces is still unclear. The aim of this study was to evaluate factors contributing to in-vitro cup formation, and to elucidate the clinical process. Extracted human molar teeth were exposed to acidic aqueous solutions at pH of 4.8 and 5.5 in combination with different loading conditions: no load (0N, control), 30N or 50N. Before and after 3 months exposure, the samples were scanned using a non-contact profilometer. A statistically significant difference between a loading of 0N and 50N was found at pH 4.8 (p < 0.002). Cup shaped lesions had formed only at pH of 4.8, in the 30N and 50N groups. The study showed that a cup can arise fully in enamel and that this requires simultaneous acidic and mechanical loading.

[European statement of consensus regarding the treatment of severe tooth wear]. / Europese consensusverklaring over de behandeling van ernstige gebitsslijtage.

In 2016, a European consensus meeting was held regarding the treatment of severe tooth wear. This meeting resulted in the publication of the European statement of consensus on the treatment of severe tooth wear in 2017. In the statement, new definitions of physiological and pathological tooth wear are described, recommendations for diagnosis and taking preventive measure are presented, and advice for counseling and monitoring is offered to better elucidate the underlying aetiological factors causing tooth wear in the patient. The decision whether restorative treatment is appropriate is multifactorial and partially dependent on the severity and the consequences of the wear and on the aesthetic and functional wishes of the patient. Restorative intervention should be delayed as long as possible, but when such intervention is indicated, the preference is for minimally invasive techniques using direct, indirect or hybrid treatment methods.

Clinical performance of full rehabilitations with direct composite in severe tooth wear patients: 3.5 Years results.

OBJECTIVES: To evaluate the mid-term clinical performance of direct composite restorations placed in patients with pathological tooth wear needing full rehabilitation with an increase of vertical dimension of occlusion. METHODS: In a prospective trial 34 patients (34.0 ±â€¯8.4 years; 25 males, 9 females) were treated with a minimal invasive additive technique using composite restorations. The restorative treatment protocol was to provide all teeth with composite build-up restorations in an increased vertical dimension of occlusion (VDO) using the DSO-technique. Recall appointments were planned after 1 month, 1 and 3 years after treatment. Restorations were scored for clinically acceptability (FDI-criteria) and scores 4 and 5 were recorded as clinically unacceptable. Frequencies of failures and Kaplan Meier survival curves are presented and effect of relevant variables was calculated with a multifactorial Cox regression (p < 0.05). RESULTS: 1256 Restorations were placed, 687 anterior, 324 premolar, and 245 molar restorations. After a mean observation time of 39.7 months a total of 69 failures were observed, of which 61 restorations were repaired (score 4) and 8 were replaced (score 5). Most common reasons for failure were (chip) fractures (n = 43) and caries (n = 11). Placement of anterior restorations in two sessions led to significant 4.6 times more failures then placed in one session. CONCLUSIONS: In patients with severe tooth wear a full rehabilitation, in an increased vertical dimension of occlusion, direct composite resin restorations show a 94.8% success and 99.3% survival rate after a period of 3.5 years.

Effect of different surface treatment techniques on the repair strength of indirect composites.

OBJECTIVES: Composite resin restorations present high survival rates and when a failure occurs repair is often possible. The aim of this study was to assess the effect of various repair techniques on indirect restorations. METHODS: LAVA Ultimate (3M), and Clearfil Estenia blocks (Kuraray) were repaired with our without surface roughness treatments, silane application and artificial ageing. Micro-shear bond stress tests were performed, while cohesive strength served as positive control. ANOVA was used for cohesive strength and effect of ageing, and linear mixed models to evaluate the effect of treatment variables on repair strength. RESULTS: Both materials reacted differently on surface treatments. Untreated (no treatment, no silane) repair strength was 16.3±6.3MPa for LAVA Ultimate and 19.0±4.3MPa for Estenia. Thermal cycling resulted in a 14-58% reduction of cohesive strength. Without cycling, all treatments resulted in a significant increase of bond strength in LAVA Ultimate (p<0.003). After cycling use of air-abrasion showed a positive trend for both substrates, significantly effective for LAVA Ultimate (p<0.04), and silane and CoJet for Estenia (p<0.024). The positive effect of HF treatment disappeared after cycling. CONCLUSION: It may be concluded that (1) the effect of surface treatment procedures on the repair bond strength of indirect composites is depended on the substrate and ageing. (2) Silane did not have a clear overall positive effect on bond strength and (3) artificial ageing had a strong negative influence on the stability of the adhesive interface and on the cohesive strength of one indirect composite resin material, but not the other.

[Intra-oral restoration and correction of single- and multi-unit dental prostheses]. / Intraorale reparatie en correctie van kronen en bruggen.

In cases of a fracture of the porcelain or non-aesthetic margin of a correctly functioning single- or multi-unit dental prosthesis, an intra-oral restoration or correction using a resin composite can generally be chosen. To establish adhesion to metal, porcelain, resin and composite, macro-mechanical, micromechanical and/or chemical retention methods are available. In order to achieve macro-mechanical retention, the preparation ofpits, grooves and/or undercuts is necessary. Micromechanical retention indicates surface roughening of the prosthodontic material at microscopic level through etching or sand-blasting. For chemical retention methods, special primers are used which may react chemically with the several prosthodontic materials. The treatment of choice is determined by the prosthodontic material and the feasibility of the retention method.

Influence of volumetric shrinkage and curing light intensity on proximal contact tightness of class II resin composite restorations: in vitro study.

BACKGROUND: Proximal contact tightness of class II resin composite restorations is influenced by a myriad of factors. Previous studies investigated the role of matrix band type and thickness, consistency of resin composite, and technique of placement. However, the effect of volumetric shrinkage of resin and intensity of curing light has yet to be determined. Thus, the aim of this study was to identify the influence of these factors on the proximal contact tightness when restoring class II cavity preparations in vitro. METHODS: Sixty artificial molars were restored with either a low-shrinkage (Filtek Silorane, 3M ESPE) or a conventional (Z100, 3M ESPE) composite and polymerized with low-intensity (Smartlite IQ2, Dentsply) or high-intensity light curing units (Demi(TM), Kerr). Proximal contact tightness was measured using the Tooth Pressure Meter. Data were statistically analyzed using one-way analysis of variance and Tukey post hoc test. RESULTS: Use of low-shrinkage composite (Filtek Silorane) resulted in significantly tighter proximal contacts compared to the use of conventional composite (Z100) when cured with the same polymerization unit (p<0.001). Moreover, the low-intensity curing unit (IQ2) resulted in significantly tighter contacts than the high-intensity unit when material is constant (p<0.001). CONCLUSIONS: Low-shrinkage resin composite and low curing light intensity is associated with tighter proximal contact values.

Creating tight proximal contacts for MOD resin composite restorations.

OBJECTIVE: The purpose of this study was to compare proximal contact tightness (PCT) of MOD resin composite restorations placed with different matricing protocols. METHODS: Forty-five ivorine lower right first molars with standardized MOD cavities were equally divided into three groups according to the restoration protocol. Group 1: Sectional matrix (Standard matrix, Palodent, Dentsply) secured with a wedge (Premier Dental Products Co.) and separation ring (BiTine I, Palodent, Dentsply, York, PA, USA) was used to restore the mesial surface first and then removed and repeated for the distal surface. Group 2: Identical to group 1, but separation rings were placed at both the mesial and distal sides (BiTine I+II, Palodent) prior to restoration. Mesial surface was restored followed by distal. Group 3: Walser matrix (O-form, Dr. Walser Dental GmbH) was used. Following composite resin restoration, PCT was measured using the tooth pressure meter. Data were analyzed using analysis of variance and a Tukey post hoc test (p<0.05). RESULTS: PCT values for mesial contacts were 2.99 ± 0.47N for group 1, 4.57 ± 0.36N for group 2, and 3.03 ± 0.79N for group 3. For the distal contacts, the values were 4.46 ± 0.44N for group 1, 5.12 ± 0.13N for group 2, and 0.76 ± 0.77N for group 3. Significantly tighter contacts were obtained for mesial and distal contacts for group 2 compared to groups 1 and 3 (p<0.05). For groups 1 and 3, mesial contacts were not significantly different (p=0.993), while distal contacts for group 1 were significantly tighter (p<0.001). CONCLUSION: Within the limitations of this study, tighter contacts can be obtained when sectional matrices and separation rings are applied to both proximal surfaces prior to placement of the resin composite in MOD cavities.

Surface roughness of etched composite resin in light of composite repair.

OBJECTIVES: In search for clinically effective composite repair protocols, the effect of various etching protocols on the surface roughness of composite resins with different filler composition were investigated. METHODS: Of two composite resins (hybrid-filled Clearfil AP-X; nano-filled Filtek Supreme XT) specimens of 3mm thick with a diameter of 7 mm were prepared (n=24). The top surface was polished with 4000-grit SiC-abrasive paper and subjected to one of eight surface treatments: (n=3): negative control (NC), 37% phosphoric acid for 20s (37PA-20s), 3% hydrofluoric acid for 20s (3HF-20s), for 120 s (3HF-120 s), 9.6% hydrofluoric acid for 20s (9.6HF-20s), for 120 s (9.6%HF-120 s), 37PA-20s followed by 9.6%HF for 120 s (37PA-20s/9.6HF-120 s) and 9.6%HF for 120 s followed by 37PA-20s (9.6HF-120s/37PA-20s). Roughness (S(a)) was measured using a 3D noncontact optical interferometer (WYKO) and surface topography imaged by SEM. Multilevel models were used to estimate the variances within a sample and between samples in each group. Using the resulting overall variances and the means for each group, the eight groups were compared consecutively using t-tests (p<0.05). RESULTS: The hybrid-filled composite resin demonstrated a significantly rougher surface than the nano-filled (p<0.05). For both composites 9.6%HF-120 s, 37PA-20s/9.6HF-120 s and 9.6%HF-120 s/37PA-20s resulted in a large increase in roughness compared to the other groups (p<0.05). For the hybrid-filled, the succeeding groups (37PA-20s, 3HF-20s, 3HF-120 s and 9.6HF-20s) resulted in a statistically significant increase in surface roughness (p<0.02). For the nano-filled only a statistically significant increase in roughness was found between 3HF-20s and 3HF-120 s (p<0.001) and between 9.6HF-20s and 9.6HF-120 s (p<0.001). SEM surface characterization revealed that the hybrid-filled composite resin was much more affected by etching than the nano-filled. SIGNIFICANCE: Composite resins should not be seen as a group of materials having identical properties when it comes to repair. The effect of etching will depend on the composition of the filler particles.

Is there one optimal repair technique for all composites?

OBJECTIVES: The aim of this study was to investigate the effectiveness of a variety of techniques to bond new composite to artificially aged composite of different compositions. METHODS: Composite resin blocks were made of five different commercially available composites (n=30) (Clearfil AP-X, Clearfil PhotoPosterior, Photo Clearfil Bright, Filtek Supreme XT and HelioMolar). After aging the composite blocks (thermo-cycling 5000×), blocks were subjected to one of 9 repair procedures: no treatment (control), diamond bur, sandblasting alumina particles, CoJet™, phosphoric acid, 3% hydrofluoric acid 20s or 120s, 9.6% hydrofluoric acid 20s or 120s. In addition, the cohesive strength of the tested composites was measured. Two-phase sandwiches ('repaired composite') were prepared using each of the 9 repair protocols, successively followed by silane and adhesive (OptiBond FL) treatment, prior to the application of the same composite. Specimens were subjected to micro-tensile bond strength testing. Data were analyzed using ANOVA and Tukey's HSD (p<0.05). RESULTS: For all composites the lowest bond strength was obtained when no specific repair protocol (control) was applied; the highest for the cohesive strength. Compared to the control for the microhybrid composite (Clearfil AP-X) five repair techniques resulted in a significantly higher repair strength (p<0.05), whereas for the nano-hybrid composite (Filtek Supreme XT) and hybrid composite containing quartz (Clearfil PhotoPosterior) only one repair technique significantly increased the bond strength (p<0.01). SIGNIFICANCE: None of the surface treatments can be recommended as a universally applicable repair technique for the different sorts of composites. To optimally repair composites, knowledge of the composition is helpful.

12-year survival of composite vs. amalgam restorations.

Information about the long-term clinical survival of large amalgam and composite restorations is still lacking. This retrospective study compares the longevity of three- and four-/five-surface amalgam and composite restorations relative to patients' caries risk. Patient records from a general practice were used for data collection. We evaluated 1949 large class II restorations (1202 amalgam/747 composite). Dates of placement, replacement, and failure were recorded, and caries risk of patients was assessed. Survival was calculated from Kaplan-Meier statistics. After 12 years, 293 amalgam and 114 composite restorations had failed. Large composite restorations showed a higher survival in the combined population and in the low-risk group. For three-surface restorations in high-risk patients, amalgam showed better survival.

Hydrofluoric acid on dentin should be avoided.

UNLABELLED: Hydrofluoric acid can be used for intra-oral repair of restorations. Contamination of tooth substrate with hydrofluoric acid cannot always be avoided. OBJECTIVES: To investigate the bonding effectiveness to hydrofluoric acid contaminated dentin by, micro-tensile bond strength testing, SEM and TEM. METHODS: For this study, 15 molar teeth were used of which dentin surfaces were subjected to five, different etching procedures. Group A, 37.5% phosphoric acid (Kerr Gel) (control group); group B, 37.5% phosphoric acid followed by 3% hydrofluoric acid (DenMat); group C, 37.5% phosphoric acid, followed by 9.6% hydrofluoric acid (Pulpdent); group D, 3% hydrofluoric acid followed by 37.5%, phosphoric acid; group E, 9.6% hydrofluoric acid followed by 37.5% phosphoric acid. After the bonding procedure (OptiBond FL, Kerr) a composite resin build-up (Clearfil AP-X, Kuraray), was made. After 1 week storage, specimens were prepared for micro-tensile bond testing, SEM- and, TEM-analysis. Data were analyzed using ANOVA and post hoc Tukey's HSD (p<0.05). RESULTS: In the control group (solely phosphoric acid), the mean microTBS was 53.4+/-10.6 MPa, which was, significantly higher than any hydrofluoric acid prepared group (group A versus groups B-E, p<0.001). No, significant differences in microTBS were found between the 3% and 9.6% hydrofluoric acid groups: group B versus group C (13.5+/-5.5 MPa and 18.7+/-4.3 MPa, respectively) or group D versus group E (19.9+/-6.8 MPa and 20.3+/-4.1 MPa, respectively). SIGNIFICANCE: Due to its adverse effect on the bond strength of composite to dentin, contact of hydrofluoric acid to dentin should be avoided.

Restoration techniques and marginal overhang in Class II composite resin restorations.

OBJECTIVES: The objective of the study was to compare in vitro interproximal overhang formation of Class II composite resin restoration when using different matrix systems. METHODS: 240 lower left molar phantom head teeth with an MO-preparation were divided into 12 groups (n=20). In six groups a circumferential matrix (Tofflemire X-thin matrix, HaweNeos 1001-c, SuperCap) was used, combined with either a hand-instrument (PFI49 or OptraContact) or separation ring (Composi-Tight Gold). In the other six groups two sectional matrix systems were used (flexible and dead-soft), with three separation rings (Composi-Tight Gold, Contact Matrix, Palodent BiTine). Matrices were secured with wooden wedges and preparations were restored with composite resin Clearfil AP-X (Kuraray) placed and polymerized in increments. After matrix removal overhang was measured on a standardized digital macroscopic image in mm(2). For analysis a multiple linear regression model was used. RESULTS: Use of circumferential matrices resulted in less overhang than sectional matrices (-0.85 mm2, p<0.001). A flexible matrix led to less overhang than dead-soft matrices (-0.54mm2, p<0.001), and no difference was found between straight and pre-contoured matrices (p=0.945). The insertion of the OptraContact resulted in a much increased overhang of 2.54 mm2 (p<0.001). The Composi-Tight Gold and the Contact Matrix System rings resulted in less overhang, -0.69 and -0.68 mm(2), respectively (both p<0.001), whereas the Palodent BiTine ring did not. CONCLUSIONS: Use of circumferential matrices or sectional flexible matrices resulted in the least marginal overhang when combined with a Contact Matrix separation ring or a Composi-Tight Gold ring.

The effect of proximal contour on marginal ridge fracture of Class II composite resin restorations.

OBJECTIVES: To compare the marginal ridge fracture strength of Class II composite resin restorations placed with a straight or contoured matrix band using composite resins with different modulus of elasticity. METHODS: In 60 artificial first molars standardized MO-preparations were ground. Two matrix systems were used: (1) A straight matrix (Standard Tofflemire Matrix, KerrHawe) in Tofflemire retainer (Produits Dentaire). (2) A contoured matrix (Standard matrix, Palodent, Dentsply). In both groups, a wooden wedge and separation ring (Composi-Tight Gold, GDS) were placed and the matrix was burnished against the adjacent tooth. Three composite resins together were used (Filtek Supreme: e-modulus 13.3 GPa (3M ESPE), Clearfil AP-X: 16.6 GPa (Kuraray) and Clearfil Majesty Posterior: 22.0 GPa (Kuraray)), resulting in six groups (n=10). Teeth were mounted into a MTS servo hydraulic testing machine (Mini Bionix II, MTS, USA) with stylus placed on the marginal ridge. Samples were loaded at a crosshead speed of 1.0mm/min until fracture occurred. Fracture resistance data were statistically analyzed using ANOVA and Scheffé's post hoc test for multiple comparison of groups (p<0.05). RESULTS: Contoured proximal surfaces (365.5+/-87.6N) resulted in significant stronger marginal ridges compared to straight surfaces (290.5+/-64.2N) (p<0.001). Clearfil AP-X (378.1+/-94.63N) provided a higher resistance to fracture than Filtek Supreme (301.4+/-67.3N) (p=0.001) and Clearfil Majesty Posterior (304.5+/-70.6N) (p=0.002). No differences were found between Filtek Supreme and Clearfil Majesty Posterior (p=0.890). CONCLUSION: Within the limitations of this in vitro study it was shown that use of a contoured matrix results in a stronger marginal ridge of a Class II composite resin restoration.