1.
Angew Chem Int Ed Engl
; 38(9): 1255-1257, 1999 May 03.
Article
in English
| MEDLINE
| ID: mdl-29711739
ABSTRACT
Bulge cleavage of two or three bases occurs when a DNA substrate is specifically cleaved oxidatively by [CoII (tfa)2 (happ)] (see picture). Hydrogen peroxide is necessary for the activation of this octahedral complex, which suggests that hydroxyl radicals are the reactive species. The complex has no significant reactivity towards the corresponding sequence in a single-stranded DNA region, and it exhibits only a low affinity towards double-stranded DNA. happ=macrocyclic ligand based on 1,10-phenanthroline, tfa=trifluoroacetate.