ABSTRACT
The novel HLA-C*08:275 allele, first described in a potential bone marrow donor from Brazil.
Subject(s)
Alleles , Exons , HLA-C Antigens , Humans , HLA-C Antigens/genetics , Brazil , Histocompatibility Testing , Tissue Donors , Base Sequence , Sequence Analysis, DNA/methods , Sequence Alignment , CodonABSTRACT
Introdução: A cefaleia pós punção dural (CPPD) é uma complicação da punção lombar, um procedimento que, apesar de bem tolerado, está sujeito a adversidades, ocorrendo devido a um vazamento persistente do líquido cefalorraquidiano (LCR) do local da punção dural. A incidência de CPPD pode estar relacionada às características dos pacientes e dos procedimentos. Notou-se que em mulheres jovens até 30 anos, o risco de CPPD é maior quando comparado aos homens, não apresentando diferença a partir da quinta década de vida. Objetivo: investigar os diferentes sintomas e efeitos gerados pelos diferentes tipos de agulha, como calibre e modo de inserção, que visem reduzir a CPPD. Métodos: Trata-se de uma revisão sistemática de literatura realizada no período de 2 de agosto a 20 de novembro de 2023 por meio de pesquisas no PubMed. Foram utilizados os descritores: "Post-Dural Puncture Headache" e suas variações do MeSH, sendo submetidos aos critérios de inclusão: estudos em humanos, nos últimos 10 anos, ensaios clínicos e ensaios clínicos controlados e randomizados. Para garantir a qualidade da revisão sistemática foi aplicada a lista de verificação PRISMA de 2020. Resultados: Após investigação estatística, observou-se que as agulhas 25W e 25S demandaram maior tempo médio para a coleta de LCR (15 e 7 min, respectivamente). Ao se comparar 25W com 20Q (3 min), 22S (5 min) e 25S quanto à esta variável, observouse diferença significativa em todas as comparações. Conclusão: As agulhas do tipo atraumática foram associadas com redução do risco de desenvolvimento de CPPD quando comparadas às convencionais. Foi constatado que, dentre as agulhas convencionais, a traumática de 25G é melhor para a prevenção de CPPD que a de 22G.
Introduction: Post-Dural Puncture Headache (PDPH) is a complication of lumbar puncture, a procedure that, despite being well-tolerated, is subject to adversities, occurring due to a persistent leakage of cerebrospinal fluid (CSF) from the site of dural puncture. The incidence of PDPH may be related to patient and procedural characteristics. It has been noted that in young women up to 30 years old, the risk of CPPD is higher compared to men, with no difference between sexes from the fifth decade of life onward. Objective: To investigate the different symptoms and effects generated by different types of needles, such as gauge and insertion method, aiming to reduce CPPD. Methods: Is a systematic literature review conducted from August to October 2023 through searches on PubMed. The descriptors "Post-Dural Puncture Headache" and its MeSH variations were used. A total of 1,839 articles were found, which were then subjected to inclusion criteria: studies conducted in the last 10 years, controlled trials, and randomized clinical trials. Results: After statistical investigation, it was observed that the 25W and 25S needles required a longer average time for cerebrospinal fluid collection (15 and 7 minutes, respectively). When comparing 25W with 20Q (3 minutes), 22S (5 minutes), and 25S regarding this variable, a significant difference was observed in all comparisons. Conclusion: Atraumatic needles were associated with a reduction in the risk of developing CPPD compared to conventional needles. It was found that among conventional needles, the traumatic 25G needle is better for preventing CPPD than the 22G needle.
ABSTRACT
The novel HLA-A*30:218 allele, first described in a potential bone marrow donor from Brazil.
Subject(s)
Alleles , Exons , HLA-A Antigens , Histocompatibility Testing , Sequence Analysis, DNA , Humans , HLA-A Antigens/genetics , Sequence Analysis, DNA/methods , Histocompatibility Testing/methods , Tissue Donors , Base Sequence , Brazil , Sequence AlignmentABSTRACT
BACKGROUND AND PURPOSE: Exercise-based interventions can be a safe alternative to improve and maintain physical and mental health during the aging process. The aim of the present study was to evaluate the effects of a 12-week training program with Dance Exergames on the mood and functional fitness profile of elderly women. METHODS: The sample (n = 22) was divided into Exergames (EG, n = 9, 70.6 ± 1.6 years) and Control Groups (CG, n = 13, 73.6 ± 2.2 years). Evaluations were carried out before and after the interventions. Each participant played, in pairs, the electronic game Dance Central 3, with the XBOX 360 Kinect console (Slim, Microsoft, USA). The EG trained for 12 weeks (24 sessions), with two weekly sessions of 50 min and the CG performed manual activities workshops. RESULTS: In functional fitness, both exercise training with exergame (EG) and the intervention model for the CG did not produce significant effects regarding interaction (group*time). Mood state presented significant effect of time intervention regarding tension (p = <0.001), depression (p = 0.001), anger (p = 0.030), fatigue (p = 0.001), and mental confusion (p = 0.004). CONCLUSION: Twelve weeks of training with a dance exergame (for, EG) and manual activities (for, CG) is enough to promote improvements in the mood state of healthy elderly women. This is an interesting result, as it shows that social interaction is as important a component as improving functional capacity.
Subject(s)
Dancing , Exergaming , Humans , Female , Aged , Brazil , Exercise/psychology , Quality of LifeABSTRACT
The novel HLA-DQB1*03:491 allele, first described in a potential bone marrow donor from Brazil.
Subject(s)
High-Throughput Nucleotide Sequencing , Polymorphism, Single Nucleotide , Humans , Alleles , Brazil , Bone Marrow Transplantation , HLA-DQ beta-Chains/geneticsABSTRACT
The novel HLA-C*04:01:145 allele, first described in a potential bone marrow donor from Brazil.
Subject(s)
HLA-C Antigens , High-Throughput Nucleotide Sequencing , Alleles , Bone Marrow Transplantation , Brazil , HLA-C Antigens/genetics , Humans , Polymorphism, Single NucleotideABSTRACT
The novel HLA-B*41:01:08 allele, first described in a potential bone marrow donor from Brazil.
Subject(s)
High-Throughput Nucleotide Sequencing , Polymorphism, Single Nucleotide , Alleles , Bone Marrow Transplantation , Brazil , HLA-B Antigens/genetics , HumansABSTRACT
The novel HLA-DRB1*03:196 allele, first described in a potential bone marrow donor from Brazil.
Subject(s)
Bone Marrow Transplantation , Polymorphism, Single Nucleotide , Alleles , Brazil , HLA-DRB1 Chains/genetics , High-Throughput Nucleotide Sequencing , HumansABSTRACT
The novel HLA-A*02:01:202 allele, first described in a potential bone marrow donor from Brazil.
Subject(s)
Bone Marrow , High-Throughput Nucleotide Sequencing , Alleles , Brazil , HLA-A Antigens/genetics , HumansABSTRACT
The novel HLA-A*29:158 allele, first described in potential bone marrow donors from Brazil.
Subject(s)
Bone Marrow , High-Throughput Nucleotide Sequencing , Alleles , Brazil , HLA-A Antigens/genetics , HumansABSTRACT
The novel HLA-A*33:221 allele, first described in a potential bone marrow donor from Brazil.
Subject(s)
Bone Marrow , High-Throughput Nucleotide Sequencing , Alleles , Brazil , HLA-A Antigens/genetics , HumansABSTRACT
Resumo Este artigo analisa como a Política Nacional de Saúde Integral da População Negra (PNSIPN) tem sido implementada na atenção à saúde em três municípios do Estado da Bahia, Brasil. Trata-se de um estudo qualitativo que faz parte da primeira etapa de uma pesquisa-ação, na qual foram realizadas entrevistas semiestruturadas com 27 profissionais de unidades de Saúde da Família, Atenção Básica e Sede do Distrito Sanitário. Após análise de conteúdo, emergiram quatro categorias: Atenção Primária à Saúde (APS); Saúde da População Negra; Atenção à saúde na diversidade; e PNSIPN. Como resultado, os profissionais apresentaram entendimento superficial sobre a APS, apesar de a reconhecerem como porta de entrada. A relevância de uma atenção à saúde específica para a população negra foi desconsiderada, sob o argumento de que todos são iguais. A diversidade racial não foi reconhecida dentro do cotidiano, sendo o termo atrelado à diversidade LGBTQIA+ e aos ciclos de vida. O dado comum nos municípios foi o desconhecimento da PNSIPN e dos meios práticos para inseri-la no cotidiano do trabalho. A ausência da política para essa população no processo de planejamento e trabalho dos serviços revela a urgência da educação permanente em saúde para a apropriação do princípio de equidade pelas gestoras e profissionais.
Abstract This study analyzes how the National Policy on Comprehensive Health of the Black Population (PNSIPN) has been implemented in three municipalities in the state of Bahia, Brazil. This qualitative study is part of an ongoing action research, in which semi-structured interviews were performed with 27 professionals from family health, primary health care, and health district headquarters. Content analysis presented four categories: primary health care (PHC); Black health; health care in diversity; and PNSIPN. Health professionals showed a superficial understanding of PHC, despite recognizing it as a gateway. A specific health care for the Black population was considered irrelevant, on the grounds that everyone is equal. Diversity was linked to the LGBTQIA+ population and life cycles, but not to ethnicity or skin color. All municipalities lacked knowledge about the PNSIPN and the practical means to implement it in their daily work. Its absence in the services' planning and work processes shows an urgent need for permanent education in health so that managers and professional can appropriate the principle of equity.
Subject(s)
Humans , Male , Female , Primary Health Care , Public Policy , Health Equity , Health of Ethnic Minorities , Health Policy , Qualitative ResearchABSTRACT
The novel HLA-DQA1*03:03:05 allele, first described in a potential bone marrow donor from Brazil.
Subject(s)
High-Throughput Nucleotide Sequencing , Polymorphism, Single Nucleotide , Alleles , Brazil , HLA-DQ alpha-Chains/genetics , HumansABSTRACT
The novel HLA-A*68:272 allele, first described in a potential bone marrow donor from Brazil.
Subject(s)
Bone Marrow Transplantation , Bone Marrow , Alleles , Brazil , HLA-A Antigens/genetics , High-Throughput Nucleotide Sequencing , HumansABSTRACT
The novel HLA-DPA1*04:03 allele, first described in a potential bone marrow donor from Brazil.
Subject(s)
HLA-DP alpha-Chains , High-Throughput Nucleotide Sequencing , Alleles , Brazil , HLA-DP alpha-Chains/genetics , HumansABSTRACT
The novel HLA-DPB1*04:01:51 allele first described in a potential bone marrow donor from Brazil.
Subject(s)
Bone Marrow Transplantation , Bone Marrow , Alleles , Brazil , HLA-DP beta-Chains , High-Throughput Nucleotide Sequencing , Humans , Polymorphism, Single NucleotideABSTRACT
Characterization of three novel HLA-DQA1 alleles: HLA-DQA1*01:02:01:15, -DQA1*03:03:01:15, and -DQA1*05:05:01:26.
Subject(s)
High-Throughput Nucleotide Sequencing , Polymorphism, Single Nucleotide , Alleles , Brazil , HLA-DQ alpha-Chains/genetics , HumansABSTRACT
Characterization of three novel HLA-DQB1 alleles: HLA-DQB1*04:02:01:11, -DQB1*05:01:01:13, and -DQB1*06:03:01:04.
Subject(s)
High-Throughput Nucleotide Sequencing , Alleles , Brazil , HLA-DQ beta-Chains/genetics , HumansABSTRACT
The novel HLA-A*02:952 allele, first described in a potential bone marrow donor from Brazil.
Subject(s)
Bone Marrow Transplantation , Bone Marrow , Alleles , Brazil , HLA-A Antigens/genetics , High-Throughput Nucleotide Sequencing , Humans , Polymorphism, Single NucleotideABSTRACT
The novel HLA-A*24:516 allele, first described in two unrelated potential bone marrow donors from Brazil.