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1.
Phase II trial of epirubicin in gastric cancer.
Scarffe, J H; Kenny, J B; Johnson, R J; Owens, S E; Giles, G R; Leveson, S H; Maley, W V.
Cancer Treat Rep ; 69(11): 1275-7, 1985 Nov.
Article in English | MEDLINE | ID: mdl-3867402

ABSTRACT

Patients with advanced inoperable or recurrent adenocarcinoma of the stomach received an iv bolus of epirubicin (75 mg/m2) every 3 weeks. Partial responses were observed in four of 24 evaluable patients (17%). Treatment was generally well tolerated; a drop in left ventricular ejection fraction was observed in one patient who had received 450 mg/m2 of epirubicin.


Subject(s)
Doxorubicin/therapeutic use , Stomach Neoplasms/drug therapy , Adenocarcinoma/drug therapy , Adult , Aged , Anemia/chemically induced , Doxorubicin/adverse effects , Drug Evaluation , Epirubicin , Female , Humans , Male , Middle Aged , Stroke Volume/drug effects
2.
Phase II evaluation of melphalan in adenocarcinoma of the pancreas.
Smith, D B; Kenny, J B; Scarffe, J H; Maley, W V.
Cancer Treat Rep ; 69(7-8): 917-8, 1985.
Article in English | MEDLINE | ID: mdl-4016799

Subject(s)
Adenocarcinoma/drug therapy , Melphalan/therapeutic use , Pancreatic Neoplasms/drug therapy , Adult , Aged , Drug Evaluation , Female , Hematologic Diseases/chemically induced , Humans , Male , Melphalan/adverse effects , Middle Aged , Nausea/chemically induced
3.
Phase II trial of vindesine in advanced gastric cancer.
Kenny, J B; Scarffe, J H; Maley, W V.
Cancer Treat Rep ; 67(1): 89-90, 1983 Jan.
Article in English | MEDLINE | ID: mdl-6311414

Subject(s)
Adenocarcinoma/drug therapy , Stomach Neoplasms/drug therapy , Vinblastine/analogs & derivatives , Adenocarcinoma/mortality , Adult , Aged , Drug Evaluation , Female , Humans , Male , Middle Aged , Peripheral Nervous System Diseases/chemically induced , Stomach Neoplasms/mortality , Time Factors , Vinblastine/adverse effects , Vinblastine/therapeutic use , Vindesine
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